1984 …2020
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Personal profile

Personal Statement

Awards:

1993-2001 Wellcome Trust Senior Research Fellow

2014 Laurens van Deenen Lecture (awarded by ICBL for out-standing and long-term contributions to lipid research)

 

SIPBS Roles & Responsibilities:

Director of Equality & Diversity; Athena SWAN lead

 

Research interests (in collaboration with Nigel Pyne)

  • Sphingosine 1-phosphate signalling in health and disease - at a cellular level (cell division, migration, survival) in model cell lines; in vascular function (e.g. regulation of vascular tone, cardioprotection); in disease (e.g. cancer of the breast, prostate, colon etc.).
  • Isoform diversity, regulation and spatial signalling involving sphingosine kinases
  • Isoform diversity and regulation of lipid phosphate phosphatases

Sphingosine 1-phosphate (S1P) is a biologically active lipid that acts as both an agonist and as an intracellular second messenger. It is key to a number of important physiological processes including formation of blood vessels, migration of immune cells, vascular permeability etc. It is formed by sphingosine kinase-catalysed phosphorylation of sphingosine whereas S1P removal is either by dephosphorylation, which may involve lipid phosphate phosphatases, or cleavage by S1P lyase.

The overall aim of research in the laboratory is to understand the molecular mechanisms by which S1P affects cell function in health and disease.

We make use of molecular, biochemical, cellular biological techniques together with disease models and patient biopsy samples.

Recent research in this laboratory has received support from the British Heart Foundation, Scottish Universities Life Sciences Alliance (SULSA), Cancer Research UK (and WeCan), Biotechnology and Biological Sciences Research Council.

Expressions of interest in joining the research activity of the lab are always welcome.

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc, MSci  (both in various biological sciences) and MPharm (pharmacy) teaching programmes. Instruction of laboratory based research projects at both undergraduate and postgraduate (MSc, MRes, PhD) level.

Education/Academic qualification

Doctor of Philosophy, University of Birmingham

Bachelor of Science, University of Nottingham

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2003 2020

Research Output 1984 2019

Open Access
File
Lysosphingolipid Receptors
Breast Neoplasms
Neoplasms
Medicine
Survival

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222

Research output: Contribution to journalArticle

Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide

Prizes

2014 Laurens van Deenen Lecture

Susan Pyne (Recipient), 23 Jun 2014

Prize: Prize (including medals and awards)

Wellcome Trust Senior Research Fellow in Basic Biomedical Sciences

Susan Pyne (Recipient), 1993

Prize: Fellowship awarded competitively

Activities 1991 2018

Tenovus Scotland (West) (External organisation)

Pyne, S. (Advisor)
2018

Activity: MembershipMembership of committee

Minerva Foundation Institute for Medical Research (External organisation)

Pyne, S. (Advisor)
2018

Activity: MembershipMembership of committee