• United Kingdom

Accepting PhD Students

20012020

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Personal profile

Personal Statement

I obtained my BSc (Hons) in Pharmacology from the University of Glasgow (1992) and my PhD in Neuroscience from the University of Bristol (1996) before undertaking postdoctoral research at the University of Chicago and Imperial College London. I took up my position here at Strathclyde in 2002.

My research interest lies primarily in the field of neuroscience and focuses on the modulation of neuronal excitability and synaptic transmission in both physiological and pathophysiological conditions. This currently takes several directions including the following: 

  1. Identifying novel roles for protease-activated receptor 2 (PAR-2) in the central nervous system (CNS).
  2. Examining how peripheral inflammation affect CNS function and animal behaviour (with Dr Hui-Rong Jiang)
  3. Determining the role of Toll-like receptor 3 (TLR3) in the CNS development. 
  4. Investigating the role of mitogen-activated protein kinase phosphatase-2 (MKP2) in the CNS.
  5. Developing novel microfluidic devices for neuroscience research (with Dr Michele Zagnoni).

A variety of preparations are utilised in our research including mammalian expression systems, cultured neurones, organotypic slice cultures and acute brain slices. Techniques used include cell death assays, electrophysiology, immunocytochemistry, overexpression of fluorescently tagged proteins of interest, molecular biological techniques including site-directed mutagenesis and real time RT-PCR and in collaboration with  Professor Judy Pratt we utilise a variety of tests to understand rodent behaviour. 

I am involved in teaching both the MPharm and BMS cohorts in numerous classes ranging from 1st to 4th year.  In addition I am lead of the recently reformed Neuroscience and Mental Health subgroup.

I am currently the Strathclyde local group representative for the British Neuroscience Association.  I am also the BNA Host Society Chair for the FENS Forum to be held in Glasgow in July 2020 and a member of the FENS Executive and Programme committees.  I am also a full member of the Society for Neuroscience and a Fellow of the Higher Education Academy.

Education/Academic qualification

Doctor of Philosophy, University of Bristol

Bachelor of Science, University of Glasgow

Keywords

  • Cellular Neurophysiology
  • Neuropharmacology
  • Neuroinflammation
  • Neurodegeneration

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Projects

Research Output

  • Open Access
    File
  • 3 Citations (Scopus)
    3 Downloads (Pure)

    Datasets

    Data for: "A microfluidic platform for the characterisation of CNS active compounds"

    MacKerron, C. (Creator), Robertson, G. (Creator), Zagnoni, M. (Creator), Bushell, T. (Creator), University of Strathclyde, 30 Nov 2017

    Dataset

    Thesis

    An investigation into the interaction between hippocampal cells and lymphocytes and its influence on hippocampal network activity

    Author: Franssen, A., 3 May 2019

    Supervisor: Bushell, T. (Supervisor) & Jiang, H. (Supervisor)

    Student thesis: Doctoral Thesis

    An investigation into the role of TLR3 activation on hippocampal function

    Author: Ritchie, L., 23 Feb 2016

    Supervisor: Bushell, T. (Supervisor) & Paul, A. (Supervisor)

    Student thesis: Doctoral Thesis

    Activities

    Senior Phase Induction Day @ Strathclyde: SIPBS Virtual Drug Discovery Workshop

    Margaret Rose Cunningham (Advisor), Zahra Rattray (Advisor), Alan McCruden (Contributor), David Breen (Contributor), Mark Barbour (Contributor), Trevor Bushell (Contributor)
    6 Jun 2019

    Activity: Other activity typesTypes of Public engagement and outreach - Media article or participation

    FENS Forum of Neuroscience 2020

    Trevor Bushell (Participant)
    14 Jul 201816 Jul 2020

    Activity: Participating in or organising an event typesOrganiser of major conference