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Personal profile

Personal Statement

Miles Houslay is internationally recognised for his work in cell signalling. He is particularly interested in understanding how the functioning of cyclic nucleotide signaling networks are regulated by spatial constraints and cross-talk. His research focus concerns the functional significance of targeted cAMP degradation by PDE4 phosphodiesterase isoforms and developing novel therapeutics for diseases such as COPD, cancer and schizophrenia. He has published over 440 research papers, holds a number of patents and has acted either as a consultant or served on scientific advisory boards of various companies in Asia, Europe, Japan, UK and USA. He has a research publication H-index of 77 (January 2013).

Keywords

  • PDE4
  • Phosphodiesterases
  • Cyclic AMP
  • phosphorylation
  • cAMP
  • rolipram
  • cell signalling
  • Protein interactions
  • PDE

Fingerprint Dive into the research topics where Miles Houslay is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 7 Similar Profiles
Type 4 Cyclic Nucleotide Phosphodiesterase Medicine & Life Sciences
Phosphoric Diester Hydrolases Medicine & Life Sciences
Nerve Growth Factor Receptor Medicine & Life Sciences
Cyclic AMP-Dependent Protein Kinases Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Schizophrenia Medicine & Life Sciences
Cyclin-Dependent Kinase 5 Medicine & Life Sciences
DNA-Activated Protein Kinase Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2015

Research Output 2005 2019

Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)

Henderson, D. J. P., Houslay, M. D., Bangma, C. H. & Hoffmann, R., 25 Jan 2019, In : Clinical Science. 133, 2, p. 269-286 18 p.

Research output: Contribution to journalArticle

Open Access
File
Phosphoric Diester Hydrolases
Prostatic Neoplasms
Biomarkers
Guideline Adherence
Androgen Receptors
15 Citations (Scopus)
106 Downloads (Pure)

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S., Adams, D. R. & Houslay, M. D., Apr 2015, In : Cellular Signalling. 27, 4, p. 756-769 14 p.

Research output: Contribution to journalArticle

Open Access
File
Type 4 Cyclic Nucleotide Phosphodiesterase
Dimerization
Catalytic Domain
Protein Isoforms
Peptide Library