• United Kingdom

Accepting PhD Students

PhD projects

Project 1: Protein kinases as potential drug targets against leishmaniasis
Project 2: Protein kinases as regulators in flagellum formation and maintenance

1993 …2019

Research output per year

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Personal profile

Personal Statement

I joined the University in 2007 and I’m currently a John Anderson Research Senior Lecturer in Molecular Parasitology and Biochemistry. I mainly teach Biochemistry to undergraduate and postgraduate students. I am involving students in current research projects to provide them with state-of-the-art methods and technologies. This allows them to make an informed decision on their future careers and provides them with appropriate background knowledge to aid them in their personal development. In my research I am investigating Leishmania protein kinases as potential drug targets to cure leishmaniasis and as crucial regulators in flagellum formation and maintenance.
As the Leader of the Infection, Immunity and Microbiology Research Group from 2011-2014 I was involved in the general organisation of SIPBS.

The following topics are currently available in my group to do a PhD (subject to funding):

“Signalling pathways in Leishmania – drug targets to treat human leishmaniasis”

“Using genetic analysis to decipher flagellum formation and maintenance in Leishmania

“Molecular genetic analysis of Leishmania to identify protein kinase drug targets”

“Kinesins and kinases – protein interaction and phenotypic analysis of genetically modified Leishmania parasites”

 

 

Research Interests

My research focuses on Leishmania protein kinases as potential drug targets and as important regulators for flagellum maintenance. Leishmania is a protozoan parasite that can cause death in infected humans and animals. Protein kinases have been shown to be essential for survival of this parasite in the infected host. Hence, specific inhibitors for parasite protein kinases have the potential to be ideal drugs to treat leishmaniasis. On the other hand Leishmania has a single flagellum containing structures conserved in all organisms forming cilia or flagella including humans. Understanding how flagellum formation and maintenance is regulated in Leishmania will help to understand and cure human disorders affecting the function of cilia and flagella. I am using phosphoproteomics, molecular parasitology and protein biochemistry to identify relevant protein kinases, their activators and substrates. This will allow me to develop enzyme assays to screen for inhibitors of the target protein kinases, which can be developed into useful medicines.

Expertise & Capabilities

  • signal transduction
  • protein kinases
  • Leishmania cell biology
  • recombinant protein production
  • protein biochemistry

Education/Academic qualification

Doctor rerum naturalium, University of Tuebingen

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Projects

Research Output

Leishmania donovani 90 kD heat shock protein - impact of phosphosites on parasite fitness, infectivity and casein kinase affinity

Hombach-Barrigah, A., Bartsch, K., Smirlis, D., Rosenqvist, H., MacDonald, A., Dingli, F., Loew, D., Späth, G. F., Rachidi, N., Wiese, M. & Clos, J., 25 Mar 2019, In : Scientific Reports. 9, 1, 16 p., 5074.

Research output: Contribution to journalArticle

Open Access
File
  • 5 Citations (Scopus)
    6 Downloads (Pure)

    An arginine deprivation response pathway is induced in Leishmania during macrophage invasion

    Goldman-Pinkovich, A., Balno, C., Strasser, R., Zeituni-Molad, M., Bendelak, K., Rentsch, D., Ephros, M., Wiese, M., Jardim, A., Myler, P. J. & Zilberstein, D., 4 Apr 2016, In : PLOS Pathogens. 12, 4, 18 p., e1005494.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 33 Citations (Scopus)
    136 Downloads (Pure)

    Thesis

    An analysis of resistance to miltefosine and paromomycin in leishmania donovani

    Author: Shaw, C., 30 Nov 2016

    Supervisor: Carter, K. (Supervisor) & Wiese, M. (Supervisor)

    Student thesis: Doctoral Thesis

    Development of technologies for a toxoplasma gondii vaccine

    Author: Al-Taie, D. A. K., 1 Oct 2019

    Supervisor: Roberts, C. (Supervisor) & Wiese, M. (Supervisor)

    Student thesis: Doctoral Thesis

    Activities

    • 2 Participation in conference

    4th conference on protein kinases of parasitic protozoa: targeting signaling pathways in parasites

    Martin Wiese (Invited speaker)
    22 Mar 201525 Mar 2015

    Activity: Participating in or organising an event typesParticipation in conference

    Kinetoplastid Molecular Cell Biology Meeting III, April 2009, Woods Hole, MA, USA

    Martin Wiese (Speaker)
    Apr 2009

    Activity: Participating in or organising an event typesParticipation in conference