• United Kingdom

20122021

Research output per year

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Research Output

2012

A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples

Caruso, P., Dempsie, Y., Stevens, H. C., McDonald, R. A., Long, L., Lu, R., White, K., Mair, K. M., McClure, J. D., Southwood, M., Upton, P., Xin, M., van Rooij, E., Olson, E. N., Morrell, N. W., MacLean, M. R. & Baker, A. H., 20 Jul 2012, In : Circulation Research. 111, 3, p. 290-300 11 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)
2013

Gender, sex hormones and pulmonary hypertension

Austin, E. D., Lahm, T., West, J., Tofovic, S. P., Johansen, A. K., MacLean, M. R., Alzoubi, A. & Oka, M., 1 Apr 2013, In : Pulmonary Circulation. 3, 2, p. 294-314 21 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression

Ciuclan, L., Hussey, M. J., Burton, V., Good, R., Duggan, N., Beach, S., Jones, P., Fox, R., Clay, I., Bonneau, O., Konstantinova, I., Pearce, A., Rowlands, D. J., Jarai, G., Westwick, J., MacLean, M. R. & Thomas, M., 1 Jan 2013, In : American Journal of Respiratory and Critical Care Medicine. 187, 1, p. 78-89 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2014

Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis

White, K., Dempsie, Y., Caruso, P., Wallace, E., McDonald, R. A., Stevens, H., Hatley, M. E., Van Rooij, E., Morrell, N. W., Maclean, M. R. & Baker, A. H., 1 Jul 2014, In : Hypertension. 64, 1, p. 185-194 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Sex-dependent influence of endogenous estrogen in pulmonary hypertension

Mair, K. M., Wright, A. F., Duggan, N., Rowlands, D. J., Hussey, M. J., Roberts, S., Fullerton, J., Nilsen, M., Loughlin, L., Thomas, M. & MacLean, M. R., 15 Aug 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 4, p. 456-467 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2015

A sex-specific microRNA-96/5-hydroxytryptamine 1B axis influences development of pulmonary hypertension

Wallace, E., Morrell, N. W., Yang, X. D., Long, L., Stevens, H., Nilsen, M., Loughlin, L., Mair, K. M., Baker, A. H. & MacLean, M. R., 15 Jun 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 12, p. 1432-1442 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Oestrogen receptor alpha in pulmonary hypertension

Wright, A. F., Ewart, M-A., Mair, K., Nilsen, M., Dempsie, Y., Loughlin, L. & MacLean, M. R., 12 Mar 2015, In : Cardiovascular Research. 106, 2, p. 206-216 11 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
8 Downloads (Pure)

Sex affects bone morphogenetic protein type II receptor signaling in pulmonary artery smooth muscle cells

Mair, K. M., Yang, X. D., Long, L., White, K., Wallace, E., Ewart, M-A., Docherty, C. K., Morrell, N. W. & MacLean, M. R., 15 Mar 2015, In : American Journal of Respiratory and Critical Care Medicine. 191, 6, p. 693-703 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute

Hemnes, A. R., Kiely, D. G., Cockrill, B. A., Safdar, Z., Wilson, V. J., Hazmi, M. A., Preston, I. R., Maclean, M. R. & Lahm, T., 1 Sep 2015, In : Pulmonary Circulation. 5, 3, p. 435-465 31 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2016

Metformin reverses development of pulmonary hypertension via aromatase inhibition

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P. & MacLean, M. R., 1 Aug 2016, In : Hypertension. 68, 2, p. 446-454 9 p.

Research output: Contribution to journalArticle

Open Access
File
34 Citations (Scopus)
10 Downloads (Pure)

Nicotinamide adenine dinucleotide phosphate oxidase-mediated redox signaling and vascular remodeling by 16α-hydroxyestrone in human pulmonary artery cells

Hood, K. Y., Montezano, A. C., Harvey, A. P., Nilsen, M., MacLean, M. R. & Touyz, R. M., 1 Sep 2016, In : Hypertension. 68, 3, p. 796-808 13 p.

Research output: Contribution to journalArticle

Open Access
File
27 Citations (Scopus)
6 Downloads (Pure)

Regulation and function of miR-214 in pulmonary arterial hypertension

Stevens, H. C., Deng, L., Grant, J. S., Pinel, K., Thomas, M., Morrell, N. W., MacLean, M. R., Baker, A. H. & Denby, L., 1 Mar 2016, In : Pulmonary Circulation. 6, 1, p. 109-117 9 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
5 Downloads (Pure)

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1

Johansen, A. K. Z., Dean, A., Morecroft, I., Hood, K., Nilsen, M., Loughlin, L., Anagnostopoulou, A., Touyz, R. M., White, K. & MacLean, M. R., 1 Mar 2016, In : Pulmonary Circulation. 6, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
16 Downloads (Pure)
2017

Serotonin signaling through the 5-HT 1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension

Hood, K. Y., Mair, K. M., Harvey, A. P., Montezano, A. C., Touyz, R. M. & MacLean, M. R., 1 Jul 2017, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 37, 7, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
7 Downloads (Pure)
2018

Role of the aryl hydrocarbon receptor in sugen 5416-induced experimental pulmonary hypertension

Dean, A., Gregorc, T., Docherty, C. K., Harvey, K. Y., Nilsen, M., Morrell, N. W. & MacLean, M. R., 1 Mar 2018, In : American Journal of Respiratory Cell and Molecular Biology. 58, 3, p. 320-330 11 p.

Research output: Contribution to journalEditorial

Open Access
File
12 Citations (Scopus)
21 Downloads (Pure)

The role of sex in the pathophysiology of pulmonary hypertension

Docherty, C. K., Harvey, K., Mair, K., Griffin, S., Denver, N. & MacLean, M., 4 Aug 2018, Sex-Specific Analysis of Cardiovascular Function. Kerkhof, P. L. M. & Miller, V. M. (eds.). Cham, Switzerland: Springer, p. 511-528 18 p. (Advances in Experimental Medicine and Biology; vol. 1065).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)
2019

Current strategies for quantification of estrogens in clinical research

Denver, N., Khan, S., Homer, N. Z. M., MacLean, M. R. & Andrew, R., 30 Sep 2019, In : Journal of Steroid Biochemistry and Molecular Biology . 192, 12 p., 105373.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
10 Downloads (Pure)

Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry

Denver, N., Khan, S., Stasinopoulos, I., Church, C., Homer, N. Z. M., MacLean, M. R. & Andrew, R., 30 Apr 2019, In : Data in Brief. 23, 5 p., 103740.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)

Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry

Denver, N., Khan, S., Stasinopoulos, I., Church, C., Homer, N. ZM., MacLean, M. R. & Andrew, R., 25 Apr 2019, In : Analytica Chimica Acta. 1054, p. 84-94 11 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
52 Downloads (Pure)

Influence of 2-methoxyestradiol and sex on hypoxia-induced pulmonary hypertension and hypoxia-inducible factor-1-α

Docherty, C. K., Nilsen, M. & MacLean, M. R., 5 Mar 2019, In : Journal of the American Heart Association. 8, 5, 30 p., e011628.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
14 Downloads (Pure)

Notch3 signalling and vascular remodelling in pulmonary arterial hypertension

Morris, H. E., Neves, K. B., Montezano, A. C., MacLean, M. R. & Touyz, R. M., 23 Dec 2019, In : Clinical Science. 133, 24, p. 2481-2498 18 p.

Research output: Contribution to journalReview article

Open Access
File

Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension

Mair, K., Harvey, K. Y., Henry, A., Hillyard, D., Nilsen, M. & MacLean, M., 30 Jun 2019, In : European Respiratory Journal. 53, 6, 1801524.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
1 Downloads (Pure)
2020

Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension

Denver, N., Homer, N. Z. M., Andrew, R., Harvey, K. Y., Morrell, N., Austin, E. D. & MacLean, M. R., 13 Feb 2020, In : Pulmonary Circulation. 10, 1, 5 p.

Research output: Contribution to journalArticle

Open Access
File

Understanding longitudinal biventricular structural and functional changes in a pulmonary hypertension Sugen–hypoxia rat model by cardiac magnetic resonance imaging

Jayasekera, G., Wilson, K. S., Buist, H., Woodward, R., Uckan, A., Hughes, C., Nilsen, M., Church, A. C., Johnson, M. K., Gallagher, L., Mullin, J., MacLean, M. R., Holmes, W. M., Peacock, A. J. & Welsh, D. J., 1 Jan 2020, In : Pulmonary Circulation. 10, 1, 11 p.

Research output: Contribution to journalArticle

Open Access
File