Projects per year
Senior Research Fellow - Cell signalling and Pharmacology.
I have been a researcher in the field of cell signalling and Pharmacology for over sixteen years specialising in the area of G-protein coupled receptors. My research area covers understanding the molecular mechanisims of GPCR signalling in the proccesses that underpin inflammation, with an emphasis on targert validation and drug discovery.
I had the privilege of being part of a group which was one of the first to recognise the biological relevance of PAR2, developed one of the first PAR2 knockout models and indeed my research career started within the Ferrell and Lockhart group, who along with my current group, have forged a world lead in the area of chronic inflammation (arthritis).
In addition to my PAR2 work I have recently developed a new area of research, investigating the role of CXCL12 in breast cancer, with a view to the development of novel CXCL12 inhibitors. Currently research focuses on inhibition of the CXCL12 receptor - CXCR4, however there has been limited success due to issues with side effects, toxicity and off target effects. Targerting the chemokine directly is a novel approach which will by pass many of the unwanted side effects evident with the CXCR4 inhibitors.
I was awarded my PG Cert in teaching, learning and assesment in 2016 where I also become a recognised fellow of the higher education academy.
I have since 2014 taught the PP904 compulsory PhD class on abstract writing, poster presentation and presentation skills. I have also been actively involved in the organisation of the CPU summer school run here in SIPBS. I have delivered lectures to the undergraduate 3rd year Biomedical cohort - Drugs and disease 3 class.
Currently I am actively teaching and the course co-ordinater for the PP904 class, I am teaching on the BM937, BM906 and MP961 all Master level courses with the latter linked to my Masters of research project student. I am also teaching/assessing the BM432, 4th year honours cohort from the Biomedical degree.
Doctor of Science, University of Paisley
1 Oct 2004 → 30 Sep 2008
Award Date: 30 Sep 2008
Preventing the damaging effects of cancer chemotherapy and radiation treatment on human endothelial cells targeting the JNK pathway
1/04/19 → 31/03/22
Project: Research - Studentship
Ross, K., McIntosh, K., Jabbar, S. K. J., Woods, S., Crowe, J., Patterson-Kane, J. C., Alexander, J., Lawrence, C. & Plevin, R., 11 Jan 2019, In : RMD Open. 5, 1, p. e000711 9 p., e000711.
Research output: Contribution to journal › ArticleOpen AccessFile16 Downloads (Pure)
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cellsNg, P. Y., McIntosh, K. A., Hargrave, G., Ho, K. H., Paul, A. & Plevin, R., 30 Nov 2018, In : Cellular Signalling. 51, p. 59-71 13 p.
Research output: Contribution to journal › ArticleOpen AccessFile3 Citations (Scopus)12 Downloads (Pure)