1993 …2020
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Research Output 1993 2019

Abstract

In vivo and in vitro toxicity of cobalt in the heart

Laovitthayanggoon, S., Henderson, C. J., Tate, R. J., Currie, S., McCluskey, C., Macdonald, M. & Grant, M. H., 3 Apr 2017. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Fibroblasts
Toxicity
Cobalt
Rats
Bearings (structural)

RNA stability in frozen/thawed clinical blood samples

Posada Estefan, O. M., Tate, R. & Grant, M., 2011, p. 9. 1 p.

Research output: Contribution to conferenceAbstract

RNA Stability
RNA
Gene Expression
Article
8 Citations (Scopus)

Absence of 5 alpha-reductase activity in the gubernaculum during descent of the fetal pig testis

Heyns, C. F., Tate, R., Sargent, N. S., Habib, F. K. & Chisholm, G. D., 1993, In : Journal of Urology. 150, 2 Pt 1, p. 510-513 4 p.

Research output: Contribution to journalArticle

Cholestenone 5 alpha-Reductase
Testis
Swine
Dihydrotestosterone
Epididymis
27 Citations (Scopus)

Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells

Laskar, P., Somani, S., Campbell, S. J., Mullin, M., Keating, P., Tate, R. J., Irving, C., Leung, H. Y. & Dufès, C., 14 Nov 2019, In : Nanoscale. 11, 42, p. 20058-20071 14 p.

Research output: Contribution to journalArticle

Dendrimers
Camptothecin
Drug delivery
Oxidation-Reduction
Genes
10 Citations (Scopus)

Cloning and sequencing of an aspergillus niger gene coding for beta-fructufuranosidase

Somiari, R. I., Brzeski, H., Tate, R., Bieleck, S. & Polak, J., Dec 1997, In : Biotechnology Letters. 19, 12, p. 1243-1247 5 p.

Research output: Contribution to journalArticle

beta-Fructofuranosidase
Aspergillus niger
Cloning
Aspergillus
Amino acids
Open Access
File
Cobalt
Rats
Fibroblasts
Proteins
Metals
20 Citations (Scopus)
Open Access
File
Chromium Alloys
U937 Cells
Chromium
Cobalt
Toxicology
8 Citations (Scopus)
Open Access
File
Surface-Active Agents
Microfluidics
Heating
Cholesterol
Alcohols
14 Citations (Scopus)
Neural Stem Cells
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Neuronal Plasticity
Cell- and Tissue-Based Therapy
38 Citations (Scopus)
Open Access
File
MicroRNAs
microRNA
Biological Availability
bioavailability
Digestion
17 Citations (Scopus)

Differential effect of finasteride on the tissue androgen concentrations in benign prostatic hyperplasia

Habib, F. K., Ross, M., Tate, R. & Chisholm, G. D., 1997, In : Clinical Endocrinology. 46, 2, p. 137-44 8 p.

Research output: Contribution to journalArticle

Cholestenone 5 alpha-Reductase
Finasteride
Prostatic Hyperplasia
Androgens
5-alpha Reductase Inhibitors
1 Citation (Scopus)

Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse

Kouskou, M., Thomson, D. M., Brett, R. R., Wheeler, L., Tate, R. J., Pratt, J. A. & Chamberlain, L. H., 31 Oct 2018, In : Experimental Neurology. 308, p. 35-46 12 p.

Research output: Contribution to journalArticle

Open Access
File
Intellectual Disability
Acylation
Corpus Callosum
Protein S
Genes
27 Citations (Scopus)
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Insulin-Secreting Cells
Cyclic AMP
Insulin
21 Citations (Scopus)

Effects of CoCr metal wear debris generated from metal-on-metal hip implants and Co ions on human monocyte-like U937 cells

Posada, O. M., Tate, R. J. & Grant, M. H., Mar 2015, In : Toxicology in Vitro. 29, 2, p. 271-280 10 p.

Research output: Contribution to journalArticle

Open Access
File
U937 Cells
Chromium
Cobalt
Debris
Hip
15 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., 2011, In : Nanomedicine: Nanotechnology, Biology and Medicine. 7, 5, p. 815-823 9 p.

Research output: Contribution to journalArticle

Bearings (structural)
Polyethyleneimine
Arginine
Gene expression
Leucine
38 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex

Aldawsari, H. M., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., Sep 2011, In : Biomaterials. 32, 25, p. 5889-5899 11 p.

Research output: Contribution to journalArticle

Bearings (structural)
Arginine
Gene expression
Leucine
Intravenous Administration

Enhanced transfection efficacy of polyethylenimine by surface modification with arginine, lysine, and leucine

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R. & Dufès, C., 2010, In : Controlled Release Society Newsletter. 27, 6, p. 12-14 3 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Leucine
Lysine
Transfection
Arginine

Etoposide upregulates survival favoring sphingosine-1-phosphate in etoposide-resistant retinoblastoma cells

Kakkassery, V., Skosyrski, S., Lüth, A., Kleuser, B., van der Giet, M., Tate, R., Reinhard, J., Faissner, A., Joachim, S. C. & Kociok, N., 15 Nov 2017, In : Pathology & Oncology Research. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Sphingosine
Retinoblastoma
Etoposide
Up-Regulation
Glucosylceramides
30 Citations (Scopus)

Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific

Stepek, G., Auchie, M., Tate, R., Watson, K., Russell, D. G., Devaney, E. & Harnett, W., 2002, In : Parasitology. 125, Pt 2, p. 155-64 10 p.

Research output: Contribution to journalArticle

Acanthocheilonema viteae
Brugia malayi
Phosphorylcholine
Sequence Homology
Gene Library
7 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
Small Interfering RNA
Green Fluorescent Proteins
Neoplasms
107 Citations (Scopus)

Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors

Iehlé, C., Délos, S., Guirou, O., Tate, R., Raynaud, J. P. & Martin, P. M., 1995, In : Journal of Steroid Biochemistry and Molecular Biology . 54, 5-6, p. 273-279 7 p.

Research output: Contribution to journalArticle

3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Cholestenone 5 alpha-Reductase
Protein Isoforms
Isoenzymes
Sterols
9 Citations (Scopus)

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

Frame, M. J., Tate, R., Adams, D. R., Morgan, K. M., Houslay, M. D., Vandenabeele, P. & Pyne, N. J., Mar 2003, In : European Journal of Biochemistry . 270, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Caspase 3
Proteolysis
Catalytic Domain
12 Citations (Scopus)

In vitro analyses of the toxicity, immunological, and gene expression effects of cobalt-chromium alloy wear debris and Co ions derived from metal-on-metal hip implants

Posada, O. M., Tate, R. J., Meek, R. M. D. & Grant, M. H., 14 Jul 2015, In : Lubricants. 3, 3, p. 539-568 30 p.

Research output: Contribution to journalArticle

Open Access
File
Cobalt alloys
Chromium alloys
Debris
Gene expression
Toxicity
8 Citations (Scopus)

Lack of immunological cross-reactivity between parasite-derived and recombinant forms of es-62, a secreted protein of acanthocheilonema viteae

Egan, C. A., Houston, K. M., Alcocer, M. J. C., Solovyova, A., Tate, R., Lochnit, G., McInnes, I. B. & Harnett, M. M., Feb 2006, In : Parasitology. 132, 2, p. 263-274 11 p.

Research output: Contribution to journalArticle

Acanthocheilonema
Acanthocheilonema viteae
cross reaction
Phosphorylcholine
Parasites
43 Citations (Scopus)

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G., Waigh, R., Tate, R., Harvey, A. & Furman, B., Apr 2008, In : British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

Weight Loss
Adipocytes
Acetyl-CoA Carboxylase
Skeletal Muscle Fibers
AMP-Activated Protein Kinases
7 Citations (Scopus)

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Aspergillus
Metabolites
Bioactivity
Complex Mixtures
13 Citations (Scopus)

Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle

Tate, R. J., Tolan, D. & Pyne, S., 1999, In : Cellular Signalling. 11, 7, p. 515-522 8 p.

Research output: Contribution to journalArticle

Molecular Cloning
Magnesium
Smooth Muscle
Base Pairing
Complementary DNA
4 Citations (Scopus)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide
112 Citations (Scopus)

Potential role for kv3.1b channels as oxygen sensors

Osipenko, O. N., Tate, R. J., Gurney, A. M. & Tate, R., 2000, In : Circulation Research. 86, 5, p. 534-40 7 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Oxygen
Smooth Muscle Myocytes
Membranes
Charybdotoxin
Open Access
File
Surface-Active Agents
Small Interfering RNA
Luciferases
Proteins
Liposomes
1 Citation (Scopus)

Properties of the cellular prion protein expressed in Xenopus oocytes

Connolly, J. G., Tate, R. J., McLennan, N. F., Brown, D., Telling, G. C., Fraser, J. & Head, M. W., 2002, In : NeuroReport. 13, 9, p. 1229-1233 4 p.

Research output: Contribution to journalArticle

Xenopus
Oocytes
PrPC Proteins
Peptide Hydrolases
RNA

Redox-sensitive, cholesterol-bearing PEGylated poly(propyleneimine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N. A. S., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y. & Dufès, C., 28 Dec 2018, In : Nanoscale. 10, 48, p. 22830-22847 18 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Cholesterol
Genes
Cells
Dendrimers
6 Citations (Scopus)

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL and interleukin-12

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., MacKenzie, G. R., Leung, H. Y. & Dufès, C., 1 Mar 2018, In : Drug Delivery. 25, 1, p. 679-689 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lactoferrin
Interleukin-12
Intravenous Administration
Prostate
Tumor Necrosis Factor-alpha
23 Citations (Scopus)
Coordination Complexes
Platinum
Drug delivery
Cytotoxicity
Pharmaceutical Preparations
83 Citations (Scopus)
1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinase 1
Phosphatidylinositols
Mitogen-Activated Protein Kinases
Smooth Muscle
16 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
HEPES
Lipids
Tromethamine
14 Citations (Scopus)

The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung

Tate, R. J., Lochhead, A., Brzeski, H., Arshavsky, V. & Pyne, N. J., 1998, In : Cell Biochemistry and Biophysics. 29, 1-2, p. 133-144 12 p.

Research output: Contribution to journalArticle

Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Enzyme Inhibitors
Hydrolysis
10 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Phosphoric Diester Hydrolases
Caspase 3
11 Citations (Scopus)
Vertebrate Photoreceptor Cells
Cyclic GMP
Phosphoric Diester Hydrolases
Lung
Messenger RNA
19 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Mitogen-Activated Protein Kinase 1
Phosphoric Diester Hydrolases
Mitogen-Activated Protein Kinases
Epidermal Growth Factor
59 Citations (Scopus)
Mitogen-Activated Protein Kinase 1
Cyclic GMP
Phosphoric Diester Hydrolases
G-Protein-Coupled Receptor Kinase 2
Mitogen-Activated Protein Kinases
2 Citations (Scopus)

The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism

Gibriel, A., Tate, R., Yu, Y., Rawson-Lax, E., Hammer, HM., Tettey, J. N. A., Pyne, N. & Converse, C., 15 Feb 2013, In : Gene. 515, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Glutamic Acid
Exons
Mutation
Proteins
Open Access
File
Receptors, Prostaglandin E, EP4 Subtype
Prostaglandin Receptors
Dinoprostone
Tumor Necrosis Factor-alpha
Cytokines
3 Citations (Scopus)
Neuromuscular Blocking Agents
Nicotinic Receptors
Ligands
Amino Acids
Muscles
5 Citations (Scopus)
Open Access
File
Lysosphingolipid Receptors
Exosomes
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Breast Neoplasms
81 Citations (Scopus)

The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells

Loveridge, C., Tonelli, F., Leclercq, T., Lim, K. G., Long, J. S., Berdyshev, E., Tate, R. J., Natarajan, V., Pitson, S. M., Pyne, N. J. & Pyne, S., 10 Dec 2010, In : Journal of Biological Chemistry . 285, 50, p. 38841-38852 12 p.

Research output: Contribution to journalArticle

Thiazoles
Cells
Degradation
Androgens
Apoptosis
15 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Thiazoles
Androgen Receptors
Oxidative Stress
Prostatic Neoplasms
sphingosine kinase
3 Citations (Scopus)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In : Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Toll-Like Receptor 3
Poly I-C
Neurons
Induced Pluripotent Stem Cells
Miniature Postsynaptic Potentials
18 Citations (Scopus)

Toxicity of cobalt-chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro

Posada, O. M., Tate, R. J. & Grant, M. H., 6 Jun 2015, In : Journal of Applied Toxicology. 35, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lymphocytes
Chromium
Cobalt
Debris
Nanoparticles