20082020

Research output per year

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Research Output

2020

Accessory proteins of the zDHHC family of S-acylation enzymes

Salaun, C., Locatelli, C., Zmuda, F., Cabrera González, J. & Chamberlain, L. H., 10 Sep 2020, (Accepted/In press) In : Journal of Cell Science. 25 p.

Research output: Contribution to journalArticle

Open Access
File
2 Downloads (Pure)
Open Access
File
3 Downloads (Pure)
2018

Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse

Kouskou, M., Thomson, D. M., Brett, R. R., Wheeler, L., Tate, R. J., Pratt, J. A. & Chamberlain, L. H., 31 Oct 2018, In : Experimental Neurology. 308, p. 35-46 12 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
32 Downloads (Pure)

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

Fort, L., Batista, J. M., Thomason, P. A., Spence, H. J., Whitelaw, J. A., Tweedy, L., Greaves, J., Martin, K. J., Anderson, K. I., Brown, P., Lilla, S., Neilson, M. P., Tafelmeyer, P., Zanivan, S., Ismail, S., Bryant, D. M., Tomkinson, N. C. O., Chamberlain, L. H., Mastick, G. S., Insall, R. H. & 1 others, Machesky, L. M., 24 Sep 2018, In : Nature Cell Biology. 20, p. 1159-1171 13 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
13 Downloads (Pure)

LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein

Sutherland, L., Ruhe, M., Gattegno-Ho, D., Mann, K., Greaves, J., Koscielniak, M., Meek, S., Lu, Z., Waterfall, M., Taylor, R., Tsakiridis, A., Brown, H., Maciver, S. K., Joshi, A., Clinton, M., Chamberlain, L. H., Smith, A. & Burdon, T., 20 Sep 2018, In : Journal of Cell Science. 13 p.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
9 Downloads (Pure)

S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19

Ampah, K. K., Greaves, J., Shun-Shion, A. S. M., Asnawi, A. W. B. A., Lidster, J. A., Chamberlain, L. H., Collins, M. O. & Peden, A. A., 25 Sep 2018, In : Journal of Cell Science. 48 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
28 Downloads (Pure)

Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons

Ritchie, L., Tate, R., Chamberlain, L. H., Robertson, G., Zagnoni, M., Sposito, T., Wray, S., Wright, J. A., Bryant, C. E., Gay, N. J. & Bushell, T. J., 30 Jun 2018, In : Neuropharmacology. 135, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
11 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
37 Downloads (Pure)
2017
Open Access
File
11 Citations (Scopus)
81 Downloads (Pure)

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry

Greaves, J., Munro, K. R., Davidson, S. C., Riviere, M., Wojno, J., Smith, T. K., Tomkinson, N. C. O. & Chamberlain, L. H., 6 Feb 2017, In : Proceedings of the National Academy of Sciences . 114, 8, 10 p.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
114 Downloads (Pure)

Peptide array–based screening reveals a large number of proteins interacting with the ankyrin-repeat domain of the zDHHC17 S-acyltransferase

Lemonidis, K., MacLeod, R., Baillie, G. S. & Chamberlain, L. H., 20 Oct 2017, In : Journal of Biological Chemistry. 292, 42, p. 17190-17202 13 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
23 Downloads (Pure)

Substrate selectivity in the zDHHC family of S-acyltransferases

Lemonidis, K., Salaun, C., Kouskou, M., Diez-Ardanuy, C., Chamberlain, L. H. & Greaves, J., 15 Jun 2017, In : Biochemical Society Transactions. 45, 3, p. 751-758 8 p.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
44 Downloads (Pure)
6 Citations (Scopus)
16 Downloads (Pure)
2016

Obesogenic and diabetogenic effects of high-calorie nutrition require adipocyte BK channels

Illison, J., Tian, L., McClafferty, H., Werno, M., Chamberlain, L. H., Leiss, V., Sassmann, A., Offermanns, S., Ruth, P., Shipston, M. J. & Lukowski, R., 7 Sep 2016, In : Diabetes.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
37 Downloads (Pure)
2015

Identification of a novel sequence motif recognised by the ankyrin-repeat domain of zDHHC17/13 S-acyl-transferases

Lemonidis, K., Sanchez-Perez, M. C. & Chamberlain, L. H., 4 Sep 2015, In : Journal of Biological Chemistry. 24 p.

Research output: Contribution to journalArticle

Open Access
File
30 Citations (Scopus)
116 Downloads (Pure)
Open Access
File
7 Citations (Scopus)
61 Downloads (Pure)

The physiology of protein S-acylation

Chamberlain, L. H. & Shipston, M. J., 1 Apr 2015, In : Physiological Reviews. 95, 2, p. 341-376 36 p.

Research output: Contribution to journalLiterature review

Open Access
File
111 Citations (Scopus)
171 Downloads (Pure)

The zDHHC family of S-acyltransferases

Lemonidis, K., Werno, M. W., Greaves, J., Diez Ardanuy, C., Sanchez Perez, M. C., Salaun, C., Thomson, D. M. & Chamberlain, L. H., Apr 2015, In : Biochemical Society Transactions. 43, 2, p. 217-221 5 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
215 Downloads (Pure)
2014

A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion

Kavanagh, D. M., Smyth, A. M., Martin, K. J., Dun, A., Brown, E. R., Gordon, S., Smillie, K. J., Chamberlain, L. H., Wilson, R. S., Yang, L., Lu, W., Cousin, M. A., Rickman, C. & Duncan, R. R., 17 Dec 2014, In : Nature Communications. 5, 14 p., 5774.

Research output: Contribution to journalArticle

Open Access
File
13 Citations (Scopus)
39 Downloads (Pure)

New links between S-acylation and cancer

Greaves, J. & Chamberlain, L., May 2014, In : Journal of Pathology. 233, 1, p. 4-6 3 p.

Research output: Contribution to journalLiterature review

20 Citations (Scopus)

The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity

Lemonidis, K., Gorleku, O. A., Sanchez Perez, M. C., Grefen, C. & Chamberlain, L. H., 1 Dec 2014, In : Molecular Biology of the Cell. 25, 24, p. 3870-3883 14 p.

Research output: Contribution to journalArticle

Open Access
File
25 Citations (Scopus)
214 Downloads (Pure)
2013

Evolving views on protein palmitoylation (Comment on DOI 10.1002/bies.201300076)

Chamberlain, L., Nov 2013, In : BioEssays. 35, 11, p. 928 1 p.

Research output: Contribution to journalLiterature review

Palmitoylation and the trafficking of peripheral membrane proteins

Chamberlain, L., Lemonidis, K., Sanchez Perez, M. C., Werno, M., Gorleku, O. A. & Greaves, J., 1 Feb 2013, In : Biochemical Society Transactions. 41, 1, p. 62-66 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

The cytosolic N-terminus of CD317/tetherin is a membrane microdomain exclusion motif.

Billcliff, P. G., Gorleku, O. A., Chamberlain, L. & Banting, G., 15 Nov 2013, In : Open Biology. 2, 11, p. 1253-1263 11 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
50 Downloads (Pure)
2012

Palmitoylation-induced aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis

Greaves, J., Lemonidis, K., Gorleku, O., Cruchaga, C., Grefen, C. & Chamberlain, L., 26 Oct 2012, In : Journal of Biological Chemistry. 287, 44, p. 37330-37339 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2011

DHHC palmitoyl transferases: substrate interactions and (patho)physiology

Greaves, J. & Chamberlain, L. H., May 2011, In : Trends in Biochemical Sciences . 36, 5, p. 245-253 9 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)

Differential palmitoylation regulates intracellular patterning of SNAP25

Greaves, J. & Chamberlain, L. H., 2011, In : Journal of Cell Science. 124, 8, p. 1351-1360 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals

Gorleku, O. A., Barns, A-M., Prescott, G. R., Greaves, J. & Chamberlain, L. H., 11 Nov 2011, In : Journal of Biological Chemistry . 286, p. 39573-39584 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Regional and developmental brain expression patterns of SNAP25 splice variants

Prescott, G. R. & Chamberlain, L. H., 28 Apr 2011, In : BMC Neuroscience. 12, 9 p., 35.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
9 Downloads (Pure)

The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain

Greaves, J., Carmichael, J. A. & Chamberlain, L. H., 1 Jun 2011, In : Molecular Biology of the Cell. 22, 11, p. 1887-1895 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2010

Palmitoylation and testis-enriched expression of the cysteine-string protein beta isoform

Gorleku, O. A. & Chamberlain, L. H., 26 May 2010, In : Biochemistry. 49, 25, p. 5308-5313 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Palmitoylation of the SNAP25 protein family: specificity and regulation by DHHC palmitoyl transferases

Greaves, J., Gorleku, O. A., Salaun, C. & Chamberlain, L. H., 6 Aug 2010, In : Journal of Biological Chemistry . 285, 32, p. 24629-24638 10 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Regulation of SNAP-25 trafficking and function by palmitoylation

Greaves, J., Prescott, G. R., Gorleku, O. A. & Chamberlain, L. H., 2010, In : Biochemical Society Transactions. 38, 1, p. 163-166 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

S-acylation by the DHHC protein family

Greaves, J. & Chamberlain, L. H., 2010, In : Biochemical Society Transactions. 38, 2, p. 522-524 3 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The intracellular dynamic of protein palmitoylation

Salaun, C., Greaves, J. & Chamberlain, L. H., 27 Dec 2010, In : Journal of Cell Biology. 191, 7, p. 1229-1238 10 p.

Research output: Contribution to journalArticle

189 Citations (Scopus)

t-SNARE protein conformations patterned by the lipid microenvironment

Rickman, C., Medine, C. N., Dun, A. R., Moulton, D. J., Mandula, O., Halemani, N. D., Rizzoli, S. O., Chamberlain, L. H. & Duncan, R. R., 30 Apr 2010, In : Journal of Biological Chemistry . 285, 18, p. 13535-13541 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2009

Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity

Bournazos, S., Hart, S. P., Chamberlain, L. H., Glennie, M. J. & Dransfield, I., 15 Jun 2009, In : Journal of Immunology. 182, 12, p. 8026-8036 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Palmitoylation of the synaptic vesicle fusion machinery

Prescott, G. R., Gorleku, O. A., Greaves, J. & Chamberlain, L. H., Aug 2009, In : Journal of Neurochemistry. 110, 4, p. 1135-1149 15 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Greaves, J., Prescott, G. R., Gorleku, O. A. & Chamberlain, L. H., 2009, In : Molecular Membrane Biology. 26, 1, p. 67-79 13 p.

Research output: Contribution to journalLiterature review

51 Citations (Scopus)

The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferases

Greaves, J., Prescott, G. R., Fukata, Y., Fukata, M., Salaun, C. & Chamberlain, L. H., 15 Mar 2009, In : Molecular Biology of the Cell. 20, 6, p. 1845-1854 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice

Greenshields, K. N., Halstead, S. K., Zitman, F. M. P., Rinaldi, S., Brennan, K. M., O'Leary, C., Chamberlain, L. H., Easton, A., Roxburgh, J., Pediani, J., Furukawa, K., Furukawa, K., Goodyear, C. S., Plomp, J. J. & Willison, H. J., 2 Mar 2009, In : Journal of Clinical Investigation. 119, 3, p. 595-610 16 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2008

Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein

Greaves, J., Salaun, C., Fukata, Y., Fukata, M. & Chamberlain, L. H., 5 Sep 2008, In : Journal of Biological Chemistry. 283, 36, p. 25014-25026 13 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels

Tian, L., Jeffries, O., McClafferty, H., Molyvdas, A., Rowe, I. C. M., Saleem, F., Chen, L., Greaves, J., Chamberlain, L. H., Knaus, H-G., Ruth, P. & Shipston, M. J., 30 Dec 2008, In : Proceedings of the National Academy of Sciences . 105, 52, p. 21006-21011 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)