20122024
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Research Output 2012 2019

2019

Evaluation of temporal aggregation processes using spatial intensity distribution analysis

Rattray, Z., Zindy, E., Buzza, K. M. & Pluen, A., 23 Sep 2019, Protein Self-Assembly: Methods and Protocols. McManus, J. J. (ed.). New York, NY: Springer, p. 141-155 15 p. (Methods in Molecular Biology; vol. 2039).

Research output: Chapter in Book/Report/Conference proceedingChapter

Biological Models
Neurodegenerative Diseases
Population
Proteins
6 Downloads (Pure)

Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty

Rattray, N. J. W., Trivedi, D. K., Xu, Y., Chandola, T., Johnson, C. H., Marshall, A. D., Mekli, K., Rattray, Z., Tampubolon, G., Vanhoutte, B., White, I. R., Wu, F. C. W., Pendleton, N., Nazroo, J. & Goodacre, R., 5 Nov 2019, In : Nature Communications. 10, 1, 12 p., 5027.

Research output: Contribution to journalArticle

Open Access
File
carnitine
Carnitine
health
phenotype
Economics
2018

A DNA-damaging lupus autoantibody synergizes with PARP inhibitors against DNA repair-deficient tumor cells

Rattray, Z., Patel, J. M., Noble, P. W., Dubljevic, V., Greenwood, D. L., Campbell, J. A. & Hansen, J. E., 30 Jul 2018, In : Cancer Research. 78, 13 (Supp), p. 2773 1 p.

Research output: Contribution to journalMeeting abstract

DNA Repair-Deficiency Disorders
Autoantibodies
DNA
Neoplasms
Poly(ADP-ribose) Polymerases

Compositions and methods for enhancing nuclear translocation

Rattray, Z. & Hansen, J. E., 1 Feb 2018, (Submitted) Patent No. 62/625198, 1 Feb 2018

Research output: Patent

Compositions and methods for inhibition of nuclear-penetrating antibodies

Rattray, Z. & Hansen, J., 1 Feb 2018, (Submitted) Patent No. 62/625213, 1 Feb 2018

Research output: Patent

3 Citations (Scopus)
12 Downloads (Pure)

Re-engineering and evaluation of anti-DNA autoantibody 3E10 for therapeutic applications

Rattray, Z., Dubljevic, V., Rattray, N., Greenwood, D. L., Johnson, C. H., Campbell, J. A. & Hansen, J. E., 12 Feb 2018, In : Biochemical and Biophysical Research Communications. 496, 3, p. 858-864 7 p.

Research output: Contribution to journalArticle

Open Access
File
Autoantibodies
DNA Repair
DNA
Neoplasms
Repair
2017

Binding proteins 2

Rattray, Z., Hansen, J., Campbell, J., Dubljevic, V. & Greenwood, D., Jul 2017, (Submitted) Patent No. WO/2019/018428, 17 Jul 2018, Priority date 17 Jul 2016, Priority No. 62/533,546

Research output: Patent

Carrier Proteins
Disclosure
DNA-Binding Proteins
Neoplasms
14 Citations (Scopus)

Environmental influences in the etiology of colorectal cancer: the premise of metabolomics

Rattray, N., Charkoftaki, G., Rattray, Z., Hansen, J. E., Vasilou, V. & Johnson, C. H., 30 Jun 2017, In : Current Pharmacology Reports. 3, 3, p. 114-125 12 p.

Research output: Contribution to journalReview article

Metabolomics
Colorectal Neoplasms
Alcohols
Microbiota
Nutrition
7 Citations (Scopus)
35 Downloads (Pure)

Evaluation of aggregate and silicone-oil counts in pre-filled siliconized syringes: An orthogonal study characterising the entire subvisible size range.

Shah, M., Rattray, Z., Day, K., Uddin, S., Curtis, R., van der walle, C. F. & Pluen, A., 9 Jan 2017, In : International Journal of Pharmaceutics. 519, 1-2, p. 58-66 9 p.

Research output: Contribution to journalArticle

Open Access
File
Silicone Oils
Syringes
Polysorbates
Monoclonal Antibodies
Spectrum Analysis
10 Downloads (Pure)

Metabolomics guided pathway analysis reveals link between cancer metastasis, cholesterol sulfate, and phospholipids

Johnson, C. H., Santidrian, A. F., LeBoeuf, S. E., Kurzy, M. E., Rattray, N., Rattray, Z., Warth, B., Ritland, M., Hoang, L. T., Loriot, C., Higa, J., Hansen, J. E., Felding, B. H. & Siuzdak, G., 31 Oct 2017, In : Cancer and Metabolism. 5, 1

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Phospholipids
Neoplasm Metastasis
Neoplasms
Adipose Tissue
2015
11 Citations (Scopus)

Characterisation of stress‐induced aggregate size distributions and morphological changes of a bi‐specific antibody using orthogonal techniques

Hamrang, Z., Hussain, M., Tingey, K., Tracka, M., Casas-Finet, J. R., Uddin, S., van der walle, C. F. & Pluen, A., 14 Jul 2015, In : Journal of Pharmaceutical Sciences. 104, 8, p. 2473-2481 8 p.

Research output: Contribution to journalArticle

Bispecific Antibodies
Particle Size
Spectrum Analysis
Hot Temperature
Monoclonal Antibodies
2014
4 Citations (Scopus)

Monitoring the kinetics of CellTrace™ calcein red-orange AM intracellular accumulation with spatial intensity distribution analysis

Hamrang, Z., McGlynn, H. J., Clarke, D., Penny, J. & Pluen, A., Sep 2014, In : BBA - General Subjects. 1840, 9, p. 2914-2923 9 p.

Research output: Contribution to journalArticle

Fluorescence
Fluorescence Spectrometry
Kinetics
Fluorophores
Monitoring
3 Citations (Scopus)

On the cellular uptake and membrane effect of the multifunctional peptide, TatLK15

Alkotaji, M., Pluen, A., Zindy, E., Hamrang, Z. & Aojula, H., 1 Jan 2014, In : Journal of Pharmaceutical Sciences. 103, 1, p. 293-304 12 p.

Research output: Contribution to journalArticle

Peptides
Membranes
Small Interfering RNA
Cell-Penetrating Peptides
Oncogene Proteins
3 Citations (Scopus)

Quantitative assessment of P-glycoprotein expression and function using confocal image analysis

Hamrang, Z., Arthanari, Y., Clarke, D. & Pluen, A., 27 Aug 2014, In : Microscopy and Microanalysis. 20, 5, p. 1329-1339 10 p.

Research output: Contribution to journalArticle

Glycoproteins
P-Glycoprotein
image analysis
Image analysis
Fluorescent Antibody Technique
4 Citations (Scopus)

Real-time evaluation of aggregation using confocal imaging and image analysis tools

Hamrang, Z., Zindy, E., Clarke, D. & Pluen, A., 7 Feb 2014, In : Analyst. 139, 3, p. 564-568 4 p.

Research output: Contribution to journalArticle

raster
image analysis
Image analysis
Spectrum Analysis
Agglomeration
61 Citations (Scopus)

Taking your breath away: metabolomics breathes life in to personalized medicine

Rattray, N., Hamrang, Z., Trivedi, D. K., Goodacre, R. & Fowler, S. J., Oct 2014, In : Trends in Biotechnology. 32, 10, p. 538-548 10 p.

Research output: Contribution to journalReview article

Precision Medicine
Metabolomics
Medicine
Volatile Organic Compounds
Volatile organic compounds
2013
45 Citations (Scopus)

Proteins behaving badly: emerging technologies in profiling biopharmaceutical aggregation

Hamrang, Z., Rattray, N. & Pluen, A., 14 Jun 2013, In : Trends in Biotechnology. 31, 8, p. 448-458 11 p.

Research output: Contribution to journalReview article

Agglomeration
Technology
Proteins
Genetic engineering
Monoclonal antibodies
2012
9 Citations (Scopus)

Raster image correlation spectroscopy as a novel tool for the quantitative assessment of protein diffusional behaviour in solution

Hamrang, Z., Pluen, A., Zindy, E. & Clarke, D., 30 Jun 2012, In : Journal of Pharmaceutical Sciences. 101, 6, p. 2082-2093 12 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Osmolar Concentration
Proteins
Fluorescence Spectrometry
Bovine Serum Albumin