BTG: Adsorption mechanism of protein onto biosurfaces

Using molecular simulation and experimental measurements, the adsorption process of proteins onto polymer surfaces will be investigated at single molecule level, focusing on the exemplar case of human serum albumin (HAS) on polyurethane (PU), which has particular relevance to biomedical applications. By studying the conformation and adsorption strength of the protein at the surface we will unravel the adsorption mechanism of HAS on PU surfaces. This will resolve some inconsistencies in previous studies regarding the suitability of PU as a material for coronary stents and give insight into how to engineer PU surfaces for this, and other, biomedical applications.