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Research Output

2019

Microfluidic-assisted silk nanoparticle tuning

Wongpinyochit, T., Totten, J. D., Johnston, B. F. & Seib, F. P., 30 Jan 2019, In : Nanoscale Advances. 1, 2, p. 873-883 11 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
16 Downloads (Pure)

Nanomedicines for the delivery of biologics

Wahlich, J., Desai, A., Greco, F., Hill, K., Jones, A. T., Mrsny, R., Pasut, G., Perrie, Y., Seib, F. P., Seymour, L. W. & Uchegbu, I. F., 3 May 2019, In : Pharmaceutics. 11, 5, 14 p., 210.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
36 Downloads (Pure)

PEGylation-dependent metabolic rewiring of macrophages with silk fibroin nanoparticles

Totten, J. D., Wongpinyochit, T., Carrola, J., Duarte, I. F. & Seib, F. P., 24 Apr 2019, In : ACS Applied Materials and Interfaces. 11, 16, p. 14515-14525 11 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
11 Downloads (Pure)

The biomedical use of silk: past, present, future

Holland, C., Numata, K., Rnjak-Kovacina, J. & Seib, F. P., 10 Jan 2019, In : Advanced Healthcare Materials. 8, 1, 26 p., 1800465.

Research output: Contribution to journalArticle

Open Access
File
55 Citations (Scopus)
83 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
1 Downloads (Pure)
2018

A review of the emerging role of silk for the treatment of the eye

Tran, S. H., Wilson, C. G. & Seib, F. P., 5 Dec 2018, In : Pharmaceutical Research. 35, 12, 16 p., 248.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
19 Citations (Scopus)
22 Downloads (Pure)

Impact of the hypoxia phenotype on the uptake and efflux of nanoparticles by human breast cancer cells

Brownlee, W. J. & Seib, F. P., 17 Aug 2018, In : Scientific Reports. 8, 11 p., 12318.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
20 Downloads (Pure)

In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain application

Osama, I., Gorenkova, N., McKittrick, C. M., Wongpinyochit, T., Goudie, A., Seib, F. P. & Carswell, H. V. O., 12 Sep 2018, In : Scientific Reports. 8, 11 p., 13655.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
13 Downloads (Pure)
Open Access
File
7 Citations (Scopus)
14 Downloads (Pure)

Reverse-engineered silk hydrogels for cell and drug delivery

Seib, F. P., 3 May 2018, In : Therapeutic Delivery. 9, 6, p. 469-487 19 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
23 Downloads (Pure)

Self-assembling hydrogels from reverse-engineered silk

Seib, P., 19 Apr 2018, Self-assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine. Azevedo, H. S. & da Silva, R. M. P. (eds.). 1 ed. Duxford, p. 27-47

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery

Newland, B., Taplan, C., Pette, D., Friedrichs, J., Steinhart, M., Wang, W., Voit, B., Seib, F. P. & Werner, C., 1 May 2018, In : Nanoscale. 10, 18, p. 8413-8421 9 p.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
11 Downloads (Pure)
2017

Biocompatibility assessment of silk nanoparticles: hemocompatibility and internalization by human blood cells

Maitz, M. F., Sperling, C., Wongpinyochit, T., Herklotz, M., Werner, C. & Seib, F. P., 30 Nov 2017, In : Nanomedicine: Nanotechnology, Biology and Medicine. 13, 8, p. 2633-2642 10 p.

Research output: Contribution to journalArticle

Open Access
File
18 Citations (Scopus)
79 Downloads (Pure)
Open Access
File
16 Citations (Scopus)
174 Downloads (Pure)

Silk hydrogels for drug and cell delivery

Seib, F. P., 12 Aug 2017, Hydrogels: Design, Synthesis & Application in Drug Delivery & Regenerative Medicine. Singh, T. R. R., Laverty, G. & Donnelly, R. (eds.). p. 208-227 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
File
27 Downloads (Pure)
Open Access
File
14 Citations (Scopus)
47 Downloads (Pure)

Silk nanoparticles - an emerging anticancer nanomedicine

Seib, F. P., 22 Mar 2017, In : AIMS Bioengineering. 42, 2, p. 239-258 20 p.

Research output: Contribution to journalArticle

Open Access
File
210 Downloads (Pure)
2016

Heparin modified polyethylene glycol microparticle aggregates for focal cancer chemotherapy

Seib, F. P., Tsurkan, M., Freudenberg, U., Kaplan, D. L. & Werner, C., 21 Oct 2016, In : ACS Biomaterials Science & Engineering. 2, 12, p. 2287-2293 7 p.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
172 Downloads (Pure)
Open Access
File
10 Citations (Scopus)
71 Downloads (Pure)
2015

Focal therapy of neuroblastoma using silk films to deliver kinase and chemotherapeutic agents in vivo

Seib, F. P., Coburn, J., Konrad, I., Klebanov, N., Jones, G. T., Blackwood, B., Charest, A., Kaplan, D. L. & Chiu, B., 1 Jul 2015, In : Acta Biomaterialia. 20, p. 32-38 7 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
207 Downloads (Pure)

PEGylated silk nanoparticles for anticancer drug delivery

Wongpinyochit, T., Uhlmann, P., Urquhart, A. J. & Seib, F. P., 9 Nov 2015, In : Biomacromolecules. 16, 11, p. 3712-3722 11 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
198 Downloads (Pure)

Tissue engineering a surrogate niche for metastatic cancer cells

Seib, F. P., Berry, J. E., Shiozawa, Y., Taichman, R. S. & Kaplan, D. L., 1 May 2015, In : Biomaterials. 51, p. 313-319 7 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
209 Downloads (Pure)
2014

A material-based platform to modulate fibronectin activity and focal adhesion assembly

Vanterpool, F. A., Cantini, M., Seib, F. P. & Salmerón-Sánchez, M., Dec 2014, In : BioResearch Open Access. 3, 6, p. 286-296 11 p.

Research output: Contribution to journalArticle

Open Access
File
22 Citations (Scopus)
40 Downloads (Pure)

Biomaterials to direct stem cell fate

Prewitz, M., Seib, P., Pompe, T. & Werner, C., May 2014, Stem cells: from basic research to therapy. volume two: tissue homeostasis and regeneration during adulthood, applications, legislation and ethics. Calegari, F. & Waskow, C. (eds.). 1 ed. Boca Raton, Vol. 2. p. 238-270 33 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multifunctional silk-heparin biomaterials for vascular tissue engineering applications

Seib, F. P., Herklotz, M., Burke, K., Maitz, M., Werner, C. & Kaplan, D., 1 Jan 2014, In : Biomaterials. 35, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Open Access
File
67 Citations (Scopus)
230 Downloads (Pure)

Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model

Chiu, B., Pilichowska, M., Seib, P., Charest, A. & Kaplan, DL., 12 Aug 2014, In : British Journal of Cancer. 111, 708 p.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
52 Downloads (Pure)
2013

pH-dependent anticancer drug release from silk nanoparticles

Seib, F. P., Jones, G., Rnjak-Kovacina, J., Lin, Y. & Kaplan, D. L., 2013, In : Advanced Healthcare Materials. 6 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Self-assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer

Seib, F. P., Pritchard, E. M. & Kaplan, D. L., 7 Jan 2013, In : Advanced Functional Materials. 23, 1, p. 58–65 8 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Silk for drug delivery applications: opportunities and challenges

Seib, F. P. & Kaplan, D., Oct 2013, In : Israel Journal of Chemistry. 53, 9-10, p. 756-766 11 p.

Research output: Contribution to journalSpecial issue

22 Citations (Scopus)

Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments

Prewitz, M., Seib, F. P., von Bonin, M., Friedrichs, J., Stißel, A., Niehage, C., Müller, K., Anastassiadis, K., Waskow, C., Hoflack, B., Bornhäuser, M. & Werner, C., 2013, In : Nature Methods . 10, 8, p. 788–794 7 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
2012

Doxorubicin-loaded silk films: drug-silk interactions and in vivo performance in human orthotopic breast cancer

Seib, F. P. & Kaplan, D. L., Nov 2012, In : Biomaterials. 33, 33, p. 8442-8450 9 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Impact of processing parameters on the haemocompatibility of Bombyx mori silk films

Seib, F. P., Maitz, M. F., Werner, C. & Kaplan, D. L., Feb 2012, In : Biomaterials. 33, 4, p. 1017-1023 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

In vitro model of metastasis to bone marrow mediates prostate cancer castration resistant growth through paracrine and extracellular matrix factors

Lescarbeau, R. M., Seib, F. P., Prewitz, M., Werner, C. & Kaplan, D. L., 1 Aug 2012, In : PLOS One. 7, 8, 11 p., e40372.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Polymeric biomaterials for stem cell bioengineering

Prewitz, M., Seib, F. P., Pompe, T. & Werner, C., 14 Sep 2012, In : Macromolecular Rapid Communications. 33, 17, p. 1420-1431 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties

Liebner, F., Dunareanu, R., Opietnik, M., Haimer, E., Wendland, M., Werner, C., Maitz, M., Seib, P., Neouze, M-A., Potthast, A. & Rosenau, T., 31 Mar 2012, In : Holzforschung. 66, 3, p. 317-321 5 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Stem cell implants for cancer therapy: TRAIL-expressing mesenchymal stem cells target cancer cells in situ

Reagan, M. R., Seib, F. P., McMillin, D. W., Sage, E. K., Mitsiades, C. S., Janes, S. M., Ghobrial, I. M. & Kaplan, D. L., Sep 2012, In : Journal of breast cancer. 15, 3, p. 273-282 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2011

Prolonged transendothelial migration of human haematopoietic stem and progenitor cells (HSPCs) towards hydrogel-released SDF1

Sobkow, L., Seib, F. P., Prodanov, L., Kurth, I., Drichel, J., Bornhäuser, M. & Werner, C., 2011, In : Annals of Hematology. 90, 8, p. 865-871 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2010

Biological activity of extracellular matrix-associated BMP-2

Seib, F. P., Lanfer, B., Bornhäuser, M. & Werner, C., Jun 2010, In : Journal of Tissue Engineering and Regenerative Medicine. 4, 4, p. 324-327 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Cancellous bone allograft seeded with human mesenchymal stromal cells: a potential good manufacturing practice-grade tool for the regeneration of bone defects

Stiehler, M., Seib, F. P., Rauh, J., Goedecke, A., Werner, C., Bornhäuser, M., Günther, K-P. & Bernstein, P., Sep 2010, In : Cytotherapy. 12, 5, p. 658-668 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2009

Endogenous bone morphogenetic proteins in human bone marrow-derived multipotent mesenchymal stromal cells

Seib, F. P., Franke, M., Jing, D., Werner, C. & Bornhäuser, M., 2009, In : European Journal of Cell Biology . 88, 5, p. 257-271 15 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Engineered extracellular matrices modulate the expression profile and feeder properties of bone marrow-derived human multipotent mesenchymal stromal cells

Seib, F. P., Müller, K., Franke, M., Grimmer, M., Bornhäuser, M. & Werner, C., 2009, In : Tissue Engineering: Parts A, B, and C. 15, 10, p. 3161-3171 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Engineering biomimetic culture systems: impact on human bone marrow-derived stem cells

Prewitz, M., Seib, F. P., Bornhäuser, M. & Werner, C., 2009, In : Blood. 114, 22, p. 3628

Research output: Contribution to journalArticle

Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs)

Seib, F. P., Prewitz, M., Werner, C. & Bornhäuser, M., 27 Nov 2009, In : Biochemical and Biophysical Research Communications. 389, 4, p. 663-667 5 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices

Lanfer, B., Seib, F. P., Freudenberg, U., Stamov, D., Bley, T., Bornhäuser, M. & Werner, C., Oct 2009, In : Biomaterials. 30, 30, p. 5950-5958 9 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Ultra lightweight cellulosic aerogels: preparation and properties

Liebner, F., Potthast, A., Rosenau, T., Haimer, E., Loidl, D., Teschegg, S., Neouze, M. A., Maitz, M., Seib, P. & Werner, C., 22 Mar 2009.

Research output: Contribution to conferencePaper

2008

Functional immobilization of signaling proteins enables control of stem cell fate

Alberti, K., Davey, R. E., Onishi, K., George, S., Salchert, K., Seib, F. P., Bornhäuser, M., Pompe, T., Nagy, A., Werner, C. & Zandstra, P. W., 2008, In : Nature Methods . 5, 7, p. 645-650 6 p.

Research output: Contribution to journalArticle

154 Citations (Scopus)
2007

Comparison of the endocytic properties of linear and branched PEIs, and cationic PAMAM dendrimers in B16f10 melanoma cells

Seib, F. P., Jones, A. T. & Duncan, R., 26 Feb 2007, In : Journal of Controlled Release. 117, 3, p. 291-300 10 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)
2006
37 Citations (Scopus)