Research output per year

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Personal profile

Personal Statement

Miles Houslay is internationally recognised for his work in cell signalling. He is particularly interested in understanding how the functioning of cyclic nucleotide signaling networks are regulated by spatial constraints and cross-talk. His research focus concerns the functional significance of targeted cAMP degradation by PDE4 phosphodiesterase isoforms and developing novel therapeutics for diseases such as COPD, cancer and schizophrenia. He has published over 440 research papers, holds a number of patents and has acted either as a consultant or served on scientific advisory boards of various companies in Asia, Europe, Japan, UK and USA. He has a research publication H-index of 77 (January 2013).


  • PDE4
  • Phosphodiesterases
  • Cyclic AMP
  • phosphorylation
  • cAMP
  • rolipram
  • cell signalling
  • Protein interactions
  • PDE

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Research Output

Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)

Henderson, D. J. P., Houslay, M. D., Bangma, C. H. & Hoffmann, R., 25 Jan 2019, In : Clinical Science. 133, 2, p. 269-286 18 p.

Research output: Contribution to journalArticle

Open Access
  • 3 Citations (Scopus)

    Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

    Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S., Adams, D. R. & Houslay, M. D., Apr 2015, In : Cellular Signalling. 27, 4, p. 756-769 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 16 Citations (Scopus)
    107 Downloads (Pure)