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19972020

Research output per year

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Article
2019
Open Access
File
11 Citations (Scopus)
15 Downloads (Pure)
2018

Dataset on the kinetics of the inhibition of PTP1B by the flavonoids and pheophytin A from Allophylus cominia

Semaan, D. G., Igoli, J. O., Young, L., Marrero, E., Gray, A. I. & Rowan, E. G., 1 Apr 2018, In : Data in Brief. 17, p. 401-406 6 p.

Research output: Contribution to journalArticle

Open Access
File
29 Downloads (Pure)
Open Access
File
12 Citations (Scopus)
29 Downloads (Pure)

Metabolomic-guided isolation of bioactive natural products from Curvularia sp., an endophytic fungus of Terminalia laxiflora

Tawfike, A. F., Abbott, G., Young, L. & Edrada-Ebel, R., 28 Feb 2018, In : Planta Medica. 84, 3, p. 182-190 10 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
15 Downloads (Pure)
2017
Open Access
File
15 Citations (Scopus)
29 Downloads (Pure)

Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers

Anthony, N. G., Baiget, J., Berretta, G., Boyd, M., Breen, D., Edwards, J., Gamble, C., Gray, A. I., Harvey, A. L., Hatziieremia, S., Ho, K. H., Huggan, J. K., Lang, S., Llona-Minguez, S., Luo, J. L., McIntosh, K., Paul, A., Plevin, R. J., Robertson, M. N., Scott, R. & 4 others, Suckling, C. J., Sutcliffe, O. B., Young, L. C. & MacKay, S. P., 24 Jul 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
138 Downloads (Pure)

In vitro anti-diabetic activity of flavonoids and pheophytins from Allophylus cominia Sw . on PTP1B, DPPIV, alpha-glucosidase and alpha-amylase enzymes

Semaan, D. G., Igoli, J. O., Young, L., Marrero, E., Gray, A. I. & Rowan, E. G., 5 May 2017, In : Journal of Ethnopharmacology. 203, p. 39-46 8 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
47 Downloads (Pure)

Metabolomic profiling of the synergistic effects of melittin in combination with cisplatin on ovarian cancer cells

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J-K., Jeon, J-W., Ferro, V. A. & Watson, D. G., 14 Apr 2017, In : Metabolites. 7, 14, p. 1-18 18 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
89 Downloads (Pure)

Metabolomic tools to assess the chemistry and bioactivity of endophytic aspergillus strain

Tawfike, A. F., Tate, R., Abbott, G., Young, L., Viegelmann, C., Schumacher, M., Diederich, M. & Edrada-Ebel, R. A., 3 Jul 2017, In : Chemistry and Biodiversity.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
108 Downloads (Pure)

Structure-activity relationships of small molecule autotaxin inhibitors with a discrete binding mode

Miller, L. M., Keune, W-J., Castagna, D., Young, L. C., Duffy, E. L., Potjewyd, F., Salgado-Polo, F., Garcia, P. E., Semaan, D., Pritchard, J. M., Perrakis, A., Macdonald, S. J. F., Jamieson, C. & Watson, A. J. B., 26 Jan 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 722-748 27 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
58 Downloads (Pure)
2016

Antimicrobial properties and cytotoxicity of sulfated (1,3)-β-D-glucan from the mycelium of the mushroom Ganoderma lucidum

Wan-Mohtar, W. A. A. Q. I., Young, L., Abbott, G. M., Clements, C., Harvey, L. M. & McNeil, B., 24 Feb 2016, In : Journal of Microbiology and Biotechnology. 26, 6, p. 999-1010 12 p.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
33 Downloads (Pure)

Effect of bee venom and its fractions on the release of pro-inflammatory cytokines in PMA-differentiated U937 cells co-stimulated with LPS

Tusiimire, J., Wallace, J., Woods, N., Dufton, M. J., Parkinson, J. A., Abbott, G., Clements, C. J., Young, L., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 19 Apr 2016, In : Vaccines. 4, 2, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
File
6 Citations (Scopus)
80 Downloads (Pure)

Metabolomic profiling of the effects of melittin on cisplatin resistant and cisplatin sensitive ovarian cancer cells using mass spectrometry and biolog microarray technology

Alonezi, S., Tusiimire, J., Wallace, J., Dufton, M. J., Parkinson, J. A., Young, L. C., Clements, C. J., Park, J. K., Jeon, J. W., Ferro, V. A. & Watson, D. G., 13 Oct 2016, In : Metabolites. 6, 4, 18 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
62 Downloads (Pure)

Using molecular networking for microbial secondary metabolite bioprospecting

Purves, K., Macintyre, L., Brennan, D., Hreggviðsson, G. Ó., Kuttner, E., Ásgeirsdóttir, M. E., Young, L. C., Green, D. H., Edrada-Ebel, R. & Duncan, K., 8 Jan 2016, In : Metabolites. 6, 1, 18 p., 2.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
87 Downloads (Pure)
2015

An LCMS method for the assay of melittin in cosmetic formulations containing bee venom

Tusiimire, J., Wallace, J., Dufton, M., Parkinson, J., Clements, C. J., Young, L., Park, J. K., Jeon, J. W. & Watson, D. G., 8 Mar 2015, In : Analytical and Bioanalytical Chemistry. 407, 13, p. 3627-3635 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Identification of a novel class of autotaxin inhibitors through cross-screening

Castagna, D., Duffy, E. L., Semaan, D., Young, L. C., Pritchard, J. M., Macdonald, S. J. F., Budd, D. C., Jamieson, C. & Watson, A. J. B., 1 Jun 2015, In : MedChemComm. 2015, 6, p. 1149-1155 6 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
65 Downloads (Pure)
2014

Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2

Translated title of the contribution: Inhibitory effect of Persea americana Mill leaf aqueous extract and its fractions on PTP1B as therapeutic target for type 2 diabetesMarrero-Faz, E., Sánchez-Calero, J., Young, L. & Harvey, A., 1 Jan 2014, In : Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas . 13, 2, p. 144-151 8 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
258 Downloads (Pure)

Efecto inhibitorio de un extracto acuoso de las hojas de Allophylus cominia (L.) Sw sobre las proteínas tirosina fosfatasa 1B y dipeptidil peptidasa IV

Translated title of the contribution: Inhibitory effect of Allophylus cominia (L.) Sw leaves aqueous extract on tyrosine phosphatase 1B and dipeptidyl peptidase IV proteinsSánchez Calero, J., Young, L. C., Marrero Faz, E. & L. Harvey, A., 30 Jun 2014, In : Revista Cubana de Farmacia. 48, 4, p. 672-683 12 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
25 Downloads (Pure)

Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge haliclona simulans

Viegelmann, C., Parker, J., Ooi, T., Clements, C., Abbott, G., Young, L., Kennedy, J., Dobson, A. D. W. & Edrada-Ebel, R., 16 May 2014, In : Marine Drugs. 12, 5, p. 2937-2952 16 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
71 Downloads (Pure)
2012

A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A(1) receptors and enhances consolidation of step-down avoidance

Harvey, A. L., Young, L. C., Kornisiuk, E., Snitcofsky, M., Colettis, N., Blanco, C., Jerusalinsky, D., Jamieson, A. G., Hartley, R. C. & Stone, T. W., 1 Oct 2012, In : Behavioural Brain Research. 234, 2, p. 184-191 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Species variation in small molecule components of animal vitreous

Mains, J., Tan, L. E., Zhang, W., Young, L., Shi, R. & Wilson, C., Jul 2012, In : Investigative Ophthalmology and Visual Science. 53, 8, p. 4778-4786 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2011

Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal alkaloids

Harvey, A. L., Young, L. C., Viljoen, A. M. & Gericke, N. P., 11 Oct 2011, In : Journal of Ethnopharmacology. 137, 3, p. 1124–1129 6 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Synthesis of a new series of 1H-imidazol-1-yl substituted 8-phenylxanthines as adenosine receptor ligands

Bansal, R., Kumar, G., Gandhi, D., Young, L. C. & Harvey, A. L., 2011, In : Chemistry and Biodiversity. 8, 7, p. 1290-1300 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Synthesis of quaternary ammonium salts of 16E-[4-(2-alkylaminoethoxy)-3-methoxybenzylidene]androstene derivatives as skeletal muscle relaxants

Bansal, R., Guleria, S., Young, L. C. & Harvey, A. L., Feb 2011, In : Steroids. 76, 3, p. 254-260 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2010

Glucose uptake stimulatory effect of akuammicine from picralima nitida (Apocynaceae)

Shittu, H., Gray, A., Furman, B. & Young, L., 12 Mar 2010, In : Phytochemistry Letters. 3, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Synthesis of 8-(cyclopentyloxy)phenyl substituted xanthine derivatives as adenosine A2A ligands

Bansal, R., Kumar, G., Gandhi, D., Yadav, R., Young, L. C. & Harvey, A. L., 2010, In : Arzneimittel Forschung. 60, 3, p. 131-136 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2009
18 Citations (Scopus)
2007

Group S8A serine proteases, including a novel enzyme cadeprin, induce long-lasting, metabotropic glutamate receptor-dependent synaptic depression in rat hippocampal slices

MacGregor, D. G., Mallon, A. P., Harvey, A. L., Young, L., Nimmo, H. G. & Stone, T. W., Oct 2007, In : European Journal of Neuroscience. 26, 7, p. 1870-80 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds

Suckling, C. J., Murphy, J. A., Khalaf, A. I., Zhou, S., Lizos, D. E., Nguyen Van Nhien, A., Yasumatsu, H., McVie, A., Young, L. C., McCraw, C., Waterman, P. G., Morris, B. J., Pratt, J. A. & Harvey, A., 1 May 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 9, p. 2649-2655 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
1997

A new potassium channel toxin from the sea anemone Heteractis magnifica: isolation, cDNA cloning, and functional expression

Gendeh, G. S., Young, L. C., de Medeiros, C. L., Jeyaseelan, K., Harvey, A. L. & Chung, M. C., 23 Sep 1997, In : BMC Biochemistry. 36, 38, p. 11461-11471 11 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
94 Citations (Scopus)