20022020

Research output per year

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Research Output

2020

The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet accelerated mouse model of ageing

Crowe, J., Lumb, F. E., Doonan, J., Broussard, M., Tarafdar, A., Pineda, M. A., Landabaso, C., Mulvey, L., Hoskisson, P. A., Babayan, S. A., Selman, C., Harnett, W. & Harnett, M. M., 12 Mar 2020, In : PLOS Pathogens. 16, 3, 33 p., e1008391.

Research output: Contribution to journalArticle

Open Access
File
6 Downloads (Pure)
2019

Site-specific glycoproteomic characterization of ES-62: the major secreted product of the parasitic worm Acanthocheilonema viteae

North, S. J., Botchway, K., Doonan, J., Lumb, F. E., Dell, A., Harnett, W. & Haslam, S. M., 30 Aug 2019, In : Glycobiology. 29, 8, p. 562-571 10 p.

Research output: Contribution to journalArticle

Open Access
File
1 Downloads (Pure)

Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model

Lumb, F. E., Crowe, J., Doonan, J., Suckling, C. J., Selman, C., Harnett, M. M. & Harnett, W., 31 Dec 2019, In : Molecular and Biochemical Parasitology. 234, 13 p., 111232.

Research output: Contribution to journalArticle

The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis

Doonan, J., Tarafdar, A., Pineda, M. A., Lumb, F. E., Crowe, J., Khan, A. M., Hoskisson, P. A., Harnett, M. M. & Harnett, W., 5 Apr 2019, In : Nature Communications. 10, 14 p., 1554.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
13 Downloads (Pure)
2018

Failure of the anti-inflammatory parasitic worm product ES-62 to provide protection in mouse models of type I diabetes, multiple sclerosis, and inflammatory bowel disease

Doonan, J., Thomas, D., Wong, M. H., Ramage, H. J., Al-Riyami, L., Lumb, F. E., Bell, K. S., Fairlie-Clarke, K. J., Suckling, C. J., Michelsen, K. S., Jiang, H-R., Cooke, A., Harnett, M. M. & Harnett, W., 17 Oct 2018, In : Molecules. 23, 10, 14 p., 2669.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
9 Downloads (Pure)

IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62

Ball, D. H., Al-Riyami, L., Harnett, W. & Harnett, M. M., 14 Mar 2018, In : Scientific Reports. 8, 1, p. 1-15 15 p., 4497.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
18 Downloads (Pure)

Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis

Doonan, J., Lumb, F. E., Pineda, M. A., Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M. & Harnett, W., 14 May 2018, In : Frontiers in Immunology. 9, 13 p., 1016.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
38 Downloads (Pure)

Small molecule analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Suckling, C. J., Alam, S., Olson, M. A., Saikh, K. U., Harnett, M. M. & Harnett, W., 1 Feb 2018, In : Scientific Reports. 8, 11 p., 2123.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
19 Downloads (Pure)

Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis

Suckling, C. J., Mukherjee, S., Khalaf, A. I., Narayan, A., Scott, F. J., Khare, S., Dhakshinamoorthy, S., Harnett, M. M. & Harnett, W., 30 Sep 2018, In : Acta Tropica. 185, p. 212-218 7 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
5 Downloads (Pure)
2017

Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells

Laté de Laté, P., Pineda, M., Harnett, M., Harnett, W., Besteiro, S. & Langsley, G., 28 Feb 2017, In : Biomedical Journal. 40, 1, p. 23-30 8 p.

Research output: Contribution to journalLiterature review

Open Access
File
2 Citations (Scopus)
94 Downloads (Pure)

Can parasitic worms cure the modern world's ills?

Harnett, M. M. & Harnett, W., 9 Jun 2017, In : Trends in Parasitology. 12 p.

Research output: Contribution to journalLiterature review

Open Access
File
15 Citations (Scopus)
24 Downloads (Pure)

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A., Corbet, M., Suckling, C. J., Harnett, M. M. & Harnett, W., 10 May 2017, In : Scientific Reports. 13 p., 1704.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
196 Downloads (Pure)

From Christian de Duve to Yoshinori Ohsumi: more to autophagy than just dining at home

Harnett, M. M., Pineda, M., Latré de Laté, P., Eason, R. J., Besteiro, S., Harnett, W. & Langsley, G., 22 Mar 2017, In : Biomedical Journal. 40, 1, p. 9-22 14 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
71 Downloads (Pure)

Parasite excretory-secretory products and their effects on metabolic syndrome

Crowe, J., Lumb, F. E., Harnett, M. M. & Harnett, W., 9 Jan 2017, In : Parasite Immunology. 33 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
27 Downloads (Pure)
2016

Brugia malayi Antigen (BmA) inhibits HIV-1 trans-infection but neither BmA nor ES-62 alter HIV-1 infectivity of DC induced CD4+ Th-cells

Mouser, E. E. I. M., Pollakis, G., Yazdanbakhsh, M., Harnett, W., de Jong, E. C. & Paxton, W. A., 25 Jan 2016, In : PLOS One. 11, 1, 18 p., e0146527.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
14 Downloads (Pure)

Testing small molecule analogues of acanthocheilonema viteae immunomodulator ES-62 against clinically relevant allergens

Janicova, L., Rzepecka, J., Rodgers, D. T., Doonan, J., Bell, K., Lumb, F. E., Suckling, C. J., Harnett, M. M. & Harnett, W., 30 Jun 2016, In : Parasite Immunology. 38, 6, p. 340-351 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
42 Downloads (Pure)

The carbohydrate-linked phosphorylcholine of the parasitic nematode product ES-62 modulates complement activation

Ahmed, U. K., Maller, N. C., Iqbal, A. J., Al-Riyami, L., Harnett, W. & Raynes, J. G., 27 May 2016, In : Journal of Biological Chemistry . 291, 22, p. 11939-11953 15 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
47 Downloads (Pure)

The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ

Eason, R. J., Bell, K. S., Marshall, F. A., Rodgers, D. T., Pineda, M. A., Steiger, C. N., Al-Riyami, L., Harnett, W. & Harnett, M. M., 21 Nov 2016, In : Scientific Reports. 6, 14 p., 37276.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
28 Downloads (Pure)

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

Coltherd, J. C., Rodgers, D. T., Lawrie, R. E., Al-Riyami, L., Suckling, C. J., Harnett, W. & Harnett, M. M., 14 Jan 2016, In : Scientific Reports. 6, 14 p., 19224.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
104 Downloads (Pure)
2015

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

Rodgers, D. T., Pineda, M. A., Suckling, C. J., Harnett, W. & Harnett, M. M., 1 Nov 2015, In : Lupus. 24, 13, p. 1437-1442 6 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
59 Downloads (Pure)

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Rzepecka, J., Pineda, M. A., Al-Riyami, L., Rodgers, D. T., Huggan, J. K., Lumb, F. E., Khalaf, A. I., Meakin, P. J., Corbet, M., Ashford, M. L., Suckling, C. J., Harnett, M. M. & Harnett, W., Jun 2015, In : Journal of Autoimmunity. 60, p. 59-73 15 p.

Research output: Contribution to journalArticle

Open Access
File
46 Citations (Scopus)
2262 Downloads (Pure)

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

Al-Riyami, L., Rodgers, D. T., Rzepecka, J., Pineda, M. A., Suckling, C. J., Harnett, M. M. & Harnett, W., 25 Mar 2015, (Accepted/In press) In : Experimental Parasitology . 5 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
53 Downloads (Pure)

The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model.

Aprahamian, T. R., Zhong, X., Amir, S., Binder, C. J., Chiang, L-K., Al-Riyami, L., Gharakhanian, R., Harnett, M. M., Harnett, W. & Rifkin, I. R., 1 Mar 2015, In : International Journal for Parasitology. 45, 4, p. 203-207 5 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
48 Downloads (Pure)

The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice

Rodgers, D. T., McGrath, M. A., Pineda, M. A., Al-Riyami, L., Rzepecka, J., Lumb, F., Harnett, W. & Harnett, M. M., 27 Mar 2015, In : Arthritis and Rheumatology. 67, 4, p. 1023-1035 13 p.

Research output: Contribution to journalArticle

Open Access
File
26 Citations (Scopus)
198 Downloads (Pure)

The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62

Bell, K. S., Al-Riyami, L., Lumb, F. E., Britton, G. J., Poole, A. W., Williams, C. M., Braun, U., Leitges, M., Harnett, M. M. & Harnett, W., Nov 2015, In : Immunology Letters. 168, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
121 Downloads (Pure)
2014

ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae

Pineda, M. A., Lumb, F., Harnett, M. M. & Harnett, W., 1 Apr 2014, In : Molecular and Biochemical Parasitology. 194, 1-2, p. 1-8 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints

Pineda, M. A., Rodgers, D. T., Al-Riyami, L., Harnett, W. & Harnett, M., Jun 2014, In : Arthritis and Rheumatism. 66, 6, p. 1492–1503 12 p.

Research output: Contribution to journalArticle

Open Access
File
35 Citations (Scopus)
73 Downloads (Pure)

Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis

Pineda, M. A., Al-Riyami, L., Harnett, W. & Harnett, M. M., 9 Jul 2014, In : Clinical and Experimental Immunology. 177, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
52 Downloads (Pure)

Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of IL-10-producing B cells and reduced plasma cell infiltration of the joints

Rodgers, D. T., Pineda, M. A., McGrath, M. A., Al-Riyami, L., Harnett, W. & Harnett, M. M., Mar 2014, In : Immunology. 141, 3, p. 457–466 10 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
62 Downloads (Pure)

Secretory products of helminth parasites as immunomodulators

Harnett, W., 1 Jul 2014, In : Molecular and Biochemical Parasitology. 195, 2, p. 130-136 7 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Rzepecka, J., Coates, M., Saggar, M., Al-Riyami, L., Coltherd, J., Tay, H. K., Huggan, J., Janicova, L., Khalaf, A., Siebeke, I., Suckling, C., Harnett, M. & Harnett, W., Aug 2014, In : International Journal for Parasitology. 44, 9, p. 669-674 6 p.

Research output: Contribution to journalArticle

Open Access
File
23 Citations (Scopus)
84 Downloads (Pure)

The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of collagen-induced arthritis

Harnett, M. M., Harnett, W. & Pineda, M. A., 9 Oct 2014, In : Inflammation and Cell Signaling . 1, 3, p. 1-19 19 p.

Research output: Contribution to journalArticle

Open Access
File
50 Downloads (Pure)
2013

Allergy and parasites

Bruschi, F., Araujo, M. I., Harnett, W. & Pinelli, E., 12 Feb 2013, In : Journal of Parasitology Research. 2013, 2 p., 502562.

Research output: Contribution to journalEditorial

Open Access
File
6 Citations (Scopus)
9 Downloads (Pure)
56 Citations (Scopus)

Impact of worms and their products on eosinophils and neutrophils in experimental asthma

Rzepecka, J. & Harnett, W., 1 Aug 2013, In : Current Molecular Medicine. 13, 7, p. 1192-1202 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62

Ball, D., Tay, H. K., Bell, K., Coates, M., Al-Riyami, L., Rzepecka, J., Harnett, W. & Harnett, M., 2013, (Accepted/In press) In : Journal of Parasitology Research. 2013, 13 p., 961268.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
107 Downloads (Pure)

Modulation of autoimmune and allergic responses by defined nematode molecules

Harnett, W., Al-Riyami, L., Rzepecka, J. & Harnett, M. M., 2013, Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology. Kennedy, M. W. & Harnett, W. (eds.). p. 144-155 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology

Kennedy, M. M. (ed.) & Harnett, W. (ed.), 23 Sep 2013, 2 ed. United KIngdom. 423 p.

Research output: Book/ReportBook

The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype

Rzepecka, J., Siebeke, I., Coltherd, J., Kean, D., Steiger, C., Al-Riyami, L., McSharry, C., Harnett, M. & Harnett, W., Mar 2013, In : International Journal for Parasitology. 43, 3-4, p. 211–223 13 p.

Research output: Contribution to journalArticle

File
42 Citations (Scopus)
108 Downloads (Pure)
2012
Open Access
27 Citations (Scopus)

Receptor usage by the Acanthocheilonema viteae-derived immunomodulator, ES-62

Harnett, W., Goodridge, H., Allen, J. & Harnett, M., 30 Sep 2012, In : Experimental Parasitology . 6 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
390 Downloads (Pure)

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites

Pineda, M., McGrath, M., Smith, P., Al-Riyami, L., Rzepecka, J., Gracie, A., Harnett, W. & Harnett, M., Oct 2012, In : Arthritis and Rheumatism. 64, 10, p. 3168–3178 11 p.

Research output: Contribution to journalArticle

File
68 Citations (Scopus)
265 Downloads (Pure)
2011

The allergenicity of 2S plant albumins: a Brazilnut model system

Alcocer, M. J. C., Murtagh, G. J., Mirotti, L., Brans, A., Harnett, W., Rundqvist, L. & Larsson, G., Dec 2011, In : Clinical and Experimental Allergy. 41, 12, p. 1827-1827 1 p.

Research output: Contribution to journalMeeting abstract

2010

Helminth-derived immunomodulators: can understanding the worm produce the pill?

Harnett, W. & Harnett, M. M., Apr 2010, In : Nature Reviews Immunology. 10, 4, p. 278-284 7 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

How do nematodes transfer phosphorylcholine to carbohydrates?

Harnett, W., Rzepecka, J. & Houston, K. M., Mar 2010, In : Trends in Parasitology. 26, 3, p. 114-118 5 p.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
125 Downloads (Pure)

Small molecule analogues of an immunomodulatory helminth product provide a novel approach to dissecting macrophage signal transduction pathways: Poster abstract

Al-Riyami, L., Rzepecka, J., Khalaf, A., Suckling, C., Harnett, M. & Harnett, W., Dec 2010, In : Immunology. 131, Supplement 1, p. 164-164 1 p.

Research output: Contribution to journalArticle

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease

Harnett, M. M., Melendez, A. J. & Harnett, W., Mar 2010, In : Clinical and Experimental Immunology. 159, 3, p. 256-67 12 p.

Research output: Contribution to journalArticle

File
52 Citations (Scopus)
58 Downloads (Pure)
2009

Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline?

Houston, K. M., Babayan, S. A., Allen, J. E. & Harnett, W., 2009, In : Parasitology. 135, 1, p. 55-61 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES-62

Harnett, W., Harnett, M. M. & Fallon, P. (ed.), 2009, Pathogen-Derived Immunomodulatory Molecules. Vol. 666. p. 88-94 6 p. (Advances in Experimental Medicine and Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Citations (Scopus)

The clinical potential of worms and their products in treating inflammatory diseases

Al-Riyammi, L. & Harnett, W., Feb 2009, In : Current Immunology Reviews. 5, 1, p. 35-41 6 p.

Research output: Contribution to journalArticle