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Personal profile

Research Interests

Atrial fibrillation is the most common cardiac arrhythmia that is encountered clinically and it is associated with significant morbidity and mortality. A significant breakthrough in the understanding of atrial fibrallation occurred in the late 1990s when it was known that ectopic electrical activity that originates within the pulmonary veins is an important trigger for this type of arrhythmia. The pulmonary veins in most species are surrounded by an external sleeve of cardiomyocytes that extends from the left atrium towards the lungs. It is these cells that are considered to be responsible for generating the abnormal electrical activity that triggers atrial fibrillation, although the underlying mechanisms are unknown.

My current focus is on understanding the mechanisms whereby pulmonary vein cardiomyocytes generate spontaeneous electrical activity, and in particular the role that intracellular Ca²+ plays in this process. I am also interested in determining how electrical activity is propagated along the pulmonary vein to the atria, where it can then trigger atrial fibrillation. Since current drug treatments for atrial fibrallation are of limited efficacy, identification of potential novel therapeutic targets for future drug development is extremely important.

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Projects 2011 2014

Research Output 2001 2019

Hibiscus acid from hibiscus sabdariffa (malvaceae) has a vasorelaxant effect on the rat aorta

Zheoat, A. M., Gray, A. I., Igoli, J. O., Ferro, V. A. & Drummond, R. M., 25 Jan 2019, In : Fitoterapia. 134, p. 5-13 9 p.

Research output: Contribution to journalArticle

Malvaceae
Hibiscus
Vasodilator Agents
Aorta
Phenylephrine

Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation

Henry, A. D., MacQuaide, N., Burton, F. L., Rankin, A. C., Rowan, E. G. & Drummond, R. M., 31 Dec 2018, In : Cell Calcium. 76, p. 36-47 12 p.

Research output: Contribution to journalArticle

Pulmonary Veins
Cardiac Myocytes
Electric Stimulation
Sarcolemma
Ryanodine Receptor Calcium Release Channel

Thesis

A comparison of the electrophysiological properties of sodium channels in cardiomyocytes of the rat pulmonary vein and atrium

Author: Hutchison, L., 1 Oct 2014

Supervisor: Rowan, E. (Supervisor) & Drummond, R. (Supervisor)

Student thesis: Doctoral Thesis

The role of intracellular Ca2+ in the arrhythmogenic activity of pulmonary vein cardiomyocytes

Author: Henry, A., 1 Oct 2014

Supervisor: Drummond, R. (Supervisor) & Rowan, E. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2013 2013

  • 1 Editorial board member

Pharmacology Research & Perspectives (Journal)

Robert Drummond (Editor)
2013 → …

Activity: Publication peer-review and editorial work typesEditorial board member