• United Kingdom

Accepting PhD Students

PhD projects

Functional characterisation of cell wall deacetylases in Corynebacterium diphtheriae<br/><br/>Modification of the bacterial cell wall is one of the most fundamental processes that bacteria use to adapt and to survive in changing environmental conditions. The ability to modify the bacterial cell wall, which is a essential component of the bacterial cell envelope, through modification and decoration is a key adaptation that bacteria use to avoid host defences (such as hydrolytic enzymes) and enhance survival in host cells. These modifications can be highly complicated such as the covalent and non-covalent attachment of proteins, lipids and polysaccharides. Important human pathogens such as Corynebacterium and Mycobacterium have taken cell wall decoration to extraordinary levels with the attachment of highly specialised mycolic acids, arabinomannan, glycolipids and proteins, which have been relatively well studied in these organisms (sometimes referred to as the Mycolata). Some of these components, such as the mycolic acids are vital components and are essential for pathogenicity and in some cases viability. Other modifications of cell wall polymers such as N-deacetylations have received relatively little attention. It is these that will be the focus of this project, where will investigate the role of cell wall deacetylases in the growth and pathogenicity of Corynebacterium diphtheriae. We will also investigate the enzymology of the C. diphtheriae enzyme to elucidate its substrate and co-factor specificity.

Network

Anthony W. Parker

  • Rutherford Appleton Laboratory

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Ryan F Seipke

  • Leeds University

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Gregory M. Greetham

  • STFC Rutherford Appleton Laboratory
  • Rutherford Appleton Laboratory

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Michael Towrie

  • STFC Rutherford Appleton Laboratory
  • Rutherford Appleton Laboratory

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Michael Goodfellow

  • University of Newcastle
  • Newcastle University

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Vartul Sangal

  • Northumbria University

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Iain C Sutcliffe

  • Northumbria University

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Ulrich Zachariae

  • University of Dundee

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Amanda L Jones

  • Northumbria University

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Jochen Blom

  • Justus-Liebig-Universitat Gießen

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Giulia Tamburrino

  • University of Dundee

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Matthew I. Hutchings

  • University of East Anglia

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Michael Murphy

  • Glasgow Royal Infirmary

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J Roger Downie

  • Glasgow University
  • University of Glasgow

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Anuradha Tarafdar

  • University of Glasgow

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Nicolle F Som

  • University of East Anglia

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Gideon Grogan

  • University of York

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Eoghan Farmer

  • Glasgow Royal Infirmary

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Melanie BOECKSTAENS

  • Free University of Brussels

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Jukka Corander

  • University of Helsinki
  • Universitetet i Oslo
  • Wellcome Trust Genome Campus

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Marc G. Chevrette

  • University of Wisconsin-Madison

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Colin S Gillespie

  • Scottish Environment Protection Agency

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Joost Willemse

  • Leiden University

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Colin Selman

  • University of Glasgow

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Eleanor Gourevitch

  • Glasgow University

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Leena Kerr

  • HERIOT-WATT UNIVERSITY

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Mark S Greener

  • University of Glasgow

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Martin A. Walsh

  • Diamond Light Source Ltd

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Thomas C. McLean

  • University of East Anglia

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Tanil Kocagoz

  • Acibadem Mehmet Ali Aydinlar University

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J Ross Fitzgerald

  • University of Edinburgh

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Fouad S. Husseini

  • School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham

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Georgia L Isom

  • Birmingham University

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Joanna M. Smith

  • Bangor University

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Ian R. Henderson

  • MRC Centre for Immune Regulation, Institute of Microbiology and Infection, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham
  • The University of Queensland
  • Birmingham University
  • National University of Singapore

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Luke D Humphreys

  • GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
  • GlaxoSmithKline

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Rachel E. Hill

  • School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham

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Peter Raspor

  • University of Ljubljana

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Sylvia Soldatou

  • University of Aberdeen
  • University of Aberdeen
  • Aalto University Foundation

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Matjaž Kirn

  • Novo mesto

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Ruth Shepherd

  • University of Glasgow

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John Howe

  • The Scottish Association for Marine Science
  • Scottish Association for Marine Science

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Pilar Prieto

  • Instituto de Agricultura Sostenible, Consejo Superior de Investigaciones Científicas (CSIC)

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Tomaž Polak

  • University of Ljubljana

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Alicia H. Russell

  • John Innes Centre

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James Gurney

  • Georgia Institute of Technology

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Aneesah M. Khan

  • University of Glasgow

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Jenny Crowe

  • University of Glasgow

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Ryan Seipke

  • University of East Anglia

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Maheshwar Mangat

  • Indian Institute of Technology Bombay

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David Robinson

  • Nottingham Trent University

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Adam F. Cunningham

  • MRC Centre for Immune Regulation, Institute of Microbiology and Infection, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham
  • Birmingham University

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Virginie Molle

  • Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II

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Mitja Pelko

  • Novo mesto

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Ana Sofia Brito

  • Université Libre de Bruxelles

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Emilio Cortes-Sanchez

  • Strathclyde Institute of Pharmacy and Biomedical Science

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Rodrigo Bacigalupe

  • Universidad CEU Cardenal Herrera
  • Rega Institute for Medical Research

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Adam Bland

  • Chester Zoo

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Matilda Urukalo

  • University of Ljubljana

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Kristofer Wollein Waldetoft

  • Georgia Institute of Technology

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Neda Benički

  • Novo mesto

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Amina Frese

  • University of York

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Christopher Russell

  • School of Electronic and Electrical Engineering, University of Leeds

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Dimitrios A. Lamprou

  • Queen's University Belfast

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Beatrice Vetter

  • University of Strathclyde

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Gideon Grogan

  • University of York

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Piaopiao Pan

  • University of Glasgow

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Lisa S. Kölln

  • Univeristy of Strathclyde

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Alexander Strecker

  • Institute for Microbiology and Wine Research, Johannes Gutenberg-University Mainz

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Malcolm W Kennedy

  • University of Glasgow

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Madeline Tong

  • SIPBS, Strathclyde Inst Pharm & Biomed Sci

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Paul Steenson

  • School of Electronic and Electrical Engineering, University of Leeds

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Margaret Smith

  • University of Aberdeen

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Sam P. Brown

  • Georgia Institute of Technology

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Crinan Jarrett

  • University of Glasgow

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Pablo Fuentes-Utrilla

  • The Royal (Dick) School of Veterinary Studies

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Gottfried Unden

  • Institute for Microbiology and Wine Research, Johannes Gutenberg-University Mainz

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Hamish Asmath

  • IInstitute of Marine Affairs

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Natalie Millán-Aguiñaga

  • Universidad Autónoma de Baja California

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Jonathan D. Hirst

  • School of Chemistry, Centre for Biomolecular Sciences, University of Nottingham

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Ruchira Nandeshwar

  • Indian Institute of Technology

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Kirti Megha

  • Indian Institute of Technology Bombay

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Alan McNally

  • Birmingham University

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Shailesh B. Lad

  • Indian Institute of Technology Bombay

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Štefan Fujs

  • Acies Bio D.O.O.

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Hrvoje Petković

  • University of Ljubljana
  • Acies Bio D.O.O.

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Vasilka Magdevska

  • Acies Bio D.O.O.

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Mahmoud M. Al Bassam

  • University of California

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Fiona Sargison

  • University of Oxford

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Rebecca Barr

  • University of Aberdeen
  • University of East Anglia

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Samuel M.M. Prudence

  • University of East Anglia

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James P R Connolly

  • Institute of Neurological Sciences

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Kiran Kondabagil

  • Indian Institute of Technology Bombay

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Sylvain Brisse

  • Institut Pasteur, Paris

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Urška Lešnik

  • Acies Bio D.O.O.

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Natalia Tschowri

  • Humboldt-Universität zu Berlin

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M.S. Kumar

  • Indian Institute of Technology Bombay

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Maggie Smith

  • University of York

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Anibal Cuetos

  • University of York
  • University of York

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Leo Jhaveri

  • University of Glasgow

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Lorna Mulvey

  • University of Glasgow

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Margaret M. Harnett

  • University of Glasgow

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Liam McAteer

  • University of Strathclyde

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Joseph Lachance

  • Georgia Institute of Technology

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J. Roger Downie

  • University of Glasgow

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Craig Allan

  • MACLAY MURRAY & SPENS

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Miguel Pineda

  • University of Glasgow

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Siddharth Tallur

  • Indian Institute of Technology Bombay

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Amber H. Mathie

  • University of Glasgow

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