Projects per year
Paul Herron is a Senior Lecturer in Microbiology. He graduated from Liverpool Polytechnic before carrying put a PhD in Microbiology at the University of Warwick. After two years at the Agricultural University Wageningen he moved to the University of Wales Swansea where he developed transposon tools for mutagenesis of streptomycetes.
His research interests include the following:
- Chromosome segregation in Streptomyces. cell division in streptomycetes is fundamentally different from other bacteria as it is inessential for growth. Despite progress on elucidating the regulatory mechanisms governing the onset of differentiation in streptomycetes, little is known about the mechanism of chromosome segregation. We are using molecular and microscopic tools to investigate this in Streptomyces. Using time lapse microscopy we have visualised trafficking of key cell division proteins and DNA replisomesduring growth and development.The role of Phospholipids in streptomycete development. The involvement of phospholipids in bacterial cell division has recently received increasing attention. Although different phospholipids are abundant in the membranes of Streptomyces, their involvement in development is not known. We are investigating changes in phospholipid profile and gene expression during differentiation.
- Oxytetracycline productivity in Streptomyces rimosus. In the commercial production of antibiotics, extensive strain improvement programs have been carried out, where the original isolate of an antibiotic-producing organism has been improved sequentially to deliver a titre of product that is commercially-viable. This "black box" methodology was carried out for Streptomyces rimosus, which makes the antibiotic oxytetracycline. To identify the basis of strain improvement we have sequenced the genomes of four S. rimosus strains and are attempting to understand the genetic changes and biochemical bottlenecks by which carbon flux is directed away from primary metabolism towards natural product biosynthesis.
- Exploitaion of Bacteriophages. In collaboration Fixed Phage Ltd. we are exploiting bacterial viruses for the treatment of plant and animal diseases
My teaching duties include Fundamental Microbiology, Intermediate Microbiology, Laboratory Methods and Skills Development, Honours Microbiology 1 and 2.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, University of Warwick
Award Date: 1 Jan 1991
Bachelor of Science, Liverpool John Moores University
Award Date: 1 Jan 1987
- Microbiology Genetics Microscopy Antibiotics
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Development of stable platform strains for improved clavulanic acid production
BBSRC (Biotech & Biological Sciences Research Council)
1/10/19 → 30/09/23
Project: Research - Studentship Case
Research Excellence Award - Applying machine learning to 'omics data for accelerated marine antibiotic discovery - Darren Scobie
1/10/19 → 30/09/22
Project: Research Studentship - Internally Allocated
- 32 Article
Phosphoproteome dynamics of streptomyces rimosus during submerged growth and antibiotic productionŠarić, E., Quinn, G. A., Nalpas, N., Paradžik, T., Kazazić, S., Filić, Ž., Šemanjski, M., Herron, P., Hunter, I., Maček, B. & Vujaklija, D., 26 Oct 2022, In: mSystems. 7, 5, 20 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Downloads (Pure)
Bilateral symmetry of linear streptomycete chromosomesAlgora-Gallardo, L., Schniete, J. K., Mark, D. R., Hunter, I. S. & Herron, P. R., 15 Nov 2021, In: Microbial Genomics. 7, 11, 13 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Paul Herron (External Examiner)11 Apr 2016
Activity: Examination types › Examination
Paul Herron (Peer reviewer)5 Apr 2016
Activity: Publication peer-review and editorial work types › Journal peer review