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Personal Statement

My research group develops optoelectronic devices to interface with neural systems in an effort to understand aspects of neural processing. We collaborate closely with leading neuroscientists and develop high-end technology using advanced semiconductor processing techniques.

Optogenetics: This technique allows neurons to be optically controlled (both activated and suppressed) and has become part of the toolkit allowing neuroscientists to further understanding of the brain. We develop novel photonic devices that allow spatio-temporal control over neural circuits by integrating micron-scale light sources (μLEDs) on to minimally invasive neural probes. These probes can optically excite neurons with laminar specificity and integrated microelectrodes can record the subsequent neural activity.

We work closely with neuroscientist, Dr Shuzo Sakata, who tests these probes in vivo. The work is summarised in the following publication: http://www.nature.com/articles/srep28381

The combination of high-density electrophysiological recordings with genetic manipulation techniques has the potential to make important discoveries in the field of neuroscience.

Microelectrode Arrays: We have developed high-density microelectrode arrays for the recording of extracellular signals from retinal tissue. This state-of-the-art system is being used to study retinal processing and encoding of dynamic visual images at Stanford University (Chichilnisky Lab) and retinal development in the mouse at the University of California Santa Cruz (Sher Lab).

An example research output from this project is detailed in the  Nature publication (doi:10.1038/nature09424) where the system was used to study colour processing in the retina. It required close collaboration between technology groups at the University of Strathclyde, the University of California Santa Cruz (Litke & Sher), AGH University, Krakow (Dabrowski & Hottowy) and neuroscientists at Stanford (Chichilnisky).

Retinal Prosthesis: We collaborate closely with the group of Prof. Daniel Palanker (Stanford) on the development of an optoelectronic retinal prosthesis to restore sight to patients with degenerative retinal diseases. Here we fabricate an implantable silicon chip that captures the visual scene through near infrared image projection, which also remotely powers the wireless device. A research driver for this project is the development of a device that can restore detailed vision to patients through a minmally invasive implant. For more information see the following publications: Nature Photonics  (doi:10.1038/nphoton.2012.104) and Nature Medicine (doi: doi:10.1038/nm.3851).

 

Keywords

  • Neurophotonics
  • Microelectrode arrays
  • Optogenetics

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Projects 2009 2022

Research Output 1998 2018

Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons

Flores, T., Lei, X., Huang, T., Lorach, H., Dalal, R., Galambos, L., Kamins, T., Mathieson, K. & Palanker, D., 30 Jun 2018, In : Journal of Neural Engineering. 15, 3, 13 p., 036011

Research output: Contribution to journalArticle

Prostheses and Implants
Electrodes
Neurons
Electric Capacitance
Miniaturization

Large scale matching of function to the genetic identity of retinal ganglion cells

Pisano, F., Zampaglione, E., McAlinden, N., Roebber, J., Dawson, M. D., Mathieson, K. & Sher, A., 13 Nov 2017, In : Scientific Reports. 7, 1, 12 p., 15395

Research output: Contribution to journalArticle

Open Access
File
recording
cells
neurology
spiking
gene expression

Thesis

Advanced technologies for spatio-temporal control of neural circuits using optogenetics

Author: Pisano, F., 1 Jul 2016

Supervisor: Mathieson, K. (Supervisor) & Riis, E. (Supervisor)

Student thesis: Doctoral Thesis

Microfabrication of high-density optoelectronic devices for optogenetic studies of neural tissue

Author: Scharf, R., 1 Jan 2016

Supervisor: Mathieson, K. (Supervisor) & Riis, E. (Supervisor)

Student thesis: Doctoral Thesis

Activities 2009 2017

External examiner for "Nanokick"

Mathieson, K. (External Examiner)
12 Jan 2017

Activity: Examination

University of Utah Bioengineering Seminar

Mathieson, K. (Invited speaker)
16 Nov 2016

Activity: Talk or presentationInvited talk