Projects per year
Personal profile
Personal Statement
Research fellow - Cell signalling and Pharmacology.
I have been a researcher in the field of cell signalling and Pharmacology for over fourteen years specialising in the area of G-protein coupled receptors. My research area covers understanding the molecular mechanisims of GPCR signalling in the proccesses that underpin inflammation, with an emphasis on targert validation and drug discovery.
I had the privilege of being part of a group which was one of the first to recognise the biological relevance of PAR2, developed one of the first PAR2 knockout models and indeed my research career started within the Ferrell and Lockhart group, who along with my current group, have forged a world lead in the area of chronic inflammation (arthritis).
Education/Academic qualification
Doctor of Science, University of Paisley
1 Oct 2004 → 30 Sep 2008
Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2018 2020
- 1 Active
Inhibition of human CXCL12 expression by novel inhibitory kappa B kinase alpha compounds - a novel approach for new drug development in breast cancer
8/10/18 → 1/01/20
Project: Internally funded project › Research (Internally Allocated)
Research Output 2007 2018
- 9 Article
Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells
Ng, P. Y., McIntosh, K. A., Hargrave, G., Ho, K. H., Paul, A. & Plevin, R., 30 Nov 2018, In : Cellular Signalling. 51, p. 59-71 13 p.Research output: Contribution to journal › Article
Purinergic Receptors
JNK Mitogen-Activated Protein Kinases
Endothelial Cells
Cytokines
Adenine Nucleotides
Inhibitory Kappa B kinase α (IKKα) inhibitors that recapitulate their selectivity in cells against isoform-related biomarkers
Anthony, N. G. , Baiget, J. , Berretta, G. , Boyd, M. , Breen, D. , Edwards, J. , Gamble, C. , Gray, A. I. , Harvey, A. L. , Hatziieremia, S. , Ho, K. H. , Huggan, J. K. , Lang, S. , Llona-Minguez, S. , Luo, J. L. , McIntosh, K. , Paul, A. , Plevin, R. J. , Robertson, M. N. , Scott, R. & 4 others , 24 Jul 2017, In : Journal of Medicinal Chemistry. 60, 16, p. 7043-7066 24 p.Research output: Contribution to journal › Article
Open Access
File
Protein Isoforms
Phosphotransferases
Biomarkers
NF-kappa B
Phosphorylation
Prizes
student