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Paul Hoskisson

Prof

Professor, Strathclyde Institute Of Pharmacy And Biomedical Sciences

https://orcid.org/0000-0003-4332-1640

Phone01415482819
Emailpaul.hoskisson@strath.ac.uk

United Kingdom

Accepting PhD Students

PhD projects

Functional characterisation of cell wall deacetylases in Corynebacterium diphtheriae

Modification of the bacterial cell wall is one of the most fundamental processes that bacteria use to adapt and to survive in changing environmental conditions. The ability to modify the bacterial cell wall, which is a essential component of the bacterial cell envelope, through modification and decoration is a key adaptation that bacteria use to avoid host defences (such as hydrolytic enzymes) and enhance survival in host cells. These modifications can be highly complicated such as the covalent and non-covalent attachment of proteins, lipids and polysaccharides. Important human pathogens such as Corynebacterium and Mycobacterium have taken cell wall decoration to extraordinary levels with the attachment of highly specialised mycolic acids, arabinomannan, glycolipids and proteins, which have been relatively well studied in these organisms (sometimes referred to as the Mycolata). Some of these components, such as the mycolic acids are vital components and are essential for pathogenicity and in some cases viability. Other modifications of cell wall polymers such as N-deacetylations have received relatively little attention. It is these that will be the focus of this project, where will investigate the role of cell wall deacetylases in the growth and pathogenicity of Corynebacterium diphtheriae. We will also investigate the enzymology of the C. diphtheriae enzyme to elucidate its substrate and co-factor specificity.

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Projects 2011 2023

15 Active
17 Finished

32 results
Status, start date (descending)

Active

Re-engineering robustness in to industrial antibiotic producing Streptomyces strains (Super Follow on Fund)

Hoskisson, P. & Hunter, I.

BBSRC (Biotech & Biological Sciences Research Council)

1/10/19 → 30/09/21

Project: Research

Understanding the development of Industrial strain lineages (IBIOIC Studentship)

BBSRC (Biotech & Biological Sciences Research Council)

1/10/19 → 30/09/23

Project: Research - Studentship Case

Doctoral Training Partnership 2018-19 University of Strathclyde | Bottura, Beatrice

McConnell, G., Hoskisson, P. & Bottura, B.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/19 → 1/04/23

Project: Research Studentship - Internally Allocated

Chance and Necessity: Evolution guided antibiotic improvement and discovery

BBSRC (Biotech & Biological Sciences Research Council)

1/10/19 → 30/09/22

Project: Research

Evolutionary genomics for the sustainable exploitation of microbes from Mexican niches: from biodiversity to application (Newton Fund) Newton Advanced Fellowship (Francisco Barona-Gomez)

17/12/18 → 16/12/21

Project: Research

Combatting antimicrobial resistance through new software for Natural Products Discovery (Tools and Resources Development Fund)

Duncan, K. & Hoskisson, P.

BBSRC (Biotech & Biological Sciences Research Council)

1/11/18 → 30/04/20

Project: Research

Doctoral Training Partnership 2018-19 University of Strathclyde | Murray, Jordan

McConnell, G., Hoskisson, P. & Murray, J.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/18 → 1/04/22

Project: Research Studentship - Internally Allocated

Industrial CASE Account - University of Strathclyde 2018 | Foylan, Shannan

McConnell, G., Hoskisson, P. & Foylan, S.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/18 → 1/04/22

Project: Research Studentship - Internally Allocated

Fast-tracking Health Innovation for NHS Scotland. MRC Confidence in Concept / R180246-103

Corrigan, D., Hoskisson, P. & Shu, W.

MRC (Medical Research Council)

1/03/18 → 28/02/20

Project: Research - Internally Allocated

Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Addington, Emily

Hoskisson, P., Duncan, K. & Addington, E.

EPSRC (Engineering and Physical Sciences Research Council)

1/01/18 → 1/07/21

Project: Research Studentship - Internally Allocated

The Use of Narrow Band LED Light in Photobioreactors and Comparative Metabolomics to Aid the Development of Marine Microalgae for Biotechnology

Duncan, K. & Hoskisson, P.

1/10/17 → 30/09/21

Project: Research

Development of Streptomyces strains to use sustainable feedstocks in fermentations

Glaxo Smithkline (UK)

1/10/16 → 31/03/20

Project: Research - Studentship Case

EPSRC Centre for Doctoral Training in Medical Devices and Health Technologies | Vezza, Vincent James

Corrigan, D., Hoskisson, P. & Vezza, V. J.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/16 → 1/10/20

Project: Research Studentship - Internally Allocated

Development of Stable Streptomyces clavuligeris strains for improved clavalunic acid production

Herron, P. & Hoskisson, P.

Glaxo Smithkline (UK)

1/10/16 → 31/03/20

Project: Research - Studentship Case

Microfluidic manufacturing and development of a novel clostridium difficile oral vaccine | Forbes, Neil Liam Andrew

Perrie, Y., Hoskisson, P. & Forbes, N. L. A.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/16 → 1/10/20

Project: Research Studentship - Internally Allocated

Finished

Genome sequencing and analysis of Streptomyces strains

BBSRC (Biotech & Biological Sciences Research Council)

1/09/18 → 28/02/19

Project: Research

Can epistasis be exploited to understand industrial antibiotic production in Streptomyces

BBSRC (Biotech & Biological Sciences Research Council)

19/02/18 → 22/11/18

Project: Research

MycoChip - A rapid onchip antibiotic susceptibility test for Mycobacterium tuberculosis (Newton Fund)

Corrigan, D. & Hoskisson, P.

British Council

12/02/18 → 14/02/20

Project: Research

Microplate - shrinking culture plates onto a microchip for a rapid antibiotic susceptibility test

Corrigan, D., Hoskisson, P. & Shu, W.

National Endowment for Science, Technology and the Arts NESTA

1/09/17 → 28/02/19

Project: Research

Assessing the biotechnological potential of Antarctic and sub Arctic sediment cores (MASTS funding)

Duncan, K. & Hoskisson, P.

University of St Andrews

5/12/16 → 11/08/17

Project: Research

Enhancing the yield of industrial Actinomycete fermentations

Hoskisson, P. & Hunter, I.

BBSRC (Biotech & Biological Sciences Research Council)

1/08/16 → 31/07/19

Project: Research

Antibiotics

Fermentation

Chemical stability

Cell growth

Biological systems

Determining the molecular-level origin of Isoniazid susceptibility and resistance in Mycobacterium tuberculosis using Two-Dimensional Infrared Spectroscopy

Simpson, N., Hoskisson, P. & Hunt, N.

Tenovus Scotland

1/12/15 → 30/11/16

Project: Research

MIMIC - Do parasitic worms and their secreted immunomudulators protect against musculosketal disease by impacting on the host microbiome?

Harnett, W. & Hoskisson, P.

Arthritis Research UK ARUK

1/10/15 → 30/06/18

Project: Research

Establishing an integrated biocatalytic Friedel-Crafts platform for the alkylation of aromatic small molecules | McKean, Iain

Burley, G., Hoskisson, P. & McKean, I.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/15 → 13/12/19

Project: Research Studentship Case - Internally allocated

Methylation

Alkylation

Methyl Green

Molecules

Labeling

Clash of the Kingdoms: How the quest for nutrients leads to pathogenicity

NERC (Natural Environment Research Council)

31/12/14 → 30/12/17

Project: Research

pathogenicity

Streptomyces

nutrients

Amoeba

genes

David Begg / NSF Studentship | Brozio, Sarah

Hoskisson, P., Lamprou, D. & Brozio, S.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/14 → 26/09/18

Project: Research Studentship - Internally Allocated

The treatment of bacterial disease of plants by bacteriophage coated nanoparticles. | Filgueira Martinez, Sara

Herron, P., Hoskisson, P. & Filgueira Martinez, S.

EPSRC (Engineering and Physical Sciences Research Council), BBSRC (Biotech & Biological Sciences Research Council)

1/01/13 → 7/06/19

Project: Research Studentship Case - Internally allocated

ULFASA: Ultrafast Laser Facility for Advanced Spectroscopy Applications

McKee, D., Ackemann, T., Fedorov, M., Fraser, H., Hoskisson, P., Hunt, N. & Tucker, N.

1/01/12 → 30/06/12

Project: Internally funded project

Non-toxigenic Corynebacterium diptheriae; a pathogen of emerging importance in Scotland

Medical Research Scotland

11/11/11 → 10/11/13

Project: Research

New Tools for Biomolecular Characterisation: Ultrafast 2D-IR Spectroscopy

Hoskisson, P. & Hunt, N.

Leverhulme Trust

1/11/11 → 31/10/14

Project: Research

BBSRC Doctoral Training Grant (DTG) | Robb, Kirsty

Hoskisson, P., Hunt, N. & Robb, K.

BBSRC (Biotech & Biological Sciences Research Council)

1/10/11 → 16/02/16

Project: Research Studentship - Internally Allocated

Systems approaches to metabolic engineering in Streptomycetes: The PEP-pyruvate-oxaloacetate node of primary metabolism

Hoskisson, P. & Hunter, I.

Scottish Funding Council SFC

1/10/11 → 30/09/15

Project: Research - Studentship

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