Projects per year
Personal profile
Personal Statement
Research fellow - Cell signalling and Pharmacology.
I have been a researcher in the field of cell signalling and Pharmacology for over fourteen years specialising in the area of G-protein coupled receptors. My research area covers understanding the molecular mechanisims of GPCR signalling in the proccesses that underpin inflammation, with an emphasis on targert validation and drug discovery.
I had the privilege of being part of a group which was one of the first to recognise the biological relevance of PAR2, developed one of the first PAR2 knockout models and indeed my research career started within the Ferrell and Lockhart group, who along with my current group, have forged a world lead in the area of chronic inflammation (arthritis).
Education/Academic qualification
Doctor of Science, University of Paisley
1 Oct 2004 → 30 Sep 2008
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Network
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Projects 2014 2020
Inhibition of human CXCL12 expression by novel inhibitory kappa B kinase alpha compounds - a novel approach for new drug development in breast cancer
8/10/18 → 1/01/20
Project: Internally funded project › Research (Internally Allocated)
Preclinical validation of novel PAR-2 inhibitors for the treatment of Osteoarthritis and Cancer
1/02/14 → 30/09/15
Project: Research
Research Output 2007 2019
- 10 Article
Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis
Schroeder, J., Ross, K., McIntosh, K., Jabbar, S. K. J., Woods, S., Crowe, J., Patterson-Kane, J. C., Alexander, J., Lawrence, C. & Plevin, R., 11 Jan 2019, 5, 1, p. e000711 9 p., e000711.Research output: Contribution to journal › Article
Open Access
File
Mitogen-Activated Protein Kinase Phosphatases
Protein Phosphatase 2
Mitogen-Activated Protein Kinase 1
Phosphoric Monoester Hydrolases
Arthritis
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
Ng, P. Y., McIntosh, K. A., Hargrave, G., Ho, K. H., Paul, A. & Plevin, R., 30 Nov 2018, In : Cellular Signalling. 51, p. 59-71 13 p.Research output: Contribution to journal › Article
Purinergic Receptors
JNK Mitogen-Activated Protein Kinases
Endothelial Cells
Cytokines
Adenine Nucleotides
Prizes
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