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Personal profile

Personal Statement

Mission
The goal of our research team is (1) to understand how sensory information is processed by brain circuits, and (2) to develop better strategies for the improvement and restoration of sensory abilities, with emphasis on hearing.

Strategy
Out strategies are (1) to study normal information processing, (2) to study abnormal information processing, and (3) to develop tools to modulate brain functions. Our main techniques are in vivo ensemble recording, optogenetics, and behavioural approaches. 

 

Research Interests

Research Projects
1. State-dependent auditory processing and perception
When we are paying attention to sound, we can vividly perceive it. When sleep, however, our perception is siginificantly diminished. But what is happening in the brain? Because our brain activity ('brain state') continuously changes, it is extremely important to address the following three questions: 1) how is each brain state organized at the level of neural circuit? 2) how do brain states affect sensory processing and perceptual decision? and 3) how are brain states regulated? We are addressing these questions by taking multidisciplinary approaches, with a focus on dynamic interplays between the auditory system and neuromodulatory systems.

2. The circuit mechanism of abnormal hearing
Brain circuits often generate auditory perception even in the absence of auditory inputs, such as auditory hallucinations. But how? We are particularly focusing on phantom auditory perception, so-called tinnitus. Tinnitus is a symptom, which is often associated with hearing loss. Considering aging society and age-related hearing loss, a better understanding of the neural basis of tinnitus is extremly urgent. We are aiming to identify neural correlates of tinnitus at the level of neuronal circuits. By using a massively parallel extracellular recording technique and a behavioural approach, we are determining relationships between tinnitus and abnormal neural population activity in the auditory thalamocortical circuit. This research program will provide further insight into the development of new treatment for tinnitus sufferers.

3. Technology development to improve and restore hearing
Once we understand both normal and abnormal states, a next step is to explore strategies to restore abnormal states into the normal one. In addition, we can also think of how we can boost our normal brain functions. To achieve these goals, we are developing new approaches and technologies. We are particularly interested in the improvement and restoration of sensory abilities by controlling neural activity. Combining advanced technologies in rodents as a model, we are developing novel strategies to improve and restore hearing.

***Our research team is currently accepting applications from prospective PhD students and postdocs. In particular, persons who have strong background in physics, mathematics, or engineering are strongly encouraged to apply. ***

 

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Projects 2011 2019

Research Output 2008 2018

Circuit mechanisms and computational models of REM sleep

Héricé, C., Patel, A. & Sakata, S., 15 Aug 2018, In : Neuroscience Research. p. 1-32 32 p.

Research output: Contribution to journalArticle

Open Access
File
REM Sleep
Sleep
Pons
Hypothalamus
Neuroanatomy

Cell type-specific and age-related changes in auditory cortical processing

Lyngholm, D. & Sakata, S., 13 Nov 2017

Research output: Contribution to conferencePoster

Hearing Loss
Auditory Cortex
Optogenetics
Parvalbumins
Inbred CBA Mouse

Thesis

Functional laminar architecture of rat primary auditory cortex following acoustic trauma

Author: Khodai, T. J., 1 Sep 2014

Supervisor: Sakata, S. (Supervisor) & Pratt, J. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2011 2018

  • 6 Invited talk
  • 4 Organiser of special symposia
  • 2 Participation in conference

State-dependent information processing in the brain

Sakata, S. (Speaker)
22 Aug 2018

Activity: Talk or presentationInvited talk

Annual Meeting of the Japan Neuroscience Society

Sakata, S. (Participant)
26 Jul 2018

Activity: Participating in or organising an eventOrganiser of special symposia