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Personal profile

Personal Statement

Nick Tomkinson studied Chemistry at The University of Sheffield and received his BSc in 1992 and his Ph.D. in 1995 under the supervision of Dr. D. Neville Jones and Professor Jim Anderson. Postdoctoral studies with Dr. Tim Willson at GlaxoSmithKline, Research Triangle Park, North Carolina (1996–1998) followed. Nick was appointed to the staff at Cardiff University in 1999 and was an EPSRC Advanced Research Fellowship (2004–2009). He moved to his current position at the University of Strathclyde in June 2011.

Research Interests

As a general theme to our research we have set out to develop synthetic methodology with three guiding principles:

  • Reactions should proceed at room temperature
  • Reactions should proceed in the presence of moisture and air
  • Catalysts/reagents should be bench stable and prepared in three synthetic steps or fewer

Realisation of these goals should provide new bond-construction methods of broad utility which, most importantly, will be accessible to synthetic chemists’ worldwide without the need for highly specialised equipment or techniques.

Education/Academic qualification

Bachelor of Science, University of Sheffield

Fingerprint Dive into the research topics where Nick Tomkinson is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Projects 2010 2023

Industrial Case Account - University of Strathclyde 2019 | Galindo, Alex

Tomkinson, N., Chamberlain, L. & Galindo, A.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/191/10/23

Project: Research Studentship Case - Internally allocatedResearch Studentship CASE (Internally Allocated)

Industrial Case Account - University of Strathclyde 2019 | Abate, Immacolata

Burley, G., Tomkinson, N. & Abate, I.

EPSRC (Engineering and Physical Sciences Research Council)

1/10/191/10/23

Project: Research Studentship Case - Internally allocatedResearch Studentship CASE (Internally Allocated)

Research Output 1993 2019

2 Citations (Scopus)

Advancements in the development of non-BET bromodomain chemical probes

Clegg, M. A., Tomkinson, N. C. O., Prinjhal, R. K. & Humphreys, P. G., 19 Feb 2019, In : ChemMedChem. 14, 4, p. 362-385 24 p.

Research output: Contribution to journalReview article

Research
Molecules
Growth
Proteins
Therapeutics

Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death

Radhi, O. A., Davidson, S., Scott, F., Zeng, R. X., Jones, D. H., Tomkinson, N. C. O., Yu, J. & Chan, E. Y. W., 27 Sep 2019, In : Journal of Biological Chemistry. 294, p. 14289-14307 19 p.

Research output: Contribution to journalArticle

Open Access
File
Salmonella
Autophagy
Cell death
Staphylococcus
Cell Death

Thesis

Building a rational model for the identification of allosteric sites

Author: Chevalier Indey, C., 1 Oct 2015

Supervisor: Tomkinson, N. (Supervisor) & MacKay, S. (Supervisor)

Student thesis: Doctoral Thesis

Design and synthesis of inhibitors of the non-canonical NF-ĸB pathway for the treatment of prostate and pancreatic cancer

Author: West, C. M., 1 Oct 2016

Supervisor: MacKay, S. (Supervisor) & Tomkinson, N. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2010 2016

PhD viva - Faye Cruickshank

Nick Tomkinson (External Examiner)
11 May 2016

Activity: Examination typesExamination

Carbonyl and Enolate Chemistry

Nick Tomkinson (Participant)
14 Jan 2016

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course