Research output per year
Research output per year
- 44 results
Search results
-
2023
Modelling solution speciation to predict pH and supersaturation for design of batch and continuous organic salt crystallisation processes
McGinty, J., Wheatcroft, H., Price, C. J. & Sefcik, J., 28 Feb 2023, In: Fluid Phase Equilibria. 565, 11 p., 113676.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)66 Downloads (Pure) -
2022
Multicomponent chiral quantification with Ultraviolet circular dichroism spectroscopy: ternary and quaternary phase diagrams of Levetiracetam
Charpentier, M. D., Venkatramanan, R., Rougeot, C., Leyssens, T., Johnston, K. & ter Horst, J. H., 5 Dec 2022, (E-pub ahead of print) In: Molecular Pharmaceutics. 20, 1, p. 616-629 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)42 Downloads (Pure) -
Temperature correction of spectra to improve solute concentration monitoring by in situ ultraviolet and mid-infrared spectrometries towards isothermal local model performance
Chong, M. W. S., McGlone, T., Chai, C. Y., Briggs, N. E. B., Brown, C. J., Perciballi, F., Dunn, J., Parrott, A. J., Dallin, P., Andrews, J., Nordon, A. & Florence, A. J., 18 Nov 2022, In: Organic Process Research and Development. 26, 11, p. 3096-3105 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)49 Downloads (Pure) -
Tuning interfacial concentration enhancement through dispersion interactions to facilitate heterogeneous nucleation
McKechnie, D., Mulheran, P. A., Sefcik, J. & Johnston, K., 29 Sept 2022, In: Journal of Physical Chemistry C. 126, 38, p. 16387-16400 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)22 Downloads (Pure) -
Comparing and quantifying the efficiency of cocrystal screening methods for Praziquantel
Charpentier, M. D., Devogelaer, J.-J., Tijink, A., Meekes, H., Tinnemans, P., Vlieg, E., de Gelder, R., Johnston, K. & ter Horst, J. H., 7 Sept 2022, In: Crystal Growth and Design. 22, 9, p. 5511-5525 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)31 Downloads (Pure) -
Phase diagram determination and process development for continuous antisolvent crystallizations
Mack, C., Hoffmann, J., Sefcik, J. & ter Horst, J. H., 6 Aug 2022, In: Crystals. 12, 8, 15 p., 1102.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)31 Downloads (Pure) -
Effect of oscillatory flow conditions on crystalliser fouling investigated through non-invasive imaging
Sheridan, R., Cardona, J., Tachtatzis, C., Chen, Y.-C., Cleary, A., Briggs, N. E. B., Florence, A., Atkinson, R., Michie, C., Andonovic, I. & Sefcik, J., 28 Apr 2022, In: Chemical Engineering Science . 252, 117188.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)47 Downloads (Pure) -
The unexpected dominance of secondary over primary nucleation
Hoffmann, J., Flannigan, J., Cashmore, A., Briuglia, M., Steendam, R. R. E., Gerard, C. J. J., Haw, M. D., Sefcik, J. & ter Horst, J. H., 17 Jan 2022, In: Faraday Discussions. 235, p. 109-131 23 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2021
Heat transfer and residence time distribution in plug flow continuous oscillatory baffled crystallisers
Briggs, N. E. B., McGinty, J., McCabe, C., Raval, V., Sefcik, J. & Florence, A. J., 20 Jul 2021, In: ACS Omega. 6, 28, p. 18352-18363 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)274 Downloads (Pure) -
2020
Quantification of particle size and concentration using in-line techniques and multivariate analysis
Ferreira, C., Cardona, J., Agimelen, O., Tachtatzis, C., Andonovic, I., Sefcik, J. & Chen, Y.-C., 31 Oct 2020, In: Powder Technology. 376, p. 1-11 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)75 Downloads (Pure) -
A structured approach to cope with impurities during industrial crystallization development
Urwin, S. J., Levilain, G., Marziano, I., Merritt, J. M., Houson, I. & Ter Horst, J. H., 21 Aug 2020, In: Organic Process Research and Development. 24, 8, p. 1443-1456 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Citations (Scopus)66 Downloads (Pure) -
2018
Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations
Brown, C. J., McGlone, T., Yerdelen, S., Srirambhatla, V., Mabbott, F., Gurung, R., Briuglia, M. L., Ahmed, B., Polyzois, H., McGinty, J., Perciballi, F., Fysikopoulos, D., Macfhionnghaile, P., Siddique, H., Raval, V., Harrington, T. S., Vassileiou, A. D., Robertson, M., Prasad, E. & Johnston, A. & 9 others, , 1 Jun 2018, In: Molecular Systems Design & Engineering. 2018, 3, p. 518-549 32 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Citations (Scopus)147 Downloads (Pure) -
Scaling up temperature cycling-induced deracemization by suppressing nonstereoselective processes
Steendam, R. R. E. & ter Horst, J. H., 2 May 2018, In: Crystal Growth and Design. 18, 5, p. 3008-3015 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)52 Downloads (Pure) -
Particle size distributions and performance of preferential crystallization of L-asparagine·H2O with tailor-made additives
Kongsamai, P., Flood, C., ter Horst, J. H. & Flood, A. E., 24 Mar 2018, (E-pub ahead of print) In: Chemical Engineering and Technology. 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)54 Downloads (Pure) -
Rapid continuous antisolvent crystallization of multi-component systems
Raza, S. A., Schacht, U., Svoboda, V., Edwards, D. P., Florence, A. J., Pulham, C. R., Sefcik, J. & Oswald, I. D. H., 3 Jan 2018, In: Crystal Growth and Design. 18, 1, p. 210-218 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)127 Downloads (Pure) -
2017
Combined chemoinformatics approach to solvent library design using clusterSim and multidimensional scaling
Johnston, A., Bhardwaj-Miglani, R., Gurung, R., Vassileiou, A. D., Florence, A. J. & Johnston, B. F., 28 Aug 2017, In: Journal of Chemical Information and Modeling. 57, 8, p. 1807-1815 9 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Crystallization diagram for antisolvent crystallization of lactose: using design of experiments to investigate continuous mixing- induced supersaturation
Macfhionnghaile, P., Svoboda, V., McGinty, J., Nordon, A. & Sefcik, J., 3 May 2017, In: Crystal Growth and Design. 17, 5, p. 2611-2621 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)289 Downloads (Pure) -
Effect of additives on the preferential crystallization of L-asparagine monohydrate
Kongsamai, P., Maneedaeng, A., Flood, C., ter Horst, J. H. & Flood, A. E., 18 Apr 2017, (E-pub ahead of print) In: European Physical Journal: Special Topics. 226, 5, p. 823-835 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)173 Downloads (Pure) -
Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts
Svoboda, V., MacFhionnghaile, P., McGinty, J., Connor, L. E., Oswald, I. D. H. & Sefcik, J., 5 Apr 2017, In: Crystal Growth and Design. 17, 4, p. 1902-1909 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)204 Downloads (Pure) -
Towards deracemization in the absence of grinding through crystal transformation, ripening, and racemization
Xiouras, C., Van Cleemput, E., Kumpen, A., Ter Horst, J. H., Van Gerven, T. & Stefanidis, G. D., 1 Feb 2017, In: Crystal Growth and Design . 17, 2, p. 882-890 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)68 Downloads (Pure) -
A factorial approach to understanding the effect of inner geometry of baffled meso-scale tubes on solids suspension and axial dispersion in continuous, oscillatory liquid-solid plug flows
Ejim, L. N., Yerdelen, S., McGlone, T., Onyemelukwe, I., Johnston, B., Florence, A. J. & Reis, N. M., 15 Jan 2017, In: Chemical Engineering Journal. 308, p. 669–682 14 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Citations (Scopus) -
2016
Solid separation from a mixed suspension through electric-field-enhanced crystallization
Li, W., Radacsi, N., Kramer, H. J. M., van der Heijden, A. E. D. M. & ter Horst, J. H., 23 Dec 2016, In: Angewandte Chemie International Edition. 55, 52, p. 16088-16091 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)128 Downloads (Pure) -
PAT-based design of agrochemical co-crystallization processes: a case-study for the selective crystallization of 1:1 and 3:2 co-crystals of p-toluenesulfonamide/triphenylphosphine oxide
Powell, K. A., Croker, D. M., Rielly, C. D. & Nagy, Z. K., 2 Oct 2016, In: Chemical Engineering Science. 152, p. 95-108 14 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Citations (Scopus)19 Downloads (Pure) -
Deracemization of a racemic compound via its conglomerate-forming salt using temperature cycling
Li, W. W., Spix, L., De Reus, S. C. A., Meekes, H., Kramer, H. J. M., Vlieg, E. & ter Horst, J. H., 7 Sept 2016, In: Crystal Growth and Design . 16, 9, p. 5563-5570 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile74 Citations (Scopus)112 Downloads (Pure) -
Filtration suppresses laser-induced nucleation of glycine in aqueous solutions
Javid, N., Kendall, T., Burns, I. S. & Sefcik, J., 3 Aug 2016, In: Crystal Growth and Design. 16, 8, p. 4196−4202 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Citations (Scopus)94 Downloads (Pure) -
Effect of oscillatory flow on nucleation kinetics of butyl paraben
Yang, H., Yu, X., Raval, V., Makkawi, Y. & Florence, A., 3 Feb 2016, In: Crystal Growth and Design . 16, 2, p. 875-886 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)79 Downloads (Pure) -
Scaling of glycine nucleation kinetics with shear rate and glass-liquid interfacial area
Forsyth, C., Burns, I. S., Mulheran, P. A. & Sefcik, J., 6 Jan 2016, In: Crystal Growth and Design. 16, 1, p. 136–144 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)186 Downloads (Pure) -
2015
Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer
Briggs, N. E. B., Schacht, U., Raval, V., McGlone, T., Sefcik, J. & Florence, A. J., 18 Dec 2015, In: Organic Process Research and Development. 19, 12, p. 1903−1911 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Citations (Scopus)256 Downloads (Pure) -
Achieving continuous manufacturing: technologies and approaches for synthesis, workup, and isolation of drug substance. May 20-21, 2014 Continuous Manufacturing Symposium
Baxendale, I. R., Braatz, R. D., Hodnett, B. K., Jensen, K. F., Johnson, M. D., Sharratt, P., Sherlock, J.-P. & Florence, A. J., 1 Mar 2015, In: Journal of Pharmaceutical Sciences. 104, 3, p. 781-791 11 p.Research output: Contribution to journal › Article › peer-review
149 Citations (Scopus) -
Achieving continuous manufacturing May 20-21, 2014 Continuous Manufacturing Symposium
Badman, C. & Trout, B. L., Mar 2015, In: Journal of Pharmaceutical Sciences. 104, 3, p. 779-780 2 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
Future supply chains enabled by continuous processing - opportunities and challenges: May 20–21, 2014 continuous manufacturing symposium
Srai, J. S., Badman, C., Krumme, M., Futran, M. & Johnston, C., Mar 2015, In: Journal of Pharmaceutical Sciences. 104, 3, p. 840-849 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile130 Citations (Scopus)144 Downloads (Pure) -
Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system
Yang, H. & Rasmuson, Å. C., 15 Jan 2015, In: Fluid Phase Equilibria. 385, p. 120-128 9 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2014
GRP receptor imaging of prostate cancer using [(99m)Tc]Demobesin 4: a first-in-man study
Mather, S. J., Nock, B. A., Maina, T., Gibson, V., Ellison, D., Murray, I., Sobnack, R., Colebrook, S., Wan, S., Halbert, G., Szysko, T., Powles, T. & Avril, N., Dec 2014, In: Molecular Imaging and Biology. 16, 6, p. 888-895 8 p.Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
Ternary phase diagrams of ethyl paraben and propyl paraben in ethanol aqueous solvents
Yang, H. & Rasmuson, Å. C., 25 Aug 2014, In: Fluid Phase Equilibria. 376, p. 69-75 7 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Influence of solvent and solid-state structure on nucleation of parabens
Yang, H., Svárd, M., Zeglinski, J. & Rasmuson, Å. C., 6 Aug 2014, In: Crystal Growth and Design . 14, 8, p. 3890-3902 13 p.Research output: Contribution to journal › Article › peer-review
57 Citations (Scopus) -
From discovery to scale-up: alpha-lipoic acid: nicotinamide co-crystals in a continuous oscillatory baffled crystalliser
Zhao, L., Raval, V., Briggs, N. E. B., Bhardwaj, R. M., McGlone, T., Oswald, I. D. H. & Florence, A. J., 14 Jul 2014, In: CrystEngComm. 16, 26, p. 5769-5780 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Citations (Scopus)217 Downloads (Pure) -
Determination of excipient based solubility increases using the CheqSol method
Etherson, K., Halbert, G. & Elliott, M., 25 Apr 2014, In: International Journal of Pharmaceutics. 465, 1-2, p. 202-209 8 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
2013
Population and size distribution of solute-rich mesospecies within mesostructured aqueous amino acid solutions
Jawor-Baczynska, A., Moore, B. D., Lee, H. S., McCormick, A. V. & Sefcik, J., 1 Dec 2013, In: Faraday Discussions. 167, p. 425–440 16 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
Nucleation of butyl paraben in different solvents
Yang, H. & Rasmuson, Å. C., 2 Oct 2013, In: Crystal Growth and Design . 13, 10, p. 4226-4238 13 p.Research output: Contribution to journal › Article › peer-review
67 Citations (Scopus) -
4th European conference for crystal growth-crystallisation in focus: from fundamentals to application
Florence, A. J., 28 Mar 2013, In: CrystEngComm. 15, 12, p. 2174-2174 1 p.Research output: Contribution to journal › Article › peer-review
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250 nm glycine-rich nanodroplets are formed on dissolution of glycine crystals but are too small to provide productive nucleation sites
Jawor-Baczynska, A., Sefcik, J. & Moore, B. D., Feb 2013, In: Crystal Growth and Design. 13, 2, p. 470-478 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile67 Citations (Scopus)139 Downloads (Pure) -
2012
Determination of metastable zone width, mean particle size and detectable number density using video imaging in an oscillatory baffled crystallizer
Brown, C. J. & Ni, X. W., 21 Apr 2012, In: CrystEngComm. 14, 8, p. 2944-2949 6 p.Research output: Contribution to journal › Article › peer-review
35 Citations (Scopus) -
2011
Evaluation of growth kinetics of antisolvent crystallization of paracetamol in an oscillatory baffled crystallizer utilizing video imaging
Brown, C. J. & Ni, X. W., 7 Sept 2011, In: Crystal Growth and Design . 11, 9, p. 3994-4000 7 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
Online evaluation of paracetamol antisolvent crystallization growth rate with video imaging in an oscillatory baffled crystallizer
Brown, C. J. & Ni, X., 2 Mar 2011, In: Crystal Growth and Design . 11, 3, p. 719-725 7 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus)