Projects per year
Awards: 1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society)
2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)
2017 Elected Fellow of the Royal Society of Biology (FRSB)
- Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease
- Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A)
- Translational biology of lysolipids (e.g. drug discovery and biomarker identification)
- Cyclic AMP/cyclic GMP signalling
The overall aim of research is to investigate the molecular mechanisms by which lysolipid receptors regulate cell biology; to determine how these mechanisms become altered in diseases and to evaluate the potential of receptors and enzymes involved in lysolipid signalling as drugable targets. Techniques in the laboratory range from in vitro cell based assays, imaging, mass spectroscopic analysis and proteomics to in vivo analysis. Recent research in this laboratory has received support from Cancer Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council and industry.
194 papers published with an H index of 58 and with 11100 citations (Google Scholar Citations).
Co-founder of Mironid Ltd
Executive member, SULSA
Head of Research, SIPBS (Aug 2006-Sept 2008)
Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc (various biological science) and MPharm (pharmacy) teaching programmes. Supervision of laboratory based research projects at both undergraduate and postgraduate (PhD) level.
Doctor of Philosophy, UMIST
Award Date: 1 Jan 1986
Bachelor of Science, University of Birmingham
Award Date: 1 Jan 1982
26/10/13 → 25/10/14
6/02/13 → 5/02/14
Validation of highly selective Sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosisSchwalm, S., Beyer, S., Hafizi, R., Traufmann, S., Geisslinger, G., Adams, D. R., Pyne, S., Pyne, N., Schaefer, L., Huwiler, A. & Pfeilschifter, J., 31 Mar 2021, In: Cellular Signalling. 79, 27 p., 109881.
Research output: Contribution to journal › Article › peer-review
A novel selective sphingosine kinase 2 inhibitor, HWG-35D, ameliorates the severity of imiquimod-induced psoriasis model by blocking Th17 differentiation of naïve CD4 T lymphocytesShin, S-H., Kim, H-Y., Yoon, H-S., Park, W-J., Adams, D. R., Pyne, N. J., Pyne, S. & Park, J-W., 8 Nov 2020, In: International Journal of Molecular Sciences. 21, 21, 17 p., 8371.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Downloads (Pure)
Pyne, Nigel (Recipient), 2010
Prize: Election to learned society
Pyne, Nigel (Recipient), 1995
Prize: Prize (including medals and awards)