1984 …2019
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Personal profile

Personal Statement

Awards: 1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society)

              2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)

              2017 Elected Fellow of the Royal Society of Biology (FRSB)

 

Research interests

  • Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease
  • Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A)
  • Translational biology of lysolipids (e.g. drug discovery and biomarker identification)
  • Cyclic AMP/cyclic GMP signalling

The overall aim of research is to investigate the molecular mechanisms by which lysolipid receptors regulate cell biology; to determine how these mechanisms become altered in diseases and to evaluate the potential of receptors and enzymes involved in lysolipid signalling as drugable targets. Techniques in the laboratory range from in vitro cell based assays, imaging, mass spectroscopic analysis and proteomics to in vivo analysis. Recent research in this laboratory has received support from Cancer Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council and industry.

185 papers published with an H index of 54 and with ~10000 citations (Google Scholar Citations).

Co-founder of Mironid Ltd

Executive member, SULSA

Head of Research, SIPBS (Aug 2006-Sept 2008)

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc (various biological science) and MPharm (pharmacy) teaching programmes. Supervision of laboratory based research projects at both undergraduate and postgraduate (PhD) level.

Education/Academic qualification

Doctor of Philosophy, UMIST

Bachelor of Science, University of Birmingham

Fingerprint Dive into the research topics where Nigel Pyne is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Lysosphingolipid Receptors Medicine & Life Sciences
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GTP-Binding Proteins Medicine & Life Sciences
Cyclic AMP Medicine & Life Sciences
Sphingosine Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2003 2015

Research Output 1984 2019

1 Citation (Scopus)

Ceramide and sphingosine 1-phosphate in adipose dysfunction

Fang, Z., Pyne, S. & Pyne, N. J., 30 Apr 2019, In : Progress in Lipid Research. 74, p. 145-159 15 p.

Research output: Contribution to journalReview article

Ceramides
Adipose Tissue
Type 2 Diabetes Mellitus
Biosynthesis
Tissue

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
File
Lysosphingolipid Receptors
Blood Pressure
Endothelium
Vasodilation
Controlled Hypotension

Thesis

Design, synthesis and biological evaluation of sphingosine kinase inhibitors for the treatment of prostate cancer

Author: Tawati, S. M. A., 1 Dec 2015

Supervisor: MacKay, S. (Supervisor) & Pyne, N. (Supervisor)

Student thesis: Doctoral Thesis

Identification of sphingosine 1-phosphate receptors in exosomes released from breast cancer cells

Author: El Buri, A. H. A., 1 Oct 2016

Supervisor: Pyne, S. (Supervisor) & Pyne, N. (Supervisor)

Student thesis: Doctoral Thesis

Prizes

science
medical science

Sandoz Prize awarded from the British Pharmacological Society

Nigel Pyne (Recipient), 1995

Prize: Prize (including medals and awards)

Activities 1989 2019

FASEB meeting on Lysolipids

Nigel Pyne (Speaker)
29 Jul 2019

Activity: Participating in or organising an event typesParticipation in conference

FASEB Meeting on Lysoplipids (Portugal)

Nigel Pyne (Chair)
29 Jul 2019

Activity: Participating in or organising an event typesKey-note speaker and plenary lectures at conferences