• United Kingdom

Accepting PhD Students

PhD projects

Functional characterisation of cell wall deacetylases in Corynebacterium diphtheriae

Modification of the bacterial cell wall is one of the most fundamental processes that bacteria use to adapt and to survive in changing environmental conditions. The ability to modify the bacterial cell wall, which is a essential component of the bacterial cell envelope, through modification and decoration is a key adaptation that bacteria use to avoid host defences (such as hydrolytic enzymes) and enhance survival in host cells. These modifications can be highly complicated such as the covalent and non-covalent attachment of proteins, lipids and polysaccharides. Important human pathogens such as Corynebacterium and Mycobacterium have taken cell wall decoration to extraordinary levels with the attachment of highly specialised mycolic acids, arabinomannan, glycolipids and proteins, which have been relatively well studied in these organisms (sometimes referred to as the Mycolata). Some of these components, such as the mycolic acids are vital components and are essential for pathogenicity and in some cases viability. Other modifications of cell wall polymers such as N-deacetylations have received relatively little attention. It is these that will be the focus of this project, where will investigate the role of cell wall deacetylases in the growth and pathogenicity of Corynebacterium diphtheriae. We will also investigate the enzymology of the C. diphtheriae enzyme to elucidate its substrate and co-factor specificity.

20042023

Research output per year

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Research Output

2020

Differential transcription of expanded gene families in central carbon metabolism of Streptomyces coelicolor A3(2)

Schniete, J. K., Reumerman, R., Kerr, L., Tucker, N. P., Hunter, I. S., Herron, P. R. & Hoskisson, P. A., 30 Mar 2020, In : Access Microbiology .

Research output: Contribution to journalArticle

Open Access
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The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet accelerated mouse model of ageing

Crowe, J., Lumb, F. E., Doonan, J., Broussard, M., Tarafdar, A., Pineda, M. A., Landabaso, C., Mulvey, L., Hoskisson, P. A., Babayan, S. A., Selman, C., Harnett, W. & Harnett, M. M., 12 Mar 2020, In : PLOS Pathogens. 16, 3, 33 p., e1008391.

Research output: Contribution to journalArticle

Open Access
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2 Downloads (Pure)
Open Access
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31 Downloads (Pure)
2019

Antibiotic Susceptibility Test

Corrigan, D. & Hoskisson, P., Sep 2019, Patent No. GB1913035.0 , 10 Sep 2019

Research output: Patent

Awakening ancient polar actinobacteria: diversity, evolution and specialized metabolite potential

Millán-Aguiñaga, N., Soldatou, S., Brozio, S., Munnoch, J. T., Howe, J., Hoskisson, P. A. & Duncan, K. R., 8 Oct 2019, In : Microbiology. 165, 11, p. 1169-1180 12 p.

Research output: Contribution to journalArticle

Open Access
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4 Downloads (Pure)

Characterization of the mode of action of Aurodox, a type III secretion system inhibitor from streptomyces goldiniensis

McHugh, R. E., O'Boyle, N., Connolly, J. P. R., Hoskisson, P. A. & Roe, A. J., 28 Feb 2019, In : Infection and Immunity. 87, 2, 12 p., e00595-18.

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)

Development of a needle shaped microelectrode for electrochemical detection of the sepsis biomarker interleukin-6 (IL-6) in real time

Russell, C., Ward, A. C., Vezza, V., Hoskisson, P., Alcorn, D., Steenson, D. P. & Corrigan, D. K., 1 Feb 2019, In : Biosensors and Bioelectronics. 126, p. 806-814 9 p.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
79 Downloads (Pure)

Expanding, integrating, sensing and responding: the role of Primary metabolism in specialised metabolite production

Fernandez-Martinez, L. T. & Hoskisson, P. A., 1 Oct 2019, In : Current Opinion in Microbiology. 51, p. 16-21 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
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21 Downloads (Pure)
1 Citation (Scopus)
Open Access
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2 Downloads (Pure)

S-adenosyl methionine cofactor modifications enhance the biocatalytic repertoire of small molecule C-alkylation

McKean, I. J. W., Sadler, J. C., Cuetos, A., Frese, A., Humphreys, L. D., Grogan, G., Hoskisson, P. A. & Burley, G. A., 2 Dec 2019, In : Angewandte Chemie International Edition. 58, 49, p. 17583-17588 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Stable individual variation in ventral spotting patterns in Phyllomedusa trinitatis (Anura: Phyllomedusidae) and other Phyllomedusa species: a minimally invasive method for recognizing individuals

Smith, J. M., Bland, A., Gourevitch, E., Hoskisson, P. A. & Downie, J. R., 18 Jun 2019, In : Phyllomedusa. 18, 1, p. 13-26 14 p.

Research output: Contribution to journalArticle

Open Access
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1 Downloads (Pure)

The lipid environment determines the activity of the Escherichia coli ammonium transporter AmtB

Dias Mirandela, G., Tamburrino, G., Hoskisson, P. A., Zachariae, U. & Javelle, A., 1 Feb 2019, In : FASEB Journal. 33, 2, p. 1989-1999 11 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
12 Downloads (Pure)

The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis

Doonan, J., Tarafdar, A., Pineda, M. A., Lumb, F. E., Crowe, J., Khan, A. M., Hoskisson, P. A., Harnett, M. M. & Harnett, W., 5 Apr 2019, In : Nature Communications. 10, 14 p., 1554.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
13 Downloads (Pure)
Open Access
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22 Downloads (Pure)
2018

Applying the mesolens to microbiology: visualising biofilm architecture and substructure

Rooney, L. M., McCann, L., Hoskisson, P. A. & McConnell, G., 26 Apr 2018. 1 p.

Research output: Contribution to conferencePoster

Open Access
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1 Downloads (Pure)

Applying the mesolens to microbiology: visualising biofilm architecture and substructure

Rooney, L. M., McCann, L., Hoskisson, P. A. & McConnell, G., 5 Jun 2018. 1 p.

Research output: Contribution to conferencePoster

Open Access
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59 Downloads (Pure)
Open Access
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66 Downloads (Pure)

Complete closed genome sequence of nontoxigenic invasive Corynebacterium diphtheriae bv. mitis strain ISS 3319

Azevedo Antunes, C., Richardson, E. J., Quick, J., Fuentes-Utrilla, P., Isom, G. L., Goodall, E. C., Möller, J., Hoskisson, P. A., Mattos-Guaraldi, A. L., Cunningham, A. F., Loman, N. J., Sangal, V., Burkovski, A. & Henderson, I. R., 1 Feb 2018, In : Genome Announcements. 6, 5, p. 1-2 2 p.

Research output: Contribution to journalArticle

Open Access
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13 Downloads (Pure)

Driving the expression of the Salmonella enterica sv Typhimurium flagellum using flhDC from Escherichia coli results in key regulatory and cellular differences

Albanna, A., Sim, M., Hoskisson, P. A., Gillespie, C., Rao, C. V. & Aldridge, P. D., 12 Nov 2018, In : Scientific Reports. 8, p. 1-11 11 p., 16705.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
9 Downloads (Pure)

Expanding primary metabolism helps generate the metabolic robustness to facilitate antibiotic biosynthesis in Streptomyces

Schniete, J. K., Cruz-Morales, P., Selem-Mojica, N., Fernández-Martínez, L. T., Hunter, I. S., Barona-Gómez, F. & Hoskisson, P. A., 6 Feb 2018, In : mBio. 9, 13 p., e02283-17.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
21 Downloads (Pure)

Gene exchange drives the ecological success of a multi-host bacterial pathogen

Richardson, E. J., Bacigalupe, R., Harrison, E. M., Weinert, L. A., Lycett, S., Vrieling, M., Robb, K., Hoskisson, P. A., Holden, M. TG., Feil, E. J., Patterson, G. K., Tong, S. YC., Shittu, A., van Wamel, W., Aanensen, D. M., Parkhill, J., Peacock, S. J., Corander, J., Holmes, M. & Fitzgerald, J. R., 25 Jun 2018, (Accepted/In press) In : Nature Ecology & Evolution. p. 1-43 43 p.

Research output: Contribution to journalArticle

Open Access
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14 Downloads (Pure)
Open Access
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18 Downloads (Pure)
Open Access
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33 Downloads (Pure)
Open Access
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1 Downloads (Pure)

Merging in-solution X-ray and neutron scattering data allows fine structural analysis of membrane-protein detergent complexes

Dias Mirandela, G., Tamburrino, G., Ivanović, M. T., Strnad, F. M., Byron, O., Rasmussen, T., Hoskisson, P. A., Hub, J. S., Zachariae, U., Gabel, F. & Javelle, A., 25 Jun 2018, In : Journal of Physical Chemistry Letters. 9, 14, p. 3910–3914 5 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
10 Downloads (Pure)
Open Access
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4 Citations (Scopus)
31 Downloads (Pure)

Regulation of specialised metabolites in Actinobacteria - expanding the paradigms

Hoskisson, P. A. & Fernández-Martínez, L. T., 6 Apr 2018, In : Environmental Microbiology Reports. p. 1-21 21 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
70 Downloads (Pure)

Sporulation-specific cell division defects in ylmE mutants of Streptomyces coelicolor are rescued by additional deletion of ylmD

Zhang, L., Willemse, J., Hoskisson, P. A. & van Wezel, G. P., 9 May 2018, In : Scientific Reports. 8, 1, p. 1-13 13 p., 7328.

Research output: Contribution to journalArticle

Open Access
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20 Downloads (Pure)
2017

Development and application of an eDNA method to detect the critically endangered trinidad golden tree frog (Phytotriades auratus) in bromeliad phytotelmata

Brozio, S., Manson, C., Gourevitch, E., Burns, T. J., Greener, M. S., Downie, J. R. & Hoskisson, P. A., 15 Feb 2017, In : PLoS ONE. 12, 2, 8 p., e0170619.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
27 Downloads (Pure)

Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability

Shaw, D. J., Robb, K., Vetter, B. V., Tong, M., Molle, V., Hunt, N. T. & Hoskisson, P. A., 5 Jul 2017, In : Scientific Reports. 7, 7 p., 4714.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
61 Downloads (Pure)

Draft genome sequence of plant growth-promoting endophytic Streptomyces sp. GKU 895 isolated from the roots of sugarcane

Kruasuwan, W., Salih, T. S., Brozio, S., Hoskisson, P. A. & Thamchaipenet, A., 11 May 2017, In : Genome Announcements. 5, 19, p. 1-2 2 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
41 Downloads (Pure)

Draft genome sequence of root-associated sugarcane growth promoting Microbispora sp. GKU 823

Kruasuwan, W., Hoskisson, P. A. & Thamchaipenet, A., 24 May 2017, (Accepted/In press) In : Genome Announcements.

Research output: Contribution to journalArticle

Open Access
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40 Downloads (Pure)

Draft genome sequence of root-associated sugarcane growth-promoting microbispora sp. strain GKU 823

Kruasuwan, W., Hoskisson, P. A. & Thamchaipenet, A., 20 Jul 2017, In : Genome Announcements. 5, 29, 2 p., e00647-17.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
15 Downloads (Pure)

Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis

Shaw, D. J., Hill, R. E., Simpson, N., Husseini, F. S., Robb, K., Greetham, G. M., Towrie, M., Parker, A. W., Robinson, D., Hirst, J. D., Hoskisson, P. A. & Hunt, N. T., 1 Dec 2017, In : Chemical Science. 8, 12, p. 8384-8399 6 p.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
35 Downloads (Pure)

Genomic analysis of endemic clones of toxigenic and non-toxigenic Corynebacterium diphtheriae in Belarus during and after the major epidemic in 1990s

Grosse-Kock, S., Kolodkina, V., Schwalbe, E. C., Blom, J., Burkovski, A., Hoskisson, P. A., Brisse, S., Smith, D., Sutcliffe, I. C., Titov, L. & Sangal, V., 13 Nov 2017, In : BMC Genomics. 18, 10 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
31 Downloads (Pure)

Growth rate control of flagellar assembly in Escherichia coli strain RP437

Sim, M., Koirala, S., Picton, D., Strahl, H., Hoskisson, P. A., Rao, C. V., Gillespie, C. S. & Aldridge, P. D., 24 Jan 2017, In : Scientific Reports. 7, p. 1-11 11 p., 41189.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
62 Downloads (Pure)

The conserved actinobacterial two-component system MtrAB coordinates chloramphenicol production with sporulation in Streptomyces venezuelae NRRL B-65442

Som, N. F., Heine, D., Holmes, N. A., Munnoch, J. T., Chandra, G., Seipke, R. F., Hoskisson, P. A., Wilkinson, B. & Hutchings, M. I., 28 Jun 2017, In : Frontiers in Microbiology. 8, 11 p., 1145.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
35 Downloads (Pure)

The E. coli dicarboxylic acid transporters DauA act as a signal transducer by interacting with the DctA uptake system

Karinou, E., Hoskisson, P. A., Strecker, A., Unden, G. & Javelle, A., 27 Nov 2017, In : Scientific Reports. 7, 30 p., 16331.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
33 Downloads (Pure)

The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2)

Som, N. F., Heine, D., Holmes, N., Knowles, F., Chandra, G., Seipke, R. F., Hoskisson, P. A., Wilkinson, B. & Hutchings, M. I., 1 Oct 2017, In : Microbiology. 163, 10, p. 1415-1419 5 p.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
22 Downloads (Pure)
2016

Coordinate regulation of antimycin and candicidin biosynthesis

McLean, T. C., Hoskisson, P. A. & Seipke, R. F., 11 Nov 2016, (Accepted/In press) In : mSphere. p. 1-35 35 p.

Research output: Contribution to journalArticle

Open Access
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71 Downloads (Pure)

Evolution, epidemiology and diversity of Corynebacterium diphtheriae: new perspectives on an old foe

Sangal, V. & Hoskisson, P. A., 30 Sep 2016, In : Infection, Genetics and Evolution. 43, p. 364-370 7 p.

Research output: Contribution to journalArticle

Open Access
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31 Citations (Scopus)
86 Downloads (Pure)

Next-generation systematics: an innovative approach to resolve the structure of complex prokaryotic taxa

Sangal, V., Goodfellow, M., Jones, A. L., schwalbe, E. C., Blom, J., Hoskisson, P. A. & Sutcliffe, I. C., 8 Nov 2016, (Accepted/In press) In : Scientific Reports. 36 p.

Research output: Contribution to journalArticle

Open Access
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275 Downloads (Pure)
2015

Adherence and invasive properties of Corynebacterium diphtheriae strains correlates with the predicted membrane-associated and secreted proteome

Sangal, V., Blom, J., Sutcliffe, I. C., von Hunolstein, C., Burkovski, A. & Hoskisson, P. A., 9 Oct 2015, In : BMC Genomics. 16, 1, 15 p., 765.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
125 Downloads (Pure)

Genomic analyses confirm close relatedness between Rhodococcus defluvii and Rhodococcus equi (Rhodococcus hoagii)

Sangal, V., Jones, A. L., Goodfellow, M., Hoskisson, P. A., Kämpfer, P. & Sutcliffe, I. C., 1 Jan 2015, In : Archives of Microbiology. 197, 1, p. 113-116 4 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
54 Downloads (Pure)

Inspiring STEM undergraduates to tackle the AMR crisis

Hoskisson, P. A., Aldridge, P. & Bowater, L., Sep 2015, In : FEMS Microbiology Letters . 362, 18, 6 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
44 Downloads (Pure)

Multidimensional infrared spectroscopy reveals the vibrational and solvation dynamics of isoniazid

Shaw, D. J., Adamczyk, K., Frederix, P. W. J. M., Simpson, N., Robb, K., Greetham, G. M., Towrie, M., Parker, A. W., Hoskisson, P. A. & Hunt, N. T., 7 Jun 2015, In : Journal of Chemical Physics. 142, 21, 212401.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
114 Downloads (Pure)

Tailoring specialized metabolite production in streptomyces

Hiltner, J. K., Hunter, I. S. & Hoskisson, P. A., 11 Mar 2015, Advances in Applied Microbiology. Vol. 91. p. 237-255 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)