Photo of Rebecca Beveridge
  • United Kingdom

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PhD projects

Development of native ion mobility mass spectrometry methods to study PROTAC systems

20132020

Research output per year

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Personal profile

Personal Statement

Rebecca is a Chancellor’s Fellow and UKRI Future Leaders Fellow who joined the University of Strathclyde in June 2020. She obtained a BSc in biochemistry and chemistry from the University of Leeds in 2011 and completed her PhD at the University of Manchester in 2015. Rebecca spent 4 years at the Institute for Molecular Pathology in Vienna, Austria as a postdoctoral researcher/ Lise Meitner Postdoctoral Fellow. Throughout her career, she has collected experience in a plethora of mass spectrometry methods to study protein structure such as native mass spectrometry, ion mobility, hydrogen-deuterium exchange, and crosslinking.

Rebecca’s current research is centered around the development of native ion mobility mass spectrometry methods to study proteins and protein complexes, particularly those that are challenging to study with conventional biochemistry methods. Such systems include intrinsically disordered proteins that exist in a wide range of different shapes, and protein complexes formed by protein-degrading molecules such as PROTACs, the complex binding modes of which are challenging to delineate.

Keywords

  • mass spectrometry
  • ion mobility
  • proteins
  • intrinsically disordered proteins
  • protein degraders

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Research Output

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

Stephani, M., Picchianti, L., Gajic, A., Beveridge, R., Skarwan, E., Sanchez de Medina Hernandez, V., Mohseni, A., Clavel, M., Zeng, Y., Naumann, C., Matuszkiewicz, M., Turco, E., Loefke, C., Li, B., Durnberger, G., Schutzbier, M., Chen, H. T., Abdrakhmanov, A., Savova, A., Chia, K-S. & 9 others, Djamei, A., Schaffner, I., Abel, S., Jiang, L., Mechtler, K., Ikeda, F., Martens, S., Clausen, T. & Dagdas, Y., 24 Mar 2020, Cold Spring Harbor, NY., 83 p.

Research output: Working paper

Open Access
File
  • A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes

    Beveridge, R., Stadlmann, J., Penninger, J. M. & Mechtler, K., 6 Feb 2020, In : Nature Communications. 11, 1, 9 p., 742.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)