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Research Output 1993 2019

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Article
2019

Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells

Laskar, P., Somani, S., Campbell, S. J., Mullin, M., Keating, P., Tate, R. J., Irving, C., Leung, H. Y. & Dufès, C., 14 Nov 2019, In : Nanoscale. 11, 42, p. 20058-20071 14 p.

Research output: Contribution to journalArticle

Dendrimers
Camptothecin
Drug delivery
Oxidation-Reduction
Genes
1 Citation (Scopus)

Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function

Neamatallah, T., Jabbar, S., Tate, R., Schroeder, J., Shweash, M., Alexander, J. & Plevin, R., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, 17 p., 3434.

Research output: Contribution to journalArticle

Open Access
File
deletion
phosphatases
macrophages
genome
Macrophages
2018
Open Access
File
Cobalt
Rats
Fibroblasts
Proteins
Metals
1 Citation (Scopus)

Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse

Kouskou, M., Thomson, D. M., Brett, R. R., Wheeler, L., Tate, R. J., Pratt, J. A. & Chamberlain, L. H., 31 Oct 2018, In : Experimental Neurology. 308, p. 35-46 12 p.

Research output: Contribution to journalArticle

Open Access
File
Intellectual Disability
Acylation
Corpus Callosum
Protein S
Genes
4 Citations (Scopus)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide
Open Access
File
Surface-Active Agents
Small Interfering RNA
Luciferases
Proteins
Liposomes

Redox-sensitive, cholesterol-bearing PEGylated poly(propyleneimine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N. A. S., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y. & Dufès, C., 28 Dec 2018, In : Nanoscale. 10, 48, p. 22830-22847 18 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Cholesterol
Genes
Cells
Dendrimers
7 Citations (Scopus)

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL and interleukin-12

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., MacKenzie, G. R., Leung, H. Y. & Dufès, C., 1 Mar 2018, In : Drug Delivery. 25, 1, p. 679-689 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lactoferrin
Interleukin-12
Intravenous Administration
Prostate
Tumor Necrosis Factor-alpha
Open Access
File
Receptors, Prostaglandin E, EP4 Subtype
Prostaglandin Receptors
Dinoprostone
Tumor Necrosis Factor-alpha
Cytokines
7 Citations (Scopus)
Open Access
File
Lysosphingolipid Receptors
Exosomes
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Breast Neoplasms
4 Citations (Scopus)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In : Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Toll-Like Receptor 3
Poly I-C
Neurons
Induced Pluripotent Stem Cells
Miniature Postsynaptic Potentials
2017
8 Citations (Scopus)
Open Access
File
Surface-Active Agents
Microfluidics
Heating
Cholesterol
Alcohols

Etoposide upregulates survival favoring sphingosine-1-phosphate in etoposide-resistant retinoblastoma cells

Kakkassery, V., Skosyrski, S., Lüth, A., Kleuser, B., van der Giet, M., Tate, R., Reinhard, J., Faissner, A., Joachim, S. C. & Kociok, N., 15 Nov 2017, In : Pathology & Oncology Research. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Sphingosine
Retinoblastoma
Etoposide
Up-Regulation
Glucosylceramides
7 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
Small Interfering RNA
Green Fluorescent Proteins
Neoplasms
7 Citations (Scopus)

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Aspergillus
Metabolites
Bioactivity
Complex Mixtures
16 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
HEPES
Lipids
Tromethamine
3 Citations (Scopus)
Open Access
File
Fatigue
Healthy Volunteers
Fatigue of materials
athletic performance
rehabilitation (people)
2015
38 Citations (Scopus)
Open Access
File
MicroRNAs
microRNA
Biological Availability
bioavailability
Digestion
21 Citations (Scopus)

Effects of CoCr metal wear debris generated from metal-on-metal hip implants and Co ions on human monocyte-like U937 cells

Posada, O. M., Tate, R. J. & Grant, M. H., Mar 2015, In : Toxicology in Vitro. 29, 2, p. 271-280 10 p.

Research output: Contribution to journalArticle

Open Access
File
U937 Cells
Chromium
Cobalt
Debris
Hip
12 Citations (Scopus)

In vitro analyses of the toxicity, immunological, and gene expression effects of cobalt-chromium alloy wear debris and Co ions derived from metal-on-metal hip implants

Posada, O. M., Tate, R. J., Meek, R. M. D. & Grant, M. H., 14 Jul 2015, In : Lubricants. 3, 3, p. 539-568 30 p.

Research output: Contribution to journalArticle

Open Access
File
Cobalt alloys
Chromium alloys
Debris
Gene expression
Toxicity
19 Citations (Scopus)

Toxicity of cobalt-chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro

Posada, O. M., Tate, R. J. & Grant, M. H., 6 Jun 2015, In : Journal of Applied Toxicology. 35, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lymphocytes
Chromium
Cobalt
Debris
Nanoparticles
21 Citations (Scopus)

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes

Lim, L. Y., Koh, P. Y., Somani, S., Al Robaian, M., Karim, R., Yean, Y. L., Mitchell, J., Tate, R. J., Edrada-Ebel, R., Blatchford, D. R., Mullin, M. & Dufès, C., Aug 2015, In : Nanomedicine: Nanotechnology, Biology and Medicine. 11, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Lactoferrin
Intravenous Administration
Tumors
Dendrimers
2014
20 Citations (Scopus)
Open Access
File
Chromium Alloys
U937 Cells
Chromium
Cobalt
Toxicology
2013
2 Citations (Scopus)

The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism

Gibriel, A., Tate, R., Yu, Y., Rawson-Lax, E., Hammer, HM., Tettey, J. N. A., Pyne, N. & Converse, C., 15 Feb 2013, In : Gene. 515, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Glutamic Acid
Exons
Mutation
Proteins
15 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Thiazoles
Androgen Receptors
Oxidative Stress
Prostatic Neoplasms
sphingosine kinase
2012
14 Citations (Scopus)
Neural Stem Cells
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Neuronal Plasticity
Cell- and Tissue-Based Therapy
24 Citations (Scopus)

Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system

Lemarié, F., Croft, D., Tate, R., Ryan, K. M. & Dufès, C., 2012, In : Biomaterials. 33, p. 2701-2709 9 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Intravenous Administration
Tumors
Genes
Dendrimers
2011
15 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., 2011, In : Nanomedicine: Nanotechnology, Biology and Medicine. 7, 5, p. 815-823 9 p.

Research output: Contribution to journalArticle

Bearings (structural)
Polyethyleneimine
Arginine
Gene expression
Leucine
38 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex

Aldawsari, H. M., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., Sep 2011, In : Biomaterials. 32, 25, p. 5889-5899 11 p.

Research output: Contribution to journalArticle

Bearings (structural)
Arginine
Gene expression
Leucine
Intravenous Administration
2010

Enhanced transfection efficacy of polyethylenimine by surface modification with arginine, lysine, and leucine

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R. & Dufès, C., 2010, In : Controlled Release Society Newsletter. 27, 6, p. 12-14 3 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Leucine
Lysine
Transfection
Arginine
82 Citations (Scopus)

The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells

Loveridge, C., Tonelli, F., Leclercq, T., Lim, K. G., Long, J. S., Berdyshev, E., Tate, R. J., Natarajan, V., Pitson, S. M., Pyne, N. J. & Pyne, S., 10 Dec 2010, In : Journal of Biological Chemistry . 285, 50, p. 38841-38852 12 p.

Research output: Contribution to journalArticle

Thiazoles
Cells
Degradation
Androgens
Apoptosis
74 Citations (Scopus)

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA

Koppu, S., Oh, Y. J., Edrada-Ebel, R., Blatchford, D. R., Tetley, L., Tate, R. & Dufès, C., 19 Apr 2010, In : Journal of Controlled Release. 143, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Plasmids
DNA
Intravenous Administration
Transferrin
2009
24 Citations (Scopus)
Coordination Complexes
Platinum
Drug delivery
Cytotoxicity
Pharmaceutical Preparations
2008
43 Citations (Scopus)

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G., Waigh, R., Tate, R., Harvey, A. & Furman, B., Apr 2008, In : British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

Weight Loss
Adipocytes
Acetyl-CoA Carboxylase
Skeletal Muscle Fibers
AMP-Activated Protein Kinases
2007
3 Citations (Scopus)
Neuromuscular Blocking Agents
Nicotinic Receptors
Ligands
Amino Acids
Muscles
2006
8 Citations (Scopus)

Lack of immunological cross-reactivity between parasite-derived and recombinant forms of es-62, a secreted protein of acanthocheilonema viteae

Egan, C. A., Houston, K. M., Alcocer, M. J. C., Solovyova, A., Tate, R., Lochnit, G., McInnes, I. B. & Harnett, M. M., Feb 2006, In : Parasitology. 132, 2, p. 263-274 11 p.

Research output: Contribution to journalArticle

Acanthocheilonema
Acanthocheilonema viteae
cross reaction
Phosphorylcholine
Parasites
2003
9 Citations (Scopus)

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

Frame, M. J., Tate, R., Adams, D. R., Morgan, K. M., Houslay, M. D., Vandenabeele, P. & Pyne, N. J., Mar 2003, In : European Journal of Biochemistry . 270, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Caspase 3
Proteolysis
Catalytic Domain
19 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Mitogen-Activated Protein Kinase 1
Phosphoric Diester Hydrolases
Mitogen-Activated Protein Kinases
Epidermal Growth Factor
132 Citations (Scopus)

Two-pore domain k channel, TASK-1, in pulmonary artery smooth muscle cells

Gurney, A. M., Osipenko, O. N., MacMillan, D., McFarlane, K. M., Tate, R. J. S. J. & Kempsill, F. E. J., 2003, In : Circulation Research. 93, p. 957-964 8 p.

Research output: Contribution to journalArticle

Membrane Potentials
Pulmonary Artery
Smooth Muscle Myocytes
Lung
Blood Vessels
2002
30 Citations (Scopus)

Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific

Stepek, G., Auchie, M., Tate, R., Watson, K., Russell, D. G., Devaney, E. & Harnett, W., 2002, In : Parasitology. 125, Pt 2, p. 155-64 10 p.

Research output: Contribution to journalArticle

Acanthocheilonema viteae
Brugia malayi
Phosphorylcholine
Sequence Homology
Gene Library
1 Citation (Scopus)

Properties of the cellular prion protein expressed in Xenopus oocytes

Connolly, J. G., Tate, R. J., McLennan, N. F., Brown, D., Telling, G. C., Fraser, J. & Head, M. W., 2002, In : NeuroReport. 13, 9, p. 1229-1233 4 p.

Research output: Contribution to journalArticle

Xenopus
Oocytes
PrPC Proteins
Peptide Hydrolases
RNA
11 Citations (Scopus)
Vertebrate Photoreceptor Cells
Cyclic GMP
Phosphoric Diester Hydrolases
Lung
Messenger RNA
2001
27 Citations (Scopus)
10 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Phosphoric Diester Hydrolases
Caspase 3
60 Citations (Scopus)
Mitogen-Activated Protein Kinase 1
Cyclic GMP
Phosphoric Diester Hydrolases
G-Protein-Coupled Receptor Kinase 2
Mitogen-Activated Protein Kinases
2000
27 Citations (Scopus)
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Insulin-Secreting Cells
Cyclic AMP
Insulin
112 Citations (Scopus)

Potential role for kv3.1b channels as oxygen sensors

Osipenko, O. N., Tate, R. J., Gurney, A. M. & Tate, R., 2000, In : Circulation Research. 86, 5, p. 534-40 7 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Oxygen
Smooth Muscle Myocytes
Membranes
Charybdotoxin
1999
13 Citations (Scopus)

Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle

Tate, R. J., Tolan, D. & Pyne, S., 1999, In : Cellular Signalling. 11, 7, p. 515-522 8 p.

Research output: Contribution to journalArticle

Molecular Cloning
Magnesium
Smooth Muscle
Base Pairing
Complementary DNA
83 Citations (Scopus)
1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinase 1
Phosphatidylinositols
Mitogen-Activated Protein Kinases
Smooth Muscle
1998
14 Citations (Scopus)

The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung

Tate, R. J., Lochhead, A., Brzeski, H., Arshavsky, V. & Pyne, N. J., 1998, In : Cell Biochemistry and Biophysics. 29, 1-2, p. 133-144 12 p.

Research output: Contribution to journalArticle

Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Enzyme Inhibitors
Hydrolysis