Research output per year
Research output per year
- 1 - 50 out of 108 results
Search results
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2024
Bad to the bone: an RNA-sequencing study identifying a role for IKK-alpha in osteosarcoma cell division and progression
Tinto, K., Bonfanti, M., Cunningham, M. R. & Plevin, R., 4 Sept 2024.Research output: Contribution to conference › Presentation/Speech › peer-review
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DRD2 activation inhibits choroidal neovascularization in patients with Parkinson's disease and age-related macular degeneration
Mathis, T., Baudin, F., Mariet, A-S., Augustin, S., Bricout, M., Przegralek, L., Roubeix, C., Benzenine, É., Blot, G., Nous, C., Kodjikian, L., Mauget-Faÿsse, M., Sahel, J-A., Plevin, R., Zeitz, C., Delarasse, C., Guillonneau, X., Creuzot-Garcher, C., Quantin, C., Hunot, S., & 1 others, 3 Sept 2024, In: Journal of Clinical Investigation . 134, 17, e174199.Research output: Contribution to journal › Article › peer-review
Open Access -
Design and synthesis of novel aminoindazole-pyrrolo[2,3-b]pyridine inhibitors of IKKα that selectively perturb cellular non-canonical NF-κB signalling
Riley, C., Ammar, U., Alsfouk, A., Anthony, N. G., Baiget, J., Berretta, G., Breen, D., Huggan, J., Lawson, C., McIntosh, K., Plevin, R., Suckling, C. J., Young, L. C., Paul, A. & Mackay, S. P., 26 Jul 2024, In: Molecules. 29, 15, 29 p., 3515.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Downloads (Pure) -
Proteinase activated receptor 2: a novel therapeutic drug target
Lozon, Y., McIntosh, K. & Plevin, R., 8 Feb 2024.Research output: Contribution to conference › Poster
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2023
A novel role for IL-1b in non-canonical NFkB signalling in U20S cells
Tinto, K., McIntosh, K., Cunningham, M. R. & Plevin, R., 31 Jul 2023.Research output: Contribution to conference › Abstract › peer-review
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IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
McIntosh, K., Khalaf, Y. H., Craig, R., West, C., McCulloch, A., Waghmare, A., Lawson, C., Chan, E. Y. W., MacKay, S., Paul, A. & Plevin, R., 31 Jul 2023, In: Cellular Signalling. 107, 11 p., 110684.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)64 Downloads (Pure) -
TAK1 is an upstream MAP 3 K regulator of a novel non-canonical NFkB pathway stimulated by IL-1b
Farhan, M., McIntosh, K. A., Cunningham, M. R., Plevin, R. & Tinto, K., 31 Jul 2023, In: British Journal of Pharmacology. 180, S1, p. 708-709 2 p., OC143.Research output: Contribution to journal › Conference abstract › peer-review
Open Access -
Concept mapping in pharmacology: quantitative evaluation and qualitative reflection
Bremner, S., Klemm, N., Ford, S., Cunningham, M. R. & Plevin, R., 1 Jul 2023.Research output: Contribution to conference › Poster
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TAK-1 inhibition prevents cytokine-mediated CXCL12 production in a bone cancer cell line
Farhan, M., Cunningham, M. R., McIntosh, K. & Plevin, R., 27 Jun 2023, In: British Journal of Pharmacology. 180, 1 p., OC012.Research output: Contribution to journal › Conference Contribution › peer-review
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2022
Interleukin-1b stimulates a novel early activation of non-canonical NF Kappa B signalling pathway linked to CXCL12 production.
McIntosh, K., Craig, R. G., McCulloch, A., MacKay, S., Paul, A. & Plevin, R., 25 Sept 2022.Research output: Contribution to conference › Abstract › peer-review
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Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome
Patkar, S., Uwanogho, D., Modo, M., Tate, R. J., Plevin, R. & Carswell, H. V. O., 22 Jul 2022, In: Frontiers in Cellular Neuroscience. 16, 15 p., 917181.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)35 Downloads (Pure) -
2020
The development of proteinase-activated receptor-2 modulators and the challenges involved
McIntosh, K. A., Cunningham, M. R., Bushell, T. & Plevin, R., 31 Dec 2020, In: Biochemical Society Transactions. 48, 6, p. 2525-2537 13 p., BST20200191.Research output: Contribution to journal › Review article › peer-review
Open AccessFile23 Citations (Scopus)241 Downloads (Pure) -
Determining the prognostic significance of IKKα in prostate cancer
Montes, M., MacKenzie, L., McAllister, M. J., Roseweir, A., McCall, P., Hatziieremia, S., Underwood, M. A., Boyd, M., Paul, A., Plevin, R., MacKay, S. P. & Edwards, J., 1 Oct 2020, In: The Prostate. 80, 14, p. 1188-1202 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)50 Downloads (Pure) -
Mitogen‐activated protein kinase phosphatase‐2 deletion modifies ventral tegmental area function and connectivity and alters reward processing
Pytka, K., Dawson, N., Tossell, K., Ungless, M. A., Plevin, R., Brett, R. R. & Bushell, T. J., 31 Jul 2020, In: European Journal of Neuroscience. 52, 2, p. 2838-2852 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)29 Downloads (Pure) -
2019
Cytotoxicity of Nubein6.8 peptide isolated from the snake venom of Naja nubiae on melanoma and ovarian carcinoma cell lines
Abdel-Ghani, L. M., Rahmy, T. R., Tawfik, M. M., Kaziri, I., Al-Obaidi, A., Rowan, E. G., Plevin, R. & Abdel-Rahman, M. A., 31 Oct 2019, In: Toxicon. 168, p. 22-31 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)51 Downloads (Pure) -
Whole genome microarray analysis of DUSP4-deletion reveals a novel role for MAP kinase phosphatase-2 (MKP-2) in macrophage gene expression and function
Neamatallah, T., Jabbar, S., Tate, R., Schroeder, J., Shweash, M., Alexander, J. & Plevin, R., 12 Jul 2019, In: International Journal of Molecular Sciences. 20, 14, 17 p., 3434.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)41 Downloads (Pure) -
Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
Schroeder, J., Ross, K., McIntosh, K., Jabbar, S. K. J., Woods, S., Crowe, J., Patterson-Kane, J. C., Alexander, J., Lawrence, C. & Plevin, R., 11 Jan 2019, In: RMD Open. 5, 1, p. e000711 9 p., e000711.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)53 Downloads (Pure) -
2018
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
Ng, P. Y., McIntosh, K. A., Hargrave, G., Ho, K. H., Paul, A. & Plevin, R., 30 Nov 2018, In: Cellular Signalling. 51, p. 59-71 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)33 Downloads (Pure) -
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
Chen, M., Zhang, J., Berger, A. H., Diolombi, M. S., Ng, C., Fung, J., Bronson, R. T., Castillo-Martin, M., Thin, T. H., Cordon-Cardo, C., Plevin, R. & Pandolfi, P. P., 26 Nov 2018, (E-pub ahead of print) In: Journal of Clinical Investigation . 129, 1, p. 215-222 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)36 Downloads (Pure) -
Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival
Choi, J. C., Wu, W., Phillips, E., Plevin, R., Sera, F., Homma, S. & Worman, H. J., 1 Jul 2018, In: Human Molecular Genetics . 27, 13, p. 2290-2305 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)28 Downloads (Pure) -
Conflicting evidence for the role of JNK as a target in breast cancer cell proliferation: comparisons between pharmacological inhibition and selective shRNA knockdown approaches
Wood, R. A., Barbour, M. J., Gould, G. W., Cunningham, M. R. & Plevin, R. J., 28 Feb 2018, In: Pharmacology Research & Perspectives. 6, 1, 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)103 Downloads (Pure) -
2017
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover
Wilkinson, D. J., Desilets, A., Lin, H., Charlton, S., Del Carmen Arques, M., Falconer, A., Bullock, C., Hsu, Y. C., Birchall, K., Hawkins, A., Thompson, P., Ferrell, W. R., Lockhart, J., Plevin, R., Zhang, Y., Blain, E., Lin, S. W., Leduc, R., Milner, J. M. & Rowan, A. D., 1 Dec 2017, In: Scientific Reports. 7, 1, 13 p., 16693.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)27 Downloads (Pure) -
Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers
Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R., & 4 others, 24 Jul 2017, (E-pub ahead of print) In: Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)188 Downloads (Pure) -
Mitochondria has a role in regulating hypoxic-dependent cell proliferation in pulmonary cells and vascular remodelling
Coats, P., Plevin, R. & Burzangi, A., 30 Apr 2017, In: Heart . 103, Suppl 2, p. A6-A7 2 p.Research output: Contribution to journal › Conference abstract › peer-review
Open Access -
An in vitro microfluidic model of microglia migration after stroke
White, S., Plevin, R., Zagnoni, M. & Carswell, H., 1 Apr 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 1 (Suppl), 1 p.Research output: Contribution to journal › Conference abstract › peer-review
Open AccessFile49 Downloads (Pure) -
2016
MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells
Barbour, M., Plevin, R. & Jiang, H-R., 13 Dec 2016, In: Scientific Reports. 6, p. 1-13 13 p., 38999.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)98 Downloads (Pure) -
Modulating PAR2 signalling by novel compounds based on GB88
Saeed, T., McIntosh, K., Jamieson, C. & Plevin, R., 12 Dec 2016. 2 p.Research output: Contribution to conference › Abstract › peer-review
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Proteinase-activated receptors (PARs) as targets for antiplatelet therapy
Cunningham, M., McIntosh, K., Bushell, T., Sloan, G. & Plevin, R., 15 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 606-612 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)161 Downloads (Pure) -
Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memory
Abdul Rahman, N. Z. B., Greenwood, S. M., Brett, R. R., Tossell, K., Ungless, M. A., Plevin, R. & Bushell, T. J., 24 Feb 2016, In: Journal of Neuroscience. 36, 8, p. 2348-2354 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)88 Downloads (Pure) -
Protease-activated receptor 2: are common functions in glial and immune cells linked to inflammation-related CNS disorders?
Bushell, T. J., Cunningham, M. R., McIntosh, K. A., Moudio, S. & Plevin, R., 2016, In: Current Drug Targets. 17, 16, p. 1861-1870 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)274 Downloads (Pure) -
2015
Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology
Huesa, C., Ortiz, A. C., Dunning, L., McGavin, L., Bennett, L., McIntosh, K., Crilly, A., Kurowska-Stolarska, M., Plevin, R., van ,t Hof, R. J., Rowan, A. D., McInnes, I. B., Goodyear, C. S., Lockhart, J. C. & Ferrell, W. R., 23 Dec 2015, (E-pub ahead of print) In: Annals of the Rheumatic Diseases. 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Citations (Scopus)246 Downloads (Pure) -
Working towards proteinase activated receptor-2 antagonists
McIntosh, K. A., Jamieson, C. & Plevin, R. J., 13 Dec 2015. 1 p.Research output: Contribution to conference › Abstract › peer-review
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2014
Adult cardiac fibroblast proliferation is modulated by calcium/calmodulin-dependent protein kinase II in normal and hypertrophied hearts
Martin, T. P., Lawan, A., Robinson, E., Grieve, D. J., Plevin, R., Paul, A. & Currie, S., 28 Feb 2014, In: Pflugers Archiv - European Journal of Physiology. 466, 2, p. 319–330 12 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
2013
MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice
Woods, S., Schroeder, J., McGachy, H. A., Plevin, R., Roberts, C. W. & Alexander, J., 15 Aug 2013, In: PLOS Pathogens. 9, 8, 14 p., e1003535.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)37 Downloads (Pure) -
T cell hypo-responsiveness against Leishmania major in MAP kinase phosphatase (MKP) 2 deficient C57BL/6 mice does not alter the healer disease phenotype
Schroeder, J., McGachy, H. A., Woods, S., Plevin, R. & Alexander, J., 21 Feb 2013, In: PLOS Neglected Tropical Diseases. 7, 2, 11 p., e2064.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)156 Downloads (Pure) -
2012
Immunomodulatory role of proteinase-activated receptor-2
Plevin, R., Sept 2012, In: Annals of the Rheumatic Diseases. 71, 9, p. 1559-66 7 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
Nuclear factor κB predicts poor outcome in patients with hormone-naive prostate cancer with high nuclear androgen receptor
MacKenzie, L., McCall, P., Hatziieremia, S., Catlow, J., Adams, C., McArdle, P., Seywright, M., Tanahill, C., Paul, A., Underwood, M., Mackay, S., Plevin, R. & Edwards, J., Sept 2012, In: Human pathology. 43, 9, p. 1491-500 10 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Protective role of MAP kinase phosphatase 2 (MKP-2) in a model of collagen antibody induced arthritis
Schroeder, J., Ross, K., Alexander, J., Lawrence, C. E. & Plevin, R., Sept 2012, In: Immunology. 137, 1 special issue, p. 585-585 1 p.Research output: Contribution to journal › Conference abstract › peer-review
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Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)
Cunningham, M. R., McIntosh, K. A., Pediani, J. D., Robben, J., Cooke, A. E., Nilsson, M., Gould, G. W., Mundell, S., Milligan, G. & Plevin, R., 11 May 2012, In: Journal of Biological Chemistry. 287, 20, p. 16656-16669 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)405 Downloads (Pure) -
Conditionally immortalised neural stem cells promote functional recovery and brain plasticity after transient focal cerebral ischaemia in mice
Patkar, S. S., Tate, R., Modo, M., Plevin, R. & Carswell, H., Jan 2012, In: Stem Cell Research. 8, 1, p. 14–25 12 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
MKP-2: out of the DUSP-bin and back into the limelight
Lawan, A., Torrance, E., Al-Harthi, S., Shweash, M., Alnasser, S., Neamatallah, T., Schroeder, J. & Plevin, R., 2012, In: Biochemical Society Transactions. 40, p. 235-239 5 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2011
Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression
Shweash, M., Adrienne McGachy, H., Schroeder, J., Neamatallah, T., Bryant, C. E., Millington, O., Mottram, J. C., Alexander, J. & Plevin, R., Sept 2011, In: Molecular Immunology. 48, 15-16, p. 1800-1808 9 p.Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
Deletion of the dual specific phosphatase-4 (DUSP-4) gene reveals an essential non-redundant role for MAP kinase phosphatase-2 (MKP-2) in proliferation and cell survival
Lawan, A., Al-Harthi, S., Cadalbert, L., McCluskey, A. G., Shweash, M., Grassia, G., Grant, A., Boyd, M., Currie, S. & Plevin, R., 15 Apr 2011, In: Journal of Biological Chemistry. 286, 15, p. 12933-12943 11 p.Research output: Contribution to journal › Article › peer-review
50 Citations (Scopus) -
Protease-activated receptor-2 (PAR-2) in the pathogenesis of osteoarthritis
Ferrell, W. R., Kelso, E. B., Lockhart, J. C., Burns, E., Plevin, R. & McInnes, I. B., Apr 2011, In: Rheumatology. 50, Supplement 3, p. 90-90 1 p.Research output: Contribution to journal › Conference Contribution › peer-review
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Inhibitory kappa B kinases as targets for pharmacological regulation
Gamble, C., McIntosh, K., Scott, R., Ho, K. H., Plevin, R. & Paul, A., 2011, In: British Journal of Pharmacology. 165, 4, p. 802–819 18 p.Research output: Contribution to journal › Article › peer-review
101 Citations (Scopus) -
2010
Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis
Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., Kelso, E. B., Donell, S. T., Cawston, T. E., Clark, I. M., Ferrell, W. R., Plevin, R., Lockhart, J. C., Leduc, R. & Rowan, A. D., Dec 2010, In: International Journal of Experimental Pathology. 91, 6, p. A40-A41 2 p.Research output: Contribution to journal › Book/Film/Article review › peer-review
76 Citations (Scopus) -
LIF-mediated maintenance of PACAP-induced neurite outgrowths in human SH-SY5Y neuroblastoma cells require PI3K but not STAT or ERK signaling pathways
Lutz, E. M., Monaghan, T. K., Pou, C., Plevin, R. & MacKenzie, C. J., Nov 2010, In: Journal of Molecular Neuroscience. 42, 3, p. 297-297 1 p.Research output: Contribution to journal › Conference Contribution › peer-review
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MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana
Al-Mutairi, M. S., Cadalbert, L. C., McGachy, H. A., Shweash, M. S., Schroeder, J., Kurnik, M., Sloss, C. M., Bryant, C. E., Alexander, J. & Plevin, R. J., Nov 2010, In: PLOS Pathogens. 6, 11, e1001192.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Citations (Scopus)414 Downloads (Pure) -
Matriptase is a novel initiator of cartilage matrix resorption in osteoarthritis
Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., Kelso, E. B., Donell, S. T., Cawston, T. E., Clarke, I. M., Ferrell, W. R., Plevin, R., Lockhart, J. C., Leduc, R. & Rowan, A. D., Oct 2010, In: Osteoarthritis and Cartilage. 18, Supplement 2, p. S9-S10 2 p.Research output: Contribution to journal › Book/Film/Article review › peer-review
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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis
Milner, J. M., Patel, A., Davidson, R. K., Swingler, T. E., Desilets, A., Young, D. A., Kelso, E. B., Donell, S. T., Cawston, T. E., Clark, I. M., Ferrell, W. R., Plevin, R., Lockhart, J. C., Leduc, R. & Rowan, A. D., Jul 2010, In: Arthritis and Rheumatism. 62, 7, p. 1955-1966 12 p.Research output: Contribution to journal › Article › peer-review
76 Citations (Scopus)