1993 …2020
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Research Output 1993 2019

2019

Camptothecin-based dendrimersomes for gene delivery and redox-responsive drug delivery to cancer cells

Laskar, P., Somani, S., Campbell, S. J., Mullin, M., Keating, P., Tate, R. J., Irving, C., Leung, H. Y. & Dufès, C., 14 Nov 2019, In : Nanoscale. 11, 42, p. 20058-20071 14 p.

Research output: Contribution to journalArticle

Dendrimers
Camptothecin
Drug delivery
Oxidation-Reduction
Genes
1 Citation (Scopus)

Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function

Neamatallah, T., Jabbar, S., Tate, R., Schroeder, J., Shweash, M., Alexander, J. & Plevin, R., 12 Jul 2019, In : International Journal of Molecular Sciences. 20, 14, 17 p., 3434.

Research output: Contribution to journalArticle

Open Access
File
deletion
phosphatases
macrophages
genome
Macrophages
2018
Open Access
File
Cobalt
Rats
Fibroblasts
Proteins
Metals
1 Citation (Scopus)

Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse

Kouskou, M., Thomson, D. M., Brett, R. R., Wheeler, L., Tate, R. J., Pratt, J. A. & Chamberlain, L. H., 31 Oct 2018, In : Experimental Neurology. 308, p. 35-46 12 p.

Research output: Contribution to journalArticle

Open Access
File
Intellectual Disability
Acylation
Corpus Callosum
Protein S
Genes
1 Citation (Scopus)

Exosomes: fighting cancer with cancer

Alyamani, H., Obeid, M. A., Tate, R. J. & Ferro, V. A., 7 Dec 2018, In : Therapeutic Delivery. 10, 1

Research output: Contribution to journalReview article

Open Access
File
Exosomes
Neoplasms
Research
4 Citations (Scopus)

Native and polyubiquitinated forms of dihydroceramide desaturase are differentially linked to human embryonic kidney cell survival

Alsanafi, M., Kelly, S. L., Jubair, K., McNaughton, M., Tate, R. J., Merrill Jr., A. H., Pyne, S. & Pyne, N. J., 13 Nov 2018, In : Molecular and Cellular Biology. 38, 18 p., e00222.

Research output: Contribution to journalArticle

Open Access
File
Cell Survival
p38 Mitogen-Activated Protein Kinases
Apoptosis
Kidney
Fenretinide
Purinergic P2Y1 Receptors
Adenosine Diphosphate
G-Protein-Coupled Receptors
Immunoprecipitation
Purinergic P2Y12 Receptors
Purinergic P2Y1 Receptors
Adenosine Diphosphate
G-Protein-Coupled Receptors
Immunoprecipitation
Purinergic P2Y12 Receptors
Open Access
File
Surface-Active Agents
Small Interfering RNA
Luciferases
Proteins
Liposomes

Redox-sensitive, cholesterol-bearing PEGylated poly(propyleneimine)-based dendrimersomes for drug and gene delivery to cancer cells

Laskar, P., Somani, S., Altwaijry, N. A. S., Mullin, M., Bowering, D., Warzecha, M., Keating, P., Tate, R. J., Leung, H. Y. & Dufès, C., 28 Dec 2018, In : Nanoscale. 10, 48, p. 22830-22847 18 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Cholesterol
Genes
Cells
Dendrimers
7 Citations (Scopus)

Regression of prostate tumors after intravenous administration of lactoferrin-bearing polypropylenimine dendriplexes encoding TNF-α, TRAIL and interleukin-12

Altwaijry, N., Somani, S., Parkinson, J. A., Tate, R. J., Keating, P., Warzecha, M., MacKenzie, G. R., Leung, H. Y. & Dufès, C., 1 Mar 2018, In : Drug Delivery. 25, 1, p. 679-689 11 p.

Research output: Contribution to journalArticle

Open Access
File
Lactoferrin
Interleukin-12
Intravenous Administration
Prostate
Tumor Necrosis Factor-alpha
Open Access
File
Receptors, Prostaglandin E, EP4 Subtype
Prostaglandin Receptors
Dinoprostone
Tumor Necrosis Factor-alpha
Cytokines
7 Citations (Scopus)
Open Access
File
Lysosphingolipid Receptors
Exosomes
Extracellular Signal-Regulated MAP Kinases
Fibroblasts
Breast Neoplasms
4 Citations (Scopus)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In : Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Toll-Like Receptor 3
Poly I-C
Neurons
Induced Pluripotent Stem Cells
Miniature Postsynaptic Potentials
2017
Open Access
File
Polymorphism
Brain
Fatigue of materials
Neurology
Nucleotides

CoCl2 induced cardiotoxicity associated with CoCr alloy orthopaedic implants

Laovitthayanggoon, S., Grant, M. H., Henderson, C. J., Tate, R. J. & Currie, S., 1 Apr 2017, In : Heart . 103, S2, p. A4 1 p., 9.

Research output: Contribution to journalMeeting abstract

Orthopedics
Fibroblasts
Metals
3T3 Cells
Ions
8 Citations (Scopus)
Open Access
File
Surface-Active Agents
Microfluidics
Heating
Cholesterol
Alcohols

Etoposide upregulates survival favoring sphingosine-1-phosphate in etoposide-resistant retinoblastoma cells

Kakkassery, V., Skosyrski, S., Lüth, A., Kleuser, B., van der Giet, M., Tate, R., Reinhard, J., Faissner, A., Joachim, S. C. & Kociok, N., 15 Nov 2017, In : Pathology & Oncology Research. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Sphingosine
Retinoblastoma
Etoposide
Up-Regulation
Glucosylceramides
7 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
Small Interfering RNA
Green Fluorescent Proteins
Neoplasms

In vitro effects of cobalt ions on CNS derived cell lines

Gomez Arnaiz, S., Tate, R., Currie, S. & Grant, M., 3 Apr 2017. 1 p.

Research output: Contribution to conferencePoster

Open Access
File
Cobalt
Cells
Ions
Assays
Metals

In vivo and in vitro toxicity of cobalt in the heart

Laovitthayanggoon, S., Henderson, C. J., Tate, R. J., Currie, S., McCluskey, C., Macdonald, M. & Grant, M. H., 3 Apr 2017. 1 p.

Research output: Contribution to conferenceAbstract

Open Access
File
Fibroblasts
Toxicity
Cobalt
Rats
Bearings (structural)
7 Citations (Scopus)

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
Metabolomics
Aspergillus
Metabolites
Bioactivity
Complex Mixtures
16 Citations (Scopus)
Open Access
File
Microfluidics
Surface-Active Agents
HEPES
Lipids
Tromethamine
3 Citations (Scopus)
Open Access
File
Fatigue
Healthy Volunteers
Fatigue of materials
athletic performance
rehabilitation (people)
2016

Brain changing tubers: gene expression changes following mediaeval tuber consumption

Woods, N., Gebril, A., Simpson, A., Iannetta, P., Kenicer, G., Tate, R. J., Pickard, B., Gray, A. I. & Ferro, V. A., 14 Dec 2016, In : Planta Medica. 81, S 01, p. S1-S381

Research output: Contribution to journalMeeting abstract

Gene expression
Hypothalamus
Brain
RNA
Gene Expression

Cobalt cardiotoxicity - effects on the contractile and non-contractile cells of the heart

Laovitthayanggoon, S., Tate, R., Currie, S. & Grant, M. H., 30 Apr 2016, In : FASEB Journal. 30, 1, 1 p., 178.7.

Research output: Contribution to journalMeeting abstract

Open Access
File
Fibroblasts
Cobalt
Isoproterenol
Cells
Gentian Violet

Investigating cobalt toxicity in the context of joint replacement patients - cobalt uptake in primary cardiac fibroblasts and in 3T3 cells

Laovitthayanggoon, S., Grant, M. H., Henderson, C. J., Tate, R. J. & Currie, S., 1 Dec 2016, In : Applied in Vitro Toxicology . 2, 4, 1 p., P-8.

Research output: Contribution to journalMeeting abstract

Open Access
File
Replacement Arthroplasties
3T3 Cells
Fibroblasts
Cobalt
Toxicity
2015
38 Citations (Scopus)
Open Access
File
MicroRNAs
microRNA
Biological Availability
bioavailability
Digestion
21 Citations (Scopus)

Effects of CoCr metal wear debris generated from metal-on-metal hip implants and Co ions on human monocyte-like U937 cells

Posada, O. M., Tate, R. J. & Grant, M. H., Mar 2015, In : Toxicology in Vitro. 29, 2, p. 271-280 10 p.

Research output: Contribution to journalArticle

Open Access
File
U937 Cells
Chromium
Cobalt
Debris
Hip
12 Citations (Scopus)

In vitro analyses of the toxicity, immunological, and gene expression effects of cobalt-chromium alloy wear debris and Co ions derived from metal-on-metal hip implants

Posada, O. M., Tate, R. J., Meek, R. M. D. & Grant, M. H., 14 Jul 2015, In : Lubricants. 3, 3, p. 539-568 30 p.

Research output: Contribution to journalArticle

Open Access
File
Cobalt alloys
Chromium alloys
Debris
Gene expression
Toxicity
5 Citations (Scopus)

Regulation of lipid metabolism by microRNAs

Tate, R., Rotondo, D. & Davidson, J., 10 Jun 2015, In : Current Opinion in Lipidology. 26, 3, p. 243-244 2 p.

Research output: Contribution to journalEditorial

Open Access
File
19 Citations (Scopus)

Toxicity of cobalt-chromium nanoparticles released from a resurfacing hip implant and cobalt ions on primary human lymphocytes in vitro

Posada, O. M., Tate, R. J. & Grant, M. H., 6 Jun 2015, In : Journal of Applied Toxicology. 35, 6, p. 614-622 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lymphocytes
Chromium
Cobalt
Debris
Nanoparticles
21 Citations (Scopus)

Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes

Lim, L. Y., Koh, P. Y., Somani, S., Al Robaian, M., Karim, R., Yean, Y. L., Mitchell, J., Tate, R. J., Edrada-Ebel, R., Blatchford, D. R., Mullin, M. & Dufès, C., Aug 2015, In : Nanomedicine: Nanotechnology, Biology and Medicine. 11, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

Open Access
File
Bearings (structural)
Lactoferrin
Intravenous Administration
Tumors
Dendrimers
2014
20 Citations (Scopus)
Open Access
File
Chromium Alloys
U937 Cells
Chromium
Cobalt
Toxicology

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search potential antimicrobial drugs

Tawfike, A. F., Edrada-Ebel, R., Tate, R., Diederich, M., Schumacher, M., Sawadogo, R., Clements, C. & Young, L., 23 Jun 2014, p. 116. 1 p.

Research output: Contribution to conferencePoster

Metabolomics
Medicinal Plants
Software
Biological Assay
Pharmaceutical Preparations
2013

Co-Cr wear particles and cobalt ions stimulate the expression of human general toxicology related genes on monocyte like U937 cells

Posada Estefan, O. M., Tate, R. & Grant, M., 7 Apr 2013.

Research output: Contribution to conferencePoster

U937 Cells
Chromium
Cobalt
Toxicology
Monocytes

Co–Cr wear products derived from metal-on-metal articulations induce apoptosis on monocyte-like U937 cells

Posada Estefan, O. M., Grant, H. & Tate, R. J., Aug 2013, In : Toxicology Letters. 28, Suppl, p. S75 1 p.

Research output: Contribution to journalMeeting abstract

Chromium Alloys
Cobalt alloys
Chromium alloys
U937 Cells
Cell death
1 Citation (Scopus)

Genetics and molecular biology: the role of retinoic acid receptor genes in acute promyelocytic leukemia

Davidson, J., Tate, R. & Rotondo, D., 14 Aug 2013, In : Current Opinion in Lipidology. 24, 4, p. 364-365 2 p.

Research output: Contribution to journalComment/debate

Acute Promyelocytic Leukemia
Retinoic Acid Receptors
Molecular biology
Tretinoin
Molecular Biology

Metabolomics studies of endophytic metabolites from Malaysian mangrove plant in the search for new potential antibiotics

Noor Wini Binti Mazlan, N., Tate, R., Clements, C. & Edrada-Ebel, R., Aug 2013, In : Planta Medica. 79, 13, 1 p., PA22.

Research output: Contribution to journalConference Contribution

Metabolomics
Metabolites
Fungi
Anti-Bacterial Agents
Malaysia
2 Citations (Scopus)

The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism

Gibriel, A., Tate, R., Yu, Y., Rawson-Lax, E., Hammer, HM., Tettey, J. N. A., Pyne, N. & Converse, C., 15 Feb 2013, In : Gene. 515, 1, p. 155-158 4 p.

Research output: Contribution to journalArticle

Retinitis Pigmentosa
Glutamic Acid
Exons
Mutation
Proteins
15 Citations (Scopus)

The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism

Tonelli, F., Alossaimi, M., Williamson, L., Tate, R. J., Watson, D. G., Chan, E., Bittman, R., Pyne, N. J. & Pyne, S., 1 Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1497-1505 9 p.

Research output: Contribution to journalArticle

Thiazoles
Androgen Receptors
Oxidative Stress
Prostatic Neoplasms
sphingosine kinase
2012
14 Citations (Scopus)
Neural Stem Cells
Middle Cerebral Artery Infarction
Transient Ischemic Attack
Neuronal Plasticity
Cell- and Tissue-Based Therapy

Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in search for new potential anti-cancer drugs

Tawfike, A. F. S., Romli, M., Tate, R., Diederich, M., Schumacher, M. & Edrada-Ebel, R., Sep 2012.

Research output: Contribution to conferencePoster

24 Citations (Scopus)

Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system

Lemarié, F., Croft, D., Tate, R., Ryan, K. M. & Dufès, C., 2012, In : Biomaterials. 33, p. 2701-2709 9 p.

Research output: Contribution to journalArticle

Gene Transfer Techniques
Intravenous Administration
Tumors
Genes
Dendrimers
2011
15 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polyethylenimine polyplex

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., 2011, In : Nanomedicine: Nanotechnology, Biology and Medicine. 7, 5, p. 815-823 9 p.

Research output: Contribution to journalArticle

Bearings (structural)
Polyethyleneimine
Arginine
Gene expression
Leucine
38 Citations (Scopus)

Enhanced gene expression in tumors after intravenous administration of arginine-, lysine- and leucine-bearing polypropylenimine polyplex

Aldawsari, H. M., Edrada-Ebel, R., Blatchford, D., Tate, R., Tetley, L. & Dufès, C., Sep 2011, In : Biomaterials. 32, 25, p. 5889-5899 11 p.

Research output: Contribution to journalArticle

Bearings (structural)
Arginine
Gene expression
Leucine
Intravenous Administration

RNA stability in frozen/thawed clinical blood samples

Posada Estefan, O. M., Tate, R. & Grant, M., 2011, p. 9. 1 p.

Research output: Contribution to conferenceAbstract

RNA Stability
RNA
Gene Expression

RNA stability in frozen/thawed clinical samples

Posada Estefan, O. M., Tate, R. & Grant, M., Aug 2011.

Research output: Contribution to conferencePoster

Posters
RNA Stability
2010

Enhanced transfection efficacy of polyethylenimine by surface modification with arginine, lysine, and leucine

Aldawsari, H. M., Sundara Raj, B., Edrada-Ebel, R., Blatchford, D., Tate, R. & Dufès, C., 2010, In : Controlled Release Society Newsletter. 27, 6, p. 12-14 3 p.

Research output: Contribution to journalArticle

Polyethyleneimine
Leucine
Lysine
Transfection
Arginine
82 Citations (Scopus)

The sphingosine kinase 1 inhibitor 2-(P-hydroxyanilino)-4-(P-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells

Loveridge, C., Tonelli, F., Leclercq, T., Lim, K. G., Long, J. S., Berdyshev, E., Tate, R. J., Natarajan, V., Pitson, S. M., Pyne, N. J. & Pyne, S., 10 Dec 2010, In : Journal of Biological Chemistry . 285, 50, p. 38841-38852 12 p.

Research output: Contribution to journalArticle

Thiazoles
Cells
Degradation
Androgens
Apoptosis