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Personal profile

Personal Statement

2009-Present, Lecturer in Molecular Microbiology, University of Strathclyde
2005-2009, Post-doctoral fellow, John Innes Centre, Norwich 
2002-2005 PhD. Molecular microbiology, University of East Anglia 
1999-2000 MSc. Human Molecular Genetics, Imperial College, London. 
1996-99 BSc. (Hons.) Biochemistry, Heriot-Watt University, Edinburgh.

The unifying theme across my research is bacterial gene regulation. Bacteria must be able to efficiently respond to changes in their environment by altering the expression of specific genes. This is most commonly achieved at the transcriptional level by proteins that either activate or repress the activity of RNA-polymerase.

Research Areas:

1. Gene regulation and signaling by bacterial enhancer binding proteins
2. Nitric oxide sensing and metalloproteins (Rrf2 family)
3. Pseudomonas aeruginosa pathogenicity
4. E. coli and Streptomyces coelicolor nitrogen metabolism

Nitric oxide is a toxic radical gas that is produced by macrophage cells as a broad range antibiotic. Bacterial pathogens have evolved a number of systems for detoxifying nitric oxide such as flavorubredoxin and flavohemoglobin in E. coli . The expression of the genes encoding these proteins is nitric oxide dependent and is controlled by the transcriptional regulators NorR and NsrR respectively. Both proteins sense nitric oxide via metal centres that control their ability to activate or repress gene expression.

Education/Academic qualification

Doctor of Philosophy, University of East Anglia

Master of Science, Imperial College London

Bachelor of Philosophy, Heriot-Watt University

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Proteins Medicine & Life Sciences
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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2022

Research Output 2003 2018

3 Citations

Community-led comparative genomic and phenotypic analysis of the aquaculture pathogen Pseudomonas baetica a390T sequenced by Ion semiconductor and Nanopore technologies

Beaton, A. , Lood, C. , Cunningham-Oakes, E. , MacFadyen, A. , Mullins, A. J. , Bestawy, W. E. , Botelho, J. , Chevalier, S. , Coleman, S. , Dalzell, C. , Dolan, S. K. , Faccenda, A. , Ghequire, M. G. K. , Higgins, S. , Kutschera, A. , Murray, J. , Redway, M. , Salih, T. , da Silva, A. C. , Smith, B. A. & 8 others Smits, N., Thomson, R., Woodcock, S., Welch, M., Cornelis, P., Lavigne, R., van Noort, V. & Tucker, N. P., 22 Mar 2018, In : FEMS Microbiology Letters . 365, 9, 12 p., fny069

Research output: Contribution to journalArticle

Open Access
File
Nanopores
Aquaculture
Semiconductors
Pseudomonas
Genome

Genomic characterisation of an international Pseudomonas aeruginosa reference panel indicates that the two major groups draw upon distinct mobile gene pools

Freschi, L., Bertelli, C., Jeukens, J., Moore, M. P., Kukavica-Ibrulj, I., Emond-Rheault, J-G., Hamel, J., Fothergill, J. L., Tucker, N. P., McClean, S., Klockgether, J., de Soyza, A., Brinkman, F. S. L., Levesque, R. C. & Winstanley, C., 12 Jun 2018, In : FEMS Microbiology Letters . 25 p.

Research output: Contribution to journalArticle

Gene Pool
Pseudomonas aeruginosa
Genome
Genomic Islands
Cystic Fibrosis

Thesis

A comparative and phylogenetic analysis of the genome of Pseudomonas aeruginosa

Author: Stewart, L., 1 Oct 2013

Supervisor: Tucker, N. (Supervisor) & Hoskisson, P. (Supervisor)

Student thesis: Doctoral Thesis

A cystic fibrosis infection monitor

Author: Ward, A., 1 Oct 2014

Supervisor: Connolly, P. (Supervisor) & Tucker, N. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2008 2014

BBSRC (Biotech & Biological Sciences Research Council) (External organisation)

Tucker, N. (Member)
Dec 20142015

Activity: MembershipMembership of council

Comparative genomics of Pseudomonas aeruginosa

Tucker, N. (Contributor)
Oct 2013

Activity: Talk or presentationInvited talk