20122019
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Research Output 2012 2019

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Article
2019

Current strategies for quantification of estrogens in clinical research

Denver, N., Khan, S., Homer, N. Z. M., MacLean, M. R. & Andrew, R., 30 Sep 2019, In : Journal of Steroid Biochemistry and Molecular Biology . 192, 12 p., 105373.

Research output: Contribution to journalArticle

Open Access
File
Metabolites
Estrogens
Research
Estradiol
Estrone
1 Citation (Scopus)

Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry

Denver, N., Khan, S., Stasinopoulos, I., Church, C., Homer, N. Z. M., MacLean, M. R. & Andrew, R., 30 Apr 2019, In : Data in Brief. 23, 5 p., 103740.

Research output: Contribution to journalArticle

Open Access
File
Catechol Estrogens
Plasma (human)
Liquid chromatography
Metabolites
Mass spectrometry
5 Citations (Scopus)

Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry

Denver, N., Khan, S., Stasinopoulos, I., Church, C., Homer, N. ZM., MacLean, M. R. & Andrew, R., 25 Apr 2019, In : Analytica Chimica Acta. 1054, p. 84-94 11 p.

Research output: Contribution to journalArticle

Open Access
File
Plasma (human)
Liquid chromatography
Metabolites
Tandem Mass Spectrometry
Liquid Chromatography
2 Citations (Scopus)

Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α

Docherty, C. K., Nilsen, M. & MacLean, M. R., 5 Mar 2019, 8, 5, 30 p., e011628.

Research output: Contribution to journalArticle

Open Access
File
Hypoxia-Inducible Factor 1
Pulmonary Hypertension
Pulmonary Artery
Smooth Muscle Myocytes
Estrogens
2017
14 Citations (Scopus)

Serotonin signaling through the 5-HT 1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. & MacLean, M. R., 1 Jul 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 7, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Open Access
File
Receptor, Serotonin, 5-HT1B
Pulmonary Hypertension
Serotonin
Reactive Oxygen Species
src-Family Kinases
2016
28 Citations (Scopus)

Metformin reverses development of pulmonary hypertension via aromatase inhibition

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P. & MacLean, M. R., 1 Aug 2016, 68, 2, p. 446-454 9 p.

Research output: Contribution to journalArticle

Open Access
File
Aromatase
Metformin
Pulmonary Hypertension
AMP-Activated Protein Kinases
Estrogens
26 Citations (Scopus)

Nicotinamide adenine dinucleotide phosphate oxidase-mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. & Touyz, R. M., 1 Sep 2016, 68, 3, p. 796-808 13 p.

Research output: Contribution to journalArticle

Open Access
File
Hydroxyestrones
NADP
Pulmonary Hypertension
Pulmonary Artery
Oxidation-Reduction
12 Citations (Scopus)

Regulation and function of miR-214 in pulmonary arterial hypertension

Stevens, H. C., Deng, L., Grant, J. S., Pinel, K., Thomas, M., Morrell, N. W., MacLean, M. R., Baker, A. H. & Denby, L., 1 Mar 2016, 6, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

Open Access
File
MicroRNAs
Pulmonary Hypertension
Heart Ventricles
Hypertrophy
Phosphoric Monoester Hydrolases
13 Citations (Scopus)

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1

Johansen, A. K. Z., Dean, A., Morecroft, I., Hood, K., Nilsen, M., Loughlin, L., Anagnostopoulou, A., Touyz, R. M., White, K. & MacLean, M. R., 1 Mar 2016, 6, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

Open Access
File
Serotonin Plasma Membrane Transport Proteins
Metabolic Networks and Pathways
Pulmonary Hypertension
Cytochrome P-450 Enzyme System
Estrogens
2015
34 Citations (Scopus)

A sex-specific microRNA-96/5-hydroxytryptamine 1B axis influences development of pulmonary hypertension

Wallace, E., Morrell, N. W., Yang, X. D., Long, L., Stevens, H., Nilsen, M., Loughlin, L., Mair, K. M., Baker, A. H. & MacLean, M. R., 15 Jun 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 12, p. 1432-1442 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Pulmonary Hypertension
Serotonin
Receptor, Serotonin, 5-HT1B
Type II Bone Morphogenetic Protein Receptors
20 Citations (Scopus)

Oestrogen receptor alpha in pulmonary hypertension

Wright, A. F., Ewart, M-A., Mair, K., Nilsen, M., Dempsie, Y., Loughlin, L. & MacLean, M. R., 12 Mar 2015, In : Cardiovascular Research. 106, 2, p. 206-216 11 p.

Research output: Contribution to journalArticle

Open Access
File
Type II Bone Morphogenetic Protein Receptors
Estrogen Receptor alpha
Pulmonary Hypertension
Smooth Muscle Myocytes
Lung
29 Citations (Scopus)

Sex affects bone morphogenetic protein type II receptor signaling in pulmonary artery smooth muscle cells

Mair, K. M., Yang, X. D., Long, L., White, K., Wallace, E., Ewart, M-A., Docherty, C. K., Morrell, N. W. & MacLean, M. R., 15 Mar 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 6, p. 693-703 11 p.

Research output: Contribution to journalArticle

Type II Bone Morphogenetic Protein Receptors
Pulmonary Artery
Smooth Muscle Myocytes
Pulmonary Hypertension
Estrogens
47 Citations (Scopus)

Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute

Hemnes, A. R., Kiely, D. G., Cockrill, B. A., Safdar, Z., Wilson, V. J., Hazmi, M. A., Preston, I. R., Maclean, M. R. & Lahm, T., 1 Sep 2015, 5, 3, p. 435-465 31 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Blood Vessels
Pregnancy
Lung
Consensus
2014
47 Citations (Scopus)

Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis

White, K., Dempsie, Y., Caruso, P., Wallace, E., McDonald, R. A., Stevens, H., Hatley, M. E., Van Rooij, E., Morrell, N. W., Maclean, M. R. & Baker, A. H., 1 Jul 2014, 64, 1, p. 185-194 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Pulmonary Hypertension
Caspase 3
Cell Death
Apoptosis
51 Citations (Scopus)

Sex-dependent influence of endogenous estrogen in pulmonary hypertension

Mair, K. M., Wright, A. F., Duggan, N., Rowlands, D. J., Hussey, M. J., Roberts, S., Fullerton, J., Nilsen, M., Loughlin, L., Thomas, M. & MacLean, M. R., 15 Aug 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 4, p. 456-467 12 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Estrogens
Aromatase Inhibitors
Aromatase
Bone Morphogenetic Protein Receptors
2013
37 Citations (Scopus)

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression

Ciuclan, L., Hussey, M. J., Burton, V., Good, R., Duggan, N., Beach, S., Jones, P., Fox, R., Clay, I., Bonneau, O., Konstantinova, I., Pearce, A., Rowlands, D. J., Jarai, G., Westwick, J., MacLean, M. R. & Thomas, M., 1 Jan 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 78-89 12 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Pulmonary Hypertension
Serotonin
Pathology
Hemodynamics
2012
179 Citations (Scopus)

A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

Caruso, P., Dempsie, Y., Stevens, H. C., McDonald, R. A., Long, L., Lu, R., White, K., Mair, K. M., McClure, J. D., Southwood, M., Upton, P., Xin, M., van Rooij, E., Olson, E. N., Morrell, N. W., MacLean, M. R. & Baker, A. H., 20 Jul 2012, In : Circulation Research. 111, 3, p. 290-300 11 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Pulmonary Artery
Lung
Smooth Muscle Myocytes
Up-Regulation