• United Kingdom

Accepting PhD Students

20032022
If you made any changes in Pure these will be visible here soon.

Research Output 2003 2019

2019
1 Citation (Scopus)
2 Downloads (Pure)

Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland

Lemonidis, K., Salih, T. S., Dancer, S. J., Hunter, I. S. & Tucker, N. P., 13 Jun 2019, In : PLoS ONE. 14, 6, 10 p., e0218185.

Research output: Contribution to journalArticle

Open Access
File
Enterococcus faecium
vancomycin
Scotland
Vancomycin
Clone Cells
2018
4 Citations (Scopus)
27 Downloads (Pure)

Community-led comparative genomic and phenotypic analysis of the aquaculture pathogen Pseudomonas baetica a390T sequenced by Ion semiconductor and Nanopore technologies

Beaton, A., Lood, C., Cunningham-Oakes, E., MacFadyen, A., Mullins, A. J., Bestawy, W. E., Botelho, J., Chevalier, S., Coleman, S., Dalzell, C., Dolan, S. K., Faccenda, A., Ghequire, M. G. K., Higgins, S., Kutschera, A., Murray, J., Redway, M., Salih, T., da Silva, A. C., Smith, B. A. & 8 others, Smits, N., Thomson, R., Woodcock, S., Welch, M., Cornelis, P., Lavigne, R., van Noort, V. & Tucker, N. P., 22 Mar 2018, In : FEMS Microbiology Letters . 365, 9, 12 p., fny069.

Research output: Contribution to journalArticle

Open Access
File
Nanopores
Aquaculture
Semiconductors
Pseudomonas
Genome
6 Citations (Scopus)
4 Downloads (Pure)

Genomic characterisation of an international Pseudomonas aeruginosa reference panel indicates that the two major groups draw upon distinct mobile gene pools

Freschi, L., Bertelli, C., Jeukens, J., Moore, M. P., Kukavica-Ibrulj, I., Emond-Rheault, J-G., Hamel, J., Fothergill, J. L., Tucker, N. P., McClean, S., Klockgether, J., de Soyza, A., Brinkman, F. S. L., Levesque, R. C. & Winstanley, C., 12 Jun 2018, In : FEMS Microbiology Letters . 25 p.

Research output: Contribution to journalArticle

Open Access
File
Gene Pool
Pseudomonas aeruginosa
Genome
Genomic Islands
Cystic Fibrosis
11 Citations (Scopus)
39 Downloads (Pure)
Open Access
File
Dielectric Spectroscopy
Staphylococcus aureus
Electrodes
Carbon
Spectroscopy
2017
17 Citations (Scopus)
66 Downloads (Pure)

Genomics of antibiotic-resistance prediction in Pseudomonas aeruginosa

Jeukens, J., Freschi, L., Kukavica-Ibrulj, I., Emond-Rheault, J-G., Tucker, N. P. & Levesque, R. C., 2 Jun 2017, In : Annals of the New York Academy of Sciences. 13 p.

Research output: Contribution to journalArticle

Open Access
File
Microbial Drug Resistance
Genomics
Pseudomonas aeruginosa
Anti-Bacterial Agents
Genotype
11 Downloads (Pure)

Natural antibiofilm agents and the need for antibiofilm drug leads

Adnan, H., Seidel, V. & Tucker, N. P., 1 Apr 2017, In : Educatum Journal of Science, Mathematics and Technology. 4, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Open Access
File
Biofilms
Coriandrum
Pharmaceutical Preparations
Pseudomonas aeruginosa
Seeds
1 Downloads (Pure)

Why antibacterial minor groove binders are a good thing

Suckling, C. J., Khalaf, A., Scott, F. J., Tucker, N., Niemenen, L., Lemonidis, K. & Hunter, I. S., 1 Nov 2017. 21 p.

Research output: Contribution to conferencePaper

Open Access
File
Binders
Bacteria
Clostridium Infections
Biological Phenomena
Clostridium
2016
13 Citations (Scopus)
44 Downloads (Pure)

Discovery, characterisation and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa

McCaughey, L. C., Josts, I., Grinter, R., White, P., Byron, O., Tucker, N. P., Matthews, J. M., Kleanthous, C., Whitchurch, C. B. & Walker, D., 28 Jul 2016, In : Biochemical Journal. 473, 15, p. 2345-2358 14 p.

Research output: Contribution to journalArticle

Open Access
File
Pyocins
Pseudomonas aeruginosa
Anti-Bacterial Agents
Proteins
Membranes
9 Citations (Scopus)
67 Downloads (Pure)

Genes required for free phage production are essential for pseudomonas aeruginosa chronic lung infections

Lemieux, A-A., Jeukens, J., Kukavica-Ibrulj, I., Fothergill, J. L., Boyle, B., Laroche, J., Tucker, N. P., Winstanley, C. & Levesque, R. C., 1 Feb 2016, In : Journal of Infectious Diseases. 213, 3, p. 395-402 8 p.

Research output: Contribution to journalArticle

Open Access
File
Prophages
Bacteriophages
Pseudomonas aeruginosa
Genomic Islands
Mutagenesis
2015
53 Citations (Scopus)
60 Downloads (Pure)

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

Freschi, L., Jeukens, J., Kukavica-Ibrulj, I., Boyle, B., Dupont, M-J., Laroche, J., Larose, S., Maaroufi, H., Fothergill, J. L., Moores, M., Winsor, G. L., Aaron, S. D., Barbeau, J., Bell, S. C., Burns, J. L., Camara, M., Cantin, A., Charette, S. J., Dewar, K., Déziel, É. & 38 others, Grimwood, K., Hancock, R. E. W., Harrison, J. J., Heeb, S., Jelsbak, L., Jia, B., Kenna, D. T., Kidd, T. J., Klockgether, J., Lam, J. S., Lamont, I. L., Lewenza, S., Loman, N., Malouin, F., Manos, J., McArthur, A. G., McKeown, J., Milot, J., Naghra, H., Nguyen, D., Pereira, S. K., Perron, G. G., Pirnay, J-P., Rainey, P. B., Rousseau, S., Santos, P. M., Stephenson, A., Taylor, V., Turton, J. F., Waglechner, N., Williams, P., Thrane, S. W., Wright, G. D., Brinkman, F. S. L., Tucker, N. P., Tümmler, B., Winstanley, C. & Levesque, R. C., 29 Sep 2015, In : Frontiers in Microbiology. 6, 8 p., 1036.

Research output: Contribution to journalArticle

Open Access
File
Genomics
Pseudomonas aeruginosa
Genome
Microbial Drug Resistance
Pseudomonas
33 Citations (Scopus)
40 Downloads (Pure)

Phenotypic and genotypic characteristics of small colony variants and their role in chronic infection

Johns, B. E., Purdy, K. J., Tucker, N. P. & Maddocks, S. E., 22 Sep 2015, In : Microbiology Insights. 8, p. 15-23 9 p.

Research output: Contribution to journalArticle

Open Access
File
Infection
Population
Bacteria
2014
49 Citations (Scopus)
87 Downloads (Pure)

Comparative genomics of isolates of a pseudomonas aeruginosa epidemic strain associated with chronic lung infections of cystic fibrosis patients

Jeukens, J., Boyle, B., Kukavica-Ibrulj, I., Ouellet, M. M., Aaron, S. D., Charette, S. J., Fothergill, J. L., Tucker, N. P., Winstanley, C. & Levesque, R. C., 5 Feb 2014, In : PLOS One. 9, 2, 15 p., e87611.

Research output: Contribution to journalArticle

Open Access
File
cystic fibrosis
Pyocyanine
Genomics
Pseudomonas aeruginosa
Cystic Fibrosis
2 Citations (Scopus)
23 Downloads (Pure)
Open Access
File
Electrochemical impedance spectroscopy
Costs
Electrodes
Carbon
Sensors
10 Citations (Scopus)
69 Downloads (Pure)

Diphtheria-like disease caused by toxigenic corynebacterium ulcerans strain

Sangal, V., Nieminen, L., Weinhardt, B., Raeside, J., Tucker, N. P., Florea, C. D., Pollock, K. G. & Hoskisson, P. A., Jul 2014, In : Emerging Infectious Diseases. 20, 7, p. 1257-1258 2 p.

Research output: Contribution to journalArticle

Open Access
File
Corynebacterium
Diphtheria
Pharyngitis
Holidays
Clindamycin
34 Citations (Scopus)

Draft genomes of 12 host-adapted and environmental isolates of Pseudomonas aeruginosa and their positions in the core genome phylogeny

Stewart, L., Ford, A., Sangal, V., Jeukens, J., Boyle, B., Kukavica-Ibrulj, I., Caim, S., Crossman, L., Hoskisson, P. A., Levesque, R. & Tucker, N. P., 30 Jun 2014, In : Pathogens and disease. 71

Research output: Contribution to journalArticle

Phylogeny
Pseudomonas aeruginosa
Genome
Genomics
Cystic Fibrosis
28 Citations (Scopus)
200 Downloads (Pure)

Lectin-like bacteriocins from pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor

McCaughey, L. C., Grinter, R., Josts, I., Roszak, A. W., Waløen, K. I., Cogdell, R. J., Milner, J., Evans, T., Kelly, S., Tucker, N. P., Byron, O., Smith, B. & Walker, D., 6 Feb 2014, In : PLOS Pathogens. 10, 2, 15 p., e1003898.

Research output: Contribution to journalArticle

Open Access
File
Rhamnose
Bacteriocins
Pseudomonas
Lectins
Lipopolysaccharides
17 Citations (Scopus)
196 Downloads (Pure)
Open Access
File
dielectric spectroscopy
Dielectric Spectroscopy
biosensors
Biosensing Techniques
Electrochemical impedance spectroscopy
7 Citations (Scopus)

Revolutionizing prokaryotic systematics through next-generation sequencing

Sangal, V., Nieminen, L., Tucker, N. P. & Hoskisson, P. A., 28 Aug 2014, New Approaches to Prokaryotic Systematics. Goodfellow, M., Sutcliffe, I. & Chun, J. (eds.). p. 75-101 27 p. (Methods in Microbiology; vol. 41).

Research output: Chapter in Book/Report/Conference proceedingChapter

Microbial Genetics
Biological Science Disciplines
Ecology
Computational Biology
Sequence Analysis

Strategy for genome sequencing analysis and assembly for comparative genomics of pseudomonas genomes

Jeukens, J., Boyle, B., Tucker, N. P. & Levesque, R. C., 2014, Pseudomonas Methods and Protocols. Filloux, A. & Ramos, J-L. (eds.). New York: Springer, p. 565-577 13 p. (Methods in Molecular Biology; vol. 1149).

Research output: Chapter in Book/Report/Conference proceedingChapter

Bacterial Genomes
Genomics
Pseudomonas
Genome
Workflow

The differing biological fates of DNA minor groove-binding (MGB) antibiotics in Gram-negative and Gram-positive bacteria

Nieminen, L. K. L., Hunter, I., Suckling, C. & Tucker, N., 1 Aug 2014, (Unpublished).

Research output: Contribution to conferencePoster

Transcriptional analysis of pseudomonas aeruginosa Infected caenorhabditis elegans

Mackenzie, A., Stewart, L., Hoskisson, P. A. & Tucker, N. P., 2014, Pseudomonas Methods and Protocols. Filloux, A. & Ramos, J-L. (eds.). New York: Springer, p. 607-612 6 p. (Methods in Molecular Biology; vol. 1149).

Research output: Chapter in Book/Report/Conference proceedingChapter

Caenorhabditis elegans
Pseudomonas aeruginosa
RNA
2013
12 Citations (Scopus)

A structural and dynamic investigation of the inhibition of catalase by nitric oxide

Candelaresi, M., Gumiero, A., Adamczyk, K., Robb, K., Bellota-Antón, C., Sangal, V., Munnoch, J., Greetham, G. M., Towrie, M., Hoskisson, P. A., Parker, A. W., Tucker, N. P., Walsh, M. A. & Hunt, N. T., 30 Oct 2013, In : Organic and Biomolecular Chemistry. 11, 44, p. 7778-7788 11 p.

Research output: Contribution to journalArticle

catalase
nitric oxide
Catalase
Nitric Oxide
Ligands
12 Citations (Scopus)
Single Nucleotide Polymorphism
Galaxies
Nucleotides
Genome
Boidae
2012

Draft genome of Corynebacterium diphtheria biovar intermedius NCTC 5011

Sangal, V., Tucker, N., Burkovski, A. & Hoskisson, P., 2012, (Accepted/In press) In : Journal of Bacteriology.

Research output: Contribution to journalArticle

Corynebacterium diphtheriae
Genome
16 Citations (Scopus)
103 Downloads (Pure)

Draft genome sequence of Corynebacterium diphtheriae biovar intermedius NCTC 5011

Sangal, V., Tucker, N. P., Burkovski, A. & Hoskisson, P. A., Sep 2012, In : Journal of Bacteriology. 194, 17, 1 p., 4738.

Research output: Contribution to journalArticle

Open Access
File
Corynebacterium diphtheriae
Genome
Nucleic Acid Databases
Human Genome
18 Citations (Scopus)

Draft genome sequence of the human pathogen streptomyces somaliensis, a significant cause of actinomycetoma

Kirby, R., Sangal, V., Tucker, N., Zakrzewska-Czerwinska, J., Wierzbicka, K., Herron, P., Chu, C-J., Chandra, G., Fahal, A., Goodfellow, M. & Hoskisson, P., Jul 2012, In : Journal of Bacteriology. 194, 13, p. 3544-3545 2 p.

Research output: Contribution to journalArticle

Mycetoma
Nucleic Acid Databases
Streptomyces
Human Genome
Genome
21 Citations (Scopus)

Measuring protein dynamics with ultrafast two-dimensional infrared spectroscopy

Adamczyk, K., Candelaresi, M., Robb, K., Gumiero, A., Walsh, M. A., Parker, A. W., Hoskisson, P. A., Tucker, N. P. & Hunt, N. T., Jun 2012, In : Measurement Science and Technology . 23, 6, 16 p., 062001.

Research output: Contribution to journalLiterature review

Infrared Spectroscopy
Infrared spectroscopy
infrared spectroscopy
isotopic labeling
proteins
13 Citations (Scopus)
Corynebacterium diphtheriae
Genome
Human Genome
Corynebacterium diphtheriae
Genome
20 Citations (Scopus)

The effect of point mutation on the equilibrium structural fluctuations of ferric Myoglobin

Adamczyk, K., Candelaresi, M., Kania, R., Robb, K., Bellota-Anton, C., Greetham, G. M., Pollard, M. R., Towrie, M., Parker, A. W., Hoskisson, P. A., Tucker, N. P. & Hunt, N. T., 2012, In : Physical Chemistry Chemical Physics. 14, 20, p. 7411-7419 9 p.

Research output: Contribution to journalArticle

myoglobin
Myoglobin
mutations
Heme
Stretching
2011
18 Citations (Scopus)

Relationship between protein structural fluctuations and rebinding dynamics in ferric haem nitrosyls

Hunt, N. T., Greetham, G. M., Towrie, M., Parker, A. W. & Tucker, N. P., 1 Feb 2011, In : Biochemical Journal. 433, p. 459-468 10 p.

Research output: Contribution to journalArticle

Heme
Nitric Oxide
Cytochromes c
Myoglobin
Proteins
12 Citations (Scopus)

Spectroscopic analysis of protein Fe-NO complexes.

Bellota-Anton, C., Munnoch, J., Robb, K., Adamczyk, K., Candelaresi, M., Parker, A. W., Dixon, R., Hutchings, M. I., Hunt, N. & Tucker, N., 2011, In : Biochemical Society Transactions. 39, p. 1293 -1298 6 p.

Research output: Contribution to journalArticle

Spectroscopic analysis
Nitric Oxide
Heme
Myoglobin
Cytochromes c
19 Citations (Scopus)

Transcriptional regulation by the dedicated nitric oxide sensor, NorR: a route towards NO detoxification

Bush, M., Ghosh, T., Tucker, N., Zhang, X. & Dixon, R., Feb 2011, In : Biochemical Society Transactions. 39, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

Detoxification
Nitric Oxide
Sensors
Adenosine Triphosphatases
Chemical activation
2010
27 Citations (Scopus)
1 Downloads (Pure)

Essential roles of three enhancer sites in sigma-54-dependent transcription by the nitric oxide sensing regulatory protein NorR

Tucker, N., Ghosh, T., Bush, M., Zhang, X. & Dixon, R., 2010, In : Nucleic Acids Research. 38, 4, p. 1182-1194 13 p.

Research output: Contribution to journalArticle

Nitric Oxide
Nucleic Acid Denaturation
Holoenzymes
Bacterial Proteins
DNA
16 Citations (Scopus)

Nitric oxide-responsive interdomain regulation targets the σ54-interaction surface in the enhancer binding protein NorR

Bush, M., Ghosh, T., Tucker, N., Zhang, X. & Dixon, R., Sep 2010, In : Molecular Microbiology. 77, 5, p. 1278-1288 11 p.

Research output: Contribution to journalArticle

Carrier Proteins
Nitric Oxide
RNA Polymerase Sigma 54
Hydrolysis
Adenosine Triphosphate
2009
85 Citations (Scopus)

There's NO stopping NsrR, a global regulator of the bacterial NO stress response

Tucker, N. P., Le Brun, N. E., Dixon, R. & Hutchings, M. I., 16 Apr 2009, In : Trends in Microbiology. 18, 4, p. 149-159 11 p.

Research output: Contribution to journalArticle

Nitric Oxide
Denitrification
Poisons
Blood Coagulation
Eukaryota
2008
34 Citations (Scopus)

Analysis of the nitric oxide-sensing non-heme iron center in the NorR regulatory protein

Tucker, N., D'Autréaux, B., Yousafzai, F. K., Fairhurst, S. A., Spiro, S. & Dixon, R., Jan 2008, In : Journal of Biological Chemistry. 283, 2, p. 908-918 10 p.

Research output: Contribution to journalArticle

Nitric Oxide
Iron
Detoxification
Proteins
Phosphoric Diester Hydrolases
13 Citations (Scopus)

Characterization of the nitric oxide-reactive transcriptional activator NorR

D'Autréaux, B., Tucker, N., Spiro, S. & Dixon, R., 2008, In : Methods in Enzmology. 437, p. 235-251 16 p.

Research output: Contribution to journalArticle

Nitric Oxide
Iron
Detoxification
Heme
Escherichia coli
101 Citations (Scopus)
59 Downloads (Pure)

The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster

Tucker, N., Hicks, M. G., Clarke, T. A., Crack, J. C., Chandra, G., Le Brun, N. E., Dixon, R. & Hutchings, M. I., Nov 2008, In : PLoS One. 3, 11, 7 p., e3623.

Research output: Contribution to journalArticle

Open Access
File
Repressor Proteins
nitric oxide
Nitric Oxide
DNA
Streptomyces coelicolor
2006
19 Citations (Scopus)

Mechanism of transcriptional regulation by the Escherichia coli nitric oxide sensor NorR

Tucker, N. P., D'autréaux, B., Spiro, S. & Dixon, R., Feb 2006, In : Biochemical Society Transactions. 34, 1, p. 191-194 4 p.

Research output: Contribution to journalConference Contribution

Escherichia coli
Nitric Oxide
Sensors
Genes
Transcription
2005
207 Citations (Scopus)

A non-haem iron centre in the transcription factor NorR senses nitric oxide

D'Autréaux, B., Tucker, N. P., Dixon, R. & Spiro, S., 29 Sep 2005, In : Nature. 437, 7059, p. 769-772 4 p.

Research output: Contribution to journalLetter

Nitric Oxide
Transcription Factors
Iron
Reactive Nitrogen Species
Flavoproteins
11 Citations (Scopus)

DNA binding properties of the Escherichia coli nitric oxide sensor NorR: towards an understanding of the regulation of flavorubredoxin expression

Tucker, N., D'autréaux, B., Spiro, S. & Dixon, R., Feb 2005, In : Biochemical Society Transactions. 33, Part 1, p. 181-183 3 p.

Research output: Contribution to journalConference Contribution

RNA Polymerase Sigma 54
Escherichia coli
Nitric Oxide
Binding Sites
Transcription Initiation Site
2004
41 Citations (Scopus)

DNA binding activity of the Escherichia coli nitric oxide sensor NorR suggests a conserved target sequence in diverse proteobacteria

Tucker, N. P., D'Autréaux, B., Studholme, D. J., Spiro, S. & Dixon, R., 2004, In : Journal of Bacteriology. 186, 19, p. 6656-6660 5 p.

Research output: Contribution to journalArticle

Proteobacteria
Conserved Sequence
Nitric Oxide
Binding Sites
Escherichia coli
2003
81 Citations (Scopus)

In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor

Waddington, S. N., Buckley, S. M. K., Nivsarkar, M., Jezzard, S., Schneider, H., Dahse, T., Kemball-Cook, G., Miah, M., Tucker, N., Dallman, M. J., Themis, M. & Coutelle, C., 15 Feb 2003, In : Blood. 101, 4, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

Gene transfer
Transfer Factor
Factor IX
Blood Coagulation Factors
Human engineering