Projects per year
Personal profile
Personal Statement
Miles Houslay is internationally recognised for his work in cell signalling. He is particularly interested in understanding how the functioning of cyclic nucleotide signaling networks are regulated by spatial constraints and cross-talk. His research focus concerns the functional significance of targeted cAMP degradation by PDE4 phosphodiesterase isoforms and developing novel therapeutics for diseases such as COPD, cancer and schizophrenia. He has published over 440 research papers, holds a number of patents and has acted either as a consultant or served on scientific advisory boards of various companies in Asia, Europe, Japan, UK and USA. He has a research publication H-index of 77 (January 2013).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- PDE4
- Phosphodiesterases
- Cyclic AMP
- phosphorylation
- cAMP
- rolipram
- cell signalling
- Protein interactions
- PDE
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Projects
- 2 Finished
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Identifying selective cAMP phosphodiesterase inhibitors for chronic obstructive pulmonary disease
Houslay, M. (Principal Investigator)
SULSA (University Administered)
1/10/12 → 30/04/15
Project: Research
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Novel Therapies For COPD - PoC
Houslay, M. (Principal Investigator) & Pyne, N. (Co-investigator)
21/08/12 → 8/08/14
Project: Research
Research output
- 13 Article
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Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)
Henderson, D. J. P., Houslay, M. D., Bangma, C. H. & Hoffmann, R., 25 Jan 2019, In: Clinical Science. 133, 2, p. 269-286 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)29 Downloads (Pure) -
Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions
Schachtrup, C., Ryu, J. K., Mammadzada, K., Khan, A. S., Carlton, P. M., Perez, A., Christian, F., Le Moan, N., Vagena, E., Baeza-Raja, B., Rafalski, V., Chan, J. P., Nitschke, R., Houslay, M. D., Ellisman, M. H., Wyss-Coray, T., Palop, J. J. & Akassoglou, K., 1 Aug 2015, In: Nature Neuroscience. 18, 8, p. 1077-1080 4 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus)