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Personal profile

Personal Statement

I joined the University in 2007 and I’m currently a John Anderson Research Senior Lecturer in Molecular Parasitology and Biochemistry. I mainly teach Biochemistry to undergraduate and postgraduate students. I am involving students in current research projects to provide them with state-of-the-art methods and technologies. This allows them to make an informed decision on their future careers and provides them with appropriate background knowledge to aid them in their personal development. In my research I am investigating Leishmania protein kinases as potential drug targets to cure leishmaniasis and as crucial regulators in flagellum formation and maintenance.
As the Leader of the Infection, Immunity and Microbiology Research Group from 2011-2014 I was involved in the general organisation of SIPBS.

The following topics are currently available in my group to do a PhD (subject to funding):

“Signalling pathways in Leishmania – drug targets to treat human leishmaniasis”

“Using genetic analysis to decipher flagellum formation and maintenance in Leishmania

“Molecular genetic analysis of Leishmania to identify protein kinase drug targets”

“Kinesins and kinases – protein interaction and phenotypic analysis of genetically modified Leishmania parasites”

 

 

Research Interests

My research focuses on Leishmania protein kinases as potential drug targets and as important regulators for flagellum maintenance. Leishmania is a protozoan parasite that can cause death in infected humans and animals. Protein kinases have been shown to be essential for survival of this parasite in the infected host. Hence, specific inhibitors for parasite protein kinases have the potential to be ideal drugs to treat leishmaniasis. On the other hand Leishmania has a single flagellum containing structures conserved in all organisms forming cilia or flagella including humans. Understanding how flagellum formation and maintenance is regulated in Leishmania will help to understand and cure human disorders affecting the function of cilia and flagella. I am using phosphoproteomics, molecular parasitology and protein biochemistry to identify relevant protein kinases, their activators and substrates. This will allow me to develop enzyme assays to screen for inhibitors of the target protein kinases, which can be developed into useful medicines.

Expertise & Capabilities

  • signal transduction
  • protein kinases
  • Leishmania cell biology
  • recombinant protein production
  • protein biochemistry

Education/Academic qualification

Doctor rerum naturalium, University of Tuebingen

Fingerprint Dive into the research topics where Martin Wiese is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2007 2019

BB/J013854/1 BBSRC DPT Studentships (with Glasgow University) | Hargrave, Kerrie

Roberts, C., Wiese, M. & Hargrave, K.

BBSRC (Biotech & Biological Sciences Research Council)

1/10/1429/03/19

Project: Research Studentship - Internally AllocatedResearch Studentship (Internally Allocated)

Transfer of Martin Wiese' grants

Wiese, M.

Deutsche Forschungsgemeinschaft German Research Foundation

1/08/0730/06/11

Project: Research - StudentshipResearch Studentship

Research Output 1993 2019

1 Citation (Scopus)

Leishmania donovani 90 kD heat shock protein - impact of phosphosites on parasite fitness, infectivity and casein kinase affinity

Hombach-Barrigah, A., Bartsch, K., Smirlis, D., Rosenqvist, H., MacDonald, A., Dingli, F., Loew, D., Späth, G. F., Rachidi, N., Wiese, M. & Clos, J., 25 Mar 2019, In : Scientific Reports. 9, 1, 16 p., 5074.

Research output: Contribution to journalArticle

Open Access
File
Casein Kinases
HSP90 Heat-Shock Proteins
Leishmania donovani
Parasites
Phosphorylation
31 Citations (Scopus)

An arginine deprivation response pathway is induced in Leishmania during macrophage invasion

Goldman-Pinkovich, A., Balno, C., Strasser, R., Zeituni-Molad, M., Bendelak, K., Rentsch, D., Ephros, M., Wiese, M., Jardim, A., Myler, P. J. & Zilberstein, D., 4 Apr 2016, In : PLOS Pathogens. 12, 4, 18 p., e1005494.

Research output: Contribution to journalArticle

Open Access
File
Macrophages
Leishmania
Arginine
Parasites
Amino Acids

Thesis

An analysis of resistance to miltefosine and paromomycin in leishmania donovani

Author: Shaw, C., 1 Oct 2013

Supervisor: Carter, K. (Supervisor) & Wiese, M. (Supervisor)

Student thesis: Doctoral Thesis

Metabolic reprogramming of dendritic cells by intracellular protozoan parasites

Author: Hargrave, K., 1 Oct 2018

Supervisor: Roberts, C. (Supervisor) & Wiese, M. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2009 2015

  • 2 Participation in conference

4th conference on protein kinases of parasitic protozoa: targeting signaling pathways in parasites

Martin Wiese (Invited speaker)
22 Mar 201525 Mar 2015

Activity: Participating in or organising an event typesParticipation in conference

Kinetoplastid Molecular Cell Biology Meeting III, April 2009, Woods Hole, MA, USA

Martin Wiese (Speaker)
Apr 2009

Activity: Participating in or organising an event typesParticipation in conference