• United Kingdom

20122021
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Research Output 2012 2019

181 Citations (Scopus)

A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

Caruso, P., Dempsie, Y., Stevens, H. C., McDonald, R. A., Long, L., Lu, R., White, K., Mair, K. M., McClure, J. D., Southwood, M., Upton, P., Xin, M., van Rooij, E., Olson, E. N., Morrell, N. W., MacLean, M. R. & Baker, A. H., 20 Jul 2012, In : Circulation Research. 111, 3, p. 290-300 11 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Pulmonary Artery
Lung
Smooth Muscle Myocytes
Up-Regulation
35 Citations (Scopus)

A sex-specific microRNA-96/5-hydroxytryptamine 1B axis influences development of pulmonary hypertension

Wallace, E., Morrell, N. W., Yang, X. D., Long, L., Stevens, H., Nilsen, M., Loughlin, L., Mair, K. M., Baker, A. H. & MacLean, M. R., 15 Jun 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 12, p. 1432-1442 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Pulmonary Hypertension
Serotonin
Receptor, Serotonin, 5-HT1B
Type II Bone Morphogenetic Protein Receptors
3 Citations (Scopus)
6 Downloads (Pure)

Current strategies for quantification of estrogens in clinical research

Denver, N., Khan, S., Homer, N. Z. M., MacLean, M. R. & Andrew, R., 30 Sep 2019, In : Journal of Steroid Biochemistry and Molecular Biology . 192, 12 p., 105373.

Research output: Contribution to journalArticle

Open Access
File
Metabolites
Estrogens
Research
Gas Chromatography-Mass Spectrometry
Estradiol
1 Citation (Scopus)

Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry

Denver, N., Khan, S., Stasinopoulos, I., Church, C., Homer, N. Z. M., MacLean, M. R. & Andrew, R., 30 Apr 2019, In : Data in Brief. 23, 5 p., 103740.

Research output: Contribution to journalArticle

Open Access
File
Catechol Estrogens
Tandem Mass Spectrometry
Liquid Chromatography
Estrogens
Temperature
8 Citations (Scopus)
39 Downloads (Pure)

Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry

Denver, N., Khan, S., Stasinopoulos, I., Church, C., Homer, N. ZM., MacLean, M. R. & Andrew, R., 25 Apr 2019, In : Analytica Chimica Acta. 1054, p. 84-94 11 p.

Research output: Contribution to journalArticle

Open Access
File
Plasma (human)
Liquid chromatography
Metabolites
Tandem Mass Spectrometry
Liquid Chromatography
48 Citations (Scopus)

Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis

White, K., Dempsie, Y., Caruso, P., Wallace, E., McDonald, R. A., Stevens, H., Hatley, M. E., Van Rooij, E., Morrell, N. W., Maclean, M. R. & Baker, A. H., 1 Jul 2014, In : Hypertension. 64, 1, p. 185-194 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Pulmonary Hypertension
Caspase 3
Cell Death
Apoptosis
47 Citations (Scopus)

Gender, sex hormones and pulmonary hypertension

Austin, E. D., Lahm, T., West, J., Tofovic, S. P., Johansen, A. K., MacLean, M. R., Alzoubi, A. & Oka, M., 1 Apr 2013, In : Pulmonary Circulation. 3, 2, p. 294-314 21 p.

Research output: Contribution to journalReview article

Gonadal Steroid Hormones
Pulmonary Hypertension
Estrogens
Dehydroepiandrosterone
Theoretical Models
37 Citations (Scopus)

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression

Ciuclan, L., Hussey, M. J., Burton, V., Good, R., Duggan, N., Beach, S., Jones, P., Fox, R., Clay, I., Bonneau, O., Konstantinova, I., Pearce, A., Rowlands, D. J., Jarai, G., Westwick, J., MacLean, M. R. & Thomas, M., 1 Jan 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 78-89 12 p.

Research output: Contribution to journalArticle

Tryptophan Hydroxylase
Pulmonary Hypertension
Serotonin
Pathology
Platelet-Derived Growth Factor Receptors
5 Citations (Scopus)
13 Downloads (Pure)

Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α

Docherty, C. K., Nilsen, M. & MacLean, M. R., 5 Mar 2019, In : Journal of the American Heart Association. 8, 5, 30 p., e011628.

Research output: Contribution to journalArticle

Open Access
File
Hypoxia-Inducible Factor 1
Pulmonary Hypertension
Pulmonary Artery
Smooth Muscle Myocytes
Estrogens
32 Citations (Scopus)
8 Downloads (Pure)

Metformin reverses development of pulmonary hypertension via aromatase inhibition

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P. & MacLean, M. R., 1 Aug 2016, In : Hypertension. 68, 2, p. 446-454 9 p.

Research output: Contribution to journalArticle

Open Access
File
Aromatase
Metformin
Pulmonary Hypertension
AMP-Activated Protein Kinases
Estrogens
27 Citations (Scopus)
6 Downloads (Pure)

Nicotinamide adenine dinucleotide phosphate oxidase-mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. & Touyz, R. M., 1 Sep 2016, In : Hypertension. 68, 3, p. 796-808 13 p.

Research output: Contribution to journalArticle

Open Access
File
NADP
Pulmonary Hypertension
Pulmonary Artery
Oxidation-Reduction
Smooth Muscle Myocytes
22 Citations (Scopus)
7 Downloads (Pure)

Oestrogen receptor alpha in pulmonary hypertension

Wright, A. F., Ewart, M-A., Mair, K., Nilsen, M., Dempsie, Y., Loughlin, L. & MacLean, M. R., 12 Mar 2015, In : Cardiovascular Research. 106, 2, p. 206-216 11 p.

Research output: Contribution to journalArticle

Open Access
File
Type II Bone Morphogenetic Protein Receptors
Estrogen Receptor alpha
Pulmonary Hypertension
Estrogen Receptors
Smooth Muscle Myocytes
12 Citations (Scopus)
5 Downloads (Pure)

Regulation and function of miR-214 in pulmonary arterial hypertension

Stevens, H. C., Deng, L., Grant, J. S., Pinel, K., Thomas, M., Morrell, N. W., MacLean, M. R., Baker, A. H. & Denby, L., 1 Mar 2016, In : Pulmonary Circulation. 6, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

Open Access
File
MicroRNAs
Pulmonary Hypertension
Heart Ventricles
Hypertrophy
Transforming Growth Factors
10 Citations (Scopus)
17 Downloads (Pure)

Role of the aryl hydrocarbon receptor in sugen 5416-induced experimental pulmonary hypertension

Dean, A., Gregorc, T., Docherty, C. K., Harvey, K. Y., Nilsen, M., Morrell, N. W. & MacLean, M. R., 1 Mar 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 3, p. 320-330 11 p.

Research output: Contribution to journalEditorial

Open Access
File
Aryl Hydrocarbon Receptors
Pulmonary Hypertension
Pulmonary Artery
Smooth Muscle Myocytes
Cytochrome P-450 CYP1A1
15 Citations (Scopus)
7 Downloads (Pure)

Serotonin signaling through the 5-HT 1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. & MacLean, M. R., 1 Jul 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 7, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Open Access
File
Receptor, Serotonin, 5-HT1B
Pulmonary Hypertension
Serotonin
Reactive Oxygen Species
src-Family Kinases
29 Citations (Scopus)

Sex affects bone morphogenetic protein type II receptor signaling in pulmonary artery smooth muscle cells

Mair, K. M., Yang, X. D., Long, L., White, K., Wallace, E., Ewart, M-A., Docherty, C. K., Morrell, N. W. & MacLean, M. R., 15 Mar 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 6, p. 693-703 11 p.

Research output: Contribution to journalArticle

Type II Bone Morphogenetic Protein Receptors
Pulmonary Artery
Smooth Muscle Myocytes
Pulmonary Hypertension
Estrogens
52 Citations (Scopus)

Sex-dependent influence of endogenous estrogen in pulmonary hypertension

Mair, K. M., Wright, A. F., Duggan, N., Rowlands, D. J., Hussey, M. J., Roberts, S., Fullerton, J., Nilsen, M., Loughlin, L., Thomas, M. & MacLean, M. R., 15 Aug 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 4, p. 456-467 12 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Estrogens
Aromatase Inhibitors
Aromatase
Bone Morphogenetic Protein Receptors
50 Citations (Scopus)

Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute

Hemnes, A. R., Kiely, D. G., Cockrill, B. A., Safdar, Z., Wilson, V. J., Hazmi, M. A., Preston, I. R., Maclean, M. R. & Lahm, T., 1 Sep 2015, In : Pulmonary Circulation. 5, 3, p. 435-465 31 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Blood Vessels
Pregnancy
Lung
Consensus
6 Citations (Scopus)

The role of sex in the pathophysiology of pulmonary hypertension

Docherty, C. K., Harvey, K. Y., Mair, K. M., Griffin, S., Denver, N. & MacLean, M. R., 4 Aug 2018, Sex-Specific Analysis of Cardiovascular Function. Kerkhof, P. L. M. & Miller, V. M. (eds.). Cham, Switzerland: Springer, p. 511-528 18 p. (Advances in Experimental Medicine and Biology; vol. 1065).

Research output: Chapter in Book/Report/Conference proceedingChapter

Pulmonary Hypertension
Estrogens
Type II Bone Morphogenetic Protein Receptors
Pulmonary Artery
Blood Vessels
15 Citations (Scopus)
16 Downloads (Pure)

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1

Johansen, A. K. Z., Dean, A., Morecroft, I., Hood, K., Nilsen, M., Loughlin, L., Anagnostopoulou, A., Touyz, R. M., White, K. & MacLean, M. R., 1 Mar 2016, In : Pulmonary Circulation. 6, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

Open Access
File
Serotonin Plasma Membrane Transport Proteins
Metabolic Networks and Pathways
Pulmonary Hypertension
Cytochrome P-450 Enzyme System
Estrogens