1993 …2020
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Research Output 1993 2019

2010
73 Citations (Scopus)

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA

Koppu, S., Oh, Y. J., Edrada-Ebel, R., Blatchford, D. R., Tetley, L., Tate, R. & Dufès, C., 19 Apr 2010, In : Journal of Controlled Release. 143, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Plasmids
DNA
Intravenous Administration
Transferrin
2009
Neural Stem Cells
Cell- and Tissue-Based Therapy
Estrogens
Stem Cells
Stroke
23 Citations (Scopus)
Coordination Complexes
Platinum
Drug delivery
Cytotoxicity
Pharmaceutical Preparations
2008
43 Citations (Scopus)

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G., Waigh, R., Tate, R., Harvey, A. & Furman, B., Apr 2008, In : British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

Weight Loss
Adipocytes
Acetyl-CoA Carboxylase
Skeletal Muscle Fibers
AMP-Activated Protein Kinases
2007
3 Citations (Scopus)
Neuromuscular Blocking Agents
Nicotinic Receptors
Ligands
Amino Acids
Muscles
2006
7 Citations (Scopus)

Lack of immunological cross-reactivity between parasite-derived and recombinant forms of es-62, a secreted protein of acanthocheilonema viteae

Egan, C. A., Houston, K. M., Alcocer, M. J. C., Solovyova, A., Tate, R., Lochnit, G., McInnes, I. B. & Harnett, M. M., Feb 2006, In : Parasitology. 132, 2, p. 263-274 11 p.

Research output: Contribution to journalArticle

Acanthocheilonema
Acanthocheilonema viteae
cross reaction
Phosphorylcholine
Parasites

Molecular determinants in pulmonary hypertension: the role of PDE5

Pyne, N. J., Murray, F., Tate, R. & MacLean, M. R., 2006, Cyclic Nucleotide Phosphodiesterases in Health and Diseases. Beavo, J., Francis, S. & Houslay, MD. (eds.). Boca Raton, p. 501-518 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phosphoric Diester Hydrolases
Pulmonary Hypertension
Molecular Structure
Nucleotides
Pharmacology
2003
9 Citations (Scopus)

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

Frame, M. J., Tate, R., Adams, D. R., Morgan, K. M., Houslay, M. D., Vandenabeele, P. & Pyne, N. J., Mar 2003, In : European Journal of Biochemistry . 270, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Caspase 3
Proteolysis
Catalytic Domain
19 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Mitogen-Activated Protein Kinase 1
Phosphoric Diester Hydrolases
Mitogen-Activated Protein Kinases
Epidermal Growth Factor
132 Citations (Scopus)

Two-pore domain k channel, TASK-1, in pulmonary artery smooth muscle cells

Gurney, A. M., Osipenko, O. N., MacMillan, D., McFarlane, K. M., Tate, R. J. S. J. & Kempsill, F. E. J., 2003, In : Circulation Research. 93, p. 957-964 8 p.

Research output: Contribution to journalArticle

Membrane Potentials
Pulmonary Artery
Smooth Muscle Myocytes
Lung
Blood Vessels
2002
30 Citations (Scopus)

Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific

Stepek, G., Auchie, M., Tate, R., Watson, K., Russell, D. G., Devaney, E. & Harnett, W., 2002, In : Parasitology. 125, Pt 2, p. 155-64 10 p.

Research output: Contribution to journalArticle

Acanthocheilonema viteae
Brugia malayi
Phosphorylcholine
Sequence Homology
Gene Library
1 Citation (Scopus)

Properties of the cellular prion protein expressed in Xenopus oocytes

Connolly, J. G., Tate, R. J., McLennan, N. F., Brown, D., Telling, G. C., Fraser, J. & Head, M. W., 2002, In : NeuroReport. 13, 9, p. 1229-1233 4 p.

Research output: Contribution to journalArticle

Xenopus
Oocytes
PrPC Proteins
Peptide Hydrolases
RNA
11 Citations (Scopus)
Vertebrate Photoreceptor Cells
Cyclic GMP
Phosphoric Diester Hydrolases
Lung
Messenger RNA
2001
27 Citations (Scopus)
10 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Phosphoric Diester Hydrolases
Caspase 3
59 Citations (Scopus)
Mitogen-Activated Protein Kinase 1
Cyclic GMP
Phosphoric Diester Hydrolases
G-Protein-Coupled Receptor Kinase 2
Mitogen-Activated Protein Kinases
2000
27 Citations (Scopus)
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Insulin-Secreting Cells
Cyclic AMP
Insulin
112 Citations (Scopus)

Potential role for kv3.1b channels as oxygen sensors

Osipenko, O. N., Tate, R. J., Gurney, A. M. & Tate, R., 2000, In : Circulation Research. 86, 5, p. 534-40 7 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Oxygen
Smooth Muscle Myocytes
Membranes
Charybdotoxin
1999
9 Citations (Scopus)

Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

Pyne, S., Rakhit, S., Conway, A. M., McKie, A., Darroch, P., Tate, R. & Pyne, N., Aug 1999, In : Biochemical Society Transactions. 27, 4, p. 404-409 6 p.

Research output: Contribution to journalLiterature review

Platelets
Blood Platelets
Genes
Cells
Apoptosis
13 Citations (Scopus)

Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle

Tate, R. J., Tolan, D. & Pyne, S., 1999, In : Cellular Signalling. 11, 7, p. 515-522 8 p.

Research output: Contribution to journalArticle

Molecular Cloning
Magnesium
Smooth Muscle
Base Pairing
Complementary DNA
83 Citations (Scopus)
1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinase 1
Phosphatidylinositols
Mitogen-Activated Protein Kinases
Smooth Muscle
1998
14 Citations (Scopus)

The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung

Tate, R. J., Lochhead, A., Brzeski, H., Arshavsky, V. & Pyne, N. J., 1998, In : Cell Biochemistry and Biophysics. 29, 1-2, p. 133-144 12 p.

Research output: Contribution to journalArticle

Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Enzyme Inhibitors
Hydrolysis
1997
10 Citations (Scopus)

Cloning and sequencing of an aspergillus niger gene coding for beta-fructufuranosidase

Somiari, R. I., Brzeski, H., Tate, R., Bieleck, S. & Polak, J., Dec 1997, In : Biotechnology Letters. 19, 12, p. 1243-1247 5 p.

Research output: Contribution to journalArticle

beta-Fructofuranosidase
Aspergillus niger
Cloning
Aspergillus
Amino acids
17 Citations (Scopus)

Differential effect of finasteride on the tissue androgen concentrations in benign prostatic hyperplasia

Habib, F. K., Ross, M., Tate, R. & Chisholm, G. D., 1997, In : Clinical Endocrinology. 46, 2, p. 137-44 8 p.

Research output: Contribution to journalArticle

Cholestenone 5 alpha-Reductase
Finasteride
Prostatic Hyperplasia
Androgens
5-alpha Reductase Inhibitors
1996
92 Citations (Scopus)

Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases

Belham, C. M., Tate, R. J., Scott, P. H., Pemberton, A. D., Miller, H. R., Wadsworth, R. M., Gould, G. W. & Plevin, R., 1996, In : Biochemical journal. 320 ( Pt 3), p. 939-46 8 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
seryl-leucyl-isoleucyl-glycyl-arginyl-leucine
Mitogen-Activated Protein Kinases
Trypsin
Chemical activation
1995
107 Citations (Scopus)

Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors

Iehlé, C., Délos, S., Guirou, O., Tate, R., Raynaud, J. P. & Martin, P. M., 1995, In : Journal of Steroid Biochemistry and Molecular Biology . 54, 5-6, p. 273-279 7 p.

Research output: Contribution to journalArticle

3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Cholestenone 5 alpha-Reductase
Protein Isoforms
Isoenzymes
Sterols
1993
8 Citations (Scopus)

Absence of 5 alpha-reductase activity in the gubernaculum during descent of the fetal pig testis

Heyns, C. F., Tate, R., Sargent, N. S., Habib, F. K. & Chisholm, G. D., 1993, In : Journal of Urology. 150, 2 Pt 1, p. 510-513 4 p.

Research output: Contribution to journalArticle

Cholestenone 5 alpha-Reductase
Testis
Swine
Dihydrotestosterone
Epididymis