Projects per year
Chancellor’s Fellow and Lecturer in Cardiovascular Pharmacology
My field of expertise is G protein-coupled receptor (GPCR)-dependent regulation of cardiovascular function with particular interest in proteinase-activated receptors (PARs) and purinergic receptor families. My research involves investigating the molecular mechanisms of GPCR involvement in the processes that underpin platelet and vascular cell function and anti-cancer therapy-induced cardiotoxicity. In SIPBS, I co-lead the Cardiovascular and Metabolic Diseases research group with Dr Susan Currie.
I am the Editor-in-Chief of Pharmacology Matters magazine and serve as a Reviewing Editor for Pharmacology Research & Perspectives (PR&P) journal. I am an elected member of the RSE Young Academy of Scotland (YAS), a member of the Ingenious & Enterprising Women Network and a Winston Churchill Memorial Trust Fellow. I am an Academy of Medical Sciences (AMS) springboard awardee and recently featured in their #MedSciLife Campaign.
Improving attainment, participation and engagement in science is very important to me therefore I mentor postdoctoral researchers across the University, undergraduate students through the Strathclyde Cares Widening Access scheme and Secondary School students through the MCR pathways in West Dunbartonshire.
I serve as Director of Outreach (in Biomolecular Sciences) with Dr Zahra Rattray (in Pharmacy) and I lead on the Career Progression working group on the SIPBS Athena SWAN Self-Assessment Team and additionally support the Organisation, Culture and Communication working group.
My research is highly collaborative and multidisciplinary with ongoing projects invested in understanding protein interacting pathways that regulate GPCR activity in cardiovascular system with the aim of identifying novel ways to target receptors for development of new therapies. Investigations include the use of artificial intelligence in the design of small molecules that target GPCRs and the development of novel PAR modulators. Approaches used in our research include SILAC quantitative proteomics, cellular imaging of therapeutic agents using Mass Spectrometry Imaging (MSI) techniques, FRET, FRET-FLIM and meso-imaging.
Current University of Strathclyde collaborators include:
- Dr Susan Currie, SIPBS
- Dr Blair Johnston, CMAC
- Professor Gail McConnell, Physics
- Professor Robin Plevin, SIPBS
- Dr David Li, SIPBS
- Dr Charles Kennedy, SIPBS
External collaborations include:
- Professor Robert Liskamp, University of Glasgow, UK
- Dr Matthew Harper, University of Cambridge, UK
- Professor Stuart Mundell, University of Bristol, UK
- Dr Patricia Martin, Glasgow Caledonian University, UK
- Dr Christopher Nile, Glasgow Dental School, University of Glasgow, UK
- Professor Atsufumi Kawabata, Kindai University, Japan
- Atomwise Ltd, US
I have an open-door policy and offer a supportive environment for highly motivated students to progress in their studies and develop their research skills.
I am a Fellow of the Higher Education Academy (HEA) with a Postgraduate Diploma in Academic Practice.
I am class coordinator for BM434 Clinical Pharmacology and I lecture on the following undergraduate and postgraduate courses:
- BM324 Fundamental Pharmacology
- BM327 BABS 3 Pharmacology Labs
- BM432 Research in Biomedical Sciences
- BM933 Advanced studies in Haematology
- BM906 Biomedical Sciences Project
I coordinate and deliver the Organisational and Staff Development Unit (OSDU) Research Bidding and Design - Getting Started course with Dr Katherine Duncan to help support early career researchers with grantmanship.
- Proteinase-activated receptors (PARs)
Cross-examining interplay between High Mobility Group Box 1 (HMGB1) and coagulation: Defining a role for G protein-coupled receptors (GPCRs) in this complex Coag-Inflammatory nexus
1/12/20 → 30/11/23
Project: Research - Studentship
A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cellsBrown, R. D. R., Veerman, B. E. P., Oh, J., Tate, R. J., Torta, F., Cunningham, M. R., Adams, D. R., Pyne, S. & Pyne, N. J., 16 Apr 2021, In: Journal of Biological Chemistry. 32 p., 100674.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Downloads (Pure)
Different responses of the blockade of the P2Y1 receptor with BPTU in human and porcine intestinal tissues and in cell culturesTraserra, S., Barber, C., MacInnes, J., Relea, L., MacPherson, L. C., Cunningham, M. R., Vergara, P., Accarino, A., Kennedy, C. & Jimenez, M., 22 Feb 2021, In: Neurogastroenterology and Motility.
Research output: Contribution to journal › Article › peer-review
Cunningham, Margaret Rose (Recipient), Apr 2014
Prize: Prize (including medals and awards)
Margaret Rose Cunningham (Member)Feb 2021 → …
Activity: Membership types › Membership of committee
Ben Veerman (Speaker), Calum McMullen (Contributor), Zahra Rattray (Contributor), Blair Johnston (Contributor), Yvonne Dempsie (Contributor), Patricia E M Martin (Contributor), Susan Currie (Contributor) & Margaret Rose Cunningham (Contributor)5 Feb 2021
Activity: Talk or presentation types › Oral presentation