1993 …2020
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Research Output 1993 2019

8 Citations (Scopus)

Absence of 5 alpha-reductase activity in the gubernaculum during descent of the fetal pig testis

Heyns, C. F., Tate, R., Sargent, N. S., Habib, F. K. & Chisholm, G. D., 1993, In : Journal of Urology. 150, 2 Pt 1, p. 510-513 4 p.

Research output: Contribution to journalArticle

Cholestenone 5 alpha-Reductase
Testis
Swine
Dihydrotestosterone
Epididymis
27 Citations (Scopus)
Open Access
File
Polymorphism
Brain
Fatigue of materials
Neurology
Nucleotides

Brain changing tubers: gene expression changes following mediaeval tuber consumption

Woods, N., Gebril, A., Simpson, A., Iannetta, P., Kenicer, G., Tate, R. J., Pickard, B., Gray, A. I. & Ferro, V. A., 14 Dec 2016, In : Planta Medica. 81, S 01, p. S1-S381

Research output: Contribution to journalMeeting abstract

Gene expression
Hypothalamus
Brain
RNA
Gene Expression

Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells

Laskar, P., Somani, S., Campbell, S. J., Mullin, M., Keating, P., Tate, R. J., Irving, C., Leung, H. Y. & Dufès, C., 15 Oct 2019, In : Nanoscale. 14 p.

Research output: Contribution to journalArticle

Dendrimers
Camptothecin
Drug delivery
Genes
Cells
Neural Stem Cells
Cell- and Tissue-Based Therapy
Estrogens
Stem Cells
Stroke
10 Citations (Scopus)

Cloning and sequencing of an aspergillus niger gene coding for beta-fructufuranosidase

Somiari, R. I., Brzeski, H., Tate, R., Bieleck, S. & Polak, J., Dec 1997, In : Biotechnology Letters. 19, 12, p. 1243-1247 5 p.

Research output: Contribution to journalArticle

beta-Fructofuranosidase
Aspergillus niger
Cloning
Aspergillus
Amino acids
Open Access
File
Cobalt
Rats
Fibroblasts
Proteins
Metals

Cobalt cardiotoxicity - effects on the contractile and non-contractile cells of the heart

Laovitthayanggoon, S., Tate, R., Currie, S. & Grant, M. H., 30 Apr 2016, In : FASEB Journal. 30, 1, 1 p., 178.7.

Research output: Contribution to journalMeeting abstract

Open Access
File
Fibroblasts
Cobalt
Isoproterenol
Cells
Gentian Violet

CoCl2 induced cardiotoxicity associated with CoCr alloy orthopaedic implants

Laovitthayanggoon, S., Grant, M. H., Henderson, C. J., Tate, R. J. & Currie, S., 1 Apr 2017, In : Heart . 103, S2, p. A4 1 p., 9.

Research output: Contribution to journalMeeting abstract

Orthopedics
Fibroblasts
Metals
3T3 Cells
Ions

Co-Cr wear particles and cobalt ions stimulate the expression of human general toxicology related genes on monocyte like U937 cells

Posada Estefan, O. M., Tate, R. & Grant, M., 7 Apr 2013.

Research output: Contribution to conferencePoster

U937 Cells
Chromium
Cobalt
Toxicology
Monocytes
20 Citations (Scopus)
Open Access
File
Chromium Alloys
U937 Cells
Chromium
Cobalt
Toxicology

Co–Cr wear products derived from metal-on-metal articulations induce apoptosis on monocyte-like U937 cells

Posada Estefan, O. M., Grant, H. & Tate, R. J., Aug 2013, In : Toxicology Letters. 28, Suppl, p. S75 1 p.

Research output: Contribution to journalMeeting abstract

Chromium Alloys
Cobalt alloys
Chromium alloys
U937 Cells
Cell death
8 Citations (Scopus)
Open Access
File
Surface-Active Agents
Microfluidics
Heating
Cholesterol
Alcohols
14 Citations (Scopus)
Neural Stem Cells
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Neuronal Plasticity
Cell- and Tissue-Based Therapy
38 Citations (Scopus)
Open Access
File
MicroRNAs
microRNA
Biological Availability
bioavailability
Digestion
17 Citations (Scopus)

Differential effect of finasteride on the tissue androgen concentrations in benign prostatic hyperplasia

Habib, F. K., Ross, M., Tate, R. & Chisholm, G. D., 1997, In : Clinical Endocrinology. 46, 2, p. 137-44 8 p.

Research output: Contribution to journalArticle

Cholestenone 5 alpha-Reductase
Finasteride
Prostatic Hyperplasia
Androgens
5-alpha Reductase Inhibitors
1 Citation (Scopus)

Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse

Kouskou, M., Thomson, D. M., Brett, R. R., Wheeler, L., Tate, R. J., Pratt, J. A. & Chamberlain, L. H., 31 Oct 2018, In : Experimental Neurology. 308, p. 35-46 12 p.

Research output: Contribution to journalArticle

Open Access
File
Intellectual Disability
Acylation
Corpus Callosum
Protein S
Genes
27 Citations (Scopus)
Cyclic Nucleotides
Phosphoric Diester Hydrolases
Insulin-Secreting Cells
Cyclic AMP
Insulin
21 Citations (Scopus)

Effects of CoCr metal wear debris generated from metal-on-metal hip implants and Co ions on human monocyte-like U937 cells

Posada, O. M., Tate, R. J. & Grant, M. H., Mar 2015, In : Toxicology in Vitro. 29, 2, p. 271-280 10 p.

Research output: Contribution to journalArticle

Open Access
File
U937 Cells
Chromium
Cobalt
Debris
Hip
15 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., 2011, In : Nanomedicine: Nanotechnology, Biology and Medicine. 7, 5, p. 815-823 9 p.

Research output: Contribution to journalArticle

Bearings (structural)
Polyethyleneimine
Arginine
Gene expression
Leucine
38 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex

Aldawsari, H. M., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., Sep 2011, In : Biomaterials. 32, 25, p. 5889-5899 11 p.

Research output: Contribution to journalArticle

Bearings (structural)
Arginine
Gene expression
Leucine
Intravenous Administration

Enhanced transfection efficacy of polyethylenimine by surface modification with arginine, lysine, and leucine

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R. & Dufès, C., 2010, In : Controlled Release Society Newsletter. 27, 6, p. 12-14 3 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Leucine
Lysine
Transfection
Arginine

Etoposide upregulates survival favoring sphingosine-1-phosphate in etoposide-resistant retinoblastoma cells

Kakkassery, V., Skosyrski, S., Lüth, A., Kleuser, B., van der Giet, M., Tate, R., Reinhard, J., Faissner, A., Joachim, S. C. & Kociok, N., 15 Nov 2017, In : Pathology & Oncology Research. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Sphingosine
Retinoblastoma
Etoposide
Up-Regulation
Glucosylceramides
1 Citation (Scopus)

Exosomes: fighting cancer with cancer

Alyamani, H., Obeid, M. A., Tate, R. J. & Ferro, V. A., 7 Dec 2018, In : Therapeutic Delivery. 10, 1

Research output: Contribution to journalReview article

Exosomes
Neoplasms
Research
30 Citations (Scopus)

Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific

Stepek, G., Auchie, M., Tate, R., Watson, K., Russell, D. G., Devaney, E. & Harnett, W., 2002, In : Parasitology. 125, Pt 2, p. 155-64 10 p.

Research output: Contribution to journalArticle

Acanthocheilonema viteae
Brugia malayi
Phosphorylcholine
Sequence Homology
Gene Library
9 Citations (Scopus)

Extracellular actions of sphingosine 1-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis

Pyne, S., Rakhit, S., Conway, A. M., McKie, A., Darroch, P., Tate, R. & Pyne, N., Aug 1999, In : Biochemical Society Transactions. 27, 4, p. 404-409 6 p.

Research output: Contribution to journalLiterature review

Platelets
Blood Platelets
Genes
Cells
Apoptosis
7 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
Small Interfering RNA
Green Fluorescent Proteins
Neoplasms
1 Citation (Scopus)

Genetics and molecular biology: the role of retinoic acid receptor genes in acute promyelocytic leukemia

Davidson, J., Tate, R. & Rotondo, D., 14 Aug 2013, In : Current Opinion in Lipidology. 24, 4, p. 364-365 2 p.

Research output: Contribution to journalComment/debate

Acute Promyelocytic Leukemia
Retinoic Acid Receptors
Molecular biology
Tretinoin
Molecular Biology
107 Citations (Scopus)

Human prostatic steroid 5 alpha-reductase isoforms--a comparative study of selective inhibitors

Iehlé, C., Délos, S., Guirou, O., Tate, R., Raynaud, J. P. & Martin, P. M., 1995, In : Journal of Steroid Biochemistry and Molecular Biology . 54, 5-6, p. 273-279 7 p.

Research output: Contribution to journalArticle

3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Cholestenone 5 alpha-Reductase
Protein Isoforms
Isoenzymes
Sterols
9 Citations (Scopus)

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)

Frame, M. J., Tate, R., Adams, D. R., Morgan, K. M., Houslay, M. D., Vandenabeele, P. & Pyne, N. J., Mar 2003, In : European Journal of Biochemistry . 270, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

Cyclic GMP
Phosphoric Diester Hydrolases
Caspase 3
Proteolysis
Catalytic Domain

Investigating cobalt toxicity in the context of joint replacement patients - cobalt uptake in primary cardiac fibroblasts and in 3T3 cells

Laovitthayanggoon, S., Grant, M. H., Henderson, C. J., Tate, R. J. & Currie, S., 1 Dec 2016, In : Applied in Vitro Toxicology . 2, 4, 1 p., P-8.

Research output: Contribution to journalMeeting abstract

Open Access
File
Replacement Arthroplasties
3T3 Cells
Fibroblasts
Cobalt
Toxicity
12 Citations (Scopus)

In vitro analyses of the toxicity, immunological, and gene expression effects of cobalt-chromium alloy wear debris and Co ions derived from metal-on-metal hip implants

Posada, O. M., Tate, R. J., Meek, R. M. D. & Grant, M. H., 14 Jul 2015, In : Lubricants. 3, 3, p. 539-568 30 p.

Research output: Contribution to journalArticle

Open Access
File
Cobalt alloys
Chromium alloys
Debris
Gene expression
Toxicity

In vitro effects of cobalt ions on CNS derived cell lines

Gomez Arnaiz, S., Tate, R., Currie, S. & Grant, M., 3 Apr 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Cobalt
Cells
Ions
Assays
Metals

In vivo and in vitro toxicity of cobalt in the heart

Laovitthayanggoon, S., Henderson, C. J., Tate, R. J., Currie, S., McCluskey, C., Macdonald, M. & Grant, M. H., 3 Apr 2017. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Fibroblasts
Toxicity
Cobalt
Rats
Bearings (structural)
7 Citations (Scopus)

Lack of immunological cross-reactivity between parasite-derived and recombinant forms of es-62, a secreted protein of acanthocheilonema viteae

Egan, C. A., Houston, K. M., Alcocer, M. J. C., Solovyova, A., Tate, R., Lochnit, G., McInnes, I. B. & Harnett, M. M., Feb 2006, In : Parasitology. 132, 2, p. 263-274 11 p.

Research output: Contribution to journalArticle

Acanthocheilonema
Acanthocheilonema viteae
cross reaction
Phosphorylcholine
Parasites
43 Citations (Scopus)

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G., Waigh, R., Tate, R., Harvey, A. & Furman, B., Apr 2008, In : British Journal of Pharmacology. 153, 8, p. 1669-1677 9 p.

Research output: Contribution to journalArticle

Weight Loss
Adipocytes
Acetyl-CoA Carboxylase
Skeletal Muscle Fibers
AMP-Activated Protein Kinases

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in search for new potential anti-cancer drugs

Tawfike, A. F. S., Romli, M., Tate, R., Diederich, M., Schumacher, M. & Edrada-Ebel, R., Sep 2012.

Research output: Contribution to conferencePoster

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Tawfike, A. F., Edrada-Ebel, R., Tate, R., Diederich, M., Schumacher, M., Sawadogo, R., Clements, C. & Young, L., 23 Jun 2014, p. 116. 1 p.

Research output: Contribution to conferencePoster

Metabolomics
Medicinal Plants
Software
Biological Assay
Pharmaceutical Preparations

Metabolomics studies of endophytic metabolites from Malaysian mangrove plant in the search for new potential antibiotics

Noor Wini Binti Mazlan, N., Tate, R., Clements, C. & Edrada-Ebel, R., Aug 2013, In : Planta Medica. 79, 13, 1 p., PA22.

Research output: Contribution to journalConference Contribution

Metabolomics
Metabolites
Fungi
Anti-Bacterial Agents
Malaysia
7 Citations (Scopus)

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Aspergillus
Metabolites
Bioactivity
Complex Mixtures
13 Citations (Scopus)

Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatases from airway smooth muscle

Tate, R. J., Tolan, D. & Pyne, S., 1999, In : Cellular Signalling. 11, 7, p. 515-522 8 p.

Research output: Contribution to journalArticle

Molecular Cloning
Magnesium
Smooth Muscle
Base Pairing
Complementary DNA

Molecular determinants in pulmonary hypertension: the role of PDE5

Pyne, N. J., Murray, F., Tate, R. & MacLean, M. R., 2006, Cyclic Nucleotide Phosphodiesterases in Health and Diseases. Beavo, J., Francis, S. & Houslay, MD. (eds.). Boca Raton, p. 501-518 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phosphoric Diester Hydrolases
Pulmonary Hypertension
Molecular Structure
Nucleotides
Pharmacology
4 Citations (Scopus)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide
Purinergic P2Y1 Receptors
Adenosine Diphosphate
G-Protein-Coupled Receptors
Immunoprecipitation
Purinergic P2Y12 Receptors
Purinergic P2Y1 Receptors
Adenosine Diphosphate
G-Protein-Coupled Receptors
Immunoprecipitation
Purinergic P2Y12 Receptors
112 Citations (Scopus)

Potential role for kv3.1b channels as oxygen sensors

Osipenko, O. N., Tate, R. J., Gurney, A. M. & Tate, R., 2000, In : Circulation Research. 86, 5, p. 534-40 7 p.

Research output: Contribution to journalArticle

Pulmonary Artery
Oxygen
Smooth Muscle Myocytes
Membranes
Charybdotoxin
Open Access
File
Surface-Active Agents
Small Interfering RNA
Luciferases
Proteins
Liposomes
1 Citation (Scopus)

Properties of the cellular prion protein expressed in Xenopus oocytes

Connolly, J. G., Tate, R. J., McLennan, N. F., Brown, D., Telling, G. C., Fraser, J. & Head, M. W., 2002, In : NeuroReport. 13, 9, p. 1229-1233 4 p.

Research output: Contribution to journalArticle

Xenopus
Oocytes
PrPC Proteins
Peptide Hydrolases
RNA

Redox-sensitive, cholesterol-bearing PEGylated poly(propyleneimine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N. A. S., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y. & Dufès, C., 28 Dec 2018, In : Nanoscale. 10, 48, p. 22830-22847 18 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Cholesterol
Genes
Cells
Dendrimers