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Personal profile

Personal Statement

Chancellor’s Fellow and Lecturer in Cardiovascular Pharmacology

My field of expertise is G protein-coupled receptor (GPCR)-dependent regulation of cardiovascular function with particular interest in proteinase-activated receptors (PARs) and purinergic receptor families.  My research involves investigating the molecular mechanisms of GPCR involvement in the processes that underpin platelet and vascular cell function and anti-cancer therapy-induced cardiotoxicity. In SIPBS, I co-lead the Cardiovascular and Metabolic Diseases research group with Dr Susan Currie.    

I am the Editor-in-Chief of Pharmacology Matters magazine and serve as a Reviewing Editor for Pharmacology Research & Perspectives (PR&P) journal.  I am an elected member of the RSE Young Academy of Scotland (YAS), a member of the Ingenious & Enterprising Women Network and a Winston Churchill Memorial Trust Fellow.  I am an Academy of Medical Sciences (AMS) springboard awardee and recently featured in their #MedSciLife Campaign. 

Improving attainment, participation and engagement in science is very important to me therefore I mentor postdoctoral researchers across the University, undergraduate students through the Strathclyde Cares Widening Access scheme and Secondary School students through the MCR pathways in West Dunbartonshire.  

I serve as Director of Outreach (in Biomolecular Sciences) with Dr Zahra Rattray (in Pharmacy) and I lead on the Career Progression working group on the SIPBS Athena SWAN Self-Assessment Team and additionally support the Organisation, Culture and Communication working group.          

Research Interests

My research is highly collaborative and multidisciplinary with ongoing projects invested in understanding protein interacting pathways that regulate GPCR activity in cardiovascular system with the aim of identifying novel ways to target receptors for development of new therapies.  Investigations include the use of artificial intelligence in the design of small molecules that target GPCRs and the development of novel PAR modulators. Approaches used in our research include SILAC quantitative proteomics, cellular imaging of therapeutic agents using Mass Spectrometry Imaging (MSI) techniques, FRET, FRET-FLIM and meso-imaging.    

Current University of Strathclyde collaborators include:

  • Dr Susan Currie, SIPBS
  • Dr Blair Johnston, CMAC
  • Professor Gail McConnell, Physics
  • Professor Robin Plevin, SIPBS
  • Dr David Li, SIPBS
  • Dr Charles Kennedy, SIPBS

 

External collaborations include:

  • Professor Robert Liskamp, University of Glasgow, UK
  • Dr Matthew Harper, University of Cambridge, UK
  • Professor Stuart Mundell, University of Bristol, UK
  • Dr Patricia Martin, Glasgow Caledonian University, UK
  • Dr Christopher Nile, Glasgow Dental School, University of Glasgow, UK
  • Professor Atsufumi Kawabata, Kindai University, Japan
  • Atomwise Ltd, US

 

I have an open-door policy and offer a supportive environment for highly motivated students to progress in their studies and develop their research skills. 

  

 

Teaching Interests

I am a Fellow of the Higher Education Academy (HEA) with a Postgraduate Diploma in Academic Practice.

I am class coordinator for BM434 Clinical Pharmacology and I lecture on the following undergraduate and postgraduate courses:

  • BM324 Fundamental Pharmacology
  • BM327 BABS 3 Pharmacology Labs
  • BM432 Research in Biomedical Sciences
  • BM933 Advanced studies in Haematology
  • BM906 Biomedical Sciences Project

 

I coordinate and deliver the Organisational and Staff Development Unit (OSDU) Research Bidding and Design - Getting Started course with Dr Katherine Duncan to help support early career researchers with grantmanship.   

Keywords

  • GPCRs
  • Proteinase-activated receptors (PARs)
  • Thrombin
  • Cardiovascular
  • Pharmacology
  • Cardiotoxicity

Fingerprint Dive into the research topics where Margaret Rose Cunningham is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 6 Similar Profiles
PAR-2 Receptor Medicine & Life Sciences
Blood Platelets Medicine & Life Sciences
G-Protein-Coupled Receptors Medicine & Life Sciences
Proteinase-Activated Receptors Medicine & Life Sciences
Platelets Chemical Compounds
Purinergic P2Y1 Receptors Medicine & Life Sciences
Hemorrhage Medicine & Life Sciences
Posters Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2015 2022

Research Output 2008 2019

1 Citation (Scopus)

Assessment of adult rat cardiac fibroblast viability following chronic sunitinib treatment

McMullen, C. J., Wood, R. A., Cunningham, M. R. & Currie, S., 1 May 2019, In : Heart . 105, suppl 4, p. A6-A7 2 p.

Research output: Contribution to journalMeeting abstract

Open Access
File
Fibroblasts
Cardiac Myocytes
Protein-Tyrosine Kinases
Extracellular Matrix
sunitinib

P2Y1 and P2Y12 receptor heterodimerisation: from recombinant systems to native detection

Safar, M. A., Wood, R., Cunningham, M. R. & Kennedy, C., 1 Aug 2019, In : British Journal of Pharmacology. 176, 16, p. 3049 1 p.

Research output: Contribution to journalMeeting abstract

Open Access
File
Purinergic P2Y1 Receptors
G-Protein-Coupled Receptors
Purinergic P2Y12 Receptors
Adenosine Diphosphate

Prizes

Sorting Nexins
Posters
Blood Platelets

BPS A J Clark Studentship

Margaret Rose Cunningham (Recipient), 2006

Prize: Fellowship awarded competitively

Activities 2005 2019

Molecular Pharmacology of Emerging GPCR Therapeutic Targets

Sophie Bradley (Organiser), Leigh Stoddart (Organiser), Margaret Rose Cunningham (Organiser)
17 Dec 2019

Activity: Participating in or organising an event typesOrganiser of special symposia

Ingenious Women Network Event:

Alejandra Aranceta Garza (Organiser), Margaret Rose Cunningham (Organiser), Emelie Combet (Organiser)
25 Sep 2019

Activity: Participating in or organising an event typesOrganiser of special symposia