Sara Ottoboni

Sara Ottoboni is a Research Assistant in the Chemical and Process Engineering department. She is undertaking specific research activities associated with the requirements of the CMAC Future Manufacturing HUB project on the development of anti-solvent and reactive crystallisation and isolation (filtration, washing and drying) workflows. 

Sara received her Ph.D. in October 2018 at Strathclyde University. Her project was related to continuous isolation, filtration, washing and drying of pharmaceutical API. Her project title is "Developing strategies and equipment for continuous isolation of active pharmaceutical ingredients (APIs) by filtration, washing and drying". During this period she spent 5 months in 2015 and 2016 at Astra Zeneca, Macclesfield, UK for an industrial placement. In 2018 she went to Roche, Basel, Switzerland for an industrial internship. She collaborated with ReMedIEs-AppB industrial partners, to develop and test a continuous isolation platform.

She is Material Engineer and she received in 2009 her bachelor degree from the Univerista' di Modena e Reggio Emilia, Italy, where her project title was "Design and characterization of structural adhesive reinforced with inorganic oxide nanoparticle for electronical applications".

The master degree was received in 2013 from the Politecnico di Milano, Italy where her project was "Symmetric diarylethene derivates:property-structure relation".

In 2008, she worked for three months at Imperial College for Prof. Aldo Roberto Boccaccini, where she worked on electrophoretic deposition to cover metallic substrates with biopolymers.

From November, 2012 to September, 2014 she worked at Politecnico di Milano, Chemistry, Material and Chemical Engineer Department, for Prof. Paolo Gronchi as a research grant from Italcementi S.P.A. During this period she worked for different projects: Study and development of new grinding aids (Italcementi S.P. A.); Development of diapers recycle technique; Study, development and characterization of corrosion protection coatings (Green car project); Study, development and characterization of superhydrophobic coatings; Study, development and characterization of polymeric composite materials.

During her PhD she won the SCI Scotland Group PhD Student Competition.

Here is reported the list of seminar she presented, publication and conferences she attended as poster presenter and as speaker.

Seminar:

• Shaping and applications of superhydrophobicity; Poliefun Seminar, 30^th January 2014

 Conference Proceeding:

• Evidences about the Interactions between Grinding Aids and Cement Particles Surface. Valerio Antonio Paterno’, Sara Ottoboni, Marco Goisis, Paolo Gronchi; Eleventh International Conference (ACI), July 2015 Ottawa, Canada
• Properties of steel surfaces coated with organic molecules.  Amani Ponzoni, Sara Ottoboni, Manfredo Guilizzoni, Maurizio Zani, Paolo Gronchi; XXX International Conference on Surface Modification Technologies (SMT30), 29^th June – 1^st  July, 2016, Milan, Italy
• Investigating the isolation performance of a novel continuous filtration unit for pharmaceutical process development and manufacturing: A case study using paracetamol and related impurities. Sara Ottoboni, Muhid Shahid, Christopher Steven, Elizabeth Meehan, Alastair Barton, Paul Firth, Richard Sutherland, Andy Mitchell, Furqan Tahir, Chris Price; FiltCon 2018, 24^th – 25^th April, 2018, Prior Lake, MN, USA

 Conference presentation:

• The impact of paracetamol impurities on face-specific properties: investigating the surface of single crystals using TOF-SIMS. Sara Ottoboni, Michael Chrubasik, Layla Mir Bruce, Hien Nguyen, Blair Johnston,  Alastair Florence, Chris Price; 12^Th International Workshop of the Crystal Growth of Organic Material & 47^th Annual British Association of Crystal Growth Conference Joint Conference, 26^th-30^th June, 2016, University of Leeds, UK
• Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: A case study using paracetamol. Sara Ottoboni, Chris John Price, Christopher Steven, Elizabeth Meehan, Alastair Barton, Andy Mitchell et al.; FILTECH 2016, 11^th-13^th October, 2016, Cologne, Germany
• Investigating the isolation performance of a novel continuous filtration unit for pharmaceutical process development and manufacturing: A case study using paracetamol and related impurities. Sara Ottoboni, Muhid Shahid, Christopher Steven, Elizabeth Meehan, Alastair Barton, Paul Firth, Richard Sutherland, Andy Mitchell, Furqan Tahir, Chris Price; FiltCon 2018, 24^th – 25^th April, 2018, Prior Lake, MN, USA

Contribution to conference presentation:

• Addressing the Challenges of Continuous Filtration, Washing and Drying. Chris Price, Sara Ottoboni; CM2017 Adoption of Continuous Manufacturing in the Pharmaceutical Industry - International Industrial, Regulatory and Academic Workshop Dublin Feb 2017
• Continuous Filtration Washing & Drying: Addressing a Critical Gap in Developing Continuous Pharmaceutical Manufacturing Processes. Chris Price, Sara Ottoboni, Christopher Steven, Paul Firth, Alastair Barton; RSC Conference, Chem Spec Munich May 2017
• Developing a Strategy to Optimise Active Pharmaceutical Ingredient Filtration and Washing.  Chris Price, Sara Ottoboni, Muhid Shahid. FiltCon 2018, 24^th – 25^th April, 2018, Prior Lake, MN, USA
• Developing a Platform for Continuous Filtration. Chris Price, Sara Ottoboni, Paul Firth and Alastair Barton; Continuous Manufacturing Today: Taking the Pulse of Emerging Technology International Society for Pharmaceutical Engineering, Continuous Manufacturing Workshop 6^th – 7^th June 2018, Arlington, VA, USA.

Conference poster:

• Superhydrophobic coatings obtained by self-assembled molecules for industrial applications. Sara Ottoboni, Amani Ponzoni, Mirko Pinali, Paolo Gronchi. ACT’14, 21^st – 23^rd October 2014, Sosnowiec, Poland
• Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: modelling and experimental approach to estimate cake properties. Sara Ottoboni, Chris PRice, Christopher Steven, Elizabeth Meehan, Alastair Barton, Andy Mitchell. APMF'17, 25^th-26^th April 2017, London, UK>
• Investigating the isolation performance of a novel continuous filtration unit for pharmaceutical process development and manufacturing: A case study using paracetamol and related impurities. Sara Ottoboni, Muhid Shahid, Christopher Steven, Elizabeth Meehan, Alastair Barton, Paul Firth, Richard Sutherland, Andy Mitchell, Furqan Tahir, Chris Price; FiltCon 2018, 24^th – 25^th April, 2018, Prior Lake, MN, USA

 Paper:

• Determinazione della bagnabilita’ delle polveri. Sara Ottoboni, Valerio Antonio Paterno’, Paolo Gronchi; Trattamenti e Finiture, October 2013
• The impact of paracetamol impurities on face-specific properties: investigating the surface of single crystals using TOF-SIMS.  Sara Ottoboni, Michael Chrubasik, Layla Mir Bruce, Hien Nguyen, Blair Johnston,  Alastair Florence, Chris Price; Crystal Growth and Design 2018, 2750-2758
• Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing. Sara Ottoboni, Chris Price, Christopher Steven, Elizabeth Meehan, Alistair Barton, Paul Firth, Andy Mitchell, Furqan Tahir; Journal of Pharmaceutical Science, Pharmaceutical Drug Delivery and Pharmaceutical Technology, 2018, 1-10.