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Personal profile

Teaching Interests

Current PhD studentship (funded for UK or EU students; covering full tuition fees and a tax free stipend for 3 years), deadline 30 May 2018. Application via CV plus cover letter to s.chalmers@strath.ac.uk or imminently via FindAPhD.com

Alzheimer’s-associated amyloid or diabetic-like hyperglycaemia each impede mitochondrial motility, potentially altering neuronal synaptic function due to changes such as localised ATP supply or calcium buffering. Does the combination of hyperglycaemia and amyloid thus pre-dispose neurons to dysfunction and degeneration?

Objectives:

  1.  investigate whether exposure of primary neuronal cultures to amyloid plus hyperglycaemia (glucose oscillations) additively affect mitochondrial motility
  2. quantify the effect of aberrant mitochondrial motility on neuronal function, particularly synaptic activity
  3. examine whether neuroprotection is afforded by modulation of mitochondria

 

Project Area: Neuroscience; Fluorescence Microscopy; Alzheimer’s Disease; Mitochondrial Physiology; Calcium Signalling

 

Techniques to be used:

  • high-resolution live-cell fluorescence imaging of dynamic organelle and cell architecture
  • primary neuronal cell culture
  • electrophysiology and calcium imaging

 

Personal Statement

I am a Chancellors Research Fellow, examining the role of mitochondria in neurodegeneration and age-associated decline of the cerebrovasculature.

Research Interests

My primary research interest is in mitochondria, with a particular focus on the involvement of these small organelles with calcium signalling processes and the changes associated with age and diseases. I use high-speed and timelapse fluorescence imaging to visualise and modulate mitochondria and calcium signals within live cells and tissue. 

Keywords

  • Mitochondria
  • Calcium
  • Neurodegeneration
  • Vascular smooth muscle
  • Fluorescence microscopy

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Projects 2012 2019

Research Output 2003 2018

Mitochondria structure and position in the local control of calcium signals in smooth muscle cells

McCarron, J. G., Saunter, C., Wilson, C., Girkin, J. M. & Chalmers, S. 6 Aug 2018 Signal Transduction and Smooth Muscle. Trebak, M. & Earley, S. (eds.). Boca Raton, Florida, p. 173-190 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry

Patnaik, S. R., Zhang, X., Biswas, L., Akhtar, S., Zhou, X., Kusuluri, D. K., Reilly, J., May-Simera, H., Chalmers, S., McCarron, J. G. & Shu, X. 1 May 2018 In : Oncotarget. 9, 33, p. 23183-23197 15 p.

Research output: Contribution to journalArticle

Open Access
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Activities 2017 2017

  • 2 Oral presentation

Impacts

Public engagement/education with p4 pupils at Kelvindale Primary School

Susan Chalmers (Participant)

Impact: Impact - for External PortalEducation, Public understanding, information and debate