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Personal profile

Personal Statement

2009-Present, Lecturer in Molecular Microbiology, University of Strathclyde
2005-2009, Post-doctoral fellow, John Innes Centre, Norwich 
2002-2005 PhD. Molecular microbiology, University of East Anglia 
1999-2000 MSc. Human Molecular Genetics, Imperial College, London. 
1996-99 BSc. (Hons.) Biochemistry, Heriot-Watt University, Edinburgh.

The unifying theme across my research is bacterial gene regulation. Bacteria must be able to efficiently respond to changes in their environment by altering the expression of specific genes. This is most commonly achieved at the transcriptional level by proteins that either activate or repress the activity of RNA-polymerase.

Research Areas:

1. Gene regulation and signaling by bacterial enhancer binding proteins
2. Nitric oxide sensing and metalloproteins (Rrf2 family)
3. Pseudomonas aeruginosa pathogenicity
4. E. coli and Streptomyces coelicolor nitrogen metabolism

Nitric oxide is a toxic radical gas that is produced by macrophage cells as a broad range antibiotic. Bacterial pathogens have evolved a number of systems for detoxifying nitric oxide such as flavorubredoxin and flavohemoglobin in E. coli . The expression of the genes encoding these proteins is nitric oxide dependent and is controlled by the transcriptional regulators NorR and NsrR respectively. Both proteins sense nitric oxide via metal centres that control their ability to activate or repress gene expression.

Education/Academic qualification

Doctor of Philosophy, University of East Anglia

Master of Science, Imperial College London

Bachelor of Philosophy, Heriot-Watt University

Fingerprint Dive into the research topics where Nicholas Tucker is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Nitric Oxide Medicine & Life Sciences
Pseudomonas aeruginosa Medicine & Life Sciences
Genome Medicine & Life Sciences
Corynebacterium diphtheriae Medicine & Life Sciences
Genomics Medicine & Life Sciences
Pseudomonas Medicine & Life Sciences
Proteins Medicine & Life Sciences
Escherichia coli Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2022

Research Output 2003 2019

Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland

Lemonidis, K., Salih, T. S., Dancer, S. J., Hunter, I. S. & Tucker, N. P., 13 Jun 2019, In : PLoS ONE. 14, 6, 10 p., e0218185.

Research output: Contribution to journalArticle

Open Access
File
Enterococcus faecium
vancomycin
Scotland
Vancomycin
Clone Cells
3 Citations (Scopus)

Community-led comparative genomic and phenotypic analysis of the aquaculture pathogen Pseudomonas baetica a390T sequenced by Ion semiconductor and Nanopore technologies

Beaton, A., Lood, C., Cunningham-Oakes, E., MacFadyen, A., Mullins, A. J., Bestawy, W. E., Botelho, J., Chevalier, S., Coleman, S., Dalzell, C., Dolan, S. K., Faccenda, A., Ghequire, M. G. K., Higgins, S., Kutschera, A., Murray, J., Redway, M., Salih, T., da Silva, A. C., Smith, B. A. & 8 othersSmits, N., Thomson, R., Woodcock, S., Welch, M., Cornelis, P., Lavigne, R., van Noort, V. & Tucker, N. P., 22 Mar 2018, In : FEMS Microbiology Letters . 365, 9, 12 p., fny069.

Research output: Contribution to journalArticle

Open Access
File
Nanopores
Aquaculture
Semiconductors
Pseudomonas
Genome

Thesis

A comparative and phylogenetic analysis of the genome of Pseudomonas aeruginosa

Author: Stewart, L., 1 Oct 2013

Supervisor: Tucker, N. (Supervisor) & Hoskisson, P. (Supervisor)

Student thesis: Doctoral Thesis

A cystic fibrosis infection monitor

Author: Ward, A., 1 Oct 2014

Supervisor: Connolly, P. (Supervisor) & Tucker, N. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2008 2014

BBSRC (Biotech & Biological Sciences Research Council) (External organisation)

Nicholas Tucker (Member)
Dec 20142015

Activity: Membership typesMembership of council

Comparative genomics of Pseudomonas aeruginosa

Nicholas Tucker (Contributor)
Oct 2013

Activity: Talk or presentation typesInvited talk