Projects per year
Personal profile
Personal Statement
Immunopharmacology lecturer and research scientist- Cell signalling and inflammation.
I have been a researcher in the field of immuno-pharmacology in relation to cell signalling and inflammation since 2004, specialising in the area of cell signalling in inflammation and G-protein coupled receptors.
My research area covers:
1) The cellular mechanisms underlying the inflammatory environment linked to breast cancer progression, with an emphasis on CXCL12 and the NFkB pathway.
2) understanding the molecular mechanisims of PAR2 signalling in the proccesses that underpin inflammation (focus on arthritis), with an emphasis on targert validation and drug discovery.
3) Understanding the molecular mechanisms that underpin IKK-alpha signalling in inflammation and cancer.
Recent preliminary projects have taken me in the direction of CXCL12 signalling in breast cancer, where I have uncovered a link between the non-canonical NFkB pathway and CXCL12 production in cancer cell lines. With the aid of first in class novel IKKa inhibitors I am in an excellent position to investigate this further. In the lab we also have several 'hit compounds' from a SULSA screen which target CXCL12 transcriptional activity, this will allow further drug discovery/evaluation work in this area. Targeting the chemokine directly is a novel approach which will by pass many of the unwanted side effects evident with inhibition of its target receptor - CXCR4.
I had the privilege of being part of a group which was one of the first to recognise the biological relevance of PAR2, developed one of the first PAR2 knockout models and indeed my research career started within the Ferrell and Lockhart group, who along with my current group, have forged a world lead in the area of chronic inflammation (arthritis).
I teach across all years in the biomedical sciences programme, with an even split across both Pharmacology and Immunology. I also coordinate and teach the Advanced Masters programme in Pharmacology, along with key PGR lead modules within the department.
I am the year 4 BMS coordinator.
Research Interests
Current Collaborators:
CXCL12-IKKa project = Professor Valerie Speirs (University of Aberdeen) and Dr Craig Jamieson (UoS)
PAR2-Osteoarthrits project = Dr Anne Crilly (University of the West of Scotland), and Dr Craig Jamieson (UoS).
IKK-alpha signalling project = Prof Robin Plevin (UoS).
Teaching Interests
I was awarded my PG Cert in teaching, learning and assesment in 2016 where I also become a recognised fellow of the higher education academy.
I have since 2014 taught and more recently co-ordinated the PP904 compulsory PhD class on abstract writing, poster presentation and presentation skills. I was also actively involved in the organisation of the CPU summer school run here in SIPBS.
I am module co-ordinator and teach on both year 3 and year 4 Pharmacology semester One classes, I also coordinate and teach on the MSc Advanced Pharmacology module. I also coordinate year 2 Introduction to Immunology.
I am teaching Pharmacology across years 2-4 and at Masters level and Immunology across years 2-3. I am actively involved in research with both Honours and Masters level students in the lab to complete wet lab projects. I am also part of the BMS accreditation team and leading the redesign of the critical analysis projects at Masters level. I am currently involved with the redesign of the Introductory content for Immunology.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Science, PAR2 mediated inhibition of TNF driven JNK signalling, University of Paisley
1 Oct 2004 → 30 Sept 2008
Award Date: 30 Sept 2008
External positions
Consultant , UNIVERSITY OF THE WEST OF SCOTLAND
21 Sept 2023 → …
Keywords
- Cellular signalling
- Research methodology
- receptors
- inflammation
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Collaborations and top research areas from the last five years
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Development of novel PAR2 antagonists to treat inflammatory disease
McIntosh, K. (Principal Investigator)
5/02/23 → 29/08/27
Project: Research
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Developing novel inhibitors to prevent the induction of CXCL12 in breast cancer fibroblasts cells
McIntosh, K. (Principal Investigator)
28/01/23 → 29/01/28
Project: Internally funded project
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IL-1β stimulates a novel axis within the NFκB pathway in endothelial cells regulated by IKKα and TAK-1
Craig, R., McIntosh, K., Ho, K. H., McCulloch, A., Riley, C., Lawson, C., MacKay, S. P., Paul, A., Coats, P. & Plevin, R., 28 Feb 2025, In: Biochemical Pharmacology. 232, 15 p., 116736.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Design and synthesis of novel aminoindazole-pyrrolo[2,3-b]pyridine inhibitors of IKKα that selectively perturb cellular non-canonical NF-κB signalling
Riley, C., Ammar, U., Alsfouk, A., Anthony, N. G., Baiget, J., Berretta, G., Breen, D., Huggan, J., Lawson, C., McIntosh, K., Plevin, R., Suckling, C. J., Young, L. C., Paul, A. & Mackay, S. P., 26 Jul 2024, In: Molecules. 29, 15, 29 p., 3515.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)34 Downloads (Pure)
Prizes
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Fellow of the Higher Education Academy
McIntosh, K. (Recipient), 10 Oct 2016
Prize: Fellowship awarded competitively
Activities
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Frontiers in Immunology (Journal)
McIntosh, K. (Peer reviewer)
5 Jul 2024Activity: Publication peer-review and editorial work types › Journal peer review
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Advanced Immunology course by university of Strathclyde, Glasgow
McIntosh, K. (Recipient)
6 Feb 2024Activity: Public Engagement and Outreach › Media Participation