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Personal profile

Personal Statement

Senior Research associate - Cell signalling and Pharmacology.

I have been a researcher in the field of cell signalling and Pharmacology for over fourteen years specialising in the area of G-protein coupled receptors. My research area covers understanding the molecular mechanisims of GPCR signalling in the proccesses that underpin inflammation, with an emphasis on targert validation and drug discovery.  

I had the privilege of being part of a group which was one of the first to recognise the biological relevance of PAR2, developed one of the first PAR2 knockout models and indeed my research career started within the Ferrell and Lockhart group, who along with my current group, have forged a world lead in the area of chronic inflammation (arthritis). 

In addition to my PAR2 work I have recently developed a new area of research, investigating the role of CXCL12 in breast cancer, with a view to the development of novel CXCL12 inhibitors. Currently research focuses on inhibition of the CXCL12 receptor - CXCR4, however there has been limited success due to issues with side effects, toxicity and off target effects. Targerting the chemokine directly is a novel approach which will by pass many of the unwanted side effects evident with the CXCR4 inhibitors.

 

Teaching Interests

I was awarded my PG Cert in teaching, learning and assesment in 2016 where I also become a recognised fellow of the higher education academy.

I have since 2014 taught the PP904 compulsory PhD class on abstract writing, poster presentation and presentation skills. I have alos been actively involved in the organisation of the CPU summer school run here in SIPBS. I have delivered lectures to the undergraduate 3rd year Biomedical cohort - Drugs and disease 3 class.

Currently I am actively teaching and the course co-ordinater for the PP904 class, I am teaching on the BM937, BM906 and MP961 all Master level courses with the latter linked to my Masters of research project student. I am also teaching/assessing the BM432, 4th year honours cohort from the Biomedical degree.

Education/Academic qualification

Doctor of Science, University of Paisley

1 Oct 200430 Sep 2008

Fingerprint Dive into the research topics where Kathryn McIntosh is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Proteinase-Activated Receptors Medicine & Life Sciences
PAR-2 Receptor Medicine & Life Sciences
Arthritis Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
seryl-leucyl-isoleucyl--glycyl-lysyl-valine Medicine & Life Sciences
Mitogen-Activated Protein Kinase Phosphatases Medicine & Life Sciences
Membranes Chemical Compounds
Purinergic Receptors Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2022

Research Output 2007 2019

Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis

Schroeder, J., Ross, K., McIntosh, K., Jabbar, S. K. J., Woods, S., Crowe, J., Patterson-Kane, J. C., Alexander, J., Lawrence, C. & Plevin, R., 11 Jan 2019, 5, 1, p. e000711 9 p., e000711.

Research output: Contribution to journalArticle

Open Access
File
Mitogen-Activated Protein Kinase Phosphatases
Protein Phosphatase 2
Mitogen-Activated Protein Kinase 1
Phosphoric Monoester Hydrolases
Arthritis

Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells

Ng, P. Y., McIntosh, K. A., Hargrave, G., Ho, K. H., Paul, A. & Plevin, R., 30 Nov 2018, In : Cellular Signalling. 51, p. 59-71 13 p.

Research output: Contribution to journalArticle

Open Access
File
Purinergic Receptors
JNK Mitogen-Activated Protein Kinases
Endothelial Cells
Cytokines
Adenine Nucleotides

Prizes

Court Medal

Kathryn McIntosh (Recipient), 25 Jun 2003

Prize: Prize (including medals and awards)

student