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Research Output 2008 2018

2018
1 Citation (Scopus)

Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse

Kouskou, M., Thomson, D. M., Brett, R. R., Wheeler, L., Tate, R. J., Pratt, J. A. & Chamberlain, L. H., 31 Oct 2018, In : Experimental Neurology. 308, p. 35-46 12 p.

Research output: Contribution to journalArticle

Open Access
File
Intellectual Disability
Acylation
Corpus Callosum
Protein S
Genes
3 Citations (Scopus)

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

Fort, L., Batista, J. M., Thomason, P. A., Spence, H. J., Whitelaw, J. A., Tweedy, L., Greaves, J., Martin, K. J., Anderson, K. I., Brown, P., Lilla, S., Neilson, M. P., Tafelmeyer, P., Zanivan, S., Ismail, S., Bryant, D. M., Tomkinson, N. C. O., Chamberlain, L. H., Mastick, G. S., Insall, R. H. & 1 othersMachesky, L. M., 24 Sep 2018, In : Nature Cell Biology. 20, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

Open Access
File
Pseudopodia
Cicatrix
Actins
Optogenetics
Chemotaxis

LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein

Sutherland, L., Ruhe, M., Gattegno-Ho, D., Mann, K., Greaves, J., Koscielniak, M., Meek, S., Lu, Z., Waterfall, M., Taylor, R., Tsakiridis, A., Brown, H., Maciver, S. K., Joshi, A., Clinton, M., Chamberlain, L. H., Smith, A. & Burdon, T., 20 Sep 2018, In : Journal of Cell Science. 13 p.

Research output: Contribution to journalArticle

Open Access
File
Leukemia Inhibitory Factor
Embryonic Stem Cells
Phosphatidylinositol 3-Kinases
Proteins
Lipoylation
2 Citations (Scopus)

S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19

Ampah, K. K., Greaves, J., Shun-Shion, A. S. M., Asnawi, A. W. B. A., Lidster, J. A., Chamberlain, L. H., Collins, M. O. & Peden, A. A., 25 Sep 2018, In : Journal of Cell Science. 48 p.

Research output: Contribution to journalArticle

Open Access
File
Q-SNARE Proteins
Acylation
Endosomes
Qa-SNARE Proteins
Acyltransferases
3 Citations (Scopus)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In : Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
Toll-Like Receptor 3
Poly I-C
Neurons
Induced Pluripotent Stem Cells
Miniature Postsynaptic Potentials
1 Citation (Scopus)
Open Access
File
Alkynes
alkynes
fatty acids
Fatty acids
Lipids
2017
5 Citations (Scopus)
Open Access
File
Neuronal Ceroid-Lipofuscinoses
1-(3'-methoxy-4'-hydroxy-phenyl)-6,7-dihydroxyisochroman
Cysteine
Mutant Proteins
Leucine
28 Citations (Scopus)

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry

Greaves, J., Munro, K. R., Davidson, S. C., Riviere, M., Wojno, J., Smith, T. K., Tomkinson, N. C. O. & Chamberlain, L. H., 6 Feb 2017, In : Proceedings of the National Academy of Sciences . 114, 8, 10 p.

Research output: Contribution to journalArticle

Open Access
File
Click Chemistry
Acyltransferases
Fatty Acids
Enzymes
Acyl Coenzyme A
2 Citations (Scopus)

Peptide array–based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase

Lemonidis, K., MacLeod, R., Baillie, G. S. & Chamberlain, L. H., 20 Oct 2017, In : Journal of Biological Chemistry. 292, 42, p. 17190-17202 13 p.

Research output: Contribution to journalArticle

Open Access
File
Ankyrin Repeat
Acyltransferases
Screening
Synaptosomal-Associated Protein 25
Peptides
4 Citations (Scopus)

Substrate selectivity in the zDHHC family of S-acyltransferases

Lemonidis, K., Salaun, C., Kouskou, M., Diez-Ardanuy, C., Chamberlain, L. H. & Greaves, J., 15 Jun 2017, In : Biochemical Society Transactions. 45, 3, p. 751-758 8 p.

Research output: Contribution to journalArticle

Open Access
File
Acyltransferases
Acylation
Substrates
Enzymes
Acyl Coenzyme A
2 Citations (Scopus)
Open Access
File
Neuroendocrine Cells
Acylation
Cell Membrane
Ionotropic Glutamate Receptors
Acyltransferases
2016
7 Citations (Scopus)

Obesogenic and diabetogenic effects of high-calorie nutrition require adipocyte BK channels

Illison, J., Tian, L., McClafferty, H., Werno, M., Chamberlain, L. H., Leiss, V., Sassmann, A., Offermanns, S., Ruth, P., Shipston, M. J. & Lukowski, R., 7 Sep 2016, In : Diabetes.

Research output: Contribution to journalArticle

Open Access
File
Large-Conductance Calcium-Activated Potassium Channels
Adipocytes
Weight Gain
Body Weight
Adipose Tissue
2015
20 Citations (Scopus)

Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases

Lemonidis, K., Sanchez-Perez, M. C. & Chamberlain, L. H., 4 Sep 2015, In : Journal of Biological Chemistry. 24 p.

Research output: Contribution to journalArticle

Open Access
File
Ankyrin Repeat
Transferases
Zinc Fingers
Zinc
Acylation
4 Citations (Scopus)
Open Access
File
Acylation
Cysteine
Protein S
Adipocytes
Facilitative Glucose Transport Proteins
80 Citations (Scopus)

The physiology of protein S-acylation

Chamberlain, L. H. & Shipston, M. J., 1 Apr 2015, In : Physiological Reviews. 95, 2, p. 341-376 36 p.

Research output: Contribution to journalLiterature review

Open Access
File
Acylation
Protein S
Protein Array Analysis
Proteins
Lipids
8 Citations (Scopus)

The zDHHC family of S-acyltransferases

Lemonidis, K., Werno, M. W., Greaves, J., Diez Ardanuy, C., Sanchez Perez, M. C., Salaun, C., Thomson, D. M. & Chamberlain, L. H., Apr 2015, In : Biochemical Society Transactions. 43, 2, p. 217-221 5 p.

Research output: Contribution to journalArticle

Open Access
File
Acyltransferases
Enzymes
Acylation
Protein S
Physiology
2014
12 Citations (Scopus)

A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion

Kavanagh, D. M., Smyth, A. M., Martin, K. J., Dun, A., Brown, E. R., Gordon, S., Smillie, K. J., Chamberlain, L. H., Wilson, R. S., Yang, L., Lu, W., Cousin, M. A., Rickman, C. & Duncan, R. R., 17 Dec 2014, In : Nature Communications. 5, 14 p., 5774.

Research output: Contribution to journalArticle

Open Access
File
synapses
Exocytosis
Synapses
SNARE Proteins
Fusion reactions
18 Citations (Scopus)

New links between S-acylation and cancer

Greaves, J. & Chamberlain, L., May 2014, In : Journal of Pathology. 233, 1, p. 4-6 3 p.

Research output: Contribution to journalLiterature review

Acylation
Enzymes
Lipoylation
Neoplasms
Intracellular Membranes
17 Citations (Scopus)

The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity

Lemonidis, K., Gorleku, O. A., Sanchez Perez, M. C., Grefen, C. & Chamberlain, L. H., 1 Dec 2014, In : Molecular Biology of the Cell. 25, 24, p. 3870-3883 14 p.

Research output: Contribution to journalArticle

Open Access
File
Acylation
Enzymes
Membrane Proteins
Synaptosomal-Associated Protein 25
Ankyrin Repeat
2013

Evolving views on protein palmitoylation (Comment on DOI 10.1002/bies.201300076)

Chamberlain, L., Nov 2013, In : BioEssays. 35, 11, p. 928 1 p.

Research output: Contribution to journalLiterature review

Lipoylation
Proteins
18 Citations (Scopus)

Palmitoylation and the trafficking of peripheral membrane proteins

Chamberlain, L., Lemonidis, K., Sanchez Perez, M. C., Werno, M., Gorleku, O. A. & Greaves, J., 1 Feb 2013, In : Biochemical Society Transactions. 41, 1, p. 62-66 5 p.

Research output: Contribution to journalArticle

Lipoylation
Membrane Proteins
Palmitates
Post Translational Protein Processing
Cytosol
9 Citations (Scopus)

The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif.

Billcliff, P. G., Gorleku, O. A., Chamberlain, L. & Banting, G., 15 Nov 2013, In : Open Biology. 2, 11, p. 1253-1263 11 p.

Research output: Contribution to journalArticle

Open Access
File
Membrane Microdomains
Membranes
Anchors
Cytology
Virus Release
2012
32 Citations (Scopus)

Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis

Greaves, J., Lemonidis, K., Gorleku, O., Cruchaga, C., Grefen, C. & Chamberlain, L., 26 Oct 2012, In : Journal of Biological Chemistry. 287, 44, p. 37330-37339 10 p.

Research output: Contribution to journalArticle

Ceroid
Lipoylation
Neuronal Ceroid-Lipofuscinoses
Mutant Proteins
Agglomeration
2011
176 Citations (Scopus)

DHHC palmitoyl transferases: substrate interactions and (patho)physiology

Greaves, J. & Chamberlain, L. H., May 2011, In : Trends in Biochemical Sciences . 36, 5, p. 245-253 9 p.

Research output: Contribution to journalArticle

Physiology
Lipoylation
Transferases
Substrates
Histidine
28 Citations (Scopus)

Differential palmitoylation regulates intracellular patterning of SNAP25

Greaves, J. & Chamberlain, L. H., 2011, In : Journal of Cell Science. 124, 8, p. 1351-1360 10 p.

Research output: Contribution to journalArticle

Lipoylation
Endosomes
Cysteine
trans-Golgi Network
Cell Membrane
29 Citations (Scopus)

Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals

Gorleku, O. A., Barns, A-M., Prescott, G. R., Greaves, J. & Chamberlain, L. H., 11 Nov 2011, In : Journal of Biological Chemistry . 286, p. 39573-39584 12 p.

Research output: Contribution to journalArticle

Sorting
Endoplasmic Reticulum
Lipoylation
Lysine
Membranes
18 Citations (Scopus)

Regional and developmental brain expression patterns of SNAP25 splice variants

Prescott, G. R. & Chamberlain, L. H., 28 Apr 2011, In : BMC Neuroscience. 12, 9 p., 35.

Research output: Contribution to journalArticle

Open Access
File
Synaptosomal-Associated Protein 25
SNARE Proteins
Messenger RNA
Exocytosis
Brain
36 Citations (Scopus)

The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain

Greaves, J., Carmichael, J. A. & Chamberlain, L. H., 1 Jun 2011, In : Molecular Biology of the Cell. 22, 11, p. 1887-1895 9 p.

Research output: Contribution to journalArticle

Transferases
Lipoylation
Membranes
Endosomes
Cell Membrane
2010
5 Citations (Scopus)

Palmitoylation and testis-enriched expression of the cysteine-string protein beta isoform

Gorleku, O. A. & Chamberlain, L. H., 26 May 2010, In : Biochemistry. 49, 25, p. 5308-5313 6 p.

Research output: Contribution to journalArticle

Lipoylation
Testis
Protein Isoforms
Cysteine
Membranes
61 Citations (Scopus)

Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases

Greaves, J., Gorleku, O. A., Salaun, C. & Chamberlain, L. H., 6 Aug 2010, In : Journal of Biological Chemistry . 285, 32, p. 24629-24638 10 p.

Research output: Contribution to journalArticle

Synaptosomal-Associated Protein 25
Lipoylation
Transferases
Cysteine
PC12 Cells
9 Citations (Scopus)

Regulation of SNAP-25 trafficking and function by palmitoylation

Greaves, J., Prescott, G. R., Gorleku, O. A. & Chamberlain, L. H., 2010, In : Biochemical Society Transactions. 38, 1, p. 163-166 4 p.

Research output: Contribution to journalArticle

Lipoylation
SNARE Proteins
Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins
Synaptosomal-Associated Protein 25
Neuroendocrine Cells
10 Citations (Scopus)

S-acylation by the DHHC protein family

Greaves, J. & Chamberlain, L. H., 2010, In : Biochemical Society Transactions. 38, 2, p. 522-524 3 p.

Research output: Contribution to journalArticle

Acylation
Acyltransferases
Protein S
Substrate Specificity
Proteins
168 Citations (Scopus)

The intracellular dynamic of protein palmitoylation

Salaun, C., Greaves, J. & Chamberlain, L. H., 27 Dec 2010, In : Journal of Cell Biology. 191, 7, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

Lipoylation
Post Translational Protein Processing
Proteins
Intracellular Membranes
Palmitates
51 Citations (Scopus)

t-SNARE protein conformations patterned by the lipid microenvironment

Rickman, C., Medine, C. N., Dun, A. R., Moulton, D. J., Mandula, O., Halemani, N. D., Rizzoli, S. O., Chamberlain, L. H. & Duncan, R. R., 30 Apr 2010, In : Journal of Biological Chemistry . 285, 18, p. 13535-13541 7 p.

Research output: Contribution to journalArticle

SNARE Proteins
Protein Conformation
Conformations
Lipids
Cell membranes
2009
34 Citations (Scopus)

Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity

Bournazos, S., Hart, S. P., Chamberlain, L. H., Glennie, M. J. & Dransfield, I., 15 Jun 2009, In : Journal of Immunology. 182, 12, p. 8026-8036 11 p.

Research output: Contribution to journalArticle

Ligands
Lipids
Immunoglobulin G
Myeloid Cells
Cholesterol
40 Citations (Scopus)

Palmitoylation of the synaptic vesicle fusion machinery

Prescott, G. R., Gorleku, O. A., Greaves, J. & Chamberlain, L. H., Aug 2009, In : Journal of Neurochemistry. 110, 4, p. 1135-1149 15 p.

Research output: Contribution to journalArticle

Lipoylation
Synaptic Vesicles
Vesicle-Associated Membrane Protein 2
Machinery
Syntaxin 1
45 Citations (Scopus)

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Greaves, J., Prescott, G. R., Gorleku, O. A. & Chamberlain, L. H., 2009, In : Molecular Membrane Biology. 26, 1, p. 67-79 13 p.

Research output: Contribution to journalLiterature review

Lipoylation
Membrane Microdomains
Protein Transport
Fats
Palmitic Acid
52 Citations (Scopus)

The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases

Greaves, J., Prescott, G. R., Fukata, Y., Fukata, M., Salaun, C. & Chamberlain, L. H., 15 Mar 2009, In : Molecular Biology of the Cell. 20, 6, p. 1845-1854 10 p.

Research output: Contribution to journalArticle

Transferases
Cysteine
Membranes
HEK293 Cells
Proline
76 Citations (Scopus)

The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice

Greenshields, K. N., Halstead, S. K., Zitman, F. M. P., Rinaldi, S., Brennan, K. M., O'Leary, C., Chamberlain, L. H., Easton, A., Roxburgh, J., Pediani, J., Furukawa, K., Furukawa, K., Goodyear, C. S., Plomp, J. J. & Willison, H. J., 2 Mar 2009, In : Journal of Clinical Investigation. 119, 3, p. 595-610 16 p.

Research output: Contribution to journalArticle

Glycolipids
Autoantibodies
Anti-Idiotypic Antibodies
Membranes
Gangliosides
2008
73 Citations (Scopus)

Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein

Greaves, J., Salaun, C., Fukata, Y., Fukata, M. & Chamberlain, L. H., 5 Sep 2008, In : Journal of Biological Chemistry. 283, 36, p. 25014-25026 13 p.

Research output: Contribution to journalArticle

Lipoylation
Membranes
Endoplasmic Reticulum
Brefeldin A
Transferases
75 Citations (Scopus)

Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels

Tian, L., Jeffries, O., McClafferty, H., Molyvdas, A., Rowe, I. C. M., Saleem, F., Chen, L., Greaves, J., Chamberlain, L. H., Knaus, H-G., Ruth, P. & Shipston, M. J., 30 Dec 2008, In : Proceedings of the National Academy of Sciences . 105, 52, p. 21006-21011 6 p.

Research output: Contribution to journalArticle

Lipoylation
Large-Conductance Calcium-Activated Potassium Channels
Potassium Channels
Cyclic AMP-Dependent Protein Kinases
Phosphorylation