Mandy obtained her PhD in Pharmacology from the University of Edinburgh in 1985 and then spend a year in the USA and three years in Cambridge before moving to The University of Glasgow in 1989. Mandy joined SIPBS in 2019. Her research has focused on the role of serotonin in the development of pulmonary arterial hypertension (PAH). As more women get PAH than men, more recently her work has focused on sex effects and oestrogen metabolism in PAH.  She has a BHF programme grant and recently won the 2017 Reynold Spector Award for Clinical Pharmacology from the American Society for Pharmacology and Experimental Therapeutics (ASPET). Other research awards include a Royal Society Wolfson Research Merit Award in 2010 and a Royal Society Leverhulme Trust Senior Research Fellowship in 2013. In 2013 she was elected as a Fellow of The Royal Society of Edinburgh (FRSE) and awarded the British Pharmacological Society AstraZeneca Prize for Women in Pharmacology. She was elected as an Ordinary Member and Trustee of Council for the Royal Society of Edinburgh and was Vice-President (Life Sciences) of the Royal Society of Edinburgh. Mandy received an MBE in the 2010 Queen’s New Years Honours list for her career and public engagement activities. She plays a key role in the University’s public engagement agenda and co-hosted monthly events for Glasgow’s Cafe Scientifique (2004-2023). In 2018 she was made a Fellow of the Academy of Medical Sciences and was the Scottish Champion for the Academy of Medical Sciences in 2018-19. In July 2019 Mandy was awarded the title of 'Distinguished Professor' by The University of Strathclyde. In December 2020 Mandy was elected onto Council of The Academy of Medical Sciences and  is their Council EDI champion and Chair of their Mentoring Advisory Group. Mandy is also a trustee of, and sits on the Board of, the Glasgow Children's Hospital Charity. In 2024 Mandy won the prestigious American Thoracic Society Pulmonary Circulation Assembly award for Leadership which is given annually in the ‘Appreciation of Decades of Leadership and Devoted Service to the Pulmonary Circulation Research Community’. Mandy now holds Emeritus status.