20012023

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Personal profile

Research Interests

Atrial fibrillation is the most common cardiac arrhythmia that is encountered clinically and it is associated with significant morbidity and mortality. A significant breakthrough in the understanding of atrial fibrallation occurred in the late 1990s when it was known that ectopic electrical activity that originates within the pulmonary veins is an important trigger for this type of arrhythmia. The pulmonary veins in most species are surrounded by an external sleeve of cardiomyocytes that extends from the left atrium towards the lungs. It is these cells that are considered to be responsible for generating the abnormal electrical activity that triggers atrial fibrillation, although the underlying mechanisms are unknown.

My current focus is on understanding the mechanisms whereby pulmonary vein cardiomyocytes generate spontaeneous electrical activity, and in particular the role that intracellular Ca²+ plays in this process. I am also interested in determining how electrical activity is propagated along the pulmonary vein to the atria, where it can then trigger atrial fibrillation. Since current drug treatments for atrial fibrallation are of limited efficacy, identification of potential novel therapeutic targets for future drug development is extremely important.

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Projects

Research Output

Open Access
File
  • 1 Citation (Scopus)
    1 Downloads (Pure)

    Hibiscus acid from hibiscus sabdariffa (malvaceae) has a vasorelaxant effect on the rat aorta

    Zheoat, A. M., Gray, A. I., Igoli, J. O., Ferro, V. A. & Drummond, R. M., 30 Apr 2019, In : Fitoterapia. 134, p. 5-13 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Citations (Scopus)
    4 Downloads (Pure)

    Thesis

    A comparison of the electrophysiological properties of sodium channels in cardiomyocytes of the rat pulmonary vein and atrium

    Author: Hutchison, L., 20 Apr 2016

    Supervisor: Rowan, E. (Supervisor) & Drummond, R. (Supervisor)

    Student thesis: Doctoral Thesis

    Phytochemical and pharmacological studies on Hibiscus sabdariffa and Polygonum salicifolium

    Author: Zheoat, A. M. A., 25 Jul 2019

    Supervisor: Ferro, V. (Supervisor) & Drummond, R. (Supervisor)

    Student thesis: Doctoral Thesis

    Activities

    • 1 Editorial board member

    Pharmacology Research & Perspectives (Journal)

    Robert Drummond (Editor)
    2013 → …

    Activity: Publication peer-review and editorial work typesEditorial board member