Projects per year
I’m a Senior Lecturer in the Departments of Electronic & Electrical Engineering and Biomedical Engineering.
My research is concerned with microbial infection control, and the development of novel disinfection and sterilisation technologies for public health applications, with particular focus on healthcare-associated infections (HAI) – the most frequent adverse event in health-care delivery worldwide, with hundreds of millions of patients affected annually.
My major research focus has been on the fundamental antimicrobial effects of violet-blue light and it's development as a cutting-edge decontamination technology for a range of infection control applications.
I have a highly interdisciplinary background, with a BSc in Immunology and Microbiology (2002), and a PhD focused on the interdisciplinary development of UV and visible-light for sterilisation and infection control applications (2006), which I conducted at The Robertson Trust Laboratory for Electronic Sterilisation Technologies (ROLEST), at Strathclyde. After completion of my PhD I continued my research at ROLEST where I worked as a Research Fellow. In 2014, I was appointed as a Lecturer through a Strathclyde Chancellors Fellowship, and I was promoted to Senior Lecturer in 2017. I have more than 70 publications, including journals, conference proceedings and presentations at scientific and medical conferences, and also have a growing IP portfolio.
Expertise & Capabilities
- applied microbiology
- microbial inactivation
- decontamination and sterilisation
- infection control
I am based in The Robertson Trust Laboratory for Electronic Sterilisation Technologies (ROLEST), in the Department of Electronic & Electrical Engineering, and my research is focused on the development of novel disinfection and infection control intervention technologies for public health applications, including prevention of healthcare and food/waterborne infections.
The majority of my research to date has focused on investigations into the fundamental antimicrobial effects of 405 nm high-intensity narrow-spectrum (HINS) light. Research has focused on determining antimicrobial sensitivity, wavelength sensitivity and the mechanism of inactivation. Much work has been focused on establishing the effects of this antimicrobial light against key pathogens including MRSA and Clostridium difficile, and I am involved in the investigation and development of this light technology for a range of disinfection applications.
One such example of this is the development of the HINS-light Environmental Decontamination System (EDS), a novel visible light system for continuous disinfection of occupied environments such as hospital isolation rooms. This research project was awarded the Times Higher Education Award for ‘Research Project of the Year’ in 2011.
I am also involved in the development of a number of other electro-technologies for development towards disinfection and sterilisation applications, including ultraviolet light, pulsed electric fields, oxidative corona and plasma technologies, and ozone.
I teach on a variety of modules in the Biomedical Engineering Department:
BE919 Research Methodology
BE428 Research Methods in Biomedical Engineering
BE207 Human Cell Biology 2
BE915 Medical Science for Engineering (Haematology and Immunology lectures)
BE101 Biomedical Engineering (sterilisation of devices lecture)
BE901 Regenerative Medicine & Tissue Engineering (sterilisation and decontamination lecture)
I also supervise a range of interdisciplinary students (EEE, BME, SIPBS) for their undergraduate and postgraduate research projects.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, An Investigation into the Light Inactivation of Medically Important Microorganisms, University of Strathclyde
Award Date: 1 Nov 2006
Bachelor of Science, Immunology and Microbiology, University of Strathclyde
Award Date: 1 Jul 2002
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Collaborations and top research areas from the last five years
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1/10/19 → 1/02/24
Project: Research Studentship - Internally Allocated
1/07/21 → 30/06/22
Project: Knowledge Exchange
Metabolomics evaluation of the photochemical impact of violet-blue light (405 nm) on ex vivo platelet concentratesSun, J., Dahiya, N., Schmitt, T., Stewart, C., Anderson, J., MacGregor, S., Maclean, M., Beger, R. D. & Atreya, C. D., 8 Sept 2023, (Accepted/In press) In: Metabolomics.
Research output: Contribution to journal › Article › peer-review
Laboratory evaluation of the broad-spectrum antibacterial efficacy of a low-irradiance visible 405-nm light system for surface-simulated decontaminationSinclair, L. G., Dougall, L. R., Ilieva, Z., McKenzie, K., Anderson, J. G., MacGregor, S. J. & Maclean, M., 31 Jul 2023, In: Health and Technology. 13, 4, p. 615-629 15 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Data for: "Viricidal Efficacy of a 405-nm Environmental Decontamination System for Inactivation of Bacteriophage Phi6: Surrogate for SARS-CoV-2"
Data for: "Violet-blue 405-nm Light-based Photoinactivation for Pathogen Reduction of Human Plasma Provides Broad Antibacterial Efficacy Without Visible Degradation of Plasma Proteins".