A comprehensive multidisciplinary approach to target the inhibitory kappa B kinase pathway to discover novel therapies in prostate cancer

MacKay, Simon (Principal Investigator)
Gray, Alexander (Co-investigator)
Harvey, Alan (Co-investigator)
Murphy, John (Co-investigator)
Paul, Andrew (Co-investigator)
Suckling, Colin (Co-investigator)

Project: Research

2 Article

2 results

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2024
Design and synthesis of novel aminoindazole-pyrrolo[2,3-b]pyridine inhibitors of IKKα that selectively perturb cellular non-canonical NF-κB signalling
Riley, C., Ammar, U., Alsfouk, A., Anthony, N. G., Baiget, J., Berretta, G., Breen, D., Huggan, J., Lawson, C., McIntosh, K., Plevin, R., Suckling, C. J., Young, L. C., Paul, A. & Mackay, S. P., 26 Jul 2024, In: Molecules. 29, 15, 29 p., 3515.
Research output: Contribution to journal › Article › peer-review

Open Access
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2 Citations (Scopus)

34 Downloads (Pure)
2017
Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers
Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N. & Scott, R. & 4 others, Suckling, C. J., Sutcliffe, O. B., Young, L. C. & MacKay, S. P., 24 Jul 2017, (E-pub ahead of print) In: Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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32 Citations (Scopus)

191 Downloads (Pure)