• United Kingdom

Accepting PhD Students

20012020

Research output per year

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Research Output

2020
2019
3 Citations (Scopus)
4 Downloads (Pure)
2018

A 340/380 nm light emitting diode illuminator for Fura-2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision

Tinning, P. W., Franssen, A. J. P. M., Hridi, S. U., Bushell, T. J. & McConnell, G., 1 Mar 2018, In : Journal of Microscopy. 269, 3, p. 212-220 9 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
41 Downloads (Pure)

Fast optical sectioning for widefield fluorescence mesoscopy with the mesolens based on HiLo microscopy

Schniete, J., Franssen, A., Dempster, J., Bushell, T. J., Amos, W. B. & McConnell, G., 2 Nov 2018, In : Scientific Reports. 8, 10 p., 16259.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
15 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
21 Downloads (Pure)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In : Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
13 Downloads (Pure)
2017
Open Access
File
53 Downloads (Pure)
Open Access
File
20 Downloads (Pure)

A microfluidic platform for the characterisation of CNS active compounds

MacKerron, C., Robertson, G., Zagnoni, M. & Bushell, T., 16 Nov 2017, In : Scientific Reports. 18 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
60 Downloads (Pure)

GABAB receptors suppress burst-firing in reticular thalamic neurons

Cain, S. M., Garcia, E., Waheed, Z., Jones, K. L., Bushell, T. J. & Snutch, T. P., 25 Jul 2017, In : Channels. p. 1-13

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
8 Downloads (Pure)

Increased expression of IL-16 in the brain of experimental autoimmune encephalomyelitis

Hridi, S. U., McCann, L., McConnell, G., Bushell, T. J. & Jiang, H-R., 10 Apr 2017, In : Brain and Neuroscience Advances. 1 p., P-M113.

Research output: Contribution to journalConference Contribution

Open Access
File
71 Downloads (Pure)
6 Citations (Scopus)
16 Downloads (Pure)
2016
Open Access
File
12 Downloads (Pure)

Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

Robertson, G., Sposito, T., Wray, S., Hardy, J., Bushell, T. J. & Zagnoni, M., 9 Oct 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, p. 379-380 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Open Access
File
22 Downloads (Pure)

Inositol trisphosphate receptor contribution to ventricular cardiac fibroblast function in healthy and hypertrophied mouse hearts

Currie, S., Martin, T. P., Salleh, H., McCluskey, C. & Bushell, T. J., 30 Apr 2016, In : FASEB Journal. 30, 1 Supplement, 1 p., 1178.2.

Research output: Contribution to journalMeeting abstract

Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memory

Abdul Rahman, N. Z. B., Greenwood, S. M., Brett, R. R., Tossell, K., Ungless, M. A., Plevin, R. & Bushell, T. J., 24 Feb 2016, In : Journal of Neuroscience. 36, 8, p. 2348-2354 6 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
59 Downloads (Pure)

Perfusion based microfluidic system for pharmacological profiling of neuronal networks

MacKerron, C., Robertson, G., Bushell, T. J. & Zagnoni, M., 9 Oct 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, CA, p. 445-446 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Open Access
File
29 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
110 Downloads (Pure)

Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Abulkassim, R., Brett, R., MacKenzie, S. M. & Bushell, T. J., 13 May 2016, In : Journal of Neuroimmunology. 295-296, p. 139-147 8 p.

Research output: Contribution to journalArticle

Open Access
File
66 Downloads (Pure)
Open Access
File
11 Citations (Scopus)
122 Downloads (Pure)

Widefield two-photon excitation without scanning: live cell microscopy with high time resolution and low photo-bleaching

Amor, R., McDonald, A., Trägårdh, J., Robb, G., Wilson, L., Abdul Rahman, N. Z., Dempster, J., Amos, W. B., Bushell, T. J. & McConnell, G., 29 Jan 2016, In : PLOS One. 11, 1, 19 p., 0147115.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
122 Downloads (Pure)
2015

Developmental regulation of tau splicing is disrupted in stem cell derived neurons from frontotemporal dementia patients with the 10+16 splice-site mutation in MAPT

Sposito, T., Preza, E., Mahoney, C. J., Setó-Salvia, N., Ryan, N. S., Morris, H. R., Arber, C., Devine, M. J., Houlden, H., Warner, T. T., Bushell, T. J., Zagnoni, M., Kunath, T., Livesey, F. J., Fox, N. C., Rossor, M. N., Hardy, J. & Wray, S., 15 Sep 2015, In : Human Molecular Genetics . 24, 18, p. 5260-5269 10 p.

Research output: Contribution to journalArticle

Open Access
File
59 Citations (Scopus)
88 Downloads (Pure)
2014

A microfluidics platform for human tau mutation neurons

Torrance, E., Robertson, G., Wray, S., Hardy, J., Bushell, T. & Zagnoni, M., 2014, MicroTAS 2014. San Diego, CA., p. 898-890 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

1 Citation (Scopus)

Calcium/calmodulin dependent protein kinase II δ modulates intracellular CA2+ release and cell proliferation in adult cardiac fibroblasts

Mohd Salleh, M., McCluskey, C., Bushell, T. & Currie, S., 31 Dec 2014, In : Heart . 100, S4

Research output: Contribution to journalMeeting abstract

Chemically induced synaptic activity between mixed primary hippocampal co-cultures in a microfluidic system

Robertson, G., Bushell, T. J. & Zagnoni, M., 27 Jun 2014, In : Integrative Biology. 6, 6, p. 636-644 9 p.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
241 Downloads (Pure)

Immune responses in neurodegenerative diseases

Shrestha, R., Shakya Shrestha, S., Millington, O., Brewer, J. & Bushell, T., 1 Mar 2014, In : Kathmandu University Medical Journal. 12, 45, p. 67-76 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways

Shrestha Maleku, R., Millington, O., Brewer, J., Dev, K. & Bushell, T., Jan 2014, In : Neuropharmacology. 76, A, p. 184-193 10 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
57 Downloads (Pure)
2011

Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways

Ledgerwood, C., Greenwood, S. M., Brett, R. R., Pratt, J. A. & Bushell, T., Jan 2011, In : British Journal of Pharmacology. 162, 1, p. 286-294 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Deletion of proteinase activated receptor 2 has limited effects on anxiety behaviours and spares reference and working memory

Abulkassim, R., Bushell, T. J. & Brett, R. R., Aug 2011, In : Journal of Psychopharmacology. 25, 8 Supplemement S, p. A51-A51 1 p.

Research output: Contribution to journalMeeting abstract

Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2

Gan, J., Greenwood, S. M., Cobb, S. R. & Bushell, T. J., Jul 2011, In : British Journal of Pharmacology. 163, 5, p. 984-994 11 p.

Research output: Contribution to journalLiterature review

26 Citations (Scopus)

In vivo real-time multiphoton imaging of T lymphocytes in the mouse brain after experimental stroke

Fumagalli, S., Coles, J. A., Ejlerskov, P., Ortolano, F., Bushell, T. J., Brewer, J. M., De Simoni, M-G., Dever, G., Garside, P., Maffia, P. & Carswell, H. V., May 2011, In : Stroke. 42, 5, p. 1429-1436 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2010

Advances in imaging of new targets for pharmacological intervention in stroke: real time tracking of T cells in the ischaemic brain

Ortolano, F., Maffia, P., Dever, G., Rodolico, G., Millington, O. R., De Simoni, M. G., Brewer, J. M., Bushell, T., Garside, P. & Carswell, H. V. O., Feb 2010, In : British Journal of Pharmacology. 159, 4, p. 808-811 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
20 Citations (Scopus)

Does receptor activation initiate the NF kappa B pathway in hippocampal neurones?

Pytka, K., Librowski, T., Filipek, B., Paul, A. & Bushell, T., 2010, In : Pharmacological Reports. 62, supplement, p. 59-59 1 p.

Research output: Contribution to journalConference Contribution

Two-pore potassium ion channels are inhibited by both Gq/11- and Gi-coupled P2Y receptors

Shakya-Shrestha, S., Parmar, M., Kennedy, C. & Bushell, T., Apr 2010, In : Molecular and Cellular Neuroscience. 43, 4, p. 363-369 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2009

Imaging T-cell movement in the brain during experimental cerebral malaria

Ortolano, F., Maffia, P., Dever, G., Hutchison, S., Benson, R., Millington, O. R., De Simoni, M. G., Bushell, T., Garside, P., Carswell, H. V. & Brewer, J. M., Mar 2009, In : Parasite Immunology. 31, 3, p. 147-150 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2008

Exposure of cultured hippocampal neurones to cannabidiol does not induce cell death but inhibits synaptic activity

Brett, R. R., Pratt, J. A., Bushell, T. & Ledgerwood, C., Jun 2008, (Unpublished).

Research output: Contribution to conferencePaper

mGlu4 potentiation of K2P2.1 is dependant on C-terminal dephosphorylation

Cain, S. M., Meadows, H. J., Dunlop, J. & Bushell, T., Jan 2008, In : Molecular and Cellular Neuroscience. 37, 1, p. 32-39 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2007
33 Citations (Scopus)
2006

Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes

Bushell, T., Plevin, R. J., Cobb, S. & Irving, A. J., 2006, In : Neuropharmacology. 50, 6, p. 714-725 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2002

Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors

Downie, D. L., Vicente-Agullo, F., Campos-Caro, A., Bushell, T., Lieb, W. R. & Franks, N. P., 2002, In : Journal of Biological Chemistry. 277, p. 10367-10373 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Molecular components of tolerance to opiates in single hippocampal neurons

Bushell, T., Endoh, T., Simen, A. A., Ren, D., Bindokas, V. P. & Miller, R. J., 2002, In : Molecular Pharmacology. 61, 1, p. 55-64 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)
2001

Amphiphilic, tri-block copolymers provide potent, membrane-targeted neuroprotection

Marks, J. D., Pan, C. Y., Bushell, T., Cromie, W. & Lee, R. C., Feb 2001, In : FASEB Journal. 15, p. 1107-1109 2 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7

Sansig, G., Bushell, T., Clarke, V. R., Rozov, A., Burnashev, N., Portet, C., Gasparini, F., Schmutz, M., Klebs, K., Shigemoto, R., Flor, P. J., Kuhn, R., Knoepfel, T., Schroeder, M., Hampson, D. R., Collett, V. J., Zhang, C., Duvoisin, R. M., Collingridge, G. L. & van der Putten, H., 2001, In : Journal of Neuroscience. 21, 22, p. 8734-8745 11 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)