BTG- Researcher-led Project

  • Thennadil, Suresh (Principal Investigator)
  • McNeil, Brian (Principal Investigator)

Project: Internally funded project

Project Details


The complexity and number of reactions involved in a fermentation process prevent the direct determination of metabolites concentration profiles. The possibility of monitoring state transitions during the course of a fermentation through the analysis of on-line near-infrared (NIR) spectra with sample-sample two-dimensional correlation spectroscopy (SS-2DCoS) will be exploited for extracting process information. SS-2DCoS has the potential to identify fermentation state transitions due to metabolic and morphological changes of the microorganism, which could have a great impact for process supervision and control. This approach will be deployed to monitor fed-batch cultures of a major industrial expression system for biopharmaceuticals, Pichia pastoris.
Effective start/end date5/09/11 → …


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