Projects per year
Personal profile
Personal Statement
Immunopharmacology lecturer and research scientist- Cell signalling and inflammation.
I have been a researcher in the field of immunopharmacology in relation to cell signalling and inflammation for over seventeen years specialising in the area of cell signalling in inflammation and G-protein coupled receptors.
My research area covers:
1) The cellular mechanisms underlying the inflammatory environment linked to breast cancer progression, with an emphasis on CXCL12 and the NFkB pathway.
2) understanding the molecular mechanisims of PAR2 signalling in the proccesses that underpin inflammation (focus on arthritis), with an emphasis on targert validation and drug discovery.
Recent preliminary projects have taken me in the direction of CXCL12 signalling in breast cancer, where I have uncovered a link between the non-canonical NFkB pathway and CXCL12 production in cancer cell lines. With the aid of first in class novel IKKa inhibitors we are in an excellent position to investigate this further. We also have several 'hit compounds' from a SULSA screen which target CXCL12 transcriptional activity, this will allow further drug discovery/evaluation work in this area. Targeting the chemokine directly is a novel approach which will by pass many of the unwanted side effects evident with inhibition of its target receptor - CXCR4.
I had the privilege of being part of a group which was one of the first to recognise the biological relevance of PAR2, developed one of the first PAR2 knockout models and indeed my research career started within the Ferrell and Lockhart group, who along with my current group, have forged a world lead in the area of chronic inflammation (arthritis).
Research Interests
Current Collaborators:
CXCL12-IKKa project = Professor Valerie Speirs (University of Aberdeen) and Dr Craig Jamieson (UoS)
PAR2-Osteoarthrits project = Professor Robin Plevin (UoS), Dr Anne Crilly (University of the West of Scotland), Dr Craig Jamieson (UoS) and Dr Zahra Rattray (UoS)
Teaching Interests
I was awarded my PG Cert in teaching, learning and assesment in 2016 where I also become a recognised fellow of the higher education academy.
I have since 2014 taught the PP904 compulsory PhD class on abstract writing, poster presentation and presentation skills. I have also been actively involved in the organisation of the CPU summer school run here in SIPBS. I have delivered lectures to the undergraduate 3rd year Biomedical cohort - Drugs and disease 3 class.
Currently I am actively teaching and the course co-ordinater for the PP904 class, I am teaching on the BM937, BM906 and MP961 all Master level courses with the latter linked to my Masters of research project student. I am also teaching/assessing the BM432, 4th year honours cohort from the Biomedical degree.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Science, PAR2 mediated inhibition of TNF driven JNK signalling, University of Paisley
1 Oct 2004 → 30 Sept 2008
Award Date: 30 Sept 2008
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Network
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Developing novel inhibitors to prevent the induction of CXCL12 in breast cancer fibroblasts cells
28/01/22 → 29/01/26
Project: Internally funded project
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Preventing the damaging effects of cancer chemotherapy and radiation treatment on human endothelial cells targeting the JNK pathway
Plevin, R., Boyd, M. & McIntosh, K.
1/04/19 → 31/08/23
Project: Research - Studentship
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IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
McIntosh, K., Khalaf, Y. H., Craig, R., West, C., McCulloch, A., Waghmare, A., Lawson, C., Chan, E. Y. W., MacKay, S., Paul, A. & Plevin, R., 31 Jul 2023, In: Cellular Signalling. 107, 11 p., 110684.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
The development of proteinase-activated receptor-2 modulators and the challenges involved
McIntosh, K. A., Cunningham, M. R., Bushell, T. & Plevin, R., 31 Dec 2020, In: Biochemical Society Transactions. 48, 6, p. 2525-2537 13 p., BST20200191.Research output: Contribution to journal › Review article › peer-review
Open AccessFile15 Citations (Scopus)139 Downloads (Pure)
Prizes
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Fellow of the Higher Education Academy
McIntosh, Kathryn (Recipient), 10 Oct 2016
Prize: Fellowship awarded competitively