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Personal profile

Personal Statement

Paul Herron is a Senior Lecturer in Microbiology. He graduated from Liverpool Polytechnic before carrying put a PhD in Microbiology at the University of Warwick. After two years at the Agricultural University Wageningen he moved to the University of Wales Swansea where he developed transposon tools for mutagenesis of streptomycetes.

Research Interests

His research interests include the following:

  • Chromosome segregation in Streptomyces. cell division in streptomycetes is fundamentally different from other bacteria as it is inessential for growth. Despite progress on elucidating the regulatory mechanisms governing the onset of differentiation in streptomycetes, little is known about the mechanism of chromosome segregation. We are using molecular and microscopic tools to investigate this in Streptomyces. Using time lapse microscopy we have visualised trafficking of key cell division proteins and DNA replisomesduring growth and development.The role of Phospholipids in streptomycete development. The involvement of phospholipids in bacterial cell division has recently received increasing attention. Although different phospholipids are abundant in the membranes of Streptomyces, their involvement in development is not known. We are investigating changes in phospholipid profile and gene expression during differentiation.
  • Oxytetracycline productivity in Streptomyces rimosus. In the commercial production of antibiotics, extensive strain improvement programs have been carried out, where the original isolate of an antibiotic-producing organism has been improved sequentially to deliver a titre of product that is commercially-viable. This "black box" methodology was carried out for Streptomyces rimosus, which makes the antibiotic oxytetracycline. To identify the basis of strain improvement we have sequenced the genomes of four S. rimosus strains and are attempting to understand the genetic changes and biochemical bottlenecks by which carbon flux is directed away from primary metabolism towards natural product biosynthesis.
  • Exploitaion of Bacteriophages. In collaboration Fixed Phage Ltd. we are exploiting bacterial viruses for the treatment of plant and animal diseases

Teaching Interests

My teaching duties include Fundamental Microbiology, Intermediate Microbiology, Laboratory Methods and Skills Development, Honours Microbiology 1 and 2.

Education/Academic qualification

Doctor of Philosophy, University of Warwick

Bachelor of Science, Liverpool John Moores University

Keywords

  • Microbiology Genetics Microscopy Antibiotics

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  • 7 Similar Profiles
Streptomyces Medicine & Life Sciences
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Streptomyces rimosus Medicine & Life Sciences
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Hyphae Medicine & Life Sciences
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Cosmids Medicine & Life Sciences
Oxytetracycline Medicine & Life Sciences

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Projects 2005 2023

Research Output 2002 2019

Streptomyces altiplanensis sp. nov., an alkalitolerant species isolated from Chilean Altiplano soil, and emended description of streptomyces chryseus (Krasil'nikov et al. 1965) Pridham 1970

Cortés-Albayay, C., Dorador, C., Schumann, P., Schniete, J. K., Herron, P., Andrews, B., Asenjo, J. & Nouioui, I., 1 Aug 2019, 69, 8, p. 2498-2505 8 p.

Research output: Contribution to journalArticle

Open Access
File
aprepitant
Streptomyces
Soil
DNA
rRNA Genes
7 Citations (Scopus)

Rapid colorimetric lactoferrin-based sandwich immunoassay on cotton swabs for the detection of foodborne pathogenic bacteria

Alamer, S., Eissa, S., Chinnappan, R., Herron, P. & Zourob, M., 1 Aug 2018, In : Talanta. 185, p. 275-280 6 p.

Research output: Contribution to journalArticle

Open Access
File
Lactoferrin
Immunoassay
Salmonella
Cotton
Pathogens

Thesis

Determination of the genetic basis of oxytetracycline productivity for Streptomyces rimosus, by the examination of genomic data

Author: MacFadyen, A., 1 Oct 2013

Supervisor: Herron, P. (Supervisor) & Edrada-Ebel, R. (Supervisor)

Student thesis: Doctoral Thesis

Development of rapid screening assays for the detection of foodborne pathogens in food

Author: Alamer, S. S. A., 1 Jul 2017

Supervisor: Herron, P. (Supervisor) & Hoskisson, P. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2008 2016

PhD Examiner

Paul Herron (External Examiner)
11 Apr 2016

Activity: Examination typesExamination

Microbiology (Journal)

Paul Herron (Peer reviewer)
5 Apr 2016

Activity: Publication peer-review and editorial work typesJournal peer review