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Personal profile

Personal Statement

Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production.


Portfolio of clinical research has covered a broad range of concepts including:

  • Population level analysis of frailty metabolism
  • Early diagnostic and theranostic biomarker detection
  • Energy metabolism across the placenta
  • Ageing effects the biological and metabolic basis of cancer

This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies.

Expertise & Capabilities

Lab has broad experience in

  • Development of cellular models of disease and ageing
  • Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis
  • Automation of pre/post processing and informatics
  • Development of imaging mass spectrometry capability.
  • Enabling of a broad range of targeted MS workflow focusing on energy metabolites


Fingerprint Dive into the research topics where Nicholas Rattray is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Metabolomics Medicine & Life Sciences
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Metabolic Networks and Pathways Medicine & Life Sciences
Metabolites Chemical Compounds
Dimethylallyltranstransferase Medicine & Life Sciences
Technology Medicine & Life Sciences
Decarboxylation Medicine & Life Sciences
Precision Medicine Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2019 2023

Research Output 2013 2019

4 Citations (Scopus)

Machine learning of designed translational control allows predictive pathway optimization in Escherichia coli

Jervis, A. J., Carbonell, P., Vinaixa, M., Dunstan, M. S., Hollywood, K. A., Robinson, C. J., Rattray, N. J. W., Yan, C., Swainston, N., Currin, A., Sung, R., Toogood, H., Taylor, S., Faulon, J. L., Breitling, R., Takano, E. & Scrutton, N. S., 18 Jan 2019, In : ACS Synthetic Biology. 8, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Open Access
Binding sites
Escherichia coli
Learning systems
Binding Sites

Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty

Rattray, N. J. W., Trivedi, D. K., Xu, Y., Chandola, T., Johnson, C. H., Marshall, A. D., Mekli, K., Rattray, Z., Tampubolon, G., Vanhoutte, B., White, I. R., Wu, F. C. W., Pendleton, N., Nazroo, J. & Goodacre, R., 5 Nov 2019, In : Nature Communications. 10, 1, 12 p., 5027.

Research output: Contribution to journalArticle

Open Access
Vitamin E

Activities 2018 2019

Workshop Lecture on Metabolomics Data Pre-Processing

Nicholas Rattray (Speaker)
13 Nov 2019

Activity: Talk or presentation typesInvited talk

Scottish Metabolomics Network Annual Symposium 2019

Nicholas Rattray (Organiser)
13 Nov 201915 Nov 2019

Activity: Participating in or organising an event typesOrganiser of major conference