• United Kingdom

Accepting PhD Students

1984 …2020

Research output per year

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Personal profile

Personal Statement

Awards: 1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society)

              2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)

              2017 Elected Fellow of the Royal Society of Biology (FRSB)

 

Research interests

  • Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease
  • Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A)
  • Translational biology of lysolipids (e.g. drug discovery and biomarker identification)
  • Cyclic AMP/cyclic GMP signalling

The overall aim of research is to investigate the molecular mechanisms by which lysolipid receptors regulate cell biology; to determine how these mechanisms become altered in diseases and to evaluate the potential of receptors and enzymes involved in lysolipid signalling as drugable targets. Techniques in the laboratory range from in vitro cell based assays, imaging, mass spectroscopic analysis and proteomics to in vivo analysis. Recent research in this laboratory has received support from Cancer Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council and industry.

185 papers published with an H index of 56 and with 10400 citations (Google Scholar Citations).

Co-founder of Mironid Ltd

Executive member, SULSA

Head of Research, SIPBS (Aug 2006-Sept 2008)

Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc (various biological science) and MPharm (pharmacy) teaching programmes. Supervision of laboratory based research projects at both undergraduate and postgraduate (PhD) level.

Education/Academic qualification

Doctor of Philosophy, UMIST

Award Date: 1 Jan 1986

Bachelor of Science, University of Birmingham

Award Date: 1 Jan 1982

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Projects

Research Output

Recent advances in the role of Sphingosine 1-phosphate in cancer

Pyne, N. J. & Pyne, S., 23 Sep 2020, In : FEBS Letters. 19 p.

Research output: Contribution to journalReview article

Open Access
File
  • Sphingosine kinase 1 regulates the survival of breast cancer stem cells and non-stem breast cancer cells by suppression of STAT1

    Hii, L-W., Chung, F. F-L., Mai, C. W., Yee, Z. Y., Chan, H. H., Raja, V. J., Dephoure, N. E., Pyne, N. J., Pyne, S. & Leong, C-O., 4 Apr 2020, In : Cells. 9, 4, 25 p., 886.

    Research output: Contribution to journalArticle

    Open Access
    File
  • Prizes

    Sandoz Prize awarded from the British Pharmacological Society

    Pyne, Nigel (Recipient), 1995

    Prize: Prize (including medals and awards)

    Activities

    61st Advances in Biological Regulation

    Nigel Pyne (Speaker)

    5 Oct 2020

    Activity: Talk or presentation typesInvited talk

    FASEB Meeting on Lysoplipids (Portugal)

    Nigel Pyne (Chair)

    29 Jul 2019

    Activity: Participating in or organising an event typesKey-note speaker and plenary lectures at conferences