1984 …2019
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Personal profile

Personal Statement

Awards: 1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society)

              2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)

              2017 Elected Fellow of the Rotal Society of Biology (FRSB)


Research interests

  • Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease
  • Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A)
  • Translational biology of lysolipids (e.g. drug discovery and biomarker identification)
  • Cyclic AMP/cyclic GMP signalling

The overall aim of research is to investigate the molecular mechanisms by which lysolipid receptors regulate cell biology; to determine how these mechanisms become altered in diseases and to evaluate the potential of receptors and enzymes involved in lysolipid signalling as drugable targets. Techniques in the laboratory range from in vitro cell based assays, imaging, mass spectroscopic analysis and proteomics to in vivo analysis. Recent research in this laboratory has received support from Cancer Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council and industry.

177 papers published with an H index of 53 and with ~8700 citations (Google Scholar Citations).

Co-founder of Mironid Ltd

Executive member, SULSA

Head of Research, SIPBS (Aug 2006-Sept 2008)

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc (various biological science) and MPharm (pharmacy) teaching programmes. Supervision of laboratory based research projects at both undergraduate and postgraduate (PhD) level.

Education/Academic qualification

Doctor of Philosophy, UMIST

Bachelor of Science, University of Birmingham

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Projects 2003 2015

Research Output 1984 2019

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse

Greig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
Lysosphingolipid Receptors
Blood Pressure
Controlled Hypotension

Topographical mapping of isoform-selectivity determinants for J-channel-binding inhibitors of sphingosine kinases 1 and 2

Adams, D. R., Tawati, S., Berretta, G., Rivas, P. L., Baiget, J., Jiang, Z., Alsfouk, A., MacKay, S. P., Pyne, N. & Pyne, S., 19 Mar 2019, In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

Protein Isoforms



medical science

Sandoz Prize awarded from the British Pharmacological Society

Nigel Pyne (Recipient), 1995

Prize: Prize (including medals and awards)

Activities 1989 2018

External PhD Examiner

Nigel Pyne (Examiner)
12 Dec 2018

Activity: Examination typesExamination

Molecular Medicine of Sphingolipids

Nigel Pyne (Speaker)
18 Oct 2018

Activity: Participating in or organising an event typesParticipation in conference