1993 …2020
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Research Output 1993 2019

1 Citation (Scopus)

Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function

Neamatallah, T., Jabbar, S., Tate, R., Schroeder, J., Shweash, M., Alexander, J. & Plevin, R., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, 17 p., 3434.

Research output: Contribution to journalArticle

Open Access
File
deletion
phosphatases
macrophages
genome
Macrophages
132 Citations (Scopus)

Two-pore domain k channel, TASK-1, in pulmonary artery smooth muscle cells

Gurney, A. M., Osipenko, O. N., MacMillan, D., McFarlane, K. M., Tate, R. J. S. J. & Kempsill, F. E. J., 2003, In : Circulation Research. 93, p. 957-964 8 p.

Research output: Contribution to journalArticle

Membrane Potentials
Pulmonary Artery
Smooth Muscle Myocytes
Lung
Blood Vessels
21 Citations (Scopus)

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes

Lim, L. Y., Koh, P. Y., Somani, S., Al Robaian, M., Karim, R., Yean, Y. L., Mitchell, J., Tate, R. J., Edrada-Ebel, R., Blatchford, D. R., Mullin, M. & Dufès, C., Aug 2015, In : Nanomedicine: Nanotechnology, Biology and Medicine. 11, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Lactoferrin
Intravenous Administration
Tumors
Dendrimers
24 Citations (Scopus)

Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system

Lemarié, F., Croft, D., Tate, R., Ryan, K. M. & Dufès, C., 2012, In : Biomaterials. 33, p. 2701-2709 9 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Intravenous Administration
Tumors
Genes
Dendrimers
74 Citations (Scopus)

Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA

Koppu, S., Oh, Y. J., Edrada-Ebel, R., Blatchford, D. R., Tetley, L., Tate, R. & Dufès, C., 19 Apr 2010, In : Journal of Controlled Release. 143, 2, p. 215-221 7 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Plasmids
DNA
Intravenous Administration
Transferrin
92 Citations (Scopus)

Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases

Belham, C. M., Tate, R. J., Scott, P. H., Pemberton, A. D., Miller, H. R., Wadsworth, R. M., Gould, G. W. & Plevin, R., 1996, In : Biochemical journal. 320 ( Pt 3), p. 939-46 8 p.

Research output: Contribution to journalArticle

PAR-2 Receptor
seryl-leucyl-isoleucyl-glycyl-arginyl-leucine
Mitogen-Activated Protein Kinases
Trypsin
Chemical activation
3 Citations (Scopus)
Open Access
File
Fatigue
Healthy Volunteers
Fatigue of materials
athletic performance
rehabilitation (people)
19 Citations (Scopus)

Toxicity of cobalt-chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro

Posada, O. M., Tate, R. J. & Grant, M. H., 6 Jun 2015, In : Journal of Applied Toxicology. 35, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lymphocytes
Chromium
Cobalt
Debris
Nanoparticles
5 Citations (Scopus)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In : Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Toll-Like Receptor 3
Poly I-C
Neurons
Induced Pluripotent Stem Cells
Miniature Postsynaptic Potentials
15 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Thiazoles
Androgen Receptors
Oxidative Stress
Prostatic Neoplasms
sphingosine kinase
83 Citations (Scopus)

The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells

Loveridge, C., Tonelli, F., Leclercq, T., Lim, K. G., Long, J. S., Berdyshev, E., Tate, R. J., Natarajan, V., Pitson, S. M., Pyne, N. J. & Pyne, S., 10 Dec 2010, In : Journal of Biological Chemistry . 285, 50, p. 38841-38852 12 p.

Research output: Contribution to journalArticle

Thiazoles
Cells
Degradation
Androgens
Apoptosis
7 Citations (Scopus)
Open Access
File
Lysosphingolipid Receptors
Exosomes
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Breast Neoplasms
3 Citations (Scopus)
Neuromuscular Blocking Agents
Nicotinic Receptors
Ligands
Amino Acids
Muscles
Open Access
File
Receptors, Prostaglandin E, EP4 Subtype
Prostaglandin Receptors
Dinoprostone
Tumor Necrosis Factor-alpha
Cytokines
2 Citations (Scopus)

The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism

Gibriel, A., Tate, R., Yu, Y., Rawson-Lax, E., Hammer, HM., Tettey, J. N. A., Pyne, N. & Converse, C., 15 Feb 2013, In : Gene. 515, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Glutamic Acid
Exons
Mutation
Proteins
60 Citations (Scopus)
Mitogen-Activated Protein Kinase 1
Cyclic GMP
Phosphoric Diester Hydrolases
G-Protein-Coupled Receptor Kinase 2
Mitogen-Activated Protein Kinases
19 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Mitogen-Activated Protein Kinase 1
Phosphoric Diester Hydrolases
Mitogen-Activated Protein Kinases
Epidermal Growth Factor
11 Citations (Scopus)
Vertebrate Photoreceptor Cells
Cyclic GMP
Phosphoric Diester Hydrolases
Lung
Messenger RNA
10 Citations (Scopus)
Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Phosphoric Diester Hydrolases
Caspase 3
14 Citations (Scopus)

The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung

Tate, R. J., Lochhead, A., Brzeski, H., Arshavsky, V. & Pyne, N. J., 1998, In : Cell Biochemistry and Biophysics. 29, 1-2, p. 133-144 12 p.

Research output: Contribution to journalArticle

Type 6 Cyclic Nucleotide Phosphodiesterases
Type 5 Cyclic Nucleotide Phosphodiesterases
Retinal Rod Photoreceptor Cells
Enzyme Inhibitors
Hydrolysis
16 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
HEPES
Lipids
Tromethamine
83 Citations (Scopus)
1-Phosphatidylinositol 4-Kinase
Mitogen-Activated Protein Kinase 1
Phosphatidylinositols
Mitogen-Activated Protein Kinases
Smooth Muscle
24 Citations (Scopus)
Coordination Complexes
Platinum
Drug delivery
Cytotoxicity
Pharmaceutical Preparations

RNA stability in frozen/thawed clinical samples

Posada Estefan, O. M., Tate, R. & Grant, M., Aug 2011.

Research output: Contribution to conferencePoster

Posters
RNA Stability

RNA stability in frozen/thawed clinical blood samples

Posada Estefan, O. M., Tate, R. & Grant, M., 2011, p. 9. 1 p.

Research output: Contribution to conferenceAbstract

RNA Stability
RNA
Gene Expression
5 Citations (Scopus)

Regulation of lipid metabolism by microRNAs

Tate, R., Rotondo, D. & Davidson, J., 10 Jun 2015, In : Current Opinion in Lipidology. 26, 3, p. 243-244 2 p.

Research output: Contribution to journalEditorial

Open Access
File
7 Citations (Scopus)

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL and interleukin-12

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., MacKenzie, G. R., Leung, H. Y. & Dufès, C., 1 Mar 2018, In : Drug Delivery. 25, 1, p. 679-689 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lactoferrin
Interleukin-12
Intravenous Administration
Prostate
Tumor Necrosis Factor-alpha

Redox-sensitive, cholesterol-bearing PEGylated poly(propyleneimine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N. A. S., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y. & Dufès, C., 28 Dec 2018, In : Nanoscale. 10, 48, p. 22830-22847 18 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Cholesterol
Genes
Cells
Dendrimers
1 Citation (Scopus)

Properties of the cellular prion protein expressed in Xenopus oocytes

Connolly, J. G., Tate, R. J., McLennan, N. F., Brown, D., Telling, G. C., Fraser, J. & Head, M. W., 2002, In : NeuroReport. 13, 9, p. 1229-1233 4 p.

Research output: Contribution to journalArticle

Xenopus
Oocytes
PrPC Proteins
Peptide Hydrolases
RNA
Open Access
File
Surface-Active Agents
Small Interfering RNA
Luciferases
Proteins
Liposomes
112 Citations (Scopus)

Potential role for kv3.1b channels as oxygen sensors

Osipenko, O. N., Tate, R. J., Gurney, A. M. & Tate, R., 2000, In : Circulation Research. 86, 5, p. 534-40 7 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Oxygen
Smooth Muscle Myocytes
Membranes
Charybdotoxin
Purinergic P2Y1 Receptors
Adenosine Diphosphate
G-Protein-Coupled Receptors
Immunoprecipitation
Purinergic P2Y12 Receptors
Purinergic P2Y1 Receptors
Adenosine Diphosphate
G-Protein-Coupled Receptors
Immunoprecipitation
Purinergic P2Y12 Receptors
4 Citations (Scopus)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide

Molecular determinants in pulmonary hypertension: the role of PDE5

Pyne, N. J., Murray, F., Tate, R. & MacLean, M. R., 2006, Cyclic Nucleotide Phosphodiesterases in Health and Diseases. Beavo, J., Francis, S. & Houslay, MD. (eds.). Boca Raton, p. 501-518 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phosphoric Diester Hydrolases
Pulmonary Hypertension
Molecular Structure
Nucleotides
Pharmacology
13 Citations (Scopus)

Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle

Tate, R. J., Tolan, D. & Pyne, S., 1999, In : Cellular Signalling. 11, 7, p. 515-522 8 p.

Research output: Contribution to journalArticle

Molecular Cloning
Magnesium
Smooth Muscle
Base Pairing
Complementary DNA
7 Citations (Scopus)

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Aspergillus
Metabolites
Bioactivity
Complex Mixtures

Metabolomics studies of endophytic metabolites from Malaysian mangrove plant in the search for new potential antibiotics

Noor Wini Binti Mazlan, N., Tate, R., Clements, C. & Edrada-Ebel, R., Aug 2013, In : Planta Medica. 79, 13, 1 p., PA22.

Research output: Contribution to journalConference Contribution

Metabolomics
Metabolites
Fungi
Anti-Bacterial Agents
Malaysia

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Tawfike, A. F., Edrada-Ebel, R., Tate, R., Diederich, M., Schumacher, M., Sawadogo, R., Clements, C. & Young, L., 23 Jun 2014, p. 116. 1 p.

Research output: Contribution to conferencePoster

Metabolomics
Medicinal Plants
Software
Biological Assay
Pharmaceutical Preparations

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in search for new potential anti-cancer drugs

Tawfike, A. F. S., Romli, M., Tate, R., Diederich, M., Schumacher, M. & Edrada-Ebel, R., Sep 2012.

Research output: Contribution to conferencePoster

43 Citations (Scopus)

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G., Waigh, R., Tate, R., Harvey, A. & Furman, B., Apr 2008, In : British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

Weight Loss
Adipocytes
Acetyl-CoA Carboxylase
Skeletal Muscle Fibers
AMP-Activated Protein Kinases
8 Citations (Scopus)

Lack of immunological cross-reactivity between parasite-derived and recombinant forms of es-62, a secreted protein of acanthocheilonema viteae

Egan, C. A., Houston, K. M., Alcocer, M. J. C., Solovyova, A., Tate, R., Lochnit, G., McInnes, I. B. & Harnett, M. M., Feb 2006, In : Parasitology. 132, 2, p. 263-274 11 p.

Research output: Contribution to journalArticle

Acanthocheilonema
Acanthocheilonema viteae
cross reaction
Phosphorylcholine
Parasites

In vivo and in vitro toxicity of cobalt in the heart

Laovitthayanggoon, S., Henderson, C. J., Tate, R. J., Currie, S., McCluskey, C., Macdonald, M. & Grant, M. H., 3 Apr 2017. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Fibroblasts
Toxicity
Cobalt
Rats
Bearings (structural)

In vitro effects of cobalt ions on CNS derived cell lines

Gomez Arnaiz, S., Tate, R., Currie, S. & Grant, M., 3 Apr 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Cobalt
Cells
Ions
Assays
Metals
12 Citations (Scopus)

In vitro analyses of the toxicity, immunological, and gene expression effects of cobalt-chromium alloy wear debris and Co ions derived from metal-on-metal hip implants

Posada, O. M., Tate, R. J., Meek, R. M. D. & Grant, M. H., 14 Jul 2015, In : Lubricants. 3, 3, p. 539-568 30 p.

Research output: Contribution to journalArticle

Open Access
File
Cobalt alloys
Chromium alloys
Debris
Gene expression
Toxicity

Investigating cobalt toxicity in the context of joint replacement patients - cobalt uptake in primary cardiac fibroblasts and in 3T3 cells

Laovitthayanggoon, S., Grant, M. H., Henderson, C. J., Tate, R. J. & Currie, S., 1 Dec 2016, In : Applied in Vitro Toxicology . 2, 4, 1 p., P-8.

Research output: Contribution to journalMeeting abstract

Open Access
File
Replacement Arthroplasties
3T3 Cells
Fibroblasts
Cobalt
Toxicity
9 Citations (Scopus)

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

Frame, M. J., Tate, R., Adams, D. R., Morgan, K. M., Houslay, M. D., Vandenabeele, P. & Pyne, N. J., Mar 2003, In : European Journal of Biochemistry . 270, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Caspase 3
Proteolysis
Catalytic Domain
107 Citations (Scopus)

Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors

Iehlé, C., Délos, S., Guirou, O., Tate, R., Raynaud, J. P. & Martin, P. M., 1995, In : Journal of Steroid Biochemistry and Molecular Biology . 54, 5-6, p. 273-279 7 p.

Research output: Contribution to journalArticle

3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Cholestenone 5 alpha-Reductase
Protein Isoforms
Isoenzymes
Sterols
1 Citation (Scopus)

Genetics and molecular biology: the role of retinoic acid receptor genes in acute promyelocytic leukemia

Davidson, J., Tate, R. & Rotondo, D., 14 Aug 2013, In : Current Opinion in Lipidology. 24, 4, p. 364-365 2 p.

Research output: Contribution to journalComment/debate

Acute Promyelocytic Leukemia
Retinoic Acid Receptors
Molecular biology
Tretinoin
Molecular Biology
7 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
Small Interfering RNA
Green Fluorescent Proteins
Neoplasms