1984 …2020

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2020

Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1

Hii, L-W., Chung, F. F-L., Mai, C. W., Yee, Z. Y., Chan, H. H., Raja, V. J., Dephoure, N. E., Pyne, N. J., Pyne, S. & Leong, C-O., 4 Apr 2020, In : Cells. 9, 4, 25 p., 886.

Research output: Contribution to journalArticle

Open Access
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2019

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
11 Downloads (Pure)

Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3

Alganga, H., Almabrouk, T. A. M., Katwan, O. J., Daly, C. J., Pyne, S., Pyne, N. J. & Kennedy, S., 31 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Rivas, P. L., Baiget, J., Jiang, Z., Alsfouk, A., MacKay, S. P., Pyne, N. J. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
1 Downloads (Pure)
2018
Open Access
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4 Citations (Scopus)
8 Downloads (Pure)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
10 Downloads (Pure)
14 Citations (Scopus)
29 Downloads (Pure)
2017
4 Citations (Scopus)
20 Downloads (Pure)

Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Pyne, N. J. & Pyne, S., 23 Feb 2017, In : Molecules. 22, 3, p. 1-18 18 p., 344.

Research output: Contribution to journalArticle

Open Access
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29 Citations (Scopus)
172 Downloads (Pure)

Sphingosine kinase 2 and multiple myeloma

Pyne, N. J. & Pyne, S., 25 Apr 2017, In : Oncotarget. 8, 24, p. 43596-43597 2 p., 17420.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
23 Downloads (Pure)
2016

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis

Boomkamp, S. D., Byun, H-S., Ubhi, S., Jiang, H-R., Pyne, S., Bittman, R. & Pyne, N. J., 1 Jan 2016, In : Chemistry and Physics of Lipids. 194, p. 2-11 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
27 Downloads (Pure)

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. & Pyne, N. J., 31 Aug 2016, In : Cellular Signalling. 28, 8, p. 946-955 10 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
65 Downloads (Pure)

Pharmacological characterization of the αvβ6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2

Slack, R. J., Hafeji, M., Rogers, R., Ludbrook, S. B., Marshall, J. F., Flint, D. J., Pyne, S. & Denyer, J. C., 7 Jan 2016, In : Pharmacology. 97, 3-4, p. 114-125 12 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
85 Downloads (Pure)
43 Citations (Scopus)
251 Downloads (Pure)

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H-R., Ubhi, S. K. & Pyne, S., 1 Jan 2016, In : Advances in Biological Regulation. 60, p. 151-159 9 p.

Research output: Contribution to journalArticle

Open Access
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87 Citations (Scopus)
91 Downloads (Pure)

Sphingosine kinases: emerging structure function insights

Adams, D. R., Pyne, S. & Pyne, N. J., 1 May 2016, In : Trends in Biochemical Sciences . 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
50 Downloads (Pure)
2014

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

Evangelisti, C., Evangelisti, C., Teti, G., Chiarini, F., Falconi, M., Melchionda, F., Pession, A., Bertaina, A., Locatelli, F., McCubrey, JA., Baek, DJ., Bittman, R., Pyne, S., Pyne, N. & Martelli, AM., 2014, In : Oncotarget. 5, 17, p. 7886-7901 16 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
120 Downloads (Pure)

Crystal structure of sphingosine kinase 1 with PF-543

Wang, J., Knapp, S., Pyne, N., Pyne, S. & Elkins, J., 27 Dec 2014, In : Medicinal Chemistry Letters. 5, 12, p. 1329-1333 5 p.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
90 Downloads (Pure)

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

Lim, K. G., Gray, A. I., Anthony, N. G., MacKay, S. P., Pyne, S. & Pyne, N. J., 25 Oct 2014, In : Archives of Toxicology. 88, 12, p. 2213-2232 20 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
517 Downloads (Pure)

Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis

Pyne, N. J. & Pyne, S., 26 Jun 2014, In : Oncogene. 33, 26, p. 3361-3363 3 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
79 Downloads (Pure)
2013
30 Citations (Scopus)

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway

Gutiérrez-Martínez, E., Fernández-Ulibarri, I., Lázaro-Diéguez, F., Johannes, L., Pyne, S., Sarri, E. & Egea, G., 15 Jun 2013, In : Journal of Cell Science. 126, 12, p. 2641-2655 15 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
Open Access
File
46 Citations (Scopus)
94 Downloads (Pure)

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

Rutherford, C., Childs, S., Ohotski, J., McGlynn, L., Riddick, M., MacFarlane, S., Tasker, D., Pyne, S., Pyne, N. J., Edwards, J. & Palmer, T. M., 21 Nov 2013, In : Cell Death and Disease. 4, 15 p., e927.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Pyne, S. & Pyne, N., 14 Jan 2013, In : Cancer Cell. 23, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors

Baek, D. J., MacRitchie, N., Anthony, N. G., Mackay, S. P., Pyne, S., Pyne, N. J. & Bittman, R., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9310-9327 18 p.

Research output: Contribution to journalArticle

Open Access
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31 Citations (Scopus)
165 Downloads (Pure)

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

Liu, Z., MacRitchie, N., Pyne, S., Pyne, N. J. & Bittman, R., 1 May 2013, In : Bioorganic and Medicinal Chemistry. 21, 9, p. 2503-2510 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Synthesis of selective inhibitors of sphingosine kinase 1

Baek, D. J., MacRitchie, N., Pyne, N., Pyne, S. & Bittman, R., 2013, In : Chemical Communications (London). 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells

Tonelli, F., Alossaimi, M., Natarajan, V., Gorshkova, I., Berdyshev, E., Bittman, R., Watson, D. G., Pyne, S. & Pyne, N. J., 2013, In : Biomolecules. 3, 2, p. 316-333 18 p.

Research output: Contribution to journalArticle

Open Access
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63 Downloads (Pure)

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells

Watson, D. G., Tonelli, F., Al Osaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N. J. & Pyne, S., Apr 2013, In : Cellular Signalling. 25, 4, p. 1011-1017 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2012

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer

Ohotski, J., Long, J., Orange, C., Elsberger, B., Mallon, E., Doughty, J., Pyne, S., Pyne, N. & Edwards, J., 10 Apr 2012, In : British Journal of Cancer. 106, 8, p. 1453-1459 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b

Lim, K. G., Tonelli, F. R., Berdyshev, E., Gorshkova, I., Leclercq, T., Pitson, S. M., Bittman, R., Pyne, S. & Pyne, N., Sep 2012, In : International Journal of Biochemistry and Cell Biology. 44, 9, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
37 Citations (Scopus)
Open Access
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10 Downloads (Pure)

FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation and actin rearrangement in MCF-7 breast cancer cells

Lim, K., Tonelli, F. R., Li, Z., Lu, X., Bittman, R., Pyne, S. & Pyne, N., 27 May 2011, In : Journal of Biological Chemistry. 286, 21, p. 18633-18640 8 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase

Berdyshev, E. V., Gorshkova, I., Usatyuk, P., Kalari, S., Zhao, Y., Pyne, N. J., Pyne, S., Sabbadini, R. A., Garcia, J. G. N. & Natarajan, V., 31 Jan 2011, In : PLoS One. 6, 1, p. e16571

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
61 Downloads (Pure)
69 Citations (Scopus)
Open Access
File
25 Citations (Scopus)
9 Downloads (Pure)

Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules

Pyne, S., Bittman, R. & Pyne, N., 2011, In : Cancer Research. 71, 21, p. 6576-6582 7 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)
2010

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

Tonelli, F., Lim, K. G., Loveridge, C., Long, J., Pitson, S. M., Tigyi, G., Bittman, R., Pyne, S. & Pyne, N. J., 2010, In : Cellular Signalling. 22, 10, p. 1536-1542 6 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)
125 Citations (Scopus)

Interaction between anandamide and sphingosine 1-phosphate in mediating vasorelaxation in rat coronary artery

Mair, K. M., Kane, K. A., Pyne, S., Pyne, N. J. & Kennedy, S., May 2010, In : British Journal of Pharmacology. 161, 1, p. 176-192 16 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Sphingosine 1-phosphate and cancer

Pyne, N. J. & Pyne, S., Jul 2010, In : Nature Reviews Cancer. 10, 7, p. 489-503 15 p.

Research output: Contribution to journalArticle

574 Citations (Scopus)

Sphingosine 1-phosphate receptor 4 uses HER2 (ErbB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells

Long, J. S., Fujiwara, Y., Edwards, J., Tannahill, C. L., Tigyi, G., Pyne, S. & Pyne, N. J., 12 Nov 2010, In : Journal of Biological Chemistry. 285, p. 35957-35966 10 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor-2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells

Long, J. S., Edwards, J., Watson, C., Tovey, S., Mair, K. M., Schiff, R., Natarajan, V., Pyne, N. J. & Pyne, S., Aug 2010, In : Molecular and Cellular Biology. 30, 15, p. 3827-3841 15 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells

Loveridge, C., Tonelli, F., Leclercq, T., Lim, K. G., Long, J. S., Berdyshev, E., Tate, R. J., Natarajan, V., Pitson, S. M., Pyne, N. J. & Pyne, S., 10 Dec 2010, In : Journal of Biological Chemistry . 285, 50, p. 38841-38852 12 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

The sphingosine kinase inhibitor N, N-dimethylsphingosine inhibits neointimal hyperplasia

McDonald, R. A., Pyne, S., Pyne, N. J., Wainwright, C. L. & Wadsworth, R. M., 2010, In : British Journal of Pharmacology. 159, 3, p. 543-553 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)