Leighton Pritchard

2025

The prevalence of Phytophthora in British plant nurseries: high-risk hosts and substrates and opportunities to influence practice

Green, S., Cooke, D. E. L., Barwell, L., Purse, B. V., Cock, P., Frederickson-Matika, D., Randall, E., Keillor, B., Pritchard, L., Thorpe, P., Pettit, T., Schlenzig, A. & Barbrook, J., 20 Jan 2025, (E-pub ahead of print) In: Plant Pathology. 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Downloads (Pure)

2024

LINgroups as a robust principled approach to compare and integrate multiple bacterial taxonomies

Mazloom, R., Pierce-Ward, N. T., Sharma, P., Pritchard, L., Brown, C. T., Vinatzer, B. A. & Heath, L. S., Nov 2024, In: IEEE/ACM Transactions on Computational Biology and Bioinformatics . 21, 6, p. 2304-2314 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Downloads (Pure)

Biological ammonium transporters: evolution and diversification

Williamson, G., Harris, T., Bizior, A., Hoskisson, P. A., Pritchard, L. & Javelle, A., 1 Sept 2024, In: FEBS Journal. 291, 17, p. 3786-3810 25 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

3 Citations (Scopus)

50 Downloads (Pure)

Genomic characterization of prophage elements in Clostridium clostridioforme: an understudied component of the intestinal microbiome

Humphrey, S., Marouli, A., Thümmler, K., Mullin, M., Pritchard, L. & Wall, D. M., 12 Aug 2024, In: Microbiology. 170, 8, 19 p., 001486.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

12 Downloads (Pure)

Genomic diversity of novel strains of mammalian gut microbiome derived Clostridium XIVa strains is driven by mobile genetic element acquisition

Kamat, M. T., Ormsby, M. J., Humphrey, S., Dixit, S., Thümmler, K., Lapsley, C., Crouch, K., Jukes, C., Hulme, H., Burchmore , R., Meikle, L. M., Pritchard, L. & Wall, D. M., 30 Jan 2024, Cold Spring Harbor, NY, p. 1-41, 41 p.

Research output: Working paper › Working Paper/Preprint

Open Access

File

25 Downloads (Pure)

Biological ammonium transporters from the Amt/Mep/Rh superfamily: mechanism, energetics, and technical limitations

Williamson, G., Bizior, A., Harris, T., Pritchard, L., Hoskisson, P. A. & Javelle, A., 1 Jan 2024, In: Bioscience Reports. 44, 1, 24 p., BSR20211209.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2 Citations (Scopus)

35 Downloads (Pure)

2023

THAPBI PICT - a fast, cautious, and accurate metabarcoding analysis pipeline

Cock, P., Cooke, D. E. L., Thorpe, P. & Pritchard, L., 18 Aug 2023, In: PeerJ. 11, 17 p., e15648.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

54 Downloads (Pure)

16S rRNA phylogeny and clustering is not a reliable proxy for genome-based taxonomy in Streptomyces

Kiepas, A. B., Hoskisson, P. A. & Pritchard, L., 15 Aug 2023, Ithaca, NY, p. 1-31, 31 p.

Research output: Working paper › Working Paper/Preprint

Open Access

File

86 Downloads (Pure)

cazy_webscraper: local compilation and interrogation of comprehensive CAZyme datasets

Hobbs, E. E. M., Gloster, T. M. & Pritchard, L., 14 Aug 2023, In: Microbial Genomics. 9, 8, 23 p., 001086.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

23 Downloads (Pure)

THAPBI PICT - a fast, cautious, and accurate metabarcoding analysis pipeline

Cock, P., Cooke, D. E. L., Thorpe, P. & Pritchard, L., 6 Apr 2023.

Research output: Working paper › Working Paper/Preprint

Open Access

2022

cazy_webscraper: local compilation and interrogation of comprehensive CAZyme datasets

Hobbs, E. E. M., Gloster, T. M. & Pritchard, L., 3 Dec 2022, (Submitted) Long Island, New York, NY, USA, 19 p.

Research output: Working paper

File

91 Downloads (Pure)

Exploiting breakdown in nonhost effector-target interactions to boost host disease resistance

McLellan, H., Harvey, S. E., Steinbrenner, J., Armstrong, M. R., He, Q., Clewes, R., Pritchard, L., Wang, W., Wang, S., Nussbaumer, T., Dohai, B., Luo, Q., Kumari, P., Duan, H., Roberts, A., Boevink, P. C., Neumann, C., Champouret, N., Hein, I. & Falter-Braun, P. & 3 others, Beynon, J., Denby, K. & Birch, P. R. J., 22 Aug 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 35, 12 p., e2114064119.

Research output: Contribution to journal › Article › peer-review

Open Access

File

22 Citations (Scopus)

28 Downloads (Pure)

LINgroups as a principled approach to compare and integrate multiple bacterial taxonomies

Mazloom, R., Pritchard, L., Brown, C. T., Vinatzer, B. A. & Heath, L. S., 7 Aug 2022, Proceedings of the 13th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics, BCB 2022: roceedings of the 13th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics. New York, N.Y., p. 1-7 7 p. 55. (Proceedings of the 13th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics, BCB 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book

Open Access

File

1 Citation (Scopus)

25 Downloads (Pure)

ActinoBase: tools and protocols for researchers working on Streptomyces and other filamentous actinobacteria

Feeney, M. A., Newitt, J. T., Addington, E., Algora-Gallardo, L., Allan, C., Balis, L., Birke, A. S., Castaño-Espriu, L., Charkoudian, L. K., Devine, R., Gayrard, D., Hamilton, J., Hennrich, O., Hoskisson, P. A., Keith-Baker, M., Klein, J. G., Kruasuwan, W., Mark, D. R., Mast, Y. & McHugh, R. E. & 24 others, McLean, T. C., Mohit, E., Munnoch, J. T., Murray, J., Noble, K., Otani, H., Parra, J., Pereira, C. F., Perry, L., Pintor-Escobar, L., Pritchard, L., Prudence, S. M. M., Russell, A. H., Schniete, J. K., Seipke, R. F., Sélem-Mojica, N., Undabarrena, A., Vind, K., van Wezel, G. P., Wilkinson, B., Worsley, S. F., Duncan, K. R., Fernández-Martínez, L. T. & Hutchings, M. I., 1 Jul 2022, In: Microbial Genomics. 8, 7, 11 p., 000824.

Research output: Contribution to journal › Article › peer-review

Open Access

File

8 Citations (Scopus)

46 Downloads (Pure)

genomeRxiv: a microbial whole-genome database and diagnostic marker design resource for classification, identification, and data sharing

Pritchard, L., Sharma, P., Mazloom, R., Pierce, T., Irber, L., Harrington, B., Heath, L., Brown, C. T. & Vinatzer, B., 27 May 2022, In: Access Microbiology . 4, 5, 1 p.

Research output: Contribution to journal › Conference Contribution › peer-review

Open Access

File

24 Downloads (Pure)

Could a focus on the "why" of taxonomy help taxonomy better respond to the needs of science and society?

Pritchard, L., Brown, C. T., Harrington, B., Heath, L. S., Pierce-Ward, N. T. & Vinatzer, B. A., 19 May 2022, In: Frontiers in Microbiology. 13, 4 p., 887310.

Research output: Contribution to journal › Article › peer-review

Open Access

File

1 Citation (Scopus)

24 Downloads (Pure)

Improved and extended multilocus sequence typing (MLST) scheme for Streptomyces reveals complex taxonomic structure

Kiepas, A., Hoskisson, P. A. & Pritchard, L., 4 Apr 2022, p. A148. 1 p.

Research output: Contribution to conference › Poster

Open Access

File

31 Downloads (Pure)

Could a focus on the "why" of taxonomy help taxonomy better respond to the needs of science and society?

Pritchard, L., Brown, C. T., Harrington, B., Heath, L. S., Pierce-Ward, N. T. & Vinatzer, B. A., 3 Mar 2022, Basel, Switzerland, p. 1-6, 6 p.

Research output: Working paper

Open Access

File

18 Downloads (Pure)

2021

Phyto-threats: addressing threats to UK forests and woodlands from phytophthora; identifying risks of spread in trade and methods for mitigation

Green, S., Cooke, D. E. L., Dunn, M., Barwell, L., Purse, B., Chapman, D. S., Valatin, G., Schlenzig, A., Barbrook, J., Pettit, T., Price, C., Pérez-Sierra, A., Frederickson-Matika, D., Pritchard, L., Thorpe, P., Cock, P., Randall, E., Keillor, B. & Marzano, M., 23 Nov 2021, In: Forests. 12, 12, 22 p., 1617.

Research output: Contribution to journal › Article › peer-review

Open Access

File

23 Citations (Scopus)

43 Downloads (Pure)

Proposal for the creation of a new genus Musicola gen. nov., reclassification of Dickeya paradisiaca (Samson et al. 2005) as Musicola paradisiaca comb. nov. and description of a new species Musicola keenii sp. nov.

Hugouvieux-Cotte-Pattat, N., Jacot-des-Combes, C., Briolay, J. & Pritchard, L., 7 Oct 2021, In: International Journal of Systematic and Evolutionary Microbiology. 71, 10, 48 p., 005037.

Research output: Contribution to journal › Article › peer-review

Open Access

File

15 Citations (Scopus)

68 Downloads (Pure)

genomeRxiv: a microbial whole-genome database for classification, identification, and data sharing

Pritchard, L., Harrington, B., Irber, L., Mazloom, R., Pierce, T., Sharma, P., Heath, L., Brown, C. T. & Vinatzer, B., 6 Apr 2021. 1 p.

Research output: Contribution to conference › Poster

Open Access

File

36 Downloads (Pure)

Intraspecies-Resolution Metabarcoding: automated primer design and a plant pathology case study

Pritchard, L., Humphris, S., Campbell, E., Watts, L., Haynes, E., Pufal, H., Cahill, G., Davey, T., Elphinstone, J. & Toth, I., 6 Apr 2021. 1 p.

Research output: Contribution to conference › Poster

Open Access

File

23 Downloads (Pure)

cazy_webscraper: For creating a local CAZy database

Hobbs, E., Gloster, T., Chapman, S. & Pritchard, L., 4 Apr 2021.

Research output: Contribution to conference › Poster

Open Access

File

71 Downloads (Pure)

Comprehensive evaluation of CAZyme prediction tools in fungal and bacterial species

Hobbs, E., Gloster, T., Chapman, S. & Pritchard, L., 4 Apr 2021.

Research output: Contribution to conference › Poster

Open Access

File

87 Downloads (Pure)

Isolation, detection and characterization of Pectobacterium and Dickeya species

van der Wolf, J. M., Cahill, G., Van Gijsegem, F., Hélias, V., Humphris, S., Li, X., Lojkowska, E. & Pritchard, L., 5 Jan 2021, Plant Diseases Caused by Dickeya and Pectobacterium Species. Van Gijsegem, F., van der Wolf, J. & Toth, I. (eds.). Cham, Switzerland: Springer, p. 149-173 25 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access

File

10 Citations (Scopus)

111 Downloads (Pure)

2020

A high-throughput genomic screen identifies a role for the plasmid-borne type II secretion system of Escherichia coli O157:H7 (Sakai) in plant-microbe interactions

Holmes, A., Pritchard, L., Hedley, P. E., Morris, J., McAteer, S. P., Gally, D. L. & Holden, N. J., 30 Nov 2020, In: Genomics. 112, 6, p. 4242-4253 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

3 Citations (Scopus)

15 Downloads (Pure)

Dataset of Escherichia coli O157: H7 genes enriched in adherence to spinach root tissue

Holmes, A., Pritchard, L., Hedley, P., Morris, J., McAteer, S. P., Gally, D. L. & Holden, N. J., 31 Aug 2020, In: Data in Brief. 31, 5 p., 105769.

Research output: Contribution to journal › Article › peer-review

Open Access

File

16 Downloads (Pure)

Easily phylotyping E. coli via the EzClermont web app and command-line tool

Waters, N. R., Abram, F., Brennan, F., Holmes, A. & Pritchard, L., 19 Jun 2020, In: Access Microbiology . 2, 9, 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

75 Citations (Scopus)

38 Downloads (Pure)

A high-throughput genomic screen identifies a role for the plasmid-borne type II secretion system of Escherichia coli O157:H7 (Sakai) in plant-microbe interactions

Holmes, A., Pritchard, L., Hedley, P., Morris, J., McAteer, S. P., Gally, D. L. & Holden, N. J., 13 Apr 2020, Cold Spring Harbor, N.Y., 30 p.

Research output: Working paper

Open Access

File

23 Downloads (Pure)

Diversity of woody-host infecting Phytophthora species in public parks and botanic gardens as revealed by metabarcoding, and opportunities for mitigation through best practice

Green, S., Riddell, C. E., Frederickson-Matika, D., Armstrong, A., Elliot, M., Forster, J., Hedley, P. E., Morris, J., Thorpe, P., Cooke, D. E. L., Sharp, P. & Pritchard, L., 21 Feb 2020, In: Sibbaldia. 18, p. 67-88 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

25 Downloads (Pure)

Pectobacterium parvum sp. nov. having a Salmonella SPI-1-like Type III secretion system and low virulence

Pasanen, M., Waleron, M., Schott, T., Cleenwerk, I., Misztak, A., Waleron, K., Pritchard, L., Bakr, R., Degefu, Y., van der Wolf, J., Vandamme, P. & Pirhonen, M., 20 Feb 2020, In: International Journal of Systematic and Evolutionary Microbiology. 70, 4, p. 2440-2448 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

47 Citations (Scopus)

41 Downloads (Pure)

Corrigendum: Pectobacterium parvum sp. nov., having a salmonella SPI-1-like type iii secretion system and low virulence (Int J Syst Evol Microbiol, 2020, 10.1099/ijsem.0.004057)

Pasanen, M., Waleron, M., Schott, T., Cleenwerck, I., Misztak, A., Waleron, K., Pritchard, L., Bakr, R., Degefu, Y., van der Wolf, J., Vandamme, P. & Pirhonen, M., 1 Jan 2020, In: International Journal of Systematic and Evolutionary Microbiology. 70, 4, 1 p., 004111.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

File

3 Citations (Scopus)

27 Downloads (Pure)

2019

Easily phylotyping E. coli via the EzClermont web app and command-line tool

Waters, N. R., Abram, F., Brennan, F., Holmes, A. & Pritchard, L., 31 Dec 2019, Cold Spring Harbor, NY, 6 p.

Research output: Working paper

Open Access

File

65 Downloads (Pure)

Toward collaborative open data science in metabolomics using Jupyter Notebooks and cloud computing

Mendez, K. M., Pritchard, L., Reinke, S. N. & Broadhurst, D. I., 31 Oct 2019, In: Metabolomics. 15, 16 p., 125.

Research output: Contribution to journal › Article › peer-review

Open Access

File

55 Citations (Scopus)

80 Downloads (Pure)

find_differential_primers.py v0.1.4: automated discovery of diagnostic PCR or qPCR primers

Pritchard, L. (Developer) & McLeod, R. (Developer), 8 Oct 2019

Research output: Digital or non-textual outputs › Software

Open Access

We need to talk about metabarcoding: identification of Phytophthora species in environmental samples

Pritchard, L., Cock, P., Thorpe, P., Clark, B., Randall, E., Green, S. & Cooke, D., 9 Jul 2019. 1 p.

Research output: Contribution to conference › Poster

Open Access

File

24 Downloads (Pure)

Metabarcoding reveals a high diversity of woody host-associated Phytophthora spp. in soils at public gardens and amenity woodlands in Britain

Riddell, C. E., Frederickson-Matika, D., Armstrong, A. C., Elliot, M., Forster, J., Hedley, P. E., Morris, J., Thorpe, P., Cooke, D. E., Pritchard, L., Sharp, P. M. & Green, S., 16 May 2019, In: PeerJ. 7, 31 p., e6931.

Research output: Contribution to journal › Article › peer-review

Open Access

File

45 Citations (Scopus)

32 Downloads (Pure)

pyani v0.2.8: average nucleotide identity (ANI) and related measures for whole genome comparisons

Pritchard, L., Cock, P. (Developer) & Esen, Ö. (Developer), 5 Mar 2019

Research output: Digital or non-textual outputs › Software

Open Access

2018

Toward assessing farm-based anaerobic digestate public health risks: comparative investigation with slurry, effect of pasteurization treatments, and use of miniature bioreactors as proxies for pathogen spiking trials

Nolan, S., Waters, N. R., Brennan, F., Auer, A., Fenton, O., Richards, K., Bolton, D. J., Pritchard, L., O'Flaherty, V. & Abram, F., 20 Jul 2018, In: Frontiers in Sustainable Food Systems. 2, 11 p., 41.

Research output: Contribution to journal › Article › peer-review

Open Access

File

19 Citations (Scopus)

33 Downloads (Pure)

Absence of curli in soil-persistent Escherichia coli is mediated by a C-di-GMP signaling defect and suggests evidence of biofilm-independent niche specialization

Somorin, Y. M., Vollmerhausen, T., Waters, N., Pritchard, L., Abram, F., Brennan, F. & O'Byrne, C., 22 Jun 2018, In: Frontiers in Microbiology. 9, 13 p., 1340.

Research output: Contribution to journal › Article › peer-review

Open Access

File

4 Citations (Scopus)

26 Downloads (Pure)

riboSeed: leveraging prokaryotic genomic architecture to assemble across ribosomal regions

Waters, N. R., Abram, F., Brennan, F., Holmes, A. & Pritchard, L., 20 Jun 2018, In: Nucleic Acids Research. 46, 11, 10 p., e68.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

39 Downloads (Pure)

2017

Metagenomic analysis of the gut microbiome of the common black slug arion ater in search of novel lignocellulose degrading enzymes

Joynson, R., Pritchard, L., Osemwekha, E. & Ferry, N., 8 Nov 2017, In: Frontiers in Microbiology. 8, 11 p., 2181.

Research output: Contribution to journal › Article › peer-review

Open Access

File

36 Citations (Scopus)

15 Downloads (Pure)

Whole-genome bacterial classification: whole genome taxonomic reclassification and a universal prokaryotic identifier scheme

Pritchard, L., 4 Apr 2017. 1 p.

Research output: Contribution to conference › Poster

Open Access

File

31 Downloads (Pure)

2016

Genomics and taxonomy in diagnostics for food security: soft-rotting enterobacterial plant pathogens

Pritchard, L., Glover, R. H., Humphris, S., Elphinstone, J. G. & Toth, I. K., 7 Jan 2016, In: Analytical Methods. 8, 1, p. 12-24 13 p.

Research output: Contribution to journal › Review article › peer-review

965 Citations (Scopus)

2015

Why genomics research on pectobacterium and dickeya makes a difference

Toth, I., Humphris, S., Campbell, E. & Pritchard, L., 12 Mar 2015, In: American Journal of Potato Research. 92, 2, p. 218-222 5 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Epidemiology of Dickeya dianthicola and Dickeya solani in ornamental hosts and potato studied using variable number tandem repeat analysis

Parkinson, N., Pritchard, L., Bryant, R., Toth, I. & Elphinstone, J., 31 Jan 2015, In: European Journal of Plant Pathology. 141, 1, p. 63-70 8 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Detection of the bacterial potato pathogens pectobacterium and dickeya spp. using conventional and real-time PCR

Humphris, S. N., Cahill, G., Elphinstone, J. G., Kelly, R., Parkinson, N. M., Pritchard, L., Toth, I. K. & Saddler, G. S., 1 Jan 2015, In: Methods in Molecular Biology. 1302, p. 1-16 17 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

2014

The zigzag model of plant-microbe interactions: is it time to move on?

Pritchard, L. & Birch, P. R. J., 9 Nov 2014, (E-pub ahead of print) In: Molecular Plant Pathology. 15, 9, p. 865-870 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Citations (Scopus)

Galaxy as a platform for identifying candidate pathogen effectors

Cock, P. J. A. & Pritchard, L., 19 Mar 2014, Plant-Pathogen Interactions: Methods and Protocols. Birch, P., Jones, J. T. & Bos, J. I. B. (eds.). 2nd ed. New York: Springer, p. 3-15 13 p. (Methods in Molecular Biology; vol. 1127).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Citations (Scopus)

On the statistics of identifying candidate pathogen effectors

Pritchard, L. & Broadhurst, D., 19 Mar 2014, Plant-Pathogen Interactions: Methods and Protocols. Birch, P., Jones, J. T. & Bos, J. I. B. (eds.). 2nd ed. New York: Springer, p. 53-64 12 p. (Methods in Molecular Biology; vol. 1127).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Citations (Scopus)

Leighton Pritchard

Research output

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