• United Kingdom

Accepting PhD Students

PhD projects

Functional characterisation of cell wall deacetylases in Corynebacterium diphtheriae

Modification of the bacterial cell wall is one of the most fundamental processes that bacteria use to adapt and to survive in changing environmental conditions. The ability to modify the bacterial cell wall, which is a essential component of the bacterial cell envelope, through modification and decoration is a key adaptation that bacteria use to avoid host defences (such as hydrolytic enzymes) and enhance survival in host cells. These modifications can be highly complicated such as the covalent and non-covalent attachment of proteins, lipids and polysaccharides. Important human pathogens such as Corynebacterium and Mycobacterium have taken cell wall decoration to extraordinary levels with the attachment of highly specialised mycolic acids, arabinomannan, glycolipids and proteins, which have been relatively well studied in these organisms (sometimes referred to as the Mycolata). Some of these components, such as the mycolic acids are vital components and are essential for pathogenicity and in some cases viability. Other modifications of cell wall polymers such as N-deacetylations have received relatively little attention. It is these that will be the focus of this project, where will investigate the role of cell wall deacetylases in the growth and pathogenicity of Corynebacterium diphtheriae. We will also investigate the enzymology of the C. diphtheriae enzyme to elucidate its substrate and co-factor specificity.

20042023
If you made any changes in Pure these will be visible here soon.

Projects 2011 2023

Antibiotics
Fermentation
Chemical stability
Cell growth
Biological systems
pathogenicity
Streptomyces
nutrients
Amoeba
genes

David Begg / NSF Studentship | Brozio, Sarah

Hoskisson, P., Lamprou, D. & Brozio, S.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/1426/09/18

Project: Research Studentship - Internally Allocated

ULFASA: Ultrafast Laser Facility for Advanced Spectroscopy Applications

McKee, D., Ackemann, T., Fedorov, M., Fraser, H., Hoskisson, P., Hunt, N. & Tucker, N.

1/01/1230/06/12

Project: Internally funded project

BBSRC Doctoral Training Grant (DTG) | Robb, Kirsty

Hoskisson, P., Hunt, N. & Robb, K.

BBSRC (Biotech & Biological Sciences Research Council)

1/10/1116/02/16

Project: Research Studentship - Internally Allocated