Trevor Bushell

Megarity, D., Vroman, R., Kriek, M., Downey, P., Bushell, T. J. & Zagnoni, M., 12 Apr 2022, (E-pub ahead of print) In: Lab on a Chip. 22, 10, p. 1989-2000 12 p.

Research output: Contribution to journal › Article › peer-review

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7 Citations (Scopus)

35 Downloads (Pure)

Anti-CD52 antibody treatment in murine experimental autoimmune encephalomyelitis induces dynamic and differential modulation of innate immune cells in peripheral immune and central nervous systems

Barbour, M., Wood, R., Harte, T., Bushell, T. J. & Jiang, H-R., 31 Mar 2022, In: Immunology. 165, 3, p. 312-327 16 p.

Research output: Contribution to journal › Article › peer-review

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3 Citations (Scopus)

33 Downloads (Pure)

Use of sedative-hypnotic medications and risk of dementia: a systematic review and meta-analysis

AlDawsari, A., Bushell, T. J., Abutheraa, N., Sakata, S., Al Hussain, S. & Kurdi, A., 23 Mar 2022, In: British Journal of Clinical Pharmacology. 88, 4, p. 1567-1589 23 p.

Research output: Contribution to journal › Review article › peer-review

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8 Citations (Scopus)

88 Downloads (Pure)

Use of sedative-hypnotic medications and risk of dementia: a systematic review and meta-analysis

AlDawsari, A., Bushell, T., Abutheraa, N., Sakata, S., Hussain, S. & Kurdi, A., 25 Jan 2022, (Accepted/In press).

Research output: Contribution to conference › Abstract › peer-review

Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines

Moudio, S., Willis, A., Pytka, K., Abulkassim, R., Brett, R. R., Webster, J. F., Wozny, C., Barbour, M., Jiang, H-R., Watson, D. G., van Kralingen, J. C., Mackenzie, S. M., Daniels, M., McColl, B. W., Sossick, S., Nuthall, H. N. & Bushell, T. J., 1 Jan 2022, In: Psychopharmacology. 239, 1, p. 229-242 14 p.

Research output: Contribution to journal › Article › peer-review

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3 Citations (Scopus)

46 Downloads (Pure)

2021

Increased levels of IL-16 in the central nervous system during neuroinflammation are associated with infiltrating immune cells and resident glial cells

Hridi, S. U., Barbour, M., Wilson, C., Franssen, A. JPM., Harte, T., Bushell, T. J. & Jiang, H-R., 27 May 2021, In: Biology. 10, 6, 15 p., 472.

Research output: Contribution to journal › Article › peer-review

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20 Citations (Scopus)

41 Downloads (Pure)

An evaluation of multi-excitation-wavelength standing-wave fluorescence microscopy (TartanSW) to improve sampling density in studies of the cell membrane and cytoskeleton

Schniete, J. K., Tinning, P. W., Scrimgeour, R. C., Robb, G., Kölln, L. S., Wesencraft, K., Paul, N. R., Bushell, T. J. & McConnell, G., 3 Feb 2021, In: Scientific Reports. 11, 10 p., 2903.

Research output: Contribution to journal › Article › peer-review

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3 Citations (Scopus)

54 Downloads (Pure)

2020

The development of proteinase-activated receptor-2 modulators and the challenges involved

McIntosh, K. A., Cunningham, M. R., Bushell, T. & Plevin, R., 31 Dec 2020, In: Biochemical Society Transactions. 48, 6, p. 2525-2537 13 p., BST20200191.

Research output: Contribution to journal › Review article › peer-review

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23 Citations (Scopus)

241 Downloads (Pure)

Mitogen‐activated protein kinase phosphatase‐2 deletion modifies ventral tegmental area function and connectivity and alters reward processing

Pytka, K., Dawson, N., Tossell, K., Ungless, M. A., Plevin, R., Brett, R. R. & Bushell, T. J., 31 Jul 2020, In: European Journal of Neuroscience. 52, 2, p. 2838-2852 15 p.

Research output: Contribution to journal › Article › peer-review

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4 Citations (Scopus)

29 Downloads (Pure)

2019

Developing a modular neuroechnology

Zagnoni, M., Bushell, T. & Megarity, D., 5 Sept 2019.

Research output: Contribution to conference › Poster › peer-review

Interleukin-16 inhibits sodium channel function and GluA1 phosphorylation via CD4- and CD9-independent mechanisms to reduce hippocampal neuronal excitability and synaptic activity

Hridi, S. U., Franssen, A. J. P. M., Jiang, H-R. & Bushell, T. J., 31 Mar 2019, In: Molecular and Cellular Neuroscience. 95, p. 71-78 8 p.

Research output: Contribution to journal › Article › peer-review

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8 Citations (Scopus)

29 Downloads (Pure)

2018

Fast optical sectioning for widefield fluorescence mesoscopy with the mesolens based on HiLo microscopy

Schniete, J., Franssen, A., Dempster, J., Bushell, T. J., Amos, W. B. & McConnell, G., 2 Nov 2018, In: Scientific Reports. 8, 10 p., 16259.

Research output: Contribution to journal › Article › peer-review

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22 Citations (Scopus)

47 Downloads (Pure)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In: Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

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16 Citations (Scopus)

42 Downloads (Pure)

A 340/380 nm light emitting diode illuminator for Fura-2 AM ratiometric Ca²⁺ imaging of live cells with better than 5 nM precision

Tinning, P. W., Franssen, A. J. P. M., Hridi, S. U., Bushell, T. J. & McConnell, G., 1 Mar 2018, In: Journal of Microscopy. 269, 3, p. 212-220 9 p.

Research output: Contribution to journal › Article › peer-review

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16 Citations (Scopus)

73 Downloads (Pure)

The therapeutic effect of anti-CD52 treatment in murine experimental autoimmune encephalomyelitis is associated with altered IL-33 and ST2 expression levels

Barbour, M., Wood, R., Hridi, S. U., Wilson, C., McKay, G., Bushell, T. J. & Jiang, H-R., 24 Feb 2018, (E-pub ahead of print) In: Journal of Neuroimmunology. p. 1-33 33 p.

Research output: Contribution to journal › Article › peer-review

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7 Citations (Scopus)

72 Downloads (Pure)

2017

The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells

Salaun, C., Ritchie, L., Greaves, J., Bushell, T. J. & Chamberlain, L. H., 31 Dec 2017, In: Molecular and Cellular Neuroscience. 85, 12 p.

Research output: Contribution to journal › Article › peer-review

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12 Citations (Scopus)

47 Downloads (Pure)

A microfluidic platform for the characterisation of CNS active compounds

MacKerron, C., Robertson, G., Zagnoni, M. & Bushell, T., 16 Nov 2017, (E-pub ahead of print) In: Scientific Reports. 18 p.

Research output: Contribution to journal › Article › peer-review

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13 Citations (Scopus)

91 Downloads (Pure)

GABAB receptors suppress burst-firing in reticular thalamic neurons

Cain, S. M., Garcia, E., Waheed, Z., Jones, K. L., Bushell, T. J. & Snutch, T. P., 25 Jul 2017, (E-pub ahead of print) In: Channels. p. 1-13

Research output: Contribution to journal › Article › peer-review

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12 Citations (Scopus)

48 Downloads (Pure)

A 340/380 nm light emitting diode illuminator for Fura-2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision

Tinning, P. W., Franssen, A., Hridi, S. U., Bushell, T. & McConnell, G., 4 Jul 2017. 1 p.

Research output: Contribution to conference › Poster › peer-review

Open Access

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77 Downloads (Pure)

Expression of IL-22 and IL-22R1 subunit in the central nervous system of experimental autoimmune encephalomyelitis mice

Wilson, C., Bushell, T. & Jiang, H-R., 15 Jun 2017.

Research output: Contribution to conference › Poster

A 340/380 nm light emitting diode illuminator for Fura-2 AM ratiometric Ca2+ imaging of live cells with better than 5 nM precision

Tinning, P. W., Franssen, A., Hridi, S. U., Bushell, T. & McConnell, G., 14 Jun 2017. 1 p.

Research output: Contribution to conference › Poster › peer-review

Open Access

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35 Downloads (Pure)

Increased expression of IL-16 in the brain of experimental autoimmune encephalomyelitis

Hridi, S. U., McCann, L., McConnell, G., Bushell, T. J. & Jiang, H-R., 10 Apr 2017, In: Brain and Neuroscience Advances. 1 p., P-M113.

Research output: Contribution to journal › Conference Contribution › peer-review

Open Access

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92 Downloads (Pure)

2016

Expression of IL-16 in central nervous system during the development of experimental autoimmune encephalomyelitis

Hridi, S. U., McCann, L., McConnell, G., Bushell, T. & Jiang, H-R., 9 Dec 2016.

Research output: Contribution to conference › Poster › peer-review

Expression of IL-22 and IL-22R1 subunit in the central nervous system of experimental autoimmune encephalomyelitis mice

Wilson, C., Bushell, T. & Jiang, H-R., 9 Dec 2016.

Research output: Contribution to conference › Poster

Open Access

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49 Downloads (Pure)

Dementia on a chip: monitoring synaptic dysfunction of patient derived human neurons

Robertson, G., Sposito, T., Wray, S., Hardy, J., Bushell, T. J. & Zagnoni, M., 9 Oct 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, California, p. 379-380 2 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Perfusion based microfluidic system for pharmacological profiling of neuronal networks

MacKerron, C., Robertson, G., Bushell, T. J. & Zagnoni, M., 9 Oct 2016, 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016). San Diego, CA, p. 445-446 2 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Open Access

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44 Downloads (Pure)

A novel microfluidic drug testing platform for studying communication between independent neural networks

MacKerron, C., Robertson, G., Bushell, T. & Zagnoni, M., 2 Jul 2016.

Research output: Contribution to conference › Paper › peer-review

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27 Downloads (Pure)

Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Abulkassim, R., Brett, R., MacKenzie, S. M. & Bushell, T. J., 13 May 2016, In: Journal of Neuroimmunology. 295-296, p. 139-147 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

104 Downloads (Pure)

Inositol trisphosphate receptor contribution to ventricular cardiac fibroblast function in healthy and hypertrophied mouse hearts

Currie, S., Martin, T. P., Salleh, H., McCluskey, C. & Bushell, T. J., 30 Apr 2016, In: FASEB Journal. 30, 1 Supplement, 1 p., 1178.2.

Research output: Contribution to journal › Conference abstract › peer-review

Proteinase-activated receptors (PARs) as targets for antiplatelet therapy

Cunningham, M., McIntosh, K., Bushell, T., Sloan, G. & Plevin, R., 15 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 606-612 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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15 Citations (Scopus)

161 Downloads (Pure)

Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memory

Abdul Rahman, N. Z. B., Greenwood, S. M., Brett, R. R., Tossell, K., Ungless, M. A., Plevin, R. & Bushell, T. J., 24 Feb 2016, In: Journal of Neuroscience. 36, 8, p. 2348-2354 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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26 Citations (Scopus)

88 Downloads (Pure)

Widefield two-photon excitation without scanning: live cell microscopy with high time resolution and low photo-bleaching

Amor, R., McDonald, A., Trägårdh, J., Robb, G., Wilson, L., Abdul Rahman, N. Z., Dempster, J., Amos, W. B., Bushell, T. J. & McConnell, G., 29 Jan 2016, In: PLOS One. 11, 1, 19 p., 0147115.

Research output: Contribution to journal › Article › peer-review

Open Access

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17 Citations (Scopus)

154 Downloads (Pure)

Protease-activated receptor 2: are common functions in glial and immune cells linked to inflammation-related CNS disorders?

Bushell, T. J., Cunningham, M. R., McIntosh, K. A., Moudio, S. & Plevin, R., 2016, In: Current Drug Targets. 17, 16, p. 1861-1870 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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14 Citations (Scopus)

274 Downloads (Pure)

2015

Developmental regulation of tau splicing is disrupted in stem cell derived neurons from frontotemporal dementia patients with the 10+16 splice-site mutation in MAPT

Sposito, T., Preza, E., Mahoney, C. J., Setó-Salvia, N., Ryan, N. S., Morris, H. R., Arber, C., Devine, M. J., Houlden, H., Warner, T. T., Bushell, T. J., Zagnoni, M., Kunath, T., Livesey, F. J., Fox, N. C., Rossor, M. N., Hardy, J. & Wray, S., 15 Sept 2015, In: Human Molecular Genetics . 24, 18, p. 5260-5269 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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109 Citations (Scopus)

110 Downloads (Pure)

Lymphocytes protect cortical neurons against excitotoxicity mediated by kainic acid, an in vitro model for neurodegeneration

Shrestha, R., Millington, O., Brewer, J. & Bushell, T., 2 May 2015, In: Kathmandu University Medical Journal. 11, 2, p. 132-138 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

2014

Calcium/calmodulin dependent protein kinase II δ modulates intracellular CA2+ release and cell proliferation in adult cardiac fibroblasts

Mohd Salleh, M., McCluskey, C., Bushell, T. & Currie, S., 31 Dec 2014, In: Heart . 100, S4

Research output: Contribution to journal › Conference abstract › peer-review

Is central nervous system an immune-privileged site?

Shrestha, R., Millington, O., Brewer, J. & Bushell, T., 11 Sept 2014, In: Kathmandu University Medical Journal. 11, 1, p. 102-107 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Chemically induced synaptic activity between mixed primary hippocampal co-cultures in a microfluidic system

Robertson, G., Bushell, T. J. & Zagnoni, M., 27 Jun 2014, In: Integrative Biology. 6, 6, p. 636-644 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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38 Citations (Scopus)

284 Downloads (Pure)

Immune responses in neurodegenerative diseases

Shrestha, R., Shakya Shrestha, S., Millington, O., Brewer, J. & Bushell, T., 1 Mar 2014, In: Kathmandu University Medical Journal. 12, 45, p. 67-76 10 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways

Shrestha Maleku, R., Millington, O., Brewer, J., Dev, K. & Bushell, T., Jan 2014, In: Neuropharmacology. 76, A, p. 184-193 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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23 Citations (Scopus)

81 Downloads (Pure)

A microfluidics platform for human tau mutation neurons

Torrance, E., Robertson, G., Wray, S., Hardy, J., Bushell, T. & Zagnoni, M., 2014, MicroTAS 2014. San Diego, CA., p. 898-890 3 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

1 Citation (Scopus)

2011

Deletion of proteinase activated receptor 2 has limited effects on anxiety behaviours and spares reference and working memory

Abulkassim, R., Bushell, T. J. & Brett, R. R., Aug 2011, In: Journal of Psychopharmacology. 25, 8 Supplemement S, p. A51-A51 1 p.

Research output: Contribution to journal › Conference abstract › peer-review

Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2

Gan, J., Greenwood, S. M., Cobb, S. R. & Bushell, T. J., Jul 2011, In: British Journal of Pharmacology. 163, 5, p. 984-994 11 p.

Research output: Contribution to journal › Literature review › peer-review

29 Citations (Scopus)

In vivo real-time multiphoton imaging of T lymphocytes in the mouse brain after experimental stroke

Fumagalli, S., Coles, J. A., Ejlerskov, P., Ortolano, F., Bushell, T. J., Brewer, J. M., De Simoni, M-G., Dever, G., Garside, P., Maffia, P. & Carswell, H. V., May 2011, In: Stroke. 42, 5, p. 1429-1436 8 p.

Research output: Contribution to journal › Article

32 Citations (Scopus)

Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways

Ledgerwood, C., Greenwood, S. M., Brett, R. R., Pratt, J. A. & Bushell, T., Jan 2011, In: British Journal of Pharmacology. 162, 1, p. 286-294 9 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

2010

Astrocytic activation and an inhibition of MAP kinases are required for proteinase-activated receptor-2-mediated protection from neurotoxicity

Greenwood, S. M. & Bushell, T. J., Jun 2010, In: Journal of Neurochemistry. 113, 6, p. 1471-1480 10 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Two-pore potassium ion channels are inhibited by both Gq/11- and Gi-coupled P2Y receptors

Shakya-Shrestha, S., Parmar, M., Kennedy, C. & Bushell, T., Apr 2010, In: Molecular and Cellular Neuroscience. 43, 4, p. 363-369 7 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Trevor Bushell

Research output

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