Projects per year
Awards: 1995 Sandoz Prize in Pharmacology (awarded by the British Pharmacological Society)
2010 Elected Member of Academy of Sciences of the Institute of Bologna (affilated with the University of Bologna, founded in 1690)
2017 Elected Fellow of the Rotal Society of Biology (FRSB)
- Lysolipid (sphingosine 1-phosphate, lysophoshatidic acid) receptor signalling in health and disease with specific focus on cancer and cardiovascular/inflammatory disease
- Cross talk regulation between lysolipid receptors and growth factor receptors/oncogenes (e.g. PDGFR, HER2, EGFR and TRK A)
- Translational biology of lysolipids (e.g. drug discovery and biomarker identification)
- Cyclic AMP/cyclic GMP signalling
The overall aim of research is to investigate the molecular mechanisms by which lysolipid receptors regulate cell biology; to determine how these mechanisms become altered in diseases and to evaluate the potential of receptors and enzymes involved in lysolipid signalling as drugable targets. Techniques in the laboratory range from in vitro cell based assays, imaging, mass spectroscopic analysis and proteomics to in vivo analysis. Recent research in this laboratory has received support from Cancer Research UK, British Heart Foundation, Biotechnology and Biological Sciences Research Council and industry.
177 papers published with an H index of 53 and with ~8700 citations (Google Scholar Citations).
Co-founder of Mironid Ltd
Executive member, SULSA
Head of Research, SIPBS (Aug 2006-Sept 2008)
Teaching Activity: lectures, workshops and tutorials to undergraduates of the BSc (various biological science) and MPharm (pharmacy) teaching programmes. Supervision of laboratory based research projects at both undergraduate and postgraduate (PhD) level.
Doctor of Philosophy, UMIST
Bachelor of Science, University of Birmingham
26/10/13 → 25/10/14
6/02/13 → 5/02/14
Research Output per year
Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouseGreig, F. H., Nader, K., Ballantyne, M. D., Kazi, Z. H., Alganga, H., Ewart, M-A., Zaborska, K. E., Fertig, B., Pyne, N. J., Pyne, S. & Kennedy, S., 5 Jan 2019, In : European Journal of Pharmacology. 842, p. 1-9 9 p.
Research output: Contribution to journal › Article
Research output: Contribution to journal › Editorial
Design, synthesis and biological evaluation of sphingosine kinase inhibitors for the treatment of prostate cancerAuthor: Tawati, S. M. A., 1 Dec 2015
Student thesis: Doctoral Thesis
Nigel Pyne (Recipient), 2010
Prize: Election to learned society
Nigel Pyne (Recipient), 1995
Prize: Prize (including medals and awards)
Activities per year
Activity: Membership › Membership of committee