Project Details
Description
EP/S035990/1 £5,495, 023 from EPSRC.Prof William J. Kerr is the Strathclyde PI.
Next generation catalysis and synthesis: Chemists seeking to discover new medicines need new reactions that will allow them to make and investigate structures that are currently difficult, or even impossible, to make. A key objective of this proposal will be to develop new reagents, catalysts, and reactions to facilitate the more efficient preparation of drug-like molecules to accelerate drug discovery. Similarly, we will develop new ways of performing some of the most common chemical transformations in the synthesis of medicines whilst avoiding the use of carcinogenic reagents
Next generation catalysis and synthesis: Chemists seeking to discover new medicines need new reactions that will allow them to make and investigate structures that are currently difficult, or even impossible, to make. A key objective of this proposal will be to develop new reagents, catalysts, and reactions to facilitate the more efficient preparation of drug-like molecules to accelerate drug discovery. Similarly, we will develop new ways of performing some of the most common chemical transformations in the synthesis of medicines whilst avoiding the use of carcinogenic reagents
Layman's description
We make the discoveries that will lead to better medicines, sooner and more efficiently than has been possible to date
| Short title | Prosperity Partnership |
|---|---|
| Acronym | PP |
| Status | Finished |
| Effective start/end date | 1/01/19 → 31/12/23 |
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Expedient discovery of a metallaphotoredox cyanomethylation for synthesizing α-aryl nitriles
Cook, G. C., McKay, B., Jamieson, C., Edwards, L. J., Harriman, C., Read, Z. S. & Bate, S. T., 1 Apr 2026, (E-pub ahead of print) In: Chemistry - A European Journal. 13 p., e70946.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Optimization of potent and selective cyclohexyl acid ERAP1 inhibitors using structure- and property-based drug design
Hryczanek, R. P., Hackett, A. S., Rowland, P., Chung, C.-W., Convery, M. A., Holmes, D. S., Hutchinson, J. P., Kitchen, S., Korczynska, J., Law, R. P., Lea, J. D., Liddle, J., Lonsdale, R., Neu, M., Nickels, L., Phillipou, A., Rowedder, J. E., Schneck, J. L., Scott-Stevens, P. & Sheehan, H. & 8 others, , 12 Dec 2024, In: ACS Medicinal Chemistry Letters . 15, 12, p. 2107–2114 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)29 Downloads (Pure) -
Antibody-proteolysis targeting chimera conjugate enables selective degradation of receptor-interacting serine/threonine-protein kinase 2 in HER2+ cell lines
Chan, K., Sathyamurthi, P. S., Queisser, M. A., Mullin, M., Shrives, H., Coe, D. M. & Burley, G. A., 15 Nov 2023, In: Bioconjugate Chemistry. 34, 11, p. 2049-2054 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Link opens in a new tab Citations (Scopus)17 Downloads (Pure)