1984 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Recent advances in the role of Sphingosine 1-phosphate in cancer

Pyne, N. J. & Pyne, S., 8 Sep 2020, (Accepted/In press) In : FEBS Letters. 43 p.

Research output: Contribution to journalReview article

Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1

Hii, L-W., Chung, F. F-L., Mai, C. W., Yee, Z. Y., Chan, H. H., Raja, V. J., Dephoure, N. E., Pyne, N. J., Pyne, S. & Leong, C-O., 4 Apr 2020, In : Cells. 9, 4, 25 p., 886.

Research output: Contribution to journalArticle

Open Access
File

Sphingosine kinases as druggable targets

Pyne, S., Adams, D. R. & Pyne, N. J., 25 Apr 2020, Lipid Signaling in Human Diseases: Handbook of Experimental Pharmacology. Gomez-Cambronero, J. & Frohman, M. A. (eds.). Cham, Switzerland, Vol. 259. p. 49-76 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

Alsanafi, M., Kelly, S. L., McNaughton, M., Merrill Jr., A. H., Pyne, N. J. & Pyne, S., 30 Apr 2020, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1865, 4, 10 p., 158631.

Research output: Contribution to journalSpecial issue

2019

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Fang, Z., Pyne, S. & Pyne, N. J., 30 Apr 2019, In : Progress in Lipid Research. 74, p. 145-159 15 p.

Research output: Contribution to journalReview article

Open Access
File
4 Citations (Scopus)
10 Downloads (Pure)

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
11 Downloads (Pure)

Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3

Alganga, H., Almabrouk, T. A. M., Katwan, O. J., Daly, C. J., Pyne, S., Pyne, N. J. & Kennedy, S., 31 Oct 2019, In : Journal of Pharmacology and Experimental Therapeutics. 371, 1, p. 63-74 12 p.

Research output: Contribution to journalArticle

Open Access

Sphingosine 1-phosphate turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Pyne, N. J. & Pyne, S., 16 Sep 2019, In : IUPHAR/BPS Guide to Pharmacology CITE. 2019, 4, 3 p.

Research output: Contribution to journalShort survey

Open Access
File
2 Downloads (Pure)

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Rivas, P. L., Baiget, J., Jiang, Z., Alsfouk, A., MacKay, S. P., Pyne, N. J. & Pyne, S., 11 Apr 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3658-3676 19 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
1 Downloads (Pure)
2018
Open Access
File
4 Citations (Scopus)
8 Downloads (Pure)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
10 Downloads (Pure)

Sphingosine 1-phosphate and cancer

Pyne, N. J., El Buri, A., Adams, D. R. & Pyne, S., 12 May 2018, In : Advances in Biological Regulation. 68, p. 97-106 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
26 Citations (Scopus)
107 Downloads (Pure)
14 Citations (Scopus)
29 Downloads (Pure)
2017
4 Citations (Scopus)
20 Downloads (Pure)

Sphingosine 1-phosphate receptor 1 signaling in mammalian cells

Pyne, N. J. & Pyne, S., 23 Feb 2017, In : Molecules. 22, 3, p. 1-18 18 p., 344.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
172 Downloads (Pure)

Sphingosine kinase1: a potential therapeutic target in pulmonary arterial hypertension?

Pyne, N. J. & Pyne, S., 30 Sep 2017, In : Trends in Molecular Medicine. 23, 9, p. 786-798 13 p.

Research output: Contribution to journalComment/debate

Open Access
File
13 Citations (Scopus)
12 Downloads (Pure)

Sphingosine kinase 2 and multiple myeloma

Pyne, N. J. & Pyne, S., 25 Apr 2017, In : Oncotarget. 8, 24, p. 43596-43597 2 p., 17420.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
23 Downloads (Pure)

Sphingosine kinase 2 in autoimmune/inflammatory disease and development of sphingosine kinase 2 inhibitors

Pyne, N. J., Adams, D. R. & Pyne, S., 31 Jul 2017, In : Trends in Pharmacological Sciences. 38, 7, p. 581-591 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
13 Citations (Scopus)
33 Downloads (Pure)
2016

Effect of ether glycerol lipids on interleukin-1β release and experimental autoimmune encephalomyelitis

Boomkamp, S. D., Byun, H-S., Ubhi, S., Jiang, H-R., Pyne, S., Bittman, R. & Pyne, N. J., 1 Jan 2016, In : Chemistry and Physics of Lipids. 194, p. 2-11 10 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
27 Downloads (Pure)

Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodeling in a hypoxic model of pulmonary arterial hypertension

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S. & Pyne, N. J., 31 Aug 2016, In : Cellular Signalling. 28, 8, p. 946-955 10 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
65 Downloads (Pure)

Pharmacological characterization of the αvβ6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2

Slack, R. J., Hafeji, M., Rogers, R., Ludbrook, S. B., Marshall, J. F., Flint, D. J., Pyne, S. & Denyer, J. C., 7 Jan 2016, In : Pharmacology. 97, 3-4, p. 114-125 12 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
85 Downloads (Pure)
43 Citations (Scopus)
251 Downloads (Pure)

Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H-R., Ubhi, S. K. & Pyne, S., 1 Jan 2016, In : Advances in Biological Regulation. 60, p. 151-159 9 p.

Research output: Contribution to journalArticle

Open Access
File
87 Citations (Scopus)
91 Downloads (Pure)

Sphingosine 1-phosphate and sphingosine kinases in health and disease: recent advances

Pyne, S., Adams, D. R. & Pyne, N. J., 1 Apr 2016, In : Progress in Lipid Research. 62, p. 93-106 14 p.

Research output: Contribution to journalLiterature review

Open Access
File
79 Citations (Scopus)
168 Downloads (Pure)

Sphingosine kinases: emerging structure function insights

Adams, D. R., Pyne, S. & Pyne, N. J., 1 May 2016, In : Trends in Biochemical Sciences . 41, 5, p. 395-409 15 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
50 Downloads (Pure)

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies

Evangelisti, C., Evangelisti, C., Buontempo, F., Lonetti, A., Orsini, E., Chiarini, F., Barata, J. T., Pyne, S., Pyne, N. J. & Martelli, A. M., 1 Nov 2016, In : Leukemia. 30, p. 2142–2151 10 p.

Research output: Contribution to journalLiterature review

Open Access
File
16 Citations (Scopus)
209 Downloads (Pure)
2014

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics

Evangelisti, C., Evangelisti, C., Teti, G., Chiarini, F., Falconi, M., Melchionda, F., Pession, A., Bertaina, A., Locatelli, F., McCubrey, JA., Baek, DJ., Bittman, R., Pyne, S., Pyne, N. & Martelli, AM., 2014, In : Oncotarget. 5, 17, p. 7886-7901 16 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
120 Downloads (Pure)

Crystal structure of sphingosine kinase 1 with PF-543

Wang, J., Knapp, S., Pyne, N., Pyne, S. & Elkins, J., 27 Dec 2014, In : Medicinal Chemistry Letters. 5, 12, p. 1329-1333 5 p.

Research output: Contribution to journalArticle

Open Access
File
52 Citations (Scopus)
90 Downloads (Pure)

Resveratrol and its oligomers: modulation of sphingolipid metabolism and signaling in disease

Lim, K. G., Gray, A. I., Anthony, N. G., MacKay, S. P., Pyne, S. & Pyne, N. J., 25 Oct 2014, In : Archives of Toxicology. 88, 12, p. 2213-2232 20 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
517 Downloads (Pure)

Selective inhibitors and allosteric activators of sphingosine kinase

Bittman, R., Pyne, N., Pyne, S., Baek, D. J., Liu, Z. & Byun, H-S., 7 Aug 2014, IPC No. C07D401/04, Patent No. PCT/GB2014/050264, Priority date 31 Jan 2013

Research output: Patent

138 Downloads (Pure)

Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis

Pyne, N. J. & Pyne, S., 26 Jun 2014, In : Oncogene. 33, 26, p. 3361-3363 3 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
79 Downloads (Pure)

The role of sphingosine 1-phosphate in inflammation and cancer

Pyne, N. J., Ohotski, J., Bittman, R. & Pyne, S., Jan 2014, In : Advances in Biological Regulation. 54, p. 121-129 9 p.

Research output: Contribution to journalLiterature review

Open Access
File
40 Citations (Scopus)
176 Downloads (Pure)
2013
30 Citations (Scopus)

Lipid phosphate phosphatase 3 participates in transport carrier formation and protein trafficking in the early secretory pathway

Gutiérrez-Martínez, E., Fernández-Ulibarri, I., Lázaro-Diéguez, F., Johannes, L., Pyne, S., Sarri, E. & Egea, G., 15 Jun 2013, In : Journal of Cell Science. 126, 12, p. 2641-2655 15 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

New perspectives on the role of sphingosine 1-phosphate in cancer

Pyne, S. & Pyne, N., 31 Mar 2013, Sphingolipids in Disease. Gulbins, E. & Petrache, I. (eds.). Vienna: Springer-Verlag, p. 55-71 17 p. (Handbook of experimental pharmacology ; no. 216).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

13 Citations (Scopus)
Open Access
File
46 Citations (Scopus)
94 Downloads (Pure)

Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

Rutherford, C., Childs, S., Ohotski, J., McGlynn, L., Riddick, M., MacFarlane, S., Tasker, D., Pyne, S., Pyne, N. J., Edwards, J. & Palmer, T. M., 21 Nov 2013, In : Cell Death and Disease. 4, 15 p., e927.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis

Pyne, N., Dubois, G. & Pyne, S., Jan 2013, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1831, 1, p. 228-238 10 p.

Research output: Contribution to journalSpecial issue

37 Citations (Scopus)

Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer

Pyne, S. & Pyne, N., 14 Jan 2013, In : Cancer Cell. 23, 1, p. 5-7 3 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors

Baek, D. J., MacRitchie, N., Anthony, N. G., Mackay, S. P., Pyne, S., Pyne, N. J. & Bittman, R., 27 Nov 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9310-9327 18 p.

Research output: Contribution to journalArticle

Open Access
File
31 Citations (Scopus)
165 Downloads (Pure)

Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators

Liu, Z., MacRitchie, N., Pyne, S., Pyne, N. J. & Bittman, R., 1 May 2013, In : Bioorganic and Medicinal Chemistry. 21, 9, p. 2503-2510 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Synthesis of selective inhibitors of sphingosine kinase 1

Baek, D. J., MacRitchie, N., Pyne, N., Pyne, S. & Bittman, R., 2013, In : Chemical Communications (London). 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The Concise Guide to PHARMACOLOGY 2013/14: overview

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., McGrath, J. C., Catterall, W. A., Spedding, M., Peters, J. A., Harmar, A. J., Abul-Hasn, N., Anderson, C. M., Anderson, C. M. H., Araiksinen, M. S., Arita, M., Arthofer, E., Barker, E. L., Barratt, C., Barnes, N. M., Bathgate, R. & 31 others, Beart, P. M., Belelli, D., Bennett, A. J., Birdsall, N. J. M., Boison, D., Bonner, T. I., Brailsford, L., Bröer, S., Brown, P., Calo, G., Carter, W. G., Catterall, W. A., Chan, S. L. F., Chao, M. V., Chiang, N., Christopoulos, A., Chun, J. J., Cidlowski, J., Clapham, D. E., Cockcroft, S., Connor, M. A., Cox, H. M., Cuthbert, A., Dautzenberg, F. M., Davenport, A. P., Dawson, P. A., Jones, R. L., Kennedy, C., Pyne, N. J., Pyne, S. & CGTP Collaborators, Dec 2013, In : British Journal of Pharmacology. 170, 8, p. 1449-58 10 p.

Research output: Contribution to journalSpecial issue

133 Citations (Scopus)

The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells

Tonelli, F., Alossaimi, M., Natarajan, V., Gorshkova, I., Berdyshev, E., Bittman, R., Watson, D. G., Pyne, S. & Pyne, N. J., 2013, In : Biomolecules. 3, 2, p. 316-333 18 p.

Research output: Contribution to journalArticle

Open Access
File
63 Downloads (Pure)

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells

Watson, D. G., Tonelli, F., Al Osaimi, M., Williamson, L., Chan, E., Gorshkova, I., Berdyshev, E., Bittman, R., Pyne, N. J. & Pyne, S., Apr 2013, In : Cellular Signalling. 25, 4, p. 1011-1017 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2012

Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer

Ohotski, J., Long, J., Orange, C., Elsberger, B., Mallon, E., Doughty, J., Pyne, S., Pyne, N. & Edwards, J., 10 Apr 2012, In : British Journal of Cancer. 106, 8, p. 1453-1459 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b

Lim, K. G., Tonelli, F. R., Berdyshev, E., Gorshkova, I., Leclercq, T., Pitson, S. M., Bittman, R., Pyne, S. & Pyne, N., Sep 2012, In : International Journal of Biochemistry and Cell Biology. 44, 9, p. 1457-1464 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Lysophospholipid receptor signalling platforms: the receptor tyrosine kinase-G-protein coupled receptor signaling complex

Pyne, N. & Pyne, S., Nov 2012, Lysophospholipid Receptors: Signaling and Biochemistry. Chun, J. (ed.). Chichester: John Wiley & Sons Inc., p. 85-102 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)