Margaret Rose Cunningham

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  SULSA Network Award - Global Pharmacology Mapping Network

  Cunningham, M. R. (Principal Investigator), Guilding, C. (Principal Investigator), White, P. (Principal Investigator), Tucker, S. (Principal Investigator), Kelly-Laubscher, R. (Principal Investigator), Angelo, T. (Co-investigator), Gorman, L. (Co-investigator), Kelly, J. (Co-investigator) & Keonig, J. (Co-investigator)

  1/06/23 → 2/07/23

  Project: Knowledge Exchange (Conference / Seminar Hosting)

  • Drug 100%
  • Pharmacology 100%
  • Clinical Pharmacology 100%
  • Student 100%
  • Drug Receptor Interactions 50%

• Heart Damage Caused by Cancer and Anti-cancer Drugs (Vacation Scholarship)

  Cunningham, M. R. (Principal Investigator), Bauer, R. (Co-investigator) & Currie, S. (Co-investigator)

  Animal Free Research UK

  27/06/22 → 19/08/22

  Project: Knowledge Exchange

• Engineering equity in STEM employment

  Essex, J. (Principal Investigator), Hendry, M. (Principal Investigator), Cunningham, M. R. (Principal Investigator), Ivaturi, A. (Principal Investigator), Wang, Y. (Principal Investigator) & McQuilken, N. (Principal Investigator)

  1/06/22 → 31/03/23

  Project: Internally funded project

  • Science, Technology, Engineering and Mathematics 100%
  • Technical Expertise 100%
  • Health and Well-Being 7%
  • Third Sector 7%
  • Social Integration 7%

• Recounting the Untold Stories of Breast Cancer: Narratives from the Patient, Clinician and Scientist Perspective

  Rattray, Z. (Principal Investigator), Rattray, N. (Co-investigator), Cunningham, M. R. (Co-investigator), Chalmers, S. (Co-investigator) & MCFADDEN, Y. (Co-investigator)

  14/01/22 → 13/01/23

  Project: Internally funded project

  • Patient 100%
  • Story-Telling 61%
  • Clinician 52%
  • Breast Cancer 50%
  • Cancer Diagnosis 11%

• SPRINT: A SuPer-Resolution time-resolved ImagiNg and specTroscopy facility for rapid biomolecular analysis

  Li, D. (Principal Investigator), Chamberlain, L. (Co-investigator), Chen, Y. (Co-investigator), Cunningham, M. R. (Co-investigator), Gould, G. (Co-investigator), Hoskisson, P. (Co-investigator), McConnell, G. (Co-investigator), Rattray, Z. (Co-investigator) & Van de Linde, S. (Co-investigator)

  BBSRC (Biotech & Biological Sciences Research Council)

  1/07/21 → 31/05/23

  Project: Research

  • Deep Learning 100%
  • Hardware 69%
  • Networks 60%
  • Field Programmable Gate Arrays 39%
  • Accuracy 37%

• Molecular mechanisms of HMGB1 release from platelets and its implication in vessel wall damage preceding thrombosis (Research Re-Boot - COVID-19 Impact)

  Cunningham, M. R. (Principal Investigator)

  Royal Society of Edinburgh

  1/06/21 → 30/11/21

  Project: Research

• Sustainable impact by design: a pilot study of effective STEM dissemination for hard-to-reach audiences

  Gonzalez-Longo, C. (Co-investigator), Essex, J. (Principal Investigator), Hendry, M. (Co-investigator), Cunningham, M. R. (Co-investigator), Giovelli, N. (Post Grad Student), Ivaturi, A. (Co-investigator), Li, R. (Co-investigator), Maddock, C. (Co-investigator), Somorin, T. (Co-investigator), Yue, H. (Co-investigator) & Egea Alvarez, A. (Co-investigator)

  1/04/21 → 31/10/23

  Project: Internally funded project

  • Cultural Users 100%
  • Workshop 50%
  • Dissemination 50%
  • Design 50%
  • Research 50%

• Cross-examining interplay between High Mobility Group Box 1 (HMGB1) and coagulation: Defining a role for G protein-coupled receptors (GPCRs) in this complex Coag-Inflammatory nexus

  BOSAKHAR, Z. Y. H. A. H. A. (Post Grad Student), Currie, S. (Co-investigator), Plevin, R. (Academic) & Cunningham, M. R. (Principal Investigator)

  1/12/20 → 30/11/23

  Project: Research - Studentship

• Probing the biology of Zinc alpha-2 glycoprotein

  Gould, G. (Principal Investigator), Cunningham, M. R. (Co-investigator) & Greig, J. (Researcher)

  Moleculomics Limited, Medical Research Scotland

  1/10/20 → 30/09/24

  Project: Research - Studentship

  • Lipid 100%
  • Raman Spectrometry 100%
  • Fatty Acid Metabolism 100%
  • Metabolic Pathway 100%
  • Fatty Acids 100%

• Obesity and Neuroinflammation: The Impact of Adipocyte-derived Extracellular Vesicles on Inflammatory Signalling Pathways of Microglia

  Colvin, C. (Post Grad Student), Gould, G. (Co-investigator), Rattray, Z. (Co-investigator) & Cunningham, M. R. (Principal Investigator)

  1/10/20 → 30/09/21

  Project: Research - Institute

• Molecular mechanisms of HMGB1 release from platelets and its implication in chemotherapy-induced peripheral neuropathy and thrombosis

  Domoto, R. (Principal Investigator), Cunningham, M. R. (Principal Investigator) & Kawabata, A. (Co-investigator)

  1/09/19 → 31/08/20

  Project: Research Fellowship

  • Platelet 100%
  • Neuropathy 100%
  • HMGB1 100%
  • Chemotherapy-Induced Peripheral Neuropathy 100%
  • Thrombin 100%

• Platelet connexins – Friend or Foe?

  Cunningham, M. R. (Principal Investigator) & McGivern, S.-J. (Researcher)

  24/06/19 → 12/08/19

  Project: Research

  • Gap Junction Protein 100%
  • Platelet 100%

• Investigating the biomolecular complexity of drug-induced cardiotoxicity by fingerprinting single cell and cardiac spheroid mass spectral information using Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS)

  Cunningham, M. R. (Principal Investigator), Veerman, B. (Post Grad Student), Johnston, B. (Co-investigator) & Currie, S. (Co-investigator)

  1/02/19 → 28/02/22

  Project: Research Studentship - Internally Allocated

  • Cardiotoxicity 100%
  • Tumor Microenvironment 50%
  • Malignant Neoplasm 50%

• Proteinase-activated receptor 4 (PAR4): a potential therapeutic target for the inhibition of thrombin-mediated cardiovasular activity

  Cunningham, M. R. (Principal Investigator), Cogan, C. (Post Grad Student) & Liskamp, R. (Co-investigator)

  1/10/18 → 31/05/19

  Project: Research - no external funding

  • Proteinase Activated Receptor 4 100%
  • Thrombin 100%
  • Thrombosis 25%
  • Blood Stasis 25%
  • Proteinase Activated Receptor 25%

• A new role for thrombin in the regulation of supervillin expression in microglia

  Cunningham, M. R. (Principal Investigator) & Koldova, R. (Researcher)

  1/10/18 → 29/04/19

  Project: Research

• Investigating interplay between thrombin receptors and the molecular mechanism that lead to cancer therapy-associated platelet dysfunction

  Cunningham, M. R. (Principal Investigator) & Sawyers, L. (Researcher)

  1/10/18 → 29/04/19

  Project: Research

• Regulation of High Mobility Group Box 1 (HMGB1) protein from human microglial cells in response to thrombin

  Cunningham, M. R. (Principal Investigator) & Butler, L. (Post Grad Student)

  1/10/18 → 31/08/19

  Project: Research

  • Microglia 100%
  • High Mobility Group B1 Protein 100%
  • Thrombin 100%
  • Cell Activity 50%
  • High-Mobility Group 50%

• Investigating the off-target effects of the clinical trial candidate PZ-128

  Cunningham, M. R. (Principal Investigator) & Brouck, L. (Researcher)

  1/10/18 → 29/04/19

  Project: Research

• Using bioinformatic tools to probe quantitative proteomic datasets and explore disease networks

  Cunningham, M. R. (Principal Investigator) & Su, Y. (Researcher)

  1/10/18 → 29/04/19

  Project: Research

• Regulation of High Mobility Group Box 1 (HMGB1) protein from human microglial cells in response to thrombin

  Butler, L. (Post Grad Student) & Cunningham, M. R. (Principal Investigator)

  1/10/18 → 30/06/19

  Project: Research

  • Thrombin 100%
  • Protein 100%
  • Regulatory Mechanism 100%
  • High-Mobility Group 100%
  • High Mobility Group B1 Protein 100%

• British Society for Cell Biology Vacation Studentship - Investigating the cellular complexity of drug-induced cardiotoxicity by fingerprinting single cell mass spectral information using ToF-SIMS

  Cunningham, M. R. (Principal Investigator), Wood, R. A. (Research Co-investigator), Chrubasik, M. (Researcher) & Gilchrist, R. (Researcher)

  25/06/18 → 18/08/18

  Project: Research - Studentship

• The Biochemical Society Summer Vacation Studentship: Project ‘The role of PAR4 in EAE models of Multiple Sclerosis’

  Wood, R. A. (Principal Investigator), Barbour, M. (Principal Investigator), McEwan, R. (Researcher), Cunningham, M. R. (Academic) & Jiang, H.-R. (Academic)

  1/06/18 → 31/07/18

  Project: Research

• 'Young Life Scientists' Symposium - Molecular Neuropharmacology in Health and Wellbeing’

  Cunningham, M. R. (Academic)

  1/06/18 → 15/11/18

  Project: Knowledge Exchange (Conference / Seminar Hosting)

  • Neuropharmacology 100%
  • Doctor of Philosophy 100%
  • Moa 100%
  • Committees 100%

• Winston Churchill Memorial Fellowship

  Cunningham, M. R. (Principal Investigator)

  1/04/18 → 31/12/19

  Project: Research Fellowship

  • Memorial 100%
  • Churchill 100%
  • Outreach 100%
  • Secondary Schools 100%
  • Asia 100%

• BPS Vacation Studentship - Investigating biophysical interactions of PAR inhibitors at the cell membrane using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS)

  Cunningham, M. R. (Principal Investigator), Wood, R. A. (Research Co-investigator) & Flight, K. (Researcher)

  26/06/17 → 1/09/17

  Project: Research - Studentship

• A multi-disciplinary approach to thrombin receptor research - A focus on the interrogation of the Proteinase-activated Receptor 4 (PAR4) interactome

  Cunningham, M. R. (Principal Investigator)

  Academy of Medical Sciences

  1/08/16 → 31/01/19

  Project: Research

  • Proteinase Activated Receptor 4 100%
  • Thrombin Receptor 100%

• The role of gelsolin family proteins in GPCR regulation

  Cunningham, M. R. (Principal Investigator) & Veerman, B. (Researcher)

  1/09/15 → 1/06/16

  Project: Research - no external funding

• Using proteomics to study novel function-disrupting PAR4 variants harboured in patient cohorts with platelet dysfunction

  Cunningham, M. R. (Principal Investigator)

  Tenovus Scotland

  1/06/15 → 29/02/16

  Project: Research

  • Vorapaxar 100%
  • Hemostatic Agent 50%
  • Thrombocyte Receptor 50%