Personal profile
Personal Statement
I joined the Department of Immunology at Strathclyde University as a lecturer in 1991 and was appointed Professor of Molecular Immunology in 2002. Immunology was one of five University departments, which merged to form Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS) in 2006. I acted as Director of Research in SIPBS from August 2009 until the end of 2013 and was previously Head of The immunology Department during the academic year, 2005-6.
My research interests lie in elucidating the molecular mechanisms by which parasitic worms modulate the host immune system. A particular focus is on ES-62, an anti-inflammatory molecule secreted by the filarial nematode Acanthocheilonema viteae, which we are currently exploiting with a view to developing novel drugs for allergic and autoimmune diseases. This interest in immunology and parasitology also extends to my areas of teaching.
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Collaborations and top research areas from the last five years
Projects
- 13 Finished
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How does the immunomodulatory parasitic worm product ES-62 rewire bone marrow cells to increase healthspan and lifespan in obesity-accelerated ageing?
Harnett, W. (Principal Investigator) & Hoskisson, P. (Co-investigator)
MRC (Medical Research Council)
1/06/21 → 31/12/24
Project: Research
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Does the parasitic worm product ES-62 resolve aberrant chronic inflammation by sensing and normalising the gut microbiome and intestinal integrity?
Harnett, W. (Principal Investigator) & Hoskisson, P. (Co-investigator)
BBSRC (Biotech & Biological Sciences Research Council)
10/05/21 → 31/10/24
Project: Research
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Alzheimer's spinal pathology: neuronal, glial, and cholesterol metabolic changes in female and male 5xFAD mice
Wang, X., Harnett, W., Shu, X. & Jiang, H.-R., 17 Apr 2026, In: International Journal of Molecular Sciences. 27, 8, 22 p., 3593.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Reduction in creatine metabolites in macrophages exposed to small molecule analogues of the anti-inflammatory parasitic worm product ES-62
Alanazi, S., Doonan, J., Lumb, F. E., Alenzi, N., Jabbar, S., Al-Riyami, L., Suckling, C. J., Harnett, W. & Watson, D. G., 19 Feb 2024, In: Parasite Immunology. 46, 2, 6 p., e13026.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)22 Downloads (Pure)
Prizes
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Associate Professorship at the Faculty of Medicine, Paris Descartes
Harnett, W. (Recipient), 1 Oct 2007
Prize: Appointment
Activities
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Molecular and Cellular Biology of Helminth Parasites IX
Harnett, W. (Chair)
30 Aug 2015 → 4 Sept 2015Activity: Presenting or Organising an Event › Participation in conference
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The parasitic worm product ES-62: a starting point for novel anti-inflammatory drug development
Harnett, W. (Invited speaker)
25 Aug 2015Activity: Talk or Presentation › Invited talk
Equipment
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EVOS FL Auto, Imaging Kit
Strathclyde Institute Of Pharmacy And Biomedical SciencesFacility/equipment: Equipment