Projects per year
Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production.
Portfolio of clinical research has covered a broad range of concepts including:
- Population level analysis of frailty metabolism
- Early diagnostic and theranostic biomarker detection
- Energy metabolism across the placenta
- Ageing effects the biological and metabolic basis of cancer
This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies.
Expertise & Capabilities
Lab has broad experience in
Expertise related to UN Sustainable Devlopment Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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ENT2 facilitates brain endothelial cell penetration and blood-brain barrier transport by a tumor-targeting anti-DNA autoantibodyRattray, Z., Deng, G., Zhang, S., Shirali, A., May, C. K., Chen, X., Cuffari, B. J., Liu, J., Zou, P., Rattray, N. J. W., Johnson, C. H., Dubljevic, V., Campbell, J. A., Huttner, A., Baehring, J. M., Zhou, J. & Hansen, J. E., 22 Jul 2021, In: JCI Insight. 6, 14, 39 p., e145875.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Downloads (Pure)
Identification of dose-dependent DNA damage and repair responses from subchronic exposure to 1,4-dioxane in mice using a systems analysis approachCharkoftaki, G., Golla, J. P., Santos-Neto, A., Orlicky, D., Garcia-Milian, R., Chen, Y., Rattray, N., Cai, Y., Wang, Y., Shern, C., Mironova, V., Wang, Y., Johnson, C. H., Thompson, D. & Vasilou, V., 10 Mar 2021, (E-pub ahead of print) In: Toxicological Sciences.
Research output: Contribution to journal › Article › peer-review
Nicholas Rattray (Recipient)10 Jul 2021
Activity: Other activity types › Types of Public engagement and outreach - Media article or participation