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Rachel Clark

Dr

  • United Kingdom

20062018
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Research Output 2006 2012

  • 11 Article
  • 2 Literature review
  • 1 Meeting abstract
2012
16 Citations (Scopus)

Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT

Clark, R. L., Clements, C. J., Barrett, M. P., Mackay, S. P., Rathnam, R. P., Owusu-Dapaah, G., Spencer, J. & Huggan, J. K., 15 Oct 2012, In : Bioorganic and Medicinal Chemistry. 20, 20, p. 6019-6033 15 p.

Research output: Contribution to journalArticle

Quinazolines
African Trypanosomiasis
Trypanosoma brucei brucei
Scaffolds
Libraries
2011
10 Citations (Scopus)

Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations

Jones, R. L., Woodward, D. F., Wang, J. W. & Clark, R. L., 2011, In : British Journal of Pharmacology. 162, 4, p. 863-879 17 p.

Research output: Contribution to journalArticle

Prostaglandins
Smooth Muscle
Aorta
Guinea Pigs
Vas Deferens
16 Citations (Scopus)

Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1,3-naphth-oxazines

Ihmaid, S., Al-Rawi, J., Bradley, C., Angove, M. J., Robertson, M. N. & Clark, R. L., 1 Jul 2011, In : Bioorganic and Medicinal Chemistry. 19, 13, p. 3983-3994 12 p.

Research output: Contribution to journalArticle

Oxazines
DNA-Activated Protein Kinase
Morpholinos
Platelets
Blood Platelets
26 Citations (Scopus)

Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Spencer, J., Rathnam, R. P., Harvey, A. L., Clements, C. J., Clark, R. L., Barrett, M. P., Wong, P. E., Male, L., Coles, S. J. & Mackay, S. P., 1 Mar 2011, In : Bioorganic and Medicinal Chemistry . 19, 5, p. 1802-1815 14 p.

Research output: Contribution to journalArticle

African Trypanosomiasis
Trypanosoma brucei brucei
Benzodiazepines
Libraries
Parasites
2010
47 Citations (Scopus)

Current strategies for drug discovery through natural products

Harvey, A., Clark, R., Mackay, S. & Johnston, B., Jun 2010, In : Expert Opinion on Drug Discovery. 5, 6, p. 559-568 10 p.

Research output: Contribution to journalLiterature review

Drug Discovery
Biological Products
Biological Assay
Pharmaceutical Preparations
3 Citations (Scopus)

The drug discovery portal: a computational platform for identifying drug leads from academia

Clark, R. L., Johnston, B. F., Mackay, S. P., Breslin, C. J., Robertson, M., Sutcliffe, O. B., Dufton, M. J. & Harvey, A. L., 2010, In : Current Pharmaceutical Design . 16, 15, p. 1697-1702 6 p.

Research output: Contribution to journalArticle

Drug Discovery
Research
Pharmaceutical Preparations
Scotland
Libraries
21 Citations (Scopus)

The drug discovery portal: a resource to enhance drug discovery from academia

Clark, R. L., Johnston, B. F., Mackay, S. P., Breslin, C. J., Robertson, M. N. & Harvey, A. L., Aug 2010, In : Drug Discovery Today. 15, 15-16, p. 679-683 5 p.

Research output: Contribution to journalLiterature review

Drug Discovery
Pharmaceutical Chemistry
Pharmaceutical Preparations
Industry
Research
3 Citations (Scopus)

The drug discovery portal: a computational platform for identifying drug leads from academia

Clark, R., Johnston, B., Mackay, S., Breslin, C., Robertson, M., Sutcliffe, O. B., Dufton, M. & Harvey, A., May 2010, In : Current Pharmaceutical Design. 16, 15, p. 1697-1702 6 p.

Research output: Contribution to journalArticle

Drug Discovery
Research
Pharmaceutical Preparations
Scotland
Libraries

The drug discovery portal library: a unique resource to enhance drug discovery in academia

Al-Shar'i, N., Al-Jaidi, B., Johnston, B. F., Robertson, M. N., Mackay, S. P. & Clark, R. L., Oct 2010, In : Journal of Pharmacy and Pharmacology. 62, 10 special issue, p. 1382-1382 1 p.

Research output: Contribution to journalMeeting abstract

Drug Discovery
Libraries
2009
45 Citations (Scopus)
tea
Tea
Support vector machines
Data structures
modeling
1 Citation (Scopus)
Flurazepam
Microsomes
Benzodiazepines
Glutathione
Hepatocytes
2007
13 Citations (Scopus)

Exploring DNA topoisomerase I inhibition by the benzo[c]phenanthridines fagaronine and ethoxidine using steered molecular dynamics

Clark, R. L., Deane, F. M., Anthony, N. G., Johnston, B. F., McCarthy, F. O. & Mackay, S. P., 15 Jul 2007, In : Bioorganic and Medicinal Chemistry . 15, 14, p. 4741-4752 12 p.

Research output: Contribution to journalArticle

Phenanthridines
Type I DNA Topoisomerase
Molecular Dynamics Simulation
Molecular dynamics
Intercalating Agents
47 Citations (Scopus)

Identification of the benzodiazepines as a new class of antileishmanial agent

Clark, R. L., Carter, K. C., Mullen, A. B., Coxon, G. D., Owusu-Dapaah, G., McFarlane, E., Dao Duong Thi, M., Grant, M. H., Tettey, J. N. A. & Mackay, S. P., Feb 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 3, p. 624-627 3 p.

Research output: Contribution to journalArticle

Sodium Compounds
Antimony Sodium Gluconate
Poisons
Benzodiazepines
Coinfection
2006
2 Citations (Scopus)
Catalytic Antibodies
Cycloaddition
Cycloaddition Reaction
Antibodies
Maleimides