Photo of Susan Pyne
  • United Kingdom

Accepting PhD Students

1984 …2021
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Personal profile

Personal Statement


1993-2001 Wellcome Trust Senior Research Fellow

2014 Laurens van Deenen Lecture (awarded by ICBL for out-standing and long-term contributions to lipid research)

2018 Fellowship Royal Society of Biology


SIPBS Roles & Responsibilities:

Director of Equality & Diversity


Research interests (in collaboration with Nigel Pyne)

  • Sphingosine 1-phosphate signalling in health and disease - at a cellular level (cell division, migration, survival) in model cell lines; in vascular function (e.g. regulation of vascular tone, cardioprotection); in disease (e.g. cancer of the breast, prostate, colon etc.).
  • Isoform diversity, regulation and spatial signalling involving sphingosine kinases
  • Isoform diversity and regulation of lipid phosphate phosphatases

Sphingosine 1-phosphate (S1P) is a biologically active lipid that acts as both an agonist and as an intracellular second messenger. It is key to a number of important physiological processes including formation of blood vessels, migration of immune cells, vascular permeability etc. It is formed by sphingosine kinase-catalysed phosphorylation of sphingosine whereas S1P removal is either by dephosphorylation, which may involve lipid phosphate phosphatases, or cleavage by S1P lyase.

The overall aim of research in the laboratory is to understand the molecular mechanisms by which S1P affects cell function in health and disease.

We make use of molecular, biochemical, cellular biological techniques together with disease models and patient biopsy samples.

Recent research in this laboratory has received support from the British Heart Foundation, Scottish Universities Life Sciences Alliance (SULSA), Cancer Research UK (and WeCan), Biotechnology and Biological Sciences Research Council.

Expressions of interest in joining the research activity of the lab are always welcome.

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc, MSci  (both in various biological sciences) and MPharm (pharmacy) teaching programmes. Instruction of laboratory based research projects at both undergraduate and postgraduate (MSc, MRes, PhD) level.

Education/Academic qualification

Doctor of Philosophy, University of Birmingham

Bachelor of Science, University of Nottingham

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Lipids Medicine & Life Sciences
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2003 2021

Research Output 1984 2020

The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells

Alsanafi, M., Kelly, S. L., McNaughton, M., Merrill Jr., A. H., Pyne, N. J. & Pyne, S., 15 Jan 2020, In : Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids. 1865, 4, p. 1-10 10 p., 158631.

Research output: Contribution to journalSpecial issue

p38 Mitogen-Activated Protein Kinases
Small Interfering RNA
MAP Kinase Signaling System
1 Citation (Scopus)

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Fang, Z., Pyne, S. & Pyne, N. J., 30 Apr 2019, In : Progress in Lipid Research. 74, p. 145-159 15 p.

Research output: Contribution to journalReview article

Adipose Tissue
Type 2 Diabetes Mellitus


Identification of sphingosine 1-phosphate receptors in exosomes released from breast cancer cells

Author: El Buri, A. H. A., 1 Oct 2016

Supervisor: Pyne, S. (Supervisor) & Pyne, N. (Supervisor)

Student thesis: Doctoral Thesis

The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells

Author: McNaughton, M., 1 Oct 2016

Supervisor: Pyne, S. (Supervisor) & Pyne, N. (Supervisor)

Student thesis: Doctoral Thesis


2014 Laurens van Deenen Lecture

Susan Pyne (Recipient), 23 Jun 2014

Prize: Prize (including medals and awards)

Wellcome Trust Senior Research Fellow in Basic Biomedical Sciences

Susan Pyne (Recipient), 1993

Prize: Fellowship awarded competitively

Activities 1991 2019

FASEB Lysophospholipids and Related Lipids in Biology and Diseases, Portugal

Susan Pyne (Invited speaker)
Jul 2019

Activity: Participating in or organising an event typesParticipation in conference

FEBS Special Meeting in Sphingolipid Biology, Portugal

Susan Pyne (Invited speaker)
May 2019

Activity: Participating in or organising an event typesParticipation in conference